IE60328B1 - Improvements in the treatment of tumors in mammals - Google Patents
Improvements in the treatment of tumors in mammalsInfo
- Publication number
- IE60328B1 IE60328B1 IE303885A IE303885A IE60328B1 IE 60328 B1 IE60328 B1 IE 60328B1 IE 303885 A IE303885 A IE 303885A IE 303885 A IE303885 A IE 303885A IE 60328 B1 IE60328 B1 IE 60328B1
- Authority
- IE
- Ireland
- Prior art keywords
- compound
- formula
- amino
- desoxy
- difluororibose
- Prior art date
Links
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- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
- 125000000025 triisopropylsilyl group Chemical group C(C)(C)[Si](C(C)C)(C(C)C)* 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- MDTPTXSNPBAUHX-UHFFFAOYSA-M trimethylsulfanium;hydroxide Chemical compound [OH-].C[S+](C)C MDTPTXSNPBAUHX-UHFFFAOYSA-M 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical class OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- 150000003738 xylenes Chemical class 0.000 description 1
- 150000003741 xylose derivatives Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67778384A | 1984-12-04 | 1984-12-04 | |
| US78641985A | 1985-10-10 | 1985-10-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE853038L IE853038L (en) | 1986-06-04 |
| IE60328B1 true IE60328B1 (en) | 1994-06-29 |
Family
ID=27101898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE303885A IE60328B1 (en) | 1984-12-04 | 1985-12-03 | Improvements in the treatment of tumors in mammals |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5464826A (https=) |
| EP (1) | EP0184365B1 (https=) |
| JP (1) | JPH0637394B2 (https=) |
| KR (2) | KR890003439B1 (https=) |
| CN (1) | CN1020194C (https=) |
| AT (1) | ATE92499T1 (https=) |
| AU (1) | AU581269B2 (https=) |
| CA (1) | CA1264738A (https=) |
| CY (1) | CY1806A (https=) |
| DE (1) | DE3587500T2 (https=) |
| DK (1) | DK162965C (https=) |
| EG (1) | EG17765A (https=) |
| ES (1) | ES8801546A1 (https=) |
| GR (1) | GR852858B (https=) |
| HK (1) | HK113693A (https=) |
| HU (1) | HU194273B (https=) |
| IE (1) | IE60328B1 (https=) |
| IL (1) | IL77133A (https=) |
| NZ (1) | NZ214364A (https=) |
| PH (1) | PH23172A (https=) |
| PT (1) | PT81559B (https=) |
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| PT86377B (pt) * | 1986-12-24 | 1990-11-20 | Lilly Co Eli | Processo para a preparacao de conjugados de imunoglobulinas com um difluoronucleosideo acilado |
| US4994558A (en) * | 1986-12-24 | 1991-02-19 | Eli Lilly And Company | Immunoglobulin conjugates |
| US4965374A (en) * | 1987-08-28 | 1990-10-23 | Eli Lilly And Company | Process for and intermediates of 2',2'-difluoronucleosides |
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| US5223608A (en) * | 1987-08-28 | 1993-06-29 | Eli Lilly And Company | Process for and intermediates of 2',2'-difluoronucleosides |
| US4914028A (en) * | 1988-02-10 | 1990-04-03 | Eli Lilly And Company | Method of preparing beta-2',2'-difluoronucleosides |
| US5644043A (en) * | 1988-02-16 | 1997-07-01 | Eli Lilly And Company | 2',3'-dideoxy-2',2'-difluoronucleosides and intermediates |
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| JPH0232093A (ja) * | 1988-06-08 | 1990-02-01 | Merrell Dow Pharmaceut Inc | 抗レトロウィルスジフルオロ化ヌクレオシド類 |
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| US3705147A (en) * | 1969-08-22 | 1972-12-05 | Univ Utah | 3-deazapyrimidine nucleosides and method of preparation thereof |
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| JPS5136467A (en) * | 1974-09-20 | 1976-03-27 | Tanabe Seiyaku Co | 11 beetaa dd2** harogeno 2** deokishiribofuranoshirurashirujudotai no seiho |
| DE2628202A1 (de) * | 1976-06-23 | 1977-12-29 | Max Planck Gesellschaft | Verfahren zur herstellung von 2'-substituierten-d-ribofuranosylpurinderivaten |
| US4058602A (en) * | 1976-08-09 | 1977-11-15 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Synthesis, structure, and antitumor activity of 5,6-dihydro-5-azacytidine |
| US4211773A (en) * | 1978-10-02 | 1980-07-08 | Sloan Kettering Institute For Cancer Research | 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides |
| US4526988A (en) * | 1983-03-10 | 1985-07-02 | Eli Lilly And Company | Difluoro antivirals and intermediate therefor |
| ZA859008B (en) * | 1984-12-04 | 1987-07-29 | Lilly Co Eli | The treatment of tumors in mammals |
| CA1295998C (en) * | 1985-07-29 | 1992-02-18 | Sai P. Sunkara | Nucleosides and their use as antineoplastic agents |
| US4914028A (en) * | 1988-02-10 | 1990-04-03 | Eli Lilly And Company | Method of preparing beta-2',2'-difluoronucleosides |
| US4983724A (en) * | 1988-02-16 | 1991-01-08 | Eli Lilly And Company | Inversion of 2,2-difluororibose to a 2,2-difluoroxylose and intermediates therefor |
| JPH0232093A (ja) * | 1988-06-08 | 1990-02-01 | Merrell Dow Pharmaceut Inc | 抗レトロウィルスジフルオロ化ヌクレオシド類 |
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1985
- 1985-11-25 EP EP85308547A patent/EP0184365B1/en not_active Expired - Lifetime
- 1985-11-25 IL IL77133A patent/IL77133A/xx not_active IP Right Cessation
- 1985-11-25 CA CA000496077A patent/CA1264738A/en not_active Expired - Lifetime
- 1985-11-25 DE DE85308547T patent/DE3587500T2/de not_active Expired - Lifetime
- 1985-11-25 AT AT85308547T patent/ATE92499T1/de not_active IP Right Cessation
- 1985-11-26 PT PT81559A patent/PT81559B/pt unknown
- 1985-11-27 GR GR852858A patent/GR852858B/el unknown
- 1985-11-28 NZ NZ214364A patent/NZ214364A/xx unknown
- 1985-11-28 PH PH33109A patent/PH23172A/en unknown
- 1985-11-28 DK DK549685A patent/DK162965C/da not_active IP Right Cessation
- 1985-12-02 AU AU50555/85A patent/AU581269B2/en not_active Expired
- 1985-12-03 ES ES549547A patent/ES8801546A1/es not_active Expired
- 1985-12-03 JP JP60273161A patent/JPH0637394B2/ja not_active Expired - Lifetime
- 1985-12-03 EG EG771/85A patent/EG17765A/xx active
- 1985-12-03 KR KR1019850009042A patent/KR890003439B1/ko not_active Expired
- 1985-12-03 IE IE303885A patent/IE60328B1/en not_active IP Right Cessation
- 1985-12-03 CN CN85109409A patent/CN1020194C/zh not_active Expired - Lifetime
- 1985-12-03 HU HU854620A patent/HU194273B/hu unknown
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1989
- 1989-05-18 KR KR1019890006677A patent/KR890003426B1/ko not_active Expired
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1993
- 1993-10-21 HK HK1136/93A patent/HK113693A/en not_active IP Right Cessation
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1994
- 1994-07-26 US US08/280,687 patent/US5464826A/en not_active Expired - Lifetime
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| CN85109409A (zh) | 1986-08-27 |
| US5464826A (en) | 1995-11-07 |
| CY1806A (en) | 1995-09-08 |
| KR890003426B1 (ko) | 1989-09-20 |
| EP0184365B1 (en) | 1993-08-04 |
| AU581269B2 (en) | 1989-02-16 |
| PT81559B (pt) | 1988-03-03 |
| PH23172A (en) | 1989-05-19 |
| HUT39188A (en) | 1986-08-28 |
| EP0184365A3 (en) | 1988-01-27 |
| DK162965C (da) | 1992-06-01 |
| KR860004920A (ko) | 1986-07-16 |
| GR852858B (https=) | 1986-03-28 |
| JPS61148193A (ja) | 1986-07-05 |
| NZ214364A (en) | 1988-11-29 |
| PT81559A (en) | 1985-12-01 |
| EG17765A (en) | 1990-08-30 |
| IL77133A (en) | 1991-01-31 |
| CN1020194C (zh) | 1993-03-31 |
| ES8801546A1 (es) | 1987-08-01 |
| JPH0637394B2 (ja) | 1994-05-18 |
| ATE92499T1 (de) | 1993-08-15 |
| DK549685A (da) | 1986-06-05 |
| HU194273B (en) | 1988-01-28 |
| EP0184365A2 (en) | 1986-06-11 |
| ES549547A0 (es) | 1987-08-01 |
| CA1264738A (en) | 1990-01-23 |
| KR890003439B1 (ko) | 1989-09-21 |
| DK549685D0 (da) | 1985-11-28 |
| HK113693A (en) | 1993-10-29 |
| DE3587500T2 (de) | 1993-12-16 |
| DE3587500D1 (de) | 1993-09-09 |
| AU5055585A (en) | 1986-06-12 |
| DK162965B (da) | 1992-01-06 |
| IE853038L (en) | 1986-06-04 |
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