IE50892B1 - Process for preparing insulin esters - Google Patents

Process for preparing insulin esters

Info

Publication number
IE50892B1
IE50892B1 IE251/81A IE25181A IE50892B1 IE 50892 B1 IE50892 B1 IE 50892B1 IE 251/81 A IE251/81 A IE 251/81A IE 25181 A IE25181 A IE 25181A IE 50892 B1 IE50892 B1 IE 50892B1
Authority
IE
Ireland
Prior art keywords
gly
process according
insulin
ala
leu
Prior art date
Application number
IE251/81A
Other languages
English (en)
Other versions
IE810251L (en
Original Assignee
Novo Industri As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK57480A external-priority patent/DK147109C/da
Application filed by Novo Industri As filed Critical Novo Industri As
Publication of IE810251L publication Critical patent/IE810251L/xx
Publication of IE50892B1 publication Critical patent/IE50892B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IE251/81A 1980-02-11 1981-02-10 Process for preparing insulin esters IE50892B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK57480A DK147109C (da) 1980-02-11 1980-02-11 Fremgangsmaade til fremstilling af humant insulin eller humane insulinestere eller et salt eller kompleks deraf
DK366280 1980-08-28

Publications (2)

Publication Number Publication Date
IE810251L IE810251L (en) 1981-08-11
IE50892B1 true IE50892B1 (en) 1986-08-06

Family

ID=26064239

Family Applications (1)

Application Number Title Priority Date Filing Date
IE251/81A IE50892B1 (en) 1980-02-11 1981-02-10 Process for preparing insulin esters

Country Status (4)

Country Link
US (1) US4343898A (OSRAM)
AT (1) AT399881B (OSRAM)
FR (1) FR2475542B1 (OSRAM)
IE (1) IE50892B1 (OSRAM)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK319780A (da) * 1980-07-24 1982-01-25 Forenede Bryggerier As Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner
EP0088117B1 (en) * 1981-09-15 1986-09-24 Nordisk Insulinlaboratorium Process for preparing human insulin or b-30 esters thereof
DK353781A (da) * 1981-08-10 1983-02-11 Novo Industri As Fremgangsmaade til fremstilling af insulinderivater
NL8201650A (nl) * 1982-04-21 1983-11-16 Akzo Nv Semisynthetische bereiding van humane insuline.
US4528134A (en) * 1982-12-27 1985-07-09 University Of Tn Research Corporation Method of separating A14 -125 I-insulin from heterogeneously labeled insulin molecules for biological studies
DK58285D0 (da) * 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
DK257988D0 (da) * 1988-05-11 1988-05-11 Novo Industri As Nye peptider
DE3844211A1 (de) * 1988-12-29 1990-07-05 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
DK134189D0 (da) * 1989-03-20 1989-03-20 Nordisk Gentofte Insulinforbindelser
US5512459A (en) * 1993-07-20 1996-04-30 Bionebraska, Inc. Enzymatic method for modification or recombinant polypeptides
JP2001521004A (ja) 1997-10-24 2001-11-06 イーライ・リリー・アンド・カンパニー 脂肪酸−アシル化インスリン類似体
CO4970787A1 (es) * 1997-12-23 2000-11-07 Lilly Co Eli Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea
CA2392844A1 (en) 1999-12-29 2001-07-12 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
AR025646A1 (es) * 2000-09-13 2002-12-04 Beta Lab Sa Cepa de levaduras metilotroficas recombinantes productoras de un precursor de insulina, construcciones de adn y metodo para obtener la cepa.
US7396903B2 (en) * 2001-11-19 2008-07-08 Novo Nordisk A/S Process for preparing insulin compounds
RU2376379C2 (ru) 2001-11-19 2009-12-20 Ново Нордиск А/С Способ получения инсулиновых соединений
UA46667C2 (en) * 2001-12-29 2006-01-16 Omakooe Ltd Liability Company Method for preparing semisynthetic human insulin
PL2319500T3 (pl) * 2004-03-12 2013-05-31 Biodel Inc Szybko działające kompozycje do dostarczania leku
US20080248999A1 (en) * 2007-04-04 2008-10-09 Biodel Inc. Amylin formulations
US20080090753A1 (en) 2004-03-12 2008-04-17 Biodel, Inc. Rapid Acting Injectable Insulin Compositions
US20080096800A1 (en) * 2004-03-12 2008-04-24 Biodel, Inc. Rapid mucosal gel or film insulin compositions
US20080085298A1 (en) * 2004-03-12 2008-04-10 Biodel, Inc. Rapid Mucosal Gel or Film Insulin Compositions
CN101166545B (zh) 2005-05-13 2011-06-15 伊莱利利公司 Glp-1聚乙二醇化的化合物
US7977454B2 (en) * 2005-07-08 2011-07-12 Biocon Limited Preparation of insulin conjugates
US7713929B2 (en) * 2006-04-12 2010-05-11 Biodel Inc. Rapid acting and long acting insulin combination formulations
US8084420B2 (en) * 2005-09-29 2011-12-27 Biodel Inc. Rapid acting and long acting insulin combination formulations
JP2009533471A (ja) * 2006-04-12 2009-09-17 バイオデル， インコーポレイテッド 即効型および長時間作用型組合せインスリン製剤
AU2007240313B2 (en) 2006-04-20 2012-02-02 Amgen Inc. GLP-1 compounds
US20090175840A1 (en) * 2008-01-04 2009-07-09 Biodel, Inc. Insulin formulations for insulin release as a function of tissue glucose levels
US20110212890A1 (en) 2008-07-30 2011-09-01 Takeda Pharmaceutical Company Limited Metastin derivative and use thereof
US9060927B2 (en) 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
US8618049B2 (en) 2009-09-08 2013-12-31 Stephen B. H. Kent Ester insulin
KR20130036290A (ko) 2010-06-23 2013-04-11 노보 노르디스크 에이/에스 추가 이황화 결합을 함유하는 인슐린 유도체
WO2011161083A1 (en) 2010-06-23 2011-12-29 Novo Nordisk A/S Human insulin containing additional disulfide bonds
WO2011161124A1 (en) 2010-06-23 2011-12-29 Novo Nordisk A/S Insulin analogues containing additional disulfide bonds
CN103533952B (zh) 2011-03-15 2017-02-15 诺沃—诺迪斯克有限公司 包含半胱氨酸置换的人胰岛素类似物和衍生物
US9260503B2 (en) 2011-06-15 2016-02-16 Novo Nordisk A/S Multi-substituted insulins
US9707276B2 (en) 2012-12-03 2017-07-18 Merck Sharp & Dohme Corp. O-glycosylated carboxy terminal portion (CTP) peptide-based insulin and insulin analogues
US20160115216A1 (en) 2013-06-07 2016-04-28 Novo Nordisk A/S Method for Making Mature Insulin Polypeptides
CN105849273B (zh) * 2013-12-23 2020-01-14 拜康研究有限公司 人胰岛素甲酯的生产方法
TW201917134A (zh) 2017-08-17 2019-05-01 丹麥商諾佛 儂迪克股份有限公司 新穎的醯基化胰島素類似物及其用途
WO2023144240A1 (en) 2022-01-26 2023-08-03 Novo Nordisk Research Centre Oxford Limited Glucose sensitive insulin derivatives and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3276961A (en) * 1963-04-08 1966-10-04 Squibb & Sons Inc Process for preparing human insulin

Also Published As

Publication number Publication date
US4343898A (en) 1982-08-10
IE810251L (en) 1981-08-11
FR2475542B1 (OSRAM) 1988-09-09
AT399881B (de) 1995-08-25
FR2475542A1 (OSRAM) 1981-08-14
ATA63681A (de) 1994-12-15

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