IE55818B1 - Pharmaceuticaly active n-acyl dipeptides - Google Patents

Pharmaceuticaly active n-acyl dipeptides

Info

Publication number
IE55818B1
IE55818B1 IE1655/83A IE165583A IE55818B1 IE 55818 B1 IE55818 B1 IE 55818B1 IE 1655/83 A IE1655/83 A IE 1655/83A IE 165583 A IE165583 A IE 165583A IE 55818 B1 IE55818 B1 IE 55818B1
Authority
IE
Ireland
Prior art keywords
hydrogen
lower alkyl
compound
carbons
methyl
Prior art date
Application number
IE1655/83A
Other languages
English (en)
Other versions
IE831655L (en
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Priority to IE109/87A priority Critical patent/IE55819B1/en
Priority to IE110/87A priority patent/IE55820B1/en
Publication of IE831655L publication Critical patent/IE831655L/xx
Publication of IE55818B1 publication Critical patent/IE55818B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
IE1655/83A 1982-07-19 1983-07-15 Pharmaceuticaly active n-acyl dipeptides IE55818B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IE109/87A IE55819B1 (en) 1982-07-19 1983-07-15 Substituted peptide compounds
IE110/87A IE55820B1 (en) 1982-07-19 1983-07-15 Substituted peptide compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39965082A 1982-07-19 1982-07-19

Publications (2)

Publication Number Publication Date
IE831655L IE831655L (en) 1984-01-19
IE55818B1 true IE55818B1 (en) 1991-01-30

Family

ID=23580391

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1655/83A IE55818B1 (en) 1982-07-19 1983-07-15 Pharmaceuticaly active n-acyl dipeptides

Country Status (21)

Country Link
JP (3) JPS5951246A (enrdf_load_stackoverflow)
KR (1) KR840005709A (enrdf_load_stackoverflow)
AU (1) AU1643283A (enrdf_load_stackoverflow)
BE (1) BE897327A (enrdf_load_stackoverflow)
CA (1) CA1244006A (enrdf_load_stackoverflow)
CH (1) CH659475A5 (enrdf_load_stackoverflow)
DE (1) DE3325850A1 (enrdf_load_stackoverflow)
DK (1) DK330683A (enrdf_load_stackoverflow)
ES (4) ES524200A0 (enrdf_load_stackoverflow)
FI (1) FI832620L (enrdf_load_stackoverflow)
FR (3) FR2530238B1 (enrdf_load_stackoverflow)
GB (1) GB2123834B (enrdf_load_stackoverflow)
GR (1) GR79602B (enrdf_load_stackoverflow)
HU (1) HU187090B (enrdf_load_stackoverflow)
IE (1) IE55818B1 (enrdf_load_stackoverflow)
IL (1) IL69136A0 (enrdf_load_stackoverflow)
IT (1) IT1163800B (enrdf_load_stackoverflow)
NL (1) NL8302562A (enrdf_load_stackoverflow)
PT (1) PT77045B (enrdf_load_stackoverflow)
SE (1) SE8304031L (enrdf_load_stackoverflow)
ZA (1) ZA834980B (enrdf_load_stackoverflow)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55159749A (en) * 1979-05-31 1980-12-12 Takeda Chem Ind Ltd Preparation of dried fish flesh
US4500518A (en) * 1984-04-19 1985-02-19 E. R. Squibb & Sons, Inc. Amino thiol dipeptides
EP0175266B1 (en) * 1984-09-12 1996-03-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antihypertensive derivatives
US4629724A (en) * 1984-12-03 1986-12-16 E. R. Squibb & Sons, Inc. Amino acid ester and amide renin inhibitors
FR2578544A1 (en) * 1985-03-11 1986-09-12 Usv Pharma Corp Antihypertension spirocyclic compounds
FI89058C (fi) * 1987-02-27 1993-08-10 Yamanouchi Pharma Co Ltd Foerfarande foer framstaellning av som remin-inhibitorer anvaenda 2-(l-alanyl-l-histidylamino)-butanol-derivat
EP1264707A3 (en) 2001-05-14 2004-05-19 Oji Paper Co., Ltd. Thermosensitive recording material and novel color developer compounds
WO2018130576A1 (en) 2017-01-10 2018-07-19 Mitsubishi Hitec Paper Europe Gmbh Novel colour developer for a thermo-sensitive recording medium, and a heat-sensitive recording material based on pla

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3751239A (en) * 1969-05-29 1973-08-07 Rohm & Haas Herbicidal compositions containing n-(1,1-dialkyl-3-chloroacetonyl) benzamides
JPS5430167A (en) * 1977-08-11 1979-03-06 Mitsubishi Chem Ind Ltd 4-aminomethyl-2-phenyloxazoles and their pharmaceutically acceptable acid salts
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
FR2480747A1 (fr) * 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique
IE51409B1 (en) * 1980-07-24 1986-12-24 Ici Ltd Amide derivatives
GR75019B (enrdf_load_stackoverflow) * 1980-09-17 1984-07-12 Univ Miami
ATE20469T1 (de) * 1980-10-23 1986-07-15 Schering Corp Carboxyalkyl-dipeptide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
CY1406A (en) * 1980-12-18 1988-04-22 Schering Corp Substituted dipeptides, processes for their preparation and pharmaceutical compositions containing them and their use in the inhibition of enkephalinase
US4514391A (en) * 1983-07-21 1985-04-30 E. R. Squibb & Sons, Inc. Hydroxy substituted peptide compounds

Also Published As

Publication number Publication date
CA1244006A (en) 1988-11-01
CH659475A5 (fr) 1987-01-30
GB2123834A (en) 1984-02-08
ES539084A0 (es) 1986-04-01
ES8707548A1 (es) 1986-05-16
PT77045B (en) 1986-02-12
JPH0532601A (ja) 1993-02-09
ES539083A0 (es) 1986-04-01
ES8707550A1 (es) 1986-04-01
IT8322114A0 (it) 1983-07-18
GR79602B (enrdf_load_stackoverflow) 1984-10-31
FR2540867A1 (fr) 1984-08-17
IT1163800B (it) 1987-04-08
JPH0526775B2 (enrdf_load_stackoverflow) 1993-04-19
SE8304031L (sv) 1984-03-30
FR2530238B1 (enrdf_load_stackoverflow) 1989-06-30
ES8504675A1 (es) 1985-04-16
DE3325850A1 (de) 1984-01-19
SE8304031D0 (sv) 1983-07-18
GB8318492D0 (en) 1983-08-10
JPS5951246A (ja) 1984-03-24
FR2540867B1 (fr) 1987-07-31
FI832620A0 (fi) 1983-07-19
KR840005709A (ko) 1984-11-16
DK330683A (da) 1984-01-20
ES539082A0 (es) 1986-05-16
FI832620A7 (fi) 1984-01-20
GB2123834B (en) 1986-10-22
HUT34040A (en) 1985-01-28
FI832620L (fi) 1984-01-20
PT77045A (en) 1983-08-01
ES524200A0 (es) 1985-04-16
AU1643283A (en) 1984-01-26
BE897327A (fr) 1984-01-19
IL69136A0 (en) 1983-10-31
IE831655L (en) 1984-01-19
JPH0517420A (ja) 1993-01-26
NL8302562A (nl) 1984-02-16
JPH0653713B2 (ja) 1994-07-20
DK330683D0 (da) 1983-07-18
JPH0645582B2 (ja) 1994-06-15
ES8707549A1 (es) 1986-04-01
ZA834980B (en) 1984-03-28
FR2540866A1 (fr) 1984-08-17
FR2530238A1 (enrdf_load_stackoverflow) 1984-01-20
HU187090B (en) 1985-11-28

Similar Documents

Publication Publication Date Title
CA1258948A (en) Hydroxy substituted peptide compounds
CA1282549C (en) Aminocarbonyl renin inhibitors
US4350704A (en) Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
AU595578B2 (en) N-heterocyclic alcohol renin inhibitors
CS237311B2 (en) Processing of carboxyalkyldipeptide
JPH08500081A (ja) ファルネシル蛋白質トランスフェラーゼの阻害剤
US5190922A (en) Terminally modified tri-, tetra- and pentapeptide anaphylatoxin receptor ligands
EP0618221A2 (en) Heterocyclic inhibitors of farnesyl protein transferase
EP0052991A1 (en) Carboxyalkyl amino acid derivatives of various substituted prolines
AU669432B2 (en) Guanidinyl- or amidinyl-substituted methylamino heterocyclic thrombin inhibitors
NZ193142A (en) Mercaptoacylpeptides and pharmaceutical compositions
JP3654908B2 (ja) Ｎｋ１およびｎｋ２アンタゴニストとしてのアシルアミノアルケニレン―アミド誘導体
JPS60136595A (ja) 置換エチレンジアミン誘導体、その製造方法及び該誘導体を含む医薬製剤
IE55818B1 (en) Pharmaceuticaly active n-acyl dipeptides
NZ211600A (en) Substituted ureido-amino and -imino acid derivatives and pharmaceutical compositions
JPS617295A (ja) メルカプトシクロアルキルカルボニルおよびメルカプトアリールカルボニルジペプチド類
EP0103496A1 (en) Acylalkylaminocarbonyl substituted amino and imino acid compounds
CA2012901A1 (en) Amino acid derivatives
HU185229B (en) Process for preparing pharmaceutically active peptides and acetates thereof
JPS6153298A (ja) アミノ酸誘導体
WO1990007521A1 (en) Renin inhibitors containing c-terminal dihydroxy amides
CA1285563C (en) Ureidoalkanoylaminocarbonyl amino and imino acids and esters
CA1310792C (en) N-heterocyclic alcohol renin inhibitors
IE65539B1 (en) Trifluoromethyl mercaptan and mercaptoacyl derivatives and method of using same
US4897483A (en) Amino acid derivatives as antihypertensives

Legal Events

Date Code Title Description
MM4A Patent lapsed