IE37319L - Therapeutic ethers - Google Patents
Therapeutic ethersInfo
- Publication number
- IE37319L IE37319L IE730287A IE28773A IE37319L IE 37319 L IE37319 L IE 37319L IE 730287 A IE730287 A IE 730287A IE 28773 A IE28773 A IE 28773A IE 37319 L IE37319 L IE 37319L
- Authority
- IE
- Ireland
- Prior art keywords
- formula
- compounds
- group
- alkyl
- feb
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1429852 Amides WELLCOME FOUNDATION Ltd 23 Feb 1973 [25 Feb 1972 28 Feb 1972] 8920/73 Addition to 1380882 Heading C2C [Also in Division A5] The invention comprises amides of the formula wherein L is -Z-A-Z-, where Z is when m is 0 or 1 and X 2 , X 3 and X 4 are H or C 1-3 alkyl; and A is -O.CO.O- or a divalent radical of a dicarboxylic or monocarboxylic acid containing 2 to 14 carbon atoms and having respectively two ester linkages or one ester and one other linkage, to the rest of the molecule, or -CH 2 -, -(CH 2 ) 2 -, or where X and X 1 are H or C 1-3 alkyl ; R and R<SP>1</SP> are H, optionally substituted saturated aliphatic hydrocarbon group having 1 to 7 carbon atoms or an unsaturated aliphatic hydrocarbon group having 2 to 4 carbon atoms; R<SP>2</SP> and R<SP>3</SP> are H, C 1-4 alkyl, R<SP>5</SP>CO, R<SP>6</SP>CO where R<SP>5</SP> and R<SP>6</SP> are H, optionally substituted aliphatic C 1-7 hydrocarbyl, or unsaturated aliphatic C 2-4 hydrocarbyl or together with R and R<SP>1</SP> respectively form C 2-4 alkylene, provided that when L is other than -Z-A-Z- at least one of R<SP>2</SP> and R<SP>3</SP> is, as appropriate, the group R<SP>5</SP>CO or R<SP>6</SP>CO and when one or more of the groups R, R<SP>1</SP>, R<SP>5</SP> and R<SP>6</SP> is a saturated aliphatic C 1-7 hydrocarbyl group substituted by NH 2 , C 1-4 alkylamino or di-(C 1-4 alkyl) amino, acid addition salts thereof. The compounds are obtained by one of the following methods:- (a) reacting in liquid mediums compounds of the Formula III wherein Alk is an alkali metal, D is R or R<SP>1</SP> and E is R<SP>2</SP> or R<SP>3</SP> with compounds of the Formula IV where B is a reactive nucleophilic group or atom; (b) acylating amines of the Formula V wherein at least one of T<SP>1</SP>, T<SP>2</SP>, T<SP>3</SP> and T<SP>4</SP> is H and otherwise T<SP>1</SP> and T<SP>2</SP> are R<SP>1</SP>CO or RCO and T<SP>3</SP> and T<SP>4</SP> are R<SP>2</SP> and R<SP>3</SP> respectively; or (c) reacting in liquid medium compounds of the Formula VII where D is R or R<SP>1</SP> and E is R<SP>2</SP> or R<SP>3</SP> and P is H or an alkali metal with compounds of the Formula VIII wherein G is the moiety of the group A that interconnects the two terminal oxygen atoms thereof. 4<SP>1</SP>-(2-Hydroxyethoxy)acetanilide is made by reacting 4-acetamidophenol with 2-chloroethanol.
[GB1429852A]
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US00229563A US3852336A (en) | 1972-02-25 | 1972-02-25 | Anthelmintic compounds |
US230126A US3862226A (en) | 1972-02-28 | 1972-02-28 | Bis-{8 beta-(4-N,N-diacetylaminophenoxy)ethyl{9 ether |
Publications (2)
Publication Number | Publication Date |
---|---|
IE37319L true IE37319L (en) | 1973-08-25 |
IE37319B1 IE37319B1 (en) | 1977-06-22 |
Family
ID=26923410
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE287/73A IE37319B1 (en) | 1972-02-25 | 1973-02-23 | Ethers and their use in the treatment of liver fluke infections |
Country Status (7)
Country | Link |
---|---|
JP (1) | JPS4897828A (en) |
CH (1) | CH590210A5 (en) |
DE (1) | DE2309100C2 (en) |
FR (1) | FR2181761B2 (en) |
GB (1) | GB1429852A (en) |
IE (1) | IE37319B1 (en) |
NL (1) | NL180507C (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1751206A2 (en) * | 2004-05-14 | 2007-02-14 | Kenneth I. Sawyer | Polyurea compositions and compounds for the preparation thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB749907A (en) * | 1952-12-04 | 1956-06-06 | Wellcome Found | Improvements in bis-(p-aminophenoxy) alkane derivatives |
US3896235A (en) * | 1970-09-01 | 1975-07-22 | Burroughs Wellcome Co | Anthelmintic ethers and composition thereof |
-
1973
- 1973-02-22 JP JP48021684A patent/JPS4897828A/ja active Pending
- 1973-02-23 NL NLAANVRAGE7302558,A patent/NL180507C/en not_active IP Right Cessation
- 1973-02-23 FR FR7306480A patent/FR2181761B2/fr not_active Expired
- 1973-02-23 DE DE2309100A patent/DE2309100C2/en not_active Expired
- 1973-02-23 CH CH265873A patent/CH590210A5/xx not_active IP Right Cessation
- 1973-02-23 IE IE287/73A patent/IE37319B1/en unknown
- 1973-02-23 GB GB892073A patent/GB1429852A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
DE2309100A1 (en) | 1973-09-06 |
DE2309100C2 (en) | 1985-06-13 |
GB1429852A (en) | 1976-03-31 |
FR2181761B2 (en) | 1975-11-21 |
NL7302558A (en) | 1973-08-28 |
IE37319B1 (en) | 1977-06-22 |
FR2181761A2 (en) | 1973-12-07 |
AU5256173A (en) | 1974-08-29 |
NL180507B (en) | 1986-10-01 |
CH590210A5 (en) | 1977-07-29 |
NL180507C (en) | 1987-03-02 |
JPS4897828A (en) | 1973-12-13 |
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