IE48399B1 - Live attenuated human hepatitis-a-virus,method for growing it in cell culture in vitro and composition comprising it - Google Patents
Live attenuated human hepatitis-a-virus,method for growing it in cell culture in vitro and composition comprising itInfo
- Publication number
- IE48399B1 IE48399B1 IE1575/79A IE157579A IE48399B1 IE 48399 B1 IE48399 B1 IE 48399B1 IE 1575/79 A IE1575/79 A IE 1575/79A IE 157579 A IE157579 A IE 157579A IE 48399 B1 IE48399 B1 IE 48399B1
- Authority
- IE
- Ireland
- Prior art keywords
- virus
- hepatitis
- cell culture
- human
- vitro
- Prior art date
Links
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- 239000000203 mixture Substances 0.000 title claims description 4
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32411—Hepatovirus, i.e. hepatitis A virus
- C12N2770/32434—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32411—Hepatovirus, i.e. hepatitis A virus
- C12N2770/32451—Methods of production or purification of viral material
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/934,293 US4164566A (en) | 1978-08-17 | 1978-08-17 | Hepatitis a virus cell culture in vitro |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE791575L IE791575L (en) | 1980-02-17 |
| IE48399B1 true IE48399B1 (en) | 1985-01-09 |
Family
ID=25465313
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1575/79A IE48399B1 (en) | 1978-08-17 | 1979-08-16 | Live attenuated human hepatitis-a-virus,method for growing it in cell culture in vitro and composition comprising it |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4164566A (https=) |
| EP (1) | EP0008559B1 (https=) |
| JP (1) | JPS5548389A (https=) |
| AT (1) | ATE2014T1 (https=) |
| CA (1) | CA1135621A (https=) |
| DE (1) | DE2964276D1 (https=) |
| DK (1) | DK158743C (https=) |
| IE (1) | IE48399B1 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6297355B1 (en) | 1978-12-22 | 2001-10-02 | Biogen, Inc. | Polypeptides displaying HBV antigenicity or hbv antigen specificity |
| US4395395A (en) * | 1979-05-21 | 1983-07-26 | The United States Of America As Represented By The Department Of Health And Human Services | Detection of non-A, non-B hepatitis associated antigen |
| PT71739B (en) | 1979-09-04 | 1982-01-26 | Merck & Co Inc | Process for preparing a cell culture of hepatitis a virus |
| US5514376A (en) * | 1979-09-04 | 1996-05-07 | Merck & Co., Inc. | Cell culture of hepatitis A virus |
| US4301250A (en) * | 1979-11-02 | 1981-11-17 | Merck & Co., Inc. | Method of producing hepatitis B surface antigen |
| PT72015B (en) * | 1979-11-13 | 1982-06-20 | Merck & Co Inc | Process for preparing "invitro" cultures of hepatitis b virus |
| US4382076A (en) * | 1979-11-26 | 1983-05-03 | Merck & Co., Inc. | Hepatitis A antibody assay |
| US4393133A (en) * | 1980-06-12 | 1983-07-12 | The Wistar Institute Of Anatomy And Biology | Human hepatoma derived cell line, process for preparation thereof, and uses therefor |
| US4301249A (en) * | 1980-07-23 | 1981-11-17 | Merck & Co., Inc. | High titer production of hepatitis A virus |
| AU8746582A (en) * | 1981-09-02 | 1983-03-10 | Biogen N.V. | Hepatitis b virus e type antigen |
| DE3135599A1 (de) * | 1981-09-09 | 1983-08-25 | Flehmig Bertram | An menschliche fibroblastenzellen adaptierte hepatitis-a-viren |
| US4721675A (en) * | 1982-02-01 | 1988-01-26 | Abbott Laboratories | Production of hepatitis A virus in vitro utilizing a persistently virus infected cell culture system |
| US4412002A (en) * | 1982-02-26 | 1983-10-25 | Merck & Co., Inc. | Process for preparing hepatitis A virus |
| USRE37381E1 (en) * | 1982-04-07 | 2001-09-18 | The United States Of America As Represented By The Department Of Health And Human Services | Vaccine against hepatitis A virus |
| US4894228A (en) * | 1982-04-07 | 1990-01-16 | The United States Of America As Represented By The Department Of Health And Human Services | Vaccine against hepatitis A virus |
| US4532215A (en) * | 1982-04-07 | 1985-07-30 | The United States Of America As Represented By The Department Of Health And Human Services | Isolation of hepatitis A virus strain HM-175 |
| US4636469A (en) * | 1982-04-07 | 1987-01-13 | The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services | Isolation of hepatitis A virus strain HM-175 |
| US4620978A (en) * | 1982-04-07 | 1986-11-04 | The United States Of America As Represented By The Department Of Health And Human Services | Hepatitis A virus purified and triply cloned |
| US5478746A (en) * | 1982-04-07 | 1995-12-26 | The United States Of America As Represented By The Department Of Health And Human Services | cDNA encoding attenuated cell culture adapted hepatitis A virus genome |
| CA1324094C (en) * | 1985-04-03 | 1993-11-09 | Dino Dina | Hepatitis a virus vaccines |
| US4783407A (en) * | 1985-09-30 | 1988-11-08 | Merck & Co., Inc. | Growth of hepatitus A virus in vero cells |
| AU613310B2 (en) * | 1986-04-01 | 1991-08-01 | Genelabs Incorporated | Immortalized virus-specific tissue cells |
| DE3633550A1 (de) * | 1986-10-02 | 1988-04-14 | Behringwerke Ag | Vaccine gegen hepatitis a |
| NZ225583A (en) * | 1987-08-06 | 1991-07-26 | Merck & Co Inc | Process for purifying hepatitis a virions (hav) |
| JPH085804B2 (ja) * | 1988-04-28 | 1996-01-24 | 財団法人化学及血清療法研究所 | Ａ型及びｂ型肝炎混合アジュバントワクチン |
| JPH0761955B2 (ja) * | 1988-04-28 | 1995-07-05 | 国立予防衛生研究所長 | 凍結乾燥ａ型肝炎ワクチン |
| JPH0751513B2 (ja) * | 1988-04-28 | 1995-06-05 | 国立予防衛生研究所長 | Ａ型肝炎ワクチン |
| US6117674A (en) * | 1988-06-30 | 2000-09-12 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Pathogen propagation in cultured three-dimensional tissue mass |
| US5549896A (en) * | 1991-05-08 | 1996-08-27 | Schweiz. Serum- & Impfinstitut Bern | Hepatitis a virus strain, method for the isolation of new hepatitis a virus strains and hepatitis a vaccines |
| AU662528B2 (en) * | 1991-05-08 | 1995-09-07 | Schweiz. Serum- & Impfinstitut Bern | New hepatitis A virus strain, method for the isolation of new hepatitis A virus strains and hepatitis A vaccines |
| US5506129A (en) * | 1991-05-24 | 1996-04-09 | Evans Medical Limited | Virus production |
| DZ1706A1 (fr) | 1992-08-07 | 2002-02-17 | Merck & Co Inc | Vaccin contre le virus de l'hepatite a. |
| HRP950097A2 (en) | 1994-03-08 | 1997-06-30 | Merck & Co Inc | Hepatitis a virus culture process |
| US6190859B1 (en) | 1995-04-17 | 2001-02-20 | The United States Of America As Represented By The Secretary Of The Army | Method and kit for detection of dengue virus |
| US6562562B2 (en) * | 2000-03-10 | 2003-05-13 | Pharmacia & Upjohn S.P.A. | Procedure for partial liver resection in nonhuman primates |
| CA2829774C (en) | 2011-03-14 | 2019-09-24 | National Research Council Of Canada | Method of viral production in cells |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3105011A (en) * | 1961-06-19 | 1963-09-24 | Parke Davis & Co | Antigens and process of producing same |
| US3935066A (en) * | 1969-07-03 | 1976-01-27 | Burroughs Wellcome Co. | Cell lines |
| US4029764A (en) * | 1974-12-09 | 1977-06-14 | Merck & Co., Inc. | Hepatitis A antigen |
| US4031203A (en) * | 1974-12-09 | 1977-06-21 | Merck & Co., Inc. | Hepatitis A antigen |
| FR2398504A1 (fr) * | 1977-07-29 | 1979-02-23 | Tours Inst Virologie | Culture de virus de l'hepatite a, in vitro. application a la production d'un antigene reactif, d'immunserums specifiques et de vaccins contre l'hepatite a |
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1978
- 1978-08-17 US US05/934,293 patent/US4164566A/en not_active Expired - Lifetime
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1979
- 1979-08-07 CA CA000333321A patent/CA1135621A/en not_active Expired
- 1979-08-16 IE IE1575/79A patent/IE48399B1/en not_active IP Right Cessation
- 1979-08-16 JP JP10364379A patent/JPS5548389A/ja active Granted
- 1979-08-16 DK DK343179A patent/DK158743C/da not_active IP Right Cessation
- 1979-08-17 DE DE7979400577T patent/DE2964276D1/de not_active Expired
- 1979-08-17 AT AT79400577T patent/ATE2014T1/de not_active IP Right Cessation
- 1979-08-17 EP EP79400577A patent/EP0008559B1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DK158743C (da) | 1990-12-10 |
| DK343179A (da) | 1980-02-18 |
| US4164566A (en) | 1979-08-14 |
| CA1135621A (en) | 1982-11-16 |
| ATE2014T1 (de) | 1982-12-15 |
| IE791575L (en) | 1980-02-17 |
| DK158743B (da) | 1990-07-09 |
| JPH0157954B2 (https=) | 1989-12-08 |
| EP0008559A1 (en) | 1980-03-05 |
| JPS5548389A (en) | 1980-04-07 |
| EP0008559B1 (en) | 1982-12-15 |
| DE2964276D1 (en) | 1983-01-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK9A | Patent expired |