IE67062B1 - Taste masking and sustained release coatings for pharmaceuticals - Google Patents
Taste masking and sustained release coatings for pharmaceuticalsInfo
- Publication number
- IE67062B1 IE67062B1 IE175291A IE175291A IE67062B1 IE 67062 B1 IE67062 B1 IE 67062B1 IE 175291 A IE175291 A IE 175291A IE 175291 A IE175291 A IE 175291A IE 67062 B1 IE67062 B1 IE 67062B1
- Authority
- IE
- Ireland
- Prior art keywords
- medicament
- coated
- granules
- coating
- ibuprofen
- Prior art date
Links
- 239000003814 drug Substances 0.000 title claims abstract description 82
- 238000000576 coating method Methods 0.000 title claims abstract description 55
- 238000013268 sustained release Methods 0.000 title abstract description 14
- 239000012730 sustained-release form Substances 0.000 title abstract description 14
- 230000000873 masking effect Effects 0.000 title description 14
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- 239000008187 granular material Substances 0.000 claims abstract description 35
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- 238000000034 method Methods 0.000 claims abstract description 31
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- 239000000203 mixture Substances 0.000 claims abstract description 16
- 230000008569 process Effects 0.000 claims abstract description 8
- 229920000642 polymer Polymers 0.000 claims description 42
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- 229960001680 ibuprofen Drugs 0.000 claims description 23
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims description 22
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- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 3
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- 239000000546 pharmaceutical excipient Substances 0.000 claims description 3
- 230000000202 analgesic effect Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 claims 2
- OQGJIIKXRSCRNW-PXRPMCEGSA-N (1s,2s)-2-(methylamino)-1-phenylpropan-1-ol;2-[4-(2-methylpropyl)phenyl]propanoic acid Chemical compound CN[C@@H](C)[C@@H](O)C1=CC=CC=C1.CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 OQGJIIKXRSCRNW-PXRPMCEGSA-N 0.000 claims 1
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- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 3
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- 241000167854 Bourreria succulenta Species 0.000 description 1
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- HEFNNWSXXWATRW-SNVBAGLBSA-N levibuprofen Chemical compound CC(C)CC1=CC=C([C@@H](C)C(O)=O)C=C1 HEFNNWSXXWATRW-SNVBAGLBSA-N 0.000 description 1
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- PTTPUWGBPLLBKW-UHFFFAOYSA-M sodium;2-[4-(2-methylpropyl)phenyl]propanoate Chemical group [Na+].CC(C)CC1=CC=C(C(C)C([O-])=O)C=C1 PTTPUWGBPLLBKW-UHFFFAOYSA-M 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical group [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/528,003 US5075114A (en) | 1990-05-23 | 1990-05-23 | Taste masking and sustained release coatings for pharmaceuticals |
| IN325CA1991 IN172428B (enExample) | 1990-05-23 | 1991-04-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE911752A1 IE911752A1 (en) | 1991-12-04 |
| IE67062B1 true IE67062B1 (en) | 1996-02-21 |
Family
ID=26324259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE175291A IE67062B1 (en) | 1990-05-23 | 1991-05-22 | Taste masking and sustained release coatings for pharmaceuticals |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5075114A (enExample) |
| EP (1) | EP0459695B1 (enExample) |
| JP (1) | JP3157190B2 (enExample) |
| AU (1) | AU639334B2 (enExample) |
| CA (1) | CA2042289C (enExample) |
| ES (1) | ES2073677T3 (enExample) |
| GR (1) | GR1002092B (enExample) |
| IE (1) | IE67062B1 (enExample) |
| IN (1) | IN172428B (enExample) |
| NZ (1) | NZ238131A (enExample) |
| PT (1) | PT97739B (enExample) |
Families Citing this family (151)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5460825A (en) * | 1990-05-23 | 1995-10-24 | Mcneil-Ppc, Inc. | Taste mask coatings for preparing chewable pharmaceutical tablets |
| ES2056470T3 (es) * | 1990-07-02 | 1994-10-01 | Boehringer Mannheim Gmbh | Proceso para la obtencion de dosis unitarias de liberacion retardada, prensadas en molde, y las dosis unitarias correspondientes. |
| WO1992015332A1 (en) * | 1991-03-04 | 1992-09-17 | Warner-Lambert Company | Novel salts/ion pairs of non-steroidal anti-inflammatory drugs in various dosage forms |
| CA2107229C (en) * | 1991-04-30 | 1997-07-22 | Thomas A. Wheatley | Taste-masked medicaments and their preparation |
| CA2079934C (en) * | 1991-10-15 | 2002-09-03 | Edward J. Roche | Taste mask coatings for preparing chewable pharmaceutical tablets |
| GR1002332B (el) * | 1992-05-21 | 1996-05-16 | Mcneil-Ppc Inc. | Νεες φαρμακευτικες συνθεσεις που περιεχουν σιμεθεικονη. |
| EP0572731A1 (en) * | 1992-06-01 | 1993-12-08 | The Procter & Gamble Company | Chewable preparation containing a decongestant |
| US5837277A (en) * | 1992-06-04 | 1998-11-17 | Smithkline Beecham Corporation | Palatable pharmaceutical compositions |
| ATE217789T1 (de) * | 1992-06-04 | 2002-06-15 | Smithkline Beecham Corp | Angenehm schmeckende pharmazeutische zusammensetzungen |
| GB9221414D0 (en) * | 1992-10-13 | 1992-11-25 | Glaxo Group Ltd | Pharmaceutical compositions |
| MX9306393A (es) * | 1992-10-16 | 1994-04-29 | Glaxo Group Ltd | Composiciones de ranitidina substancialmente libres de sabor amargo, proceso para su preparacion y composiciones farmaceuticas que las contienen. |
| EP0670716B1 (en) * | 1992-11-30 | 2003-03-26 | Kv Pharmaceutical Company | Tastemasked pharmaceutical materials |
| CA2110313C (en) * | 1992-12-01 | 2004-10-26 | Edward John Roche | Pharmaceutical compositions containing a guanidinothiazole compound and antacids |
| US6313202B1 (en) * | 1993-05-28 | 2001-11-06 | Eastman Chemical Company | Cellulose ester blends |
| US5631023A (en) * | 1993-07-09 | 1997-05-20 | R.P. Scherer Corporation | Method for making freeze dried drug dosage forms |
| CA2128820A1 (en) * | 1993-07-27 | 1995-01-28 | Walter G. Gowan, Jr. | Rapidly disintegrating pharmaceutical dosage form and process for preparation thereof |
| CA2128821A1 (en) * | 1993-07-27 | 1995-01-28 | Dilip J. Gole | Freeze-dried pharmaceutical dosage form and process for separation thereof |
| US5622980A (en) * | 1993-08-17 | 1997-04-22 | Applied Analytical Industries, Inc. | Oral compositions of H2-antagonists |
| HUT72408A (en) * | 1993-09-10 | 1996-04-29 | Egyt Gyogyszervegyeszeti Gyar | Process for producing tablets containing acetyl-salicylic acid |
| US5536505A (en) * | 1993-12-15 | 1996-07-16 | Eastman Chemical Company | Controlled release matrix system using cellulose acetate/poly-2-ethyl-2-oxazoline blends |
| US5470865A (en) * | 1994-08-30 | 1995-11-28 | Eli Lilly And Company | Pharmaceutical composition |
| US5529783A (en) * | 1994-12-19 | 1996-06-25 | Mcneil-Ppc, Inc. | Rotor granulation and coating of acetaminophen, pseudoephedrine, chlorpheniramine, and, optionally dextromethorphan |
| AUPN605795A0 (en) * | 1995-10-19 | 1995-11-09 | F.H. Faulding & Co. Limited | Analgesic pharmaceutical composition |
| US8071128B2 (en) | 1996-06-14 | 2011-12-06 | Kyowa Hakko Kirin Co., Ltd. | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
| EP0942752B1 (en) | 1996-08-23 | 2005-04-20 | Algos Pharmaceutical Corporation | Anticonvulsant containing composition for treating neuropathic pain |
| AU722289B2 (en) * | 1996-10-01 | 2000-07-27 | Aptalis Pharmatech, Inc. | Taste-masked microcapsule compositions and methods of manufacture |
| JP3001440B2 (ja) * | 1996-11-25 | 2000-01-24 | 日本電気通信システム株式会社 | 仮想ｌａｎ方式 |
| US5904937A (en) * | 1997-10-03 | 1999-05-18 | Fmc Corporation | Taste masked pharmaceutical compositions |
| UA65607C2 (uk) | 1998-03-04 | 2004-04-15 | Орто-Макнейл Фармацевтикал, Інк. | Фармацевтична композиція (варіанти) та спосіб її приготування |
| US6270790B1 (en) | 1998-08-18 | 2001-08-07 | Mxneil-Ppc, Inc. | Soft, convex shaped chewable tablets having reduced friability |
| BR9916361A (pt) * | 1998-12-18 | 2002-11-05 | Abbott Lab | Forma de dosagem de tabletes de liberação controlada, formulação de tablete de liberação controlada, composição granular para prensagem em uma forma de dosagem de tablete de liberação controlada, e, métodos para preparar uma composição granular, para preparar uma forma de dosagem de tabletes de liberação controlada de divalproex sódio e para tratar epilepsia |
| US6270807B1 (en) | 1999-03-02 | 2001-08-07 | L. Perrigo Company | Taste-masked pharmaceutical composition |
| US6211246B1 (en) | 1999-06-10 | 2001-04-03 | Mcneil-Ppc, Inc. | Rapidly absorbed liquid compositions |
| US6428809B1 (en) * | 1999-08-18 | 2002-08-06 | Microdose Technologies, Inc. | Metering and packaging of controlled release medication |
| US6451345B1 (en) | 2000-01-20 | 2002-09-17 | Eurand Pharmaceuticals Ltd. | Functional coating of linezolid microcapsules for taste-masking and associated formulation for oral administration |
| US20020119196A1 (en) * | 2000-12-21 | 2002-08-29 | Narendra Parikh | Texture masked particles containing an active ingredient |
| US20020122823A1 (en) * | 2000-12-29 | 2002-09-05 | Bunick Frank J. | Soft tablet containing dextrose monohydrate |
| EP1390015A1 (en) * | 2001-05-31 | 2004-02-25 | Cima Labs Inc. | Taste-masking of highly water-soluble drugs |
| GB0113839D0 (en) * | 2001-06-07 | 2001-08-01 | Boots Co Plc | Therapeutic agents |
| US7914811B2 (en) | 2001-06-29 | 2011-03-29 | Mcneil-Ppc, Inc. | Brittle-coating, soft core dosage form |
| US20030060422A1 (en) | 2001-08-31 | 2003-03-27 | Balaji Venkataraman | Tannate compositions and methods of treatment |
| US6982094B2 (en) | 2001-09-28 | 2006-01-03 | Mcneil-Ppc, Inc. | Systems, methods and apparatuses for manufacturing dosage forms |
| US6742646B2 (en) * | 2001-09-28 | 2004-06-01 | Mcneil-Ppc, Inc. | Systems, methods and apparatuses for manufacturing dosage forms |
| US7217381B2 (en) * | 2001-09-28 | 2007-05-15 | Mcneil-Ppc, Inc. | Systems, methods and apparatuses for manufacturing dosage forms |
| WO2003026626A2 (en) * | 2001-09-28 | 2003-04-03 | Mcneil-Ppc, Inc. | Modified release dosage forms |
| US7122143B2 (en) | 2001-09-28 | 2006-10-17 | Mcneil-Ppc, Inc. | Methods for manufacturing dosage forms |
| US7101573B2 (en) * | 2001-09-28 | 2006-09-05 | Mcneil-Pcc, Inc. | Simethicone solid oral dosage form |
| US7838026B2 (en) | 2001-09-28 | 2010-11-23 | Mcneil-Ppc, Inc. | Burst-release polymer composition and dosage forms comprising the same |
| US7323192B2 (en) | 2001-09-28 | 2008-01-29 | Mcneil-Ppc, Inc. | Immediate release tablet |
| US6837696B2 (en) * | 2001-09-28 | 2005-01-04 | Mcneil-Ppc, Inc. | Apparatus for manufacturing dosage forms |
| US6767200B2 (en) * | 2001-09-28 | 2004-07-27 | Mcneil-Ppc, Inc. | Systems, methods and apparatuses for manufacturing dosage forms |
| US9358214B2 (en) | 2001-10-04 | 2016-06-07 | Adare Pharmaceuticals, Inc. | Timed, sustained release systems for propranolol |
| US6723348B2 (en) * | 2001-11-16 | 2004-04-20 | Ethypharm | Orodispersible tablets containing fexofenadine |
| US6753009B2 (en) | 2002-03-13 | 2004-06-22 | Mcneil-Ppc, Inc. | Soft tablet containing high molecular weight polyethylene oxide |
| US7169450B2 (en) * | 2002-05-15 | 2007-01-30 | Mcneil-Ppc, Inc. | Enrobed core |
| US20040081695A1 (en) * | 2002-09-28 | 2004-04-29 | Sowden Harry S | Dosage forms having an inner core and an outer shell |
| US7807197B2 (en) | 2002-09-28 | 2010-10-05 | Mcneil-Ppc, Inc. | Composite dosage forms having an inlaid portion |
| US20040109889A1 (en) * | 2002-12-04 | 2004-06-10 | Bunick Frank J. | Surface treatment composition for soft substrates |
| US8367111B2 (en) | 2002-12-31 | 2013-02-05 | Aptalis Pharmatech, Inc. | Extended release dosage forms of propranolol hydrochloride |
| US20040258752A1 (en) * | 2003-01-31 | 2004-12-23 | Paruthi Manoj Kumar | Taste masking pharmaceutical composition and process for its preparation |
| US20040265373A1 (en) * | 2003-06-27 | 2004-12-30 | David Wynn | Soft tablet containing high molecular weight cellulosics |
| US20040265372A1 (en) * | 2003-06-27 | 2004-12-30 | David Wynn | Soft tablet containing high molecular weight cellulosics |
| US7632521B2 (en) | 2003-07-15 | 2009-12-15 | Eurand, Inc. | Controlled release potassium chloride tablets |
| JP2007501810A (ja) * | 2003-08-11 | 2007-02-01 | メルク フロスト カナダ リミテツド | 一段階被覆法を用いて作製された着香味遮蔽製薬製剤 |
| US20050069590A1 (en) * | 2003-09-30 | 2005-03-31 | Buehler Gail K. | Stable suspensions for medicinal dosages |
| US20050074514A1 (en) * | 2003-10-02 | 2005-04-07 | Anderson Oliver B. | Zero cycle molding systems, methods and apparatuses for manufacturing dosage forms |
| US20050175689A1 (en) * | 2003-10-27 | 2005-08-11 | Yamanouchi Pharmaceutical Co., Ltd. | Coated fine particles containing drug for intrabuccally fast disintegrating tablet |
| CA2543454A1 (en) * | 2003-10-27 | 2005-05-06 | Astellas Pharma Inc. | Drug-containing coated microparticles for quick-disintegrating oral tablets |
| US7201920B2 (en) | 2003-11-26 | 2007-04-10 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of opioid containing dosage forms |
| JP5168711B2 (ja) * | 2004-03-25 | 2013-03-27 | アステラス製薬株式会社 | ソリフェナシンまたはその塩の固形製剤用組成物 |
| US8545881B2 (en) * | 2004-04-19 | 2013-10-01 | Eurand Pharmaceuticals, Ltd. | Orally disintegrating tablets and methods of manufacture |
| US8747895B2 (en) | 2004-09-13 | 2014-06-10 | Aptalis Pharmatech, Inc. | Orally disintegrating tablets of atomoxetine |
| US9884014B2 (en) | 2004-10-12 | 2018-02-06 | Adare Pharmaceuticals, Inc. | Taste-masked pharmaceutical compositions |
| NZ589750A (en) | 2004-10-21 | 2012-07-27 | Aptalis Pharmatech Inc | Taste-masked pharmaceutical compositions with gastrosoluble pore-formers |
| US20060087051A1 (en) * | 2004-10-27 | 2006-04-27 | Bunick Frank J | Dosage forms having a microreliefed surface and methods and apparatus for their production |
| US20060088593A1 (en) * | 2004-10-27 | 2006-04-27 | Bunick Frank J | Dosage forms having a microreliefed surface and methods and apparatus for their production |
| US20060088587A1 (en) * | 2004-10-27 | 2006-04-27 | Bunick Frank J | Dosage forms having a microreliefed surface and methods and apparatus for their production |
| US20060088586A1 (en) * | 2004-10-27 | 2006-04-27 | Bunick Frank J | Dosage forms having a microreliefed surface and methods and apparatus for their production |
| US20070190133A1 (en) * | 2004-10-27 | 2007-08-16 | Bunick Frank J | Dosage forms having a microreliefed surface and methods and apparatus for their production |
| US8383159B2 (en) * | 2004-10-27 | 2013-02-26 | Mcneil-Ppc, Inc. | Dosage forms having a microreliefed surface and methods and apparatus for their production |
| US20070281022A1 (en) * | 2004-10-27 | 2007-12-06 | Bunick Frank J | Dosage forms having a microreliefed surface and methods and apparatus for their production |
| WO2006070735A1 (ja) * | 2004-12-27 | 2006-07-06 | Astellas Pharma Inc. | ソリフェナシンまたはその塩の安定な粒子状医薬組成物 |
| US8673352B2 (en) | 2005-04-15 | 2014-03-18 | Mcneil-Ppc, Inc. | Modified release dosage form |
| US9161918B2 (en) | 2005-05-02 | 2015-10-20 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
| US7815939B2 (en) * | 2005-07-20 | 2010-10-19 | Astellas Pharma Inc. | Coated fine particles containing drug for intrabuccally fast disintegrating dosage forms |
| CA2616012A1 (en) * | 2005-07-20 | 2007-01-25 | Astellas Pharma Inc. | Drug-containing coated fine particle for intrabuccally disintegrating preparation and method of producing the same |
| US8778395B2 (en) | 2005-08-11 | 2014-07-15 | Andrx Labs, Llc | Diltiazem controlled release formulation and method of manufacture |
| US20070077300A1 (en) * | 2005-09-30 | 2007-04-05 | Wynn David W | Oral compositions containing a salivation inducing agent |
| KR20090009214A (ko) * | 2006-03-28 | 2009-01-22 | 맥네일-피피씨, 인코포레이티드 | 불균일 투여형 피복물 |
| US20070286903A1 (en) * | 2006-06-13 | 2007-12-13 | Becicka Brian T | Composition and method for taste masking |
| WO2008008801A2 (en) * | 2006-07-11 | 2008-01-17 | Mcneil Nutritionals, Llc | Solid oral dosage vitamin and mineral compositions |
| AU2007309281B2 (en) | 2006-10-20 | 2013-10-31 | Johnson & Johnson Consumer Inc. | Acetaminophen / ibuprofen combinations |
| US20080194307A1 (en) * | 2007-02-13 | 2008-08-14 | Jeff Sanger | Sports-based game of chance |
| GB2447898B (en) * | 2007-03-24 | 2011-08-17 | Reckitt Benckiser Healthcare | A tablet having improved stability with at least two actives |
| WO2008154178A1 (en) * | 2007-06-06 | 2008-12-18 | Novus International Inc. | Dietary supplements for promotion of growth, repair, and maintenance of bone and joints |
| US20090004248A1 (en) * | 2007-06-29 | 2009-01-01 | Frank Bunick | Dual portion dosage lozenge form |
| US20090074866A1 (en) * | 2007-09-17 | 2009-03-19 | Jen-Chi Chen | Dip coated compositions containing copolymer of polyvinyl alcohol and polyethylene glycol and a gum |
| US8439033B2 (en) | 2007-10-09 | 2013-05-14 | Microdose Therapeutx, Inc. | Inhalation device |
| AU2008318851B2 (en) | 2007-10-31 | 2014-04-17 | Mcneil-Ppc, Inc. | Orally disintegrated dosage form |
| US8357395B2 (en) * | 2007-12-21 | 2013-01-22 | Mcneil-Ppc, Inc. | Manufacture of tablet |
| ES2384305T3 (es) * | 2008-02-19 | 2012-07-03 | Mcneil-Ppc, Inc. | Composiciones de revestimiento por inmersión que contienen un almidón con elevado contenido de amilosa |
| AU2009223061B2 (en) | 2008-03-11 | 2014-10-09 | Depomed Inc. | Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic |
| US8372432B2 (en) | 2008-03-11 | 2013-02-12 | Depomed, Inc. | Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic |
| CA2729015A1 (en) * | 2008-06-26 | 2009-12-30 | Mcneil-Ppc, Inc. | Coated particles containing pharmaceutically active agents |
| AU2009268640A1 (en) | 2008-07-08 | 2010-01-14 | Hyperbranch Medical Technology, Inc. | Self-contained medical applicators for multiple component formulations, and methods of use thereof |
| AU2009279521A1 (en) * | 2008-08-08 | 2010-02-11 | Mcneil-Ppc, Inc. | Use of sucralose as a granulating agent |
| WO2010051312A1 (en) * | 2008-10-31 | 2010-05-06 | Mcneil-Ppc, Inc. | Osmotic tablet with a compressed outer coating |
| US20100247586A1 (en) * | 2009-03-27 | 2010-09-30 | Andreas Hugerth | Multi-Portion Intra-Oral Dosage Form With Organoleptic Properties |
| RU2715680C2 (ru) * | 2009-06-22 | 2020-03-03 | ВАЙЕТ ЭлЭлСи | Таблетки ибупрофена натрия и способы изготовления фармацевтических композиций, включающих ибупрофен натрия |
| WO2011002702A1 (en) | 2009-06-29 | 2011-01-06 | Mcneil-Ppc, Inc. | Pharmaceutical tablet containing a liquid filled capsule |
| US8858210B2 (en) | 2009-09-24 | 2014-10-14 | Mcneil-Ppc, Inc. | Manufacture of variable density dosage forms utilizing radiofrequency energy |
| WO2012039788A1 (en) | 2010-09-22 | 2012-03-29 | Mcneil-Ppc, Inc. | Multi-layered orally disintegrating tablet and the manufacture thereof |
| US8313768B2 (en) | 2009-09-24 | 2012-11-20 | Mcneil-Ppc, Inc. | Manufacture of tablet having immediate release region and sustained release region |
| US8871263B2 (en) | 2009-09-24 | 2014-10-28 | Mcneil-Ppc, Inc. | Manufacture of tablet in a die utilizing radiofrequency energy and meltable binder |
| US20110077222A1 (en) * | 2009-09-30 | 2011-03-31 | Mallinckrodt Inc. | Sustained-Release Opiate and Opiate Derivative Compositions |
| US8901113B2 (en) | 2009-09-30 | 2014-12-02 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse |
| SG10201407965XA (en) | 2009-12-02 | 2015-02-27 | Aptalis Pharma Ltd | Fexofenadine microcapsules and compositions containing them |
| US20110150989A1 (en) * | 2009-12-22 | 2011-06-23 | Mallinkckrodt Inc. | Methods of Producing Stabilized Solid Dosage Pharmaceutical Compositions Containing Morphinans |
| WO2011087765A2 (en) | 2009-12-22 | 2011-07-21 | Mallinckrodt Inc. | Methods of producing stabilized solid pharmaceutical compositions containing morphinans |
| US9198861B2 (en) | 2009-12-22 | 2015-12-01 | Mallinckrodt Llc | Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans |
| US8597681B2 (en) | 2009-12-22 | 2013-12-03 | Mallinckrodt Llc | Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans |
| EP2521584B1 (en) | 2010-01-05 | 2018-10-17 | MicroDose Therapeutx, Inc. | Inhalation device |
| KR20130106399A (ko) | 2010-09-22 | 2013-09-27 | 맥네일-피피씨, 인코포레이티드 | 에너지가 가해진 분말 블렌드로부터의 정제의 제조 |
| US8741885B1 (en) | 2011-05-17 | 2014-06-03 | Mallinckrodt Llc | Gastric retentive extended release pharmaceutical compositions |
| US8858963B1 (en) | 2011-05-17 | 2014-10-14 | Mallinckrodt Llc | Tamper resistant composition comprising hydrocodone and acetaminophen for rapid onset and extended duration of analgesia |
| US9050335B1 (en) | 2011-05-17 | 2015-06-09 | Mallinckrodt Llc | Pharmaceutical compositions for extended release of oxycodone and acetaminophen resulting in a quick onset and prolonged period of analgesia |
| US9233491B2 (en) | 2012-05-01 | 2016-01-12 | Johnson & Johnson Consumer Inc. | Machine for production of solid dosage forms |
| US9445971B2 (en) | 2012-05-01 | 2016-09-20 | Johnson & Johnson Consumer Inc. | Method of manufacturing solid dosage form |
| US9511028B2 (en) | 2012-05-01 | 2016-12-06 | Johnson & Johnson Consumer Inc. | Orally disintegrating tablet |
| US20130295174A1 (en) | 2012-05-01 | 2013-11-07 | Mcneil-Ppc, Inc. | Tablet comprising a first and second region |
| ES2691982T3 (es) | 2012-11-30 | 2018-11-29 | Acura Pharmaceuticals, Inc. | Liberación autorregulada de un principio activo farmacéutico |
| EP3091966B1 (en) | 2014-01-10 | 2019-07-31 | Johnson & Johnson Consumer Inc. | Process for making tablet using radiofrequency and lossy coated particles |
| US9616029B2 (en) | 2014-03-26 | 2017-04-11 | Sun Pharma Advanced Research Company Ltd. | Abuse deterrent immediate release coated reservoir solid dosage form |
| US20150328162A1 (en) * | 2014-05-15 | 2015-11-19 | Mario Medri | Pharmaceutical preparations |
| EP2952103B1 (de) * | 2014-06-05 | 2019-05-08 | Symrise AG | Stoffgemische |
| MA40859A (fr) | 2014-10-29 | 2017-09-05 | Johnson & Johnson Consumer Inc | Particules de cadotril |
| WO2017040607A1 (en) | 2015-08-31 | 2017-03-09 | Acura Pharmaceuticals, Inc. | Methods and compositions for self-regulated release of active pharmaceutical ingredient |
| JP6812104B2 (ja) * | 2015-12-28 | 2021-01-13 | エスエス製薬株式会社 | 経口固形組成物 |
| CA3044867A1 (en) | 2016-11-28 | 2018-05-31 | Gerard P. Mcnally | Process for making a coated dosage form |
| US10493026B2 (en) | 2017-03-20 | 2019-12-03 | Johnson & Johnson Consumer Inc. | Process for making tablet using radiofrequency and lossy coated particles |
| US10500155B2 (en) | 2017-05-22 | 2019-12-10 | Johnson & Johnson Consumer Inc. | Lozenge dosage form having a disintegrative tablet portion and a candy glass shell portion |
| EP3703516A4 (en) | 2017-11-02 | 2021-08-18 | BioVentures, LLC | USE OF AMINO ACID SUPPLEMENTATION FOR IMPROVED MUSCLE PROTEIN SYNTHESIS |
| US20190166878A1 (en) | 2017-12-06 | 2019-06-06 | Nutriquest, Llc | Feed additive compositions |
| JP7582869B2 (ja) | 2018-05-18 | 2024-11-13 | アナベックス ライフ サイエンス コーポレイション | レスポンダ選択および治療の最適化されたｓｉｇｍａ－１アゴニスト方法 |
| MX2021003944A (es) | 2018-10-05 | 2021-07-16 | Isp Investments Llc | Composicion del recubrimiento de pelicula liso alto en solidos que comprende eter de celulosa soluble en agua, proceso para la preparacion de este y metodo de uso del mismo. |
| WO2020171069A1 (ja) * | 2019-02-20 | 2020-08-27 | サントリーホールディングス株式会社 | タンパク質含有経口組成物及びタンパク質含有経口組成物の風味改善方法 |
| GB2604052A (en) | 2019-09-19 | 2022-08-24 | Univ Texas Tech System | Swine maternal neonatal pheromone |
| EP4046751B1 (fr) | 2021-02-22 | 2026-02-11 | Comadur S.A. | Procédé de fabrication d'un outil de coupe avec orifices de lubrification de formes complexes et outil de coupe avec des orifices de lubrification de formes complexes |
| WO2023115066A1 (en) | 2021-12-17 | 2023-06-22 | Elanco Us Inc. | Methods of improving the nutritional status of immune stressed animals |
| KR20250159205A (ko) | 2023-03-03 | 2025-11-10 | 그래즈 이노베이션 | 지방산의 강화된 대사성 산화를 위한 조성물 |
| WO2024223532A1 (en) | 2023-04-28 | 2024-10-31 | Behrooz Kasraee | A dietary supplement combination and use thereof for improving muscle performance |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK150008C (da) * | 1981-11-20 | 1987-05-25 | Benzon As Alfred | Fremgangsmaade til fremstilling af et farmaceutisk oralt polydepotpraeparat |
| US4643892A (en) * | 1983-07-20 | 1987-02-17 | Warner-Lambert Company | Magnesium trisilicate suitable for preparation of medicament adsorbates of analgesics |
| US4894233A (en) * | 1984-10-05 | 1990-01-16 | Sharma Shri C | Novel drug delivery system for decongestants |
| IE58110B1 (en) * | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| GB8618811D0 (en) * | 1986-08-01 | 1986-09-10 | Approved Prescription Services | Sustained release ibuprofen formulation |
| US4800087A (en) * | 1986-11-24 | 1989-01-24 | Mehta Atul M | Taste-masked pharmaceutical compositions |
| US4835187A (en) * | 1987-06-15 | 1989-05-30 | American Home Products Corporation | Spray dried ibuprofen |
| US4915949A (en) * | 1987-07-13 | 1990-04-10 | Alza Corporation | Dispenser with movable matrix comprising a plurality of tiny pills |
| US4915953A (en) * | 1987-09-03 | 1990-04-10 | Alza Corporation | Dosage form for delivering acetaminophen or phenylpropanolamine |
| US4837031A (en) * | 1987-09-17 | 1989-06-06 | Mallinckrodt, Inc. | Compositions containing ibuprofen |
| US4851226A (en) * | 1987-11-16 | 1989-07-25 | Mcneil Consumer Products Company | Chewable medicament tablet containing means for taste masking |
| NZ226822A (en) * | 1987-11-16 | 1990-03-27 | Mcneil Consumer Prod | Chewable medicament tablet containing means for taste masking |
| US4835188A (en) * | 1987-12-08 | 1989-05-30 | American Home Products Corporation | Spray dried ibuprofen |
-
1990
- 1990-05-23 US US07/528,003 patent/US5075114A/en not_active Expired - Lifetime
-
1991
- 1991-04-29 IN IN325CA1991 patent/IN172428B/en unknown
- 1991-05-10 CA CA002042289A patent/CA2042289C/en not_active Expired - Lifetime
- 1991-05-10 GR GR910100204A patent/GR1002092B/el not_active IP Right Cessation
- 1991-05-13 NZ NZ238131A patent/NZ238131A/en unknown
- 1991-05-21 JP JP14418391A patent/JP3157190B2/ja not_active Expired - Lifetime
- 1991-05-21 AU AU77234/91A patent/AU639334B2/en not_active Expired
- 1991-05-22 PT PT97739A patent/PT97739B/pt not_active IP Right Cessation
- 1991-05-22 IE IE175291A patent/IE67062B1/en not_active IP Right Cessation
- 1991-05-22 EP EP91304631A patent/EP0459695B1/en not_active Expired - Lifetime
- 1991-05-22 ES ES91304631T patent/ES2073677T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH06316536A (ja) | 1994-11-15 |
| CA2042289C (en) | 1998-12-08 |
| JP3157190B2 (ja) | 2001-04-16 |
| EP0459695A1 (en) | 1991-12-04 |
| GR1002092B (en) | 1995-12-28 |
| US5075114A (en) | 1991-12-24 |
| NZ238131A (en) | 1992-09-25 |
| IE911752A1 (en) | 1991-12-04 |
| PT97739B (pt) | 1998-10-30 |
| ES2073677T3 (es) | 1995-08-16 |
| CA2042289A1 (en) | 1991-11-24 |
| AU639334B2 (en) | 1993-07-22 |
| AU7723491A (en) | 1991-11-28 |
| PT97739A (pt) | 1992-03-31 |
| EP0459695B1 (en) | 1995-03-15 |
| GR910100204A (el) | 1992-07-30 |
| IN172428B (enExample) | 1993-07-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK9A | Patent expired |