IE49880B1 - Penicillin derivatives - Google Patents

Penicillin derivatives

Info

Publication number
IE49880B1
IE49880B1 IE111/80A IE11180A IE49880B1 IE 49880 B1 IE49880 B1 IE 49880B1 IE 111/80 A IE111/80 A IE 111/80A IE 11180 A IE11180 A IE 11180A IE 49880 B1 IE49880 B1 IE 49880B1
Authority
IE
Ireland
Prior art keywords
formula
amino
compound
penicillanate
salts
Prior art date
Application number
IE111/80A
Other languages
English (en)
Original Assignee
Leo Pharm Prod Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27449109&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IE49880(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Leo Pharm Prod Ltd filed Critical Leo Pharm Prod Ltd
Publication of IE49880B1 publication Critical patent/IE49880B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
IE111/80A 1979-02-13 1980-01-21 Penicillin derivatives IE49880B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB7905020 1979-02-13
GB7921341 1979-06-19
GB7927761 1979-08-09
GB7939473 1979-11-14

Publications (1)

Publication Number Publication Date
IE49880B1 true IE49880B1 (en) 1986-01-08

Family

ID=27449109

Family Applications (2)

Application Number Title Priority Date Filing Date
IE2654/83A IE49881B1 (en) 1979-02-13 1980-01-21 B-lactam intermediates
IE111/80A IE49880B1 (en) 1979-02-13 1980-01-21 Penicillin derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IE2654/83A IE49881B1 (en) 1979-02-13 1980-01-21 B-lactam intermediates

Country Status (33)

Country Link
US (2) US4840944A (US06174465-20010116-C00003.png)
AR (1) AR230286A1 (US06174465-20010116-C00003.png)
AT (1) AT368507B (US06174465-20010116-C00003.png)
AU (1) AU532531B2 (US06174465-20010116-C00003.png)
CA (1) CA1230113A (US06174465-20010116-C00003.png)
CH (2) CH646436A5 (US06174465-20010116-C00003.png)
CS (1) CS234015B2 (US06174465-20010116-C00003.png)
CY (1) CY1205A (US06174465-20010116-C00003.png)
DD (1) DD149529A5 (US06174465-20010116-C00003.png)
DE (2) DE3005164C2 (US06174465-20010116-C00003.png)
DK (1) DK160943C (US06174465-20010116-C00003.png)
ES (1) ES8101596A1 (US06174465-20010116-C00003.png)
FI (2) FI73220C (US06174465-20010116-C00003.png)
FR (1) FR2449089A1 (US06174465-20010116-C00003.png)
GB (2) GB2044255B (US06174465-20010116-C00003.png)
GR (1) GR74091B (US06174465-20010116-C00003.png)
HK (1) HK5684A (US06174465-20010116-C00003.png)
HU (1) HU182604B (US06174465-20010116-C00003.png)
IE (2) IE49881B1 (US06174465-20010116-C00003.png)
IL (1) IL59203A (US06174465-20010116-C00003.png)
IT (1) IT1147306B (US06174465-20010116-C00003.png)
KE (1) KE3309A (US06174465-20010116-C00003.png)
LU (1) LU82164A1 (US06174465-20010116-C00003.png)
MA (1) MA18731A1 (US06174465-20010116-C00003.png)
MY (1) MY8500006A (US06174465-20010116-C00003.png)
NL (1) NL8000775A (US06174465-20010116-C00003.png)
NZ (1) NZ192762A (US06174465-20010116-C00003.png)
PH (1) PH16326A (US06174465-20010116-C00003.png)
PL (1) PL125079B1 (US06174465-20010116-C00003.png)
PT (1) PT70805A (US06174465-20010116-C00003.png)
SE (2) SE446186B (US06174465-20010116-C00003.png)
SG (1) SG43783G (US06174465-20010116-C00003.png)
YU (1) YU42659B (US06174465-20010116-C00003.png)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE449103B (sv) * 1979-03-05 1987-04-06 Pfizer Sett att framstella penicillansyra-1,1-dioxid samt estrar derav
US4420426A (en) 1979-03-05 1983-12-13 Pfizer Inc. 6-Alpha-halopenicillanic acid 1,1-dioxides
US4714761A (en) * 1979-03-05 1987-12-22 Pfizer Inc. 6,6-dihalopenicillanic acid 1,1-dioxides and process
US4244951A (en) * 1979-05-16 1981-01-13 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US4309347A (en) * 1979-05-16 1982-01-05 Pfizer Inc. Penicillanoyloxymethyl penicillanate 1,1,1',1'-tetraoxide
US4364957A (en) * 1979-09-26 1982-12-21 Pfizer Inc. Bis-esters of alkanediols as antibacterial agents
US4342768A (en) * 1979-10-22 1982-08-03 Pfizer Inc. Bis-esters of 1,1-alkanediols with 6-beta-hydroxymethylpenicillanic acid 1,1-dioxide and beta-lactam antibiotics
US4432970A (en) * 1979-11-23 1984-02-21 Pfizer Inc. 6-beta-Halopenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
FI67553C (fi) * 1980-01-21 1985-04-10 Bristol Myers Co Foerfarande foer framstaellning av en terapeutiskt anvaendbar 2beta-klormetyl-2alfa-metylpenam-3alfa-karboxylsyrasulfon sater och estrar daerav
IL61880A (en) * 1980-01-21 1984-11-30 Bristol Myers Co 2beta-chloromethyl-2alpha-methylpenam-3alpha-carboxylic acid sulfone derivatives,their preparation and pharmaceutical compositions containing them
US4340539A (en) 1980-01-21 1982-07-20 Bristol-Myers Company Derivatives of 6-bromo penicillanic acid
US4488994A (en) * 1980-09-08 1984-12-18 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
IE51516B1 (en) * 1980-10-06 1987-01-07 Leo Pharm Prod Ltd 1,1-dioxapenicillanoyloxymethyl 6-(d-alpha-amino-alpha-phenylacetamido)penicillanate napsylate
IL64009A (en) * 1980-10-31 1984-09-30 Rech Applications Therap Crystalline 1,1-dioxopenicillanoyloxymethyl 6-(d-alpha-amino-alpha-phenylacetamido)penicillanate tosylate hydrates,their production and pharmaceutical compositions containing them
US4474698A (en) * 1980-12-11 1984-10-02 Pfizer Inc. Process for preparing esters of penicillanic acid sulfone
US4380512A (en) * 1980-12-11 1983-04-19 Bristol-Myers Company 2β-Chloromethyl-2α-methylpenam-3α-carboxylic acid sulfone and salts and esters thereof
IN157669B (US06174465-20010116-C00003.png) * 1981-03-23 1986-05-17 Pfizer
US4381263A (en) * 1981-03-23 1983-04-26 Pfizer Inc. Process for the preparation of penicillanic acid esters
US4321196A (en) 1981-03-23 1982-03-23 Pfizer Inc. Bis-esters of methanediol with acetonides of ampicillin or amoxicillin and penicillanic acid 1,1-dioxide
US4393001A (en) 1981-03-23 1983-07-12 Pfizer Inc. Intermediates for production of 1,1-dioxopenicillanoyloxymethyl 6-(2-amino-2-phenylacetamido)penicillanates
US4419284A (en) 1981-03-23 1983-12-06 Pfizer Inc. Preparation of halomethyl esters (and related esters) of penicillanic acid 1,1-dioxide
US4376076A (en) 1981-03-23 1983-03-08 Pfizer Inc. Bis-esters of 1,1-alkanediols with 6-beta-hydroxymethylpenicillanic acid 1,1-dioxide
IN159362B (US06174465-20010116-C00003.png) * 1981-03-23 1987-05-09 Pfizer
US4444687A (en) * 1981-06-08 1984-04-24 Bristol-Myers Company 2β-Chloromethyl-2α-methylpenam-3α-carboxylic acid sulfone methylene diol mixed esters
DE3277456D1 (de) * 1981-09-09 1987-11-19 Pfizer Antibacterial 6-(2-amino-2-(4-acyloxy-phenyl) acetamido) penicillanoyloxymethyl esters
US4582829A (en) * 1981-09-09 1986-04-15 Pfizer Inc. Antibacterial 6'-(2-amino-2-[4-acyloxyphenyl]acetamido)penicillanoyloxymethyl penicillanate 1,1-dioxide compounds
US4540687A (en) * 1981-09-09 1985-09-10 Pfizer Inc. Antibacterial 6'-(2-amino-2-[4-acyloxyphenyl]acetamido)penicillanoyloxymethyl penicillanate 1,1-dioxide compounds
US4351840A (en) * 1981-09-18 1982-09-28 Pfizer Inc. Antibacterial esters of resorcinol with ampicillin and penicillanic acid 1,1-dioxide derivatives
US4457924A (en) * 1981-12-22 1984-07-03 Pfizer, Inc. 1,1-Alkanediol dicarboxylate linked antibacterial agents
US4359472A (en) 1981-12-22 1982-11-16 Pfizer Inc. Bis-hydroxymethyl carbonate bridged antibacterial agents
US4452796A (en) * 1982-06-14 1984-06-05 Pfizer Inc. 6-Aminoalkylpenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
EP0084730A1 (en) * 1982-01-22 1983-08-03 Beecham Group Plc Esters of penicillin derivatives with beta-lactamase inhibitors, their preparation and their use
US4444686A (en) * 1982-01-25 1984-04-24 Pfizer Inc. Crystalline penicillin ester intermediate
US4432987A (en) * 1982-04-23 1984-02-21 Pfizer Inc. Crystalline benzenesulfonate salts of sultamicillin
IT1190897B (it) * 1982-06-29 1988-02-24 Opos Biochimica Srl Procedimento per la preparazione dell'estere 1-etossicarbonilossietilico dell'acido 6-(d(-)-alfa aminoalfa fenilacetamido)-penicillanico
WO1984001776A1 (en) * 1982-10-26 1984-05-10 Beecham Group Plc Beta-lactam compounds, preparation and use
US4530792A (en) * 1982-11-01 1985-07-23 Pfizer Inc. Process and intermediates for preparation of 1,1-dioxopenicillanoyloxymethyl 6-beta-aminopenicillanate
IL67637A0 (en) * 1983-01-07 1983-05-15 Orvet Bv Preparation of 1'-ethoxycarbonyl-oxyethyl esters of penicillins and novel intermediates
US4868297A (en) * 1982-12-06 1989-09-19 Pfizer Inc. Process for preparing sultamicillin and analogs
US4462934A (en) * 1983-03-31 1984-07-31 Pfizer Inc. Bis-esters of dicarboxylic acids with amoxicillin and certain hydroxymethylpenicillanate 1,1-dioxides
US4536393A (en) * 1983-06-06 1985-08-20 Pfizer Inc. 6-(Aminomethyl)penicillanic acid 1,1-dioxide esters and intermediates therefor
JPH01139584A (ja) * 1987-11-25 1989-06-01 Yoshitomi Pharmaceut Ind Ltd ペニシラン酸化合物の製造法
KR910009271B1 (ko) * 1989-06-20 1991-11-08 김영설 1,1-디옥소페닐실라노일 옥시메틸 D-6-[α-(메틸렌아미노)페닐-아세트아미도]-페니실라네이트와 그의 파라-톨루엔술폰산염
DE69103003T2 (de) * 1990-04-13 1994-11-03 Pfizer Inc., Groton, Conn. Verfahren für sultamicillinzwischenprodukt.
ES2161602B1 (es) * 1999-04-08 2003-02-16 Asturpharma S A Sintesis de 6-(d-alfa-(bencilidenaminofenilacetamido))penicilanato de 1,1-dioxopenicilanoiloximetilo y analogos. nuevos intermedios para la sintesis de sultamicilina.
WO2007004239A1 (en) * 2005-07-06 2007-01-11 Morepen Laboratories Limited New polymorphic form of sultamicillin tosylate and a process therefor
TR201922977A2 (tr) * 2019-12-31 2021-07-26 T C Erciyes Ueniversitesi Penisilin türevleri ve bunların sentezlenmesi için yöntem
CN115385934A (zh) * 2022-10-26 2022-11-25 北京纳百生物科技有限公司 一种舒巴坦半抗原及其合成方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1303491A (US06174465-20010116-C00003.png) * 1970-03-24 1973-01-17
GB1335718A (en) * 1971-05-05 1973-10-31 Leo Pharm Prod Ltd Penicillin esters salts thereof and methods for their preparation
US3838152A (en) * 1971-10-07 1974-09-24 American Home Prod Poly alpha-amino penicillins
GB1467604A (en) * 1974-06-27 1977-03-16 Toyama Chemical Co Ltd Bis-type penicillins and process for producing the same
GB1573614A (en) * 1976-02-25 1980-08-28 Leo Pharm Prod Ltd Amidinopenicillanoyloxyalkyl cephalosporanates
GB1578128A (en) * 1976-03-30 1980-11-05 Leo Pharm Prod Ltd Amidinopenicillanoyloxyalkyl amoxycillinates
GB1579931A (en) * 1976-04-15 1980-11-26 Leo Pharm Prod Ltd Bis-penicillanoyl-oxy-alkanes
IN149747B (US06174465-20010116-C00003.png) * 1977-06-07 1982-04-03 Pfizer
US4197240A (en) * 1977-12-23 1980-04-08 Yeda Research And Development Co. Ltd. Penicillin derivatives
US4244951A (en) * 1979-05-16 1981-01-13 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide

Also Published As

Publication number Publication date
AR230286A1 (es) 1984-03-01
IE49881B1 (en) 1986-01-08
DE3005164A1 (de) 1980-08-21
FR2449089B1 (US06174465-20010116-C00003.png) 1983-06-10
IL59203A0 (en) 1980-05-30
ES488494A0 (es) 1980-12-16
US4342772A (en) 1982-08-03
YU42659B (en) 1988-10-31
IT1147306B (it) 1986-11-19
MA18731A1 (fr) 1980-10-01
FI800411A (fi) 1980-08-14
SE8404462L (sv) 1984-09-05
SG43783G (en) 1985-01-11
SE8404462D0 (sv) 1984-09-05
FI870555A (fi) 1987-02-11
SE8001099L (sv) 1980-08-14
DE3005164C2 (de) 1986-06-26
DD149529A5 (de) 1981-07-15
FI73220C (fi) 1987-09-10
IT8019865A0 (it) 1980-02-12
GB2044255B (en) 1983-05-11
AT368507B (de) 1982-10-25
FI76807B (fi) 1988-08-31
CH645902A5 (de) 1984-10-31
NL8000775A (nl) 1980-08-15
SE461913B (sv) 1990-04-09
IL59203A (en) 1982-12-31
HU182604B (en) 1984-02-28
PT70805A (en) 1980-03-01
CY1205A (en) 1983-12-31
MY8500006A (en) 1985-12-31
AU532531B2 (en) 1983-10-06
US4840944A (en) 1989-06-20
CA1230113A (en) 1987-12-08
DK160943C (da) 1991-10-21
GB2108107B (en) 1983-09-01
SE446186B (sv) 1986-08-18
KE3309A (en) 1983-08-19
DK160943B (da) 1991-05-06
LU82164A1 (fr) 1980-09-24
DE3050895C2 (US06174465-20010116-C00003.png) 1989-05-03
ATA61580A (de) 1982-02-15
CH646436A5 (de) 1984-11-30
CS234015B2 (en) 1985-03-14
AU5546280A (en) 1980-08-21
YU24480A (en) 1983-04-30
GB2108107A (en) 1983-05-11
IE832654L (en) 1980-08-13
GR74091B (US06174465-20010116-C00003.png) 1984-06-06
FI76807C (fi) 1988-12-12
FI870555A0 (fi) 1987-02-11
FR2449089A1 (fr) 1980-09-12
HK5684A (en) 1984-01-20
PL125079B1 (en) 1983-03-31
ES8101596A1 (es) 1980-12-16
PL221964A1 (US06174465-20010116-C00003.png) 1980-12-01
PH16326A (en) 1983-09-05
DK59480A (da) 1980-08-14
FI73220B (fi) 1987-05-29
GB2044255A (en) 1980-10-15
NZ192762A (en) 1984-10-19

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