JPS5659773A - Preparation of benzo ij quinolidine-2-carboxylic derivative and its preparation - Google Patents

Preparation of benzo ij quinolidine-2-carboxylic derivative and its preparation

Info

Publication number
JPS5659773A
JPS5659773A JP13580779A JP13580779A JPS5659773A JP S5659773 A JPS5659773 A JP S5659773A JP 13580779 A JP13580779 A JP 13580779A JP 13580779 A JP13580779 A JP 13580779A JP S5659773 A JPS5659773 A JP S5659773A
Authority
JP
Japan
Prior art keywords
formula
compound
preparation
quinolidine
benzo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13580779A
Other languages
Japanese (ja)
Other versions
JPS6344157B2 (en
Inventor
Hiroshi Ishikawa
Fujio Tafusa
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP13580779A priority Critical patent/JPS5659773A/en
Publication of JPS5659773A publication Critical patent/JPS5659773A/en
Publication of JPS6344157B2 publication Critical patent/JPS6344157B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:Benzo[ij]quinolidine-2-carboxylic acid derivatives of formula I (R1 is Br; R2 is Cl, F) and their salts.
EXAMPLE: 9-Fluoro-8-bromo-5-methyl-6, 7-dihydro-1-oxo-1H, 5H-benzo[ ij ]quinolidine-2-carboxylic acid.
USE: Antibacterial and synthetic intermediate of compounds used as antibacterials: they have outstanding activity against gram-positive and -negative bacteria, especially being very effective on Streptococcus, Psedomonas and Enterobacter. They show antibacterial activity also against Escherichia coli, Staphylococcus, further Serratia and Klebsiella and low toxicity.
PREPARATION: A compound of formula II reacts with another compound of formula III (R4, R5 are lower alkyl) to form a compound of formula IV, which is cyclized to give a compound of formula V. The product is hydrolyzed to give the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP13580779A 1979-10-19 1979-10-19 Preparation of benzo ij quinolidine-2-carboxylic derivative and its preparation Granted JPS5659773A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13580779A JPS5659773A (en) 1979-10-19 1979-10-19 Preparation of benzo ij quinolidine-2-carboxylic derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13580779A JPS5659773A (en) 1979-10-19 1979-10-19 Preparation of benzo ij quinolidine-2-carboxylic derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS5659773A true JPS5659773A (en) 1981-05-23
JPS6344157B2 JPS6344157B2 (en) 1988-09-02

Family

ID=15160275

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13580779A Granted JPS5659773A (en) 1979-10-19 1979-10-19 Preparation of benzo ij quinolidine-2-carboxylic derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5659773A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0249158A (en) * 1988-08-11 1990-02-19 Showa Aircraft Ind Co Ltd Sensor for detecting fault by ultrasonic wave

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS516156A (en) * 1974-07-05 1976-01-19 Chugai Ro Kogyo Kaisha Ltd

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS516156A (en) * 1974-07-05 1976-01-19 Chugai Ro Kogyo Kaisha Ltd

Also Published As

Publication number Publication date
JPS6344157B2 (en) 1988-09-02

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