IE37782L - Penicillin compounds - Google Patents

Penicillin compounds

Info

Publication number
IE37782L
IE37782L IE720645A IE64572A IE37782L IE 37782 L IE37782 L IE 37782L IE 720645 A IE720645 A IE 720645A IE 64572 A IE64572 A IE 64572A IE 37782 L IE37782 L IE 37782L
Authority
IE
Ireland
Prior art keywords
acylamido
syn
isomers
org
beta
Prior art date
Application number
IE720645A
Other versions
IE37782B1 (en
Original Assignee
Glaxo Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB1508271A external-priority patent/GB1399086A/en
Application filed by Glaxo Lab Ltd filed Critical Glaxo Lab Ltd
Publication of IE37782L publication Critical patent/IE37782L/en
Publication of IE37782B1 publication Critical patent/IE37782B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/42—Singly bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/14—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Abstract

6 beta-Acylamido-penam-3 alpha-carboxylic acids and their non-toxic derivs. in which the acylamido gp. has the structure R-C(=N ORa)-CO-NH- (where R is H or an org. gp. and Ra is an etherified monovalent org. gp. linked to the O-atom via a C-atom), the cpd. being present as the syn or anti isomer or as a mixt. of these isomers, partic. cpds. of formula (I): (where B is S or SO), have antibacterial activity against gram-positive organisms as well as Haemophilus influenzae. The syn isomers are active against penicillinase-producing Staphylococci and are resistant to various beta-lactamases. [FR2137898A1]
IE645/72A 1971-05-14 1972-05-12 Penicillin compounds IE37782B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1508271A GB1399086A (en) 1971-05-14 1971-05-14 Cephalosporin compounds

Publications (2)

Publication Number Publication Date
IE37782L true IE37782L (en) 1972-11-14
IE37782B1 IE37782B1 (en) 1977-10-12

Family

ID=10052709

Family Applications (1)

Application Number Title Priority Date Filing Date
IE645/72A IE37782B1 (en) 1971-05-14 1972-05-12 Penicillin compounds

Country Status (14)

Country Link
JP (1) JPS5248997B1 (en)
AT (1) AT329176B (en)
AU (2) AU475444B2 (en)
BE (1) BE783448A (en)
CH (1) CH579571A5 (en)
DE (1) DE2223287A1 (en)
ES (1) ES402650A1 (en)
FR (2) FR2137898A1 (en)
HU (1) HU172017B (en)
IE (1) IE37782B1 (en)
IL (1) IL39428A (en)
NL (1) NL7206466A (en)
PL (1) PL101031B1 (en)
ZA (2) ZA723224B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1443950A (en) * 1972-10-25 1976-07-28 Glaxo Lab Ltd Acylamido-penam-carboxylic acids and their derivatives
KR100965040B1 (en) 2005-07-11 2010-06-21 미쓰비시 타나베 파마 코퍼레이션 An oxime derivative and preparations thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2542812A (en) * 1946-04-03 1951-02-20 Walter H Hartung Preparation of aminoacidamides
DE1159449B (en) * 1961-03-22 1963-12-19 Gruenenthal Chemie Process for the preparation of 6-acylaminopenicillanic acids and their salts
SE311519B (en) * 1962-12-14 1969-06-16 Astra Ab

Also Published As

Publication number Publication date
CH579571A5 (en) 1976-09-15
AU475444B2 (en) 1976-08-26
NL7206466A (en) 1972-11-16
AT329176B (en) 1976-04-26
AU4229872A (en) 1974-01-03
AU4229972A (en) 1973-12-20
JPS5248997B1 (en) 1977-12-14
ATA420772A (en) 1975-07-15
FR2137898A1 (en) 1972-12-29
FR2287231B1 (en) 1978-09-01
HU172017B (en) 1978-05-28
ZA723223B (en) 1973-02-28
IL39428A (en) 1977-01-31
FR2287231A1 (en) 1976-05-07
IE37782B1 (en) 1977-10-12
ZA723224B (en) 1973-03-28
AU474163B2 (en) 1976-07-15
BE783448A (en) 1972-11-13
ES402650A1 (en) 1976-01-01
DE2223287A1 (en) 1972-12-07
FR2137898B1 (en) 1976-04-16
IL39428A0 (en) 1972-07-26
PL101031B1 (en) 1978-11-30

Similar Documents

Publication Publication Date Title
IE36209B1 (en) 2,2'-methylenediphenols, compositions based thereon and method for preparing both
SE7611047L (en) PROCEDURE FOR PREPARING ANTIBACTERIAL SUBJECT
IE36881L (en) 7, 7-disubstituted cepalosporins and 6, 6-disubstituted¹penicillins
IE37782L (en) Penicillin compounds
IE44445L (en) Pseudomonic acid amides
ES480405A1 (en) Novel macrolide antibiotics and preparation thereof
IE44295L (en) Preparation of clavulanic acid
SE7509139L (en) PROCEDURE FOR THE PREPARATION OF CEPHALOSPORINE ASSOCIATIONS
IE40057L (en) 4- oxo -1- pyridinyl penicillin and cephalosporin¹derivatives
GB1002182A (en) Fungicidal preparations
NL6813094A (en) Tetramycin antibiotic
GB1501643A (en) Antibacterial substituted azetidinones
JPS5655388A (en) Benzo ij quinolidine-2-carboxylic acid derivative, and its preparation
IE43538L (en) Cephalosporin derivatives.
IE40517B1 (en) 7-(substituted phenyl-acetamido)-3-heterocyclic thiomethyl-3cephem-4-carboxylic acids
IE39543L (en) Cephalosporins
JPS56127381A (en) Beta-lactam compound and its preparation
KR940002254A (en) Pyridone isoxoxazole cefe compound and preparation method thereof
GB1420283A (en) Aminoglycoside antibiotics and preparation thereof from micromonospora
FR2267791A1 (en)
JPS56127382A (en) Beta-lactam compound and its preparation
GB1477672A (en) Penicillin compositions
JPS5659773A (en) Preparation of benzo ij quinolidine-2-carboxylic derivative and its preparation
JPS54103872A (en) Antibiotic pseudomonic acid derivative and its preparation
PT64720A (en) Broad-spectrum cephalosporin antibiotics resistant to beta-lactamase - 7-(alpha-(4pethyl-2,3-dioxo-piperazinocarbonylamino)-para-hydroxy- phenylacetamido)-ceph-3-em-4-carboxylic acids