IE38375B1 - Bicycloalkyl derivatives - Google Patents
Bicycloalkyl derivativesInfo
- Publication number
- IE38375B1 IE38375B1 IE1824/73A IE182473A IE38375B1 IE 38375 B1 IE38375 B1 IE 38375B1 IE 1824/73 A IE1824/73 A IE 1824/73A IE 182473 A IE182473 A IE 182473A IE 38375 B1 IE38375 B1 IE 38375B1
- Authority
- IE
- Ireland
- Prior art keywords
- oct
- trans
- alkyl
- acid
- compounds
- Prior art date
Links
- 150000001602 bicycloalkyls Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- MGNZXYYWBUKAII-UHFFFAOYSA-N cyclohexa-1,3-diene Chemical compound C1CC=CC=C1 MGNZXYYWBUKAII-UHFFFAOYSA-N 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 3
- 150000001408 amides Chemical class 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- -1 2-phenylbicyclo- [2,2,2]oct-3-yl group Chemical group 0.000 abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Natural products CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- WEVYAHXRMPXWCK-UHFFFAOYSA-N methyl cyanide Natural products CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 2
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- ILPBINAXDRFYPL-UHFFFAOYSA-N 2-octene Chemical compound CCCCCC=CC ILPBINAXDRFYPL-UHFFFAOYSA-N 0.000 abstract 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Chemical class CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 abstract 1
- 150000001242 acetic acid derivatives Chemical class 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000001539 anorectic effect Effects 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 238000007796 conventional method Methods 0.000 abstract 1
- 206010061428 decreased appetite Diseases 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- RIFGWPKJUGCATF-UHFFFAOYSA-N ethyl chloroformate Chemical compound CCOC(Cl)=O RIFGWPKJUGCATF-UHFFFAOYSA-N 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- IMKVSWPEZCELRM-UHFFFAOYSA-N ethyl p-methylcinnamate Natural products CCOC(=O)C=CC1=CC=C(C)C=C1 IMKVSWPEZCELRM-UHFFFAOYSA-N 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 238000006396 nitration reaction Methods 0.000 abstract 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical class CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229940066769 systemic antihistamines substituted alkylamines Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/41—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrogenolysis or reduction of carboxylic groups or functional derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/44—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
- C07C47/235—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/38—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
- C07C47/453—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/38—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
- C07C47/457—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/132—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5093172A GB1444717A (en) | 1972-11-04 | 1972-11-04 | Bicycloalkyl derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE38375L IE38375L (en) | 1974-05-04 |
| IE38375B1 true IE38375B1 (en) | 1978-03-01 |
Family
ID=10457988
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1824/73A IE38375B1 (en) | 1972-11-04 | 1973-10-12 | Bicycloalkyl derivatives |
Country Status (11)
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1549174A (en) * | 1975-05-08 | 1979-08-01 | Lilly Industries Ltd | Amine derivatives |
| GB1551035A (en) * | 1975-07-24 | 1979-08-22 | Lilly Industries Ltd | Derivatives of bicyclo (2,2,2)oct-3-ylmethylamine |
| US4215074A (en) * | 1978-07-15 | 1980-07-29 | Lilly Industries Limited | Process for preparing cis-bicyclooctylamines |
| GB2367554A (en) * | 2000-10-04 | 2002-04-10 | Lilly Co Eli | Pharmacologically active amines |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1468808A1 (de) * | 1965-04-21 | 1969-04-17 | Du Pont | Verfahren zur Herstellung von substituierten Phenylbicyclo-(2,2,2)-octanen |
-
1972
- 1972-11-04 GB GB5093172A patent/GB1444717A/en not_active Expired
-
1973
- 1973-10-12 IE IE1824/73A patent/IE38375B1/xx unknown
- 1973-10-23 IL IL43470A patent/IL43470A/en unknown
- 1973-10-30 SE SE7314756A patent/SE419980B/xx unknown
- 1973-10-31 BE BE137315A patent/BE806808A/xx not_active IP Right Cessation
- 1973-10-31 FR FR7338821A patent/FR2205324B1/fr not_active Expired
- 1973-11-01 NL NLAANVRAGE7315031,A patent/NL182143C/xx not_active IP Right Cessation
- 1973-11-02 JP JP48123891A patent/JPS5747664B2/ja not_active Expired
- 1973-11-02 DK DK593573AA patent/DK142111B/da not_active IP Right Cessation
- 1973-11-02 CH CH1542273A patent/CH588440A5/xx not_active IP Right Cessation
- 1973-11-02 DE DE2354931A patent/DE2354931C2/de not_active Expired
-
1982
- 1982-02-05 JP JP57018087A patent/JPS5936973B2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5936973B2 (ja) | 1984-09-06 |
| DK142111C (enrdf_load_stackoverflow) | 1981-02-02 |
| DK142111B (da) | 1980-09-01 |
| NL7315031A (enrdf_load_stackoverflow) | 1974-05-07 |
| IL43470A (en) | 1976-08-31 |
| SE419980B (sv) | 1981-09-07 |
| NL182143B (nl) | 1987-08-17 |
| JPS49132058A (enrdf_load_stackoverflow) | 1974-12-18 |
| BE806808A (fr) | 1974-04-30 |
| JPS5747664B2 (enrdf_load_stackoverflow) | 1982-10-12 |
| IL43470A0 (en) | 1974-01-14 |
| FR2205324A1 (enrdf_load_stackoverflow) | 1974-05-31 |
| FR2205324B1 (enrdf_load_stackoverflow) | 1976-05-14 |
| DE2354931A1 (de) | 1974-05-09 |
| NL182143C (nl) | 1988-01-18 |
| IE38375L (en) | 1974-05-04 |
| JPS57171941A (en) | 1982-10-22 |
| DE2354931C2 (de) | 1983-12-08 |
| GB1444717A (en) | 1976-08-04 |
| CH588440A5 (enrdf_load_stackoverflow) | 1977-05-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1465229A (en) | Cyclic amino acids | |
| GB1432576A (en) | Substituted phenylacetic acids | |
| ATE14423T1 (de) | Hydroxamsaeurederivate vom typ der mannich-basen mit verbesserter biologischer verfuegbarkeit von nicht-steroiden entzuendungshemmern, verfahren zur herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzung. | |
| GB1180749A (en) | A New Polycyclic Amine and Processes for its Production | |
| GB1358624A (en) | Phenylacetic acid derivatives process for their preparation and applications thereof | |
| GB1282742A (en) | Antibacterial penicillin derivatives | |
| GB1367598A (en) | Derivatives of delta 1-pyrroline their method of preparation and their applications | |
| IE38375B1 (en) | Bicycloalkyl derivatives | |
| GB1528723A (en) | 1-nitro-9-n-substituted aminoalkylamino-acridines their salts and a method of preparing same | |
| GB1321424A (en) | N-phenyl-n-disubstituted aminoalkyl-2-amino indanes | |
| GB1411700A (en) | Penicillins and production thereof | |
| GB1398800A (en) | Trisubstituted imidazoles | |
| GB1349138A (en) | Quinazoline derivative | |
| IE37422B1 (en) | Benzofuran derivatives and a process for the manufacture thereof | |
| GB1427404A (en) | Tricyclic pharmacological agents and methods of making them | |
| GB1418595A (en) | N- 2-alkoxybenzoyl- amino acids and a process for producing the same | |
| IE35930B1 (en) | Amines and a process for the manufacture thereof | |
| GB1446701A (en) | Vincamine 2-ketoglutarate and process for the production thereof | |
| GB1490558A (en) | Phenylethylamine derivatives | |
| GB1472344A (en) | Methylene dibenzocycloheptanes | |
| GB1262333A (en) | New hydantoins their preparation and compositions containing them | |
| GB1425911A (en) | Phenylacetic acid derivatives, process for their preparation and therapeutic composition containing same | |
| US2463940A (en) | N-(2-phenylacetoxyethyl)-phenylacetamide | |
| GB1216947A (en) | Norbornene-2,3-dicarboximide and norbornane-2,3-dicarboximide derivatives and method for preparing them | |
| GB1333524A (en) | Penicilloic acid derivatives |