ATE2014T1 - Lebendes, attenuiertes virus des hepatitis a beim menschen, verfahren zu seiner zuechtung in zellkultur in vitro und dieses virus enthaltende zusammensetzung. - Google Patents

Lebendes, attenuiertes virus des hepatitis a beim menschen, verfahren zu seiner zuechtung in zellkultur in vitro und dieses virus enthaltende zusammensetzung.

Info

Publication number
ATE2014T1
ATE2014T1 AT79400577T AT79400577T ATE2014T1 AT E2014 T1 ATE2014 T1 AT E2014T1 AT 79400577 T AT79400577 T AT 79400577T AT 79400577 T AT79400577 T AT 79400577T AT E2014 T1 ATE2014 T1 AT E2014T1
Authority
AT
Austria
Prior art keywords
virus
hepatitis
cell culture
vitro
live
Prior art date
Application number
AT79400577T
Other languages
English (en)
Inventor
Philip J. Provost
Maurice R. Hilleman
Original Assignee
Merck & Co. Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co. Inc. filed Critical Merck & Co. Inc.
Application granted granted Critical
Publication of ATE2014T1 publication Critical patent/ATE2014T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32411—Hepatovirus, i.e. hepatitis A virus
    • C12N2770/32434—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32411—Hepatovirus, i.e. hepatitis A virus
    • C12N2770/32451—Methods of production or purification of viral material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT79400577T 1978-08-17 1979-08-17 Lebendes, attenuiertes virus des hepatitis a beim menschen, verfahren zu seiner zuechtung in zellkultur in vitro und dieses virus enthaltende zusammensetzung. ATE2014T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/934,293 US4164566A (en) 1978-08-17 1978-08-17 Hepatitis a virus cell culture in vitro
EP79400577A EP0008559B1 (de) 1978-08-17 1979-08-17 Lebendes, attenuiertes Virus des Hepatitis A beim Menschen, Verfahren zu seiner Züchtung in Zellkultur in vitro und dieses Virus enthaltende Zusammensetzung

Publications (1)

Publication Number Publication Date
ATE2014T1 true ATE2014T1 (de) 1982-12-15

Family

ID=25465313

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79400577T ATE2014T1 (de) 1978-08-17 1979-08-17 Lebendes, attenuiertes virus des hepatitis a beim menschen, verfahren zu seiner zuechtung in zellkultur in vitro und dieses virus enthaltende zusammensetzung.

Country Status (8)

Country Link
US (1) US4164566A (de)
EP (1) EP0008559B1 (de)
JP (1) JPS5548389A (de)
AT (1) ATE2014T1 (de)
CA (1) CA1135621A (de)
DE (1) DE2964276D1 (de)
DK (1) DK158743C (de)
IE (1) IE48399B1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6297355B1 (en) 1978-12-22 2001-10-02 Biogen, Inc. Polypeptides displaying HBV antigenicity or hbv antigen specificity
US4395395A (en) * 1979-05-21 1983-07-26 The United States Of America As Represented By The Department Of Health And Human Services Detection of non-A, non-B hepatitis associated antigen
US5514376A (en) * 1979-09-04 1996-05-07 Merck & Co., Inc. Cell culture of hepatitis A virus
PT71739B (en) 1979-09-04 1982-01-26 Merck & Co Inc Process for preparing a cell culture of hepatitis a virus
US4301250A (en) * 1979-11-02 1981-11-17 Merck & Co., Inc. Method of producing hepatitis B surface antigen
PT72015B (en) * 1979-11-13 1982-06-20 Merck & Co Inc Process for preparing "invitro" cultures of hepatitis b virus
US4382076A (en) * 1979-11-26 1983-05-03 Merck & Co., Inc. Hepatitis A antibody assay
US4393133A (en) * 1980-06-12 1983-07-12 The Wistar Institute Of Anatomy And Biology Human hepatoma derived cell line, process for preparation thereof, and uses therefor
US4301249A (en) * 1980-07-23 1981-11-17 Merck & Co., Inc. High titer production of hepatitis A virus
AU8746582A (en) * 1981-09-02 1983-03-10 Biogen N.V. Hepatitis b virus e type antigen
DE3135599A1 (de) * 1981-09-09 1983-08-25 Flehmig Bertram An menschliche fibroblastenzellen adaptierte hepatitis-a-viren
US4721675A (en) * 1982-02-01 1988-01-26 Abbott Laboratories Production of hepatitis A virus in vitro utilizing a persistently virus infected cell culture system
US4412002A (en) * 1982-02-26 1983-10-25 Merck & Co., Inc. Process for preparing hepatitis A virus
US4894228A (en) * 1982-04-07 1990-01-16 The United States Of America As Represented By The Department Of Health And Human Services Vaccine against hepatitis A virus
US4636469A (en) * 1982-04-07 1987-01-13 The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services Isolation of hepatitis A virus strain HM-175
US5478746A (en) * 1982-04-07 1995-12-26 The United States Of America As Represented By The Department Of Health And Human Services cDNA encoding attenuated cell culture adapted hepatitis A virus genome
USRE37381E1 (en) * 1982-04-07 2001-09-18 The United States Of America As Represented By The Department Of Health And Human Services Vaccine against hepatitis A virus
US4620978A (en) * 1982-04-07 1986-11-04 The United States Of America As Represented By The Department Of Health And Human Services Hepatitis A virus purified and triply cloned
US4532215A (en) * 1982-04-07 1985-07-30 The United States Of America As Represented By The Department Of Health And Human Services Isolation of hepatitis A virus strain HM-175
CA1324094C (en) * 1985-04-03 1993-11-09 Dino Dina Hepatitis a virus vaccines
US4783407A (en) * 1985-09-30 1988-11-08 Merck & Co., Inc. Growth of hepatitus A virus in vero cells
EP0261233A4 (de) * 1986-04-01 1988-08-29 Genelabs Inc Immortalisierte virus-spezifische gewebezellen.
DE3633550A1 (de) * 1986-10-02 1988-04-14 Behringwerke Ag Vaccine gegen hepatitis a
NZ225583A (en) * 1987-08-06 1991-07-26 Merck & Co Inc Process for purifying hepatitis a virions (hav)
JPH0751513B2 (ja) * 1988-04-28 1995-06-05 国立予防衛生研究所長 Ａ型肝炎ワクチン
JPH085804B2 (ja) * 1988-04-28 1996-01-24 財団法人化学及血清療法研究所 Ａ型及びｂ型肝炎混合アジュバントワクチン
JPH0761955B2 (ja) * 1988-04-28 1995-07-05 国立予防衛生研究所長 凍結乾燥ａ型肝炎ワクチン
US6117674A (en) * 1988-06-30 2000-09-12 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Pathogen propagation in cultured three-dimensional tissue mass
DE542949T1 (de) * 1991-05-08 1993-09-02 Schweiz. Serum- & Impfinstitut Bern, Bern Hepatitis a virusstamm, verfahren zur isolierung eines hepatitis a virusstammes und vakzine hepatitis a.
US5549896A (en) * 1991-05-08 1996-08-27 Schweiz. Serum- & Impfinstitut Bern Hepatitis a virus strain, method for the isolation of new hepatitis a virus strains and hepatitis a vaccines
US5506129A (en) * 1991-05-24 1996-04-09 Evans Medical Limited Virus production
DZ1706A1 (fr) 1992-08-07 2002-02-17 Merck & Co Inc Vaccin contre le virus de l'hepatite a.
HRP950097A2 (en) 1994-03-08 1997-06-30 Merck & Co Inc Hepatitis a virus culture process
US6190859B1 (en) 1995-04-17 2001-02-20 The United States Of America As Represented By The Secretary Of The Army Method and kit for detection of dengue virus
US6562562B2 (en) * 2000-03-10 2003-05-13 Pharmacia & Upjohn S.P.A. Procedure for partial liver resection in nonhuman primates
CA2829774C (en) 2011-03-14 2019-09-24 National Research Council Of Canada Method of viral production in cells

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3105011A (en) * 1961-06-19 1963-09-24 Parke Davis & Co Antigens and process of producing same
US3935066A (en) * 1969-07-03 1976-01-27 Burroughs Wellcome Co. Cell lines
US4031203A (en) * 1974-12-09 1977-06-21 Merck & Co., Inc. Hepatitis A antigen
US4029764A (en) * 1974-12-09 1977-06-14 Merck & Co., Inc. Hepatitis A antigen
FR2398504A1 (fr) * 1977-07-29 1979-02-23 Tours Inst Virologie Culture de virus de l'hepatite a, in vitro. application a la production d'un antigene reactif, d'immunserums specifiques et de vaccins contre l'hepatite a

Also Published As

Publication number Publication date
IE48399B1 (en) 1985-01-09
IE791575L (en) 1980-02-17
DK158743B (da) 1990-07-09
US4164566A (en) 1979-08-14
CA1135621A (en) 1982-11-16
JPH0157954B2 (de) 1989-12-08
JPS5548389A (en) 1980-04-07
EP0008559B1 (de) 1982-12-15
DK158743C (da) 1990-12-10
EP0008559A1 (de) 1980-03-05
DK343179A (da) 1980-02-18
DE2964276D1 (en) 1983-01-20

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time