IE58277B1 - 1 , 25-dihydroxylated vitamin d2 compounds and intermediates in the preparation thereof - Google Patents

1 , 25-dihydroxylated vitamin d2 compounds and intermediates in the preparation thereof

Info

Publication number
IE58277B1
IE58277B1 IE114984A IE114984A IE58277B1 IE 58277 B1 IE58277 B1 IE 58277B1 IE 114984 A IE114984 A IE 114984A IE 114984 A IE114984 A IE 114984A IE 58277 B1 IE58277 B1 IE 58277B1
Authority
IE
Ireland
Prior art keywords
vitamin
compound
trans
dihydroxy
epi
Prior art date
Application number
IE114984A
Other languages
English (en)
Other versions
IE841149L (en
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Publication of IE841149L publication Critical patent/IE841149L/en
Publication of IE58277B1 publication Critical patent/IE58277B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Dram (AREA)
IE114984A 1983-05-09 1984-05-09 1 , 25-dihydroxylated vitamin d2 compounds and intermediates in the preparation thereof IE58277B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49286383A 1983-05-09 1983-05-09

Publications (2)

Publication Number Publication Date
IE841149L IE841149L (en) 1984-11-09
IE58277B1 true IE58277B1 (en) 1993-08-25

Family

ID=23957917

Family Applications (1)

Application Number Title Priority Date Filing Date
IE114984A IE58277B1 (en) 1983-05-09 1984-05-09 1 , 25-dihydroxylated vitamin d2 compounds and intermediates in the preparation thereof

Country Status (5)

Country Link
JP (1) JPS60501261A (enrdf_load_stackoverflow)
BE (1) BE899612A (enrdf_load_stackoverflow)
FR (1) FR2545824B1 (enrdf_load_stackoverflow)
GB (3) GB2139627B (enrdf_load_stackoverflow)
IE (1) IE58277B1 (enrdf_load_stackoverflow)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4769181A (en) * 1983-11-07 1988-09-06 Wisconsin Alumni Research Foundation 1,25-dihydroxyvitamin D2 compounds
JP2608322B2 (ja) * 1988-04-11 1997-05-07 日清製粉株式会社 １α，２５‐ジヒドロキシビタミンＤ▲下２▼類の製造法
US5260290A (en) * 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
US5030772A (en) * 1990-02-14 1991-07-09 Deluca Hector F Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives
US5571802A (en) * 1993-02-19 1996-11-05 Wisconsin Alumni Research Foundation Method of treating post menopausal osteoporosis with hexafluro-vitamin D
JP2002506429A (ja) * 1997-05-16 2002-02-26 ウィメン アンド インファンツ ホスピタル ３−エピビタミンｄ２化合物及びその使用法
WO1998051678A1 (en) 1997-05-16 1998-11-19 Women & Infants Hospital CYCLIC ETHER VITAMIN D3 COMPOUNDS, 1α (OH) 3-EPI-VITAMIN D3 COMPOUNDS AND USES THEREOF
WO2002030430A1 (en) * 2000-10-06 2002-04-18 Abbott Laboratories Use of vitamin d2 compounds for alopecia

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL188286C (nl) * 1978-01-16 1992-05-18 Wisconsin Alumni Res Found Werkwijze voor het bereiden van een 1alfa-hydroxyvitamine d verbinding.
US4195027A (en) * 1978-01-16 1980-03-25 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
US4267117A (en) * 1978-06-19 1981-05-12 The Upjohn Company Compounds and process
US4264513A (en) * 1979-05-21 1981-04-28 Wisconsin Alumni Research Foundation 1α-hydroxy-25-keto-27-nor-cholecalciferol and processes for preparing same

Also Published As

Publication number Publication date
FR2545824B1 (fr) 1987-11-20
JPH0364498B2 (enrdf_load_stackoverflow) 1991-10-07
GB2139627A (en) 1984-11-14
GB2158442A (en) 1985-11-13
GB2158443B (en) 1987-02-04
GB8411794D0 (en) 1984-06-13
GB2139627B (en) 1987-02-04
BE899612A (fr) 1984-08-31
JPS60501261A (ja) 1985-08-08
GB2158443A (en) 1985-11-13
IE841149L (en) 1984-11-09
GB8507474D0 (en) 1985-05-01
GB8507475D0 (en) 1985-05-01
GB2158442B (en) 1987-02-04
FR2545824A1 (fr) 1984-11-16

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Legal Events

Date Code Title Description
MM4A Patent lapsed