IE36225B1 - Improvements relating to insulin derivatives - Google Patents
Improvements relating to insulin derivativesInfo
- Publication number
- IE36225B1 IE36225B1 IE4672A IE4672A IE36225B1 IE 36225 B1 IE36225 B1 IE 36225B1 IE 4672 A IE4672 A IE 4672A IE 4672 A IE4672 A IE 4672A IE 36225 B1 IE36225 B1 IE 36225B1
- Authority
- IE
- Ireland
- Prior art keywords
- blocked
- gps
- prepns
- derivs
- pref
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 5
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- 102000004877 Insulin Human genes 0.000 abstract 2
- 108090001061 Insulin Proteins 0.000 abstract 2
- 230000002218 hypoglycaemic effect Effects 0.000 abstract 2
- 229940125396 insulin Drugs 0.000 abstract 2
- 125000004080 3-carboxypropanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C(O[H])=O 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- -1 glutaryl Chemical group 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C07K14/625—Extraction from natural sources
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB338871A GB1381274A (en) | 1971-01-28 | 1971-01-28 | Insulin derivatives |
| GB338771A GB1381273A (en) | 1971-01-28 | 1971-01-28 | Insulin derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE36225L IE36225L (en) | 1972-07-28 |
| IE36225B1 true IE36225B1 (en) | 1976-09-15 |
Family
ID=26238276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE4672A IE36225B1 (en) | 1971-01-28 | 1972-01-12 | Improvements relating to insulin derivatives |
Country Status (8)
| Country | Link |
|---|---|
| AU (1) | AU472582B2 (enExample) |
| BE (1) | BE778538A (enExample) |
| CH (1) | CH547777A (enExample) |
| DE (1) | DE2204053A1 (enExample) |
| FR (1) | FR2123524A1 (enExample) |
| IE (1) | IE36225B1 (enExample) |
| NL (1) | NL7201179A (enExample) |
| SE (1) | SE382452B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8309123B2 (en) | 2007-12-19 | 2012-11-13 | Farid Bennis | Pharmaceutical compositions and methods for the oral delivery of insulin |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE791585A (fr) * | 1971-11-18 | 1973-05-17 | Nat Res Dev | Derives de l'insuline |
| BE791949A (fr) * | 1971-11-27 | 1973-05-28 | Schering Ag | Derives d'insuline, leur preparation et leur utilisation |
| US3847893A (en) * | 1972-03-01 | 1974-11-12 | Bayer Ag | Process for the preparation of insulin derivatives cross-linked by a dicarboxylic acid group at the amino a-1 glycine and amino b-29 lysine |
| US3907763A (en) * | 1972-03-01 | 1975-09-23 | Bayer Ag | Insulin derivatives crosslinked by a dicarboxylic acid moiety |
| DE2252157C3 (de) * | 1972-10-25 | 1976-03-18 | Hoechst Ag | Zwischenprodukte zur herstellung von insulin, insulin-analogen und -derivaten und verfahren zur herstellung von insulin, insulin analogen und derivaten |
| DE2253327A1 (de) * | 1972-10-31 | 1974-05-09 | Hoechst Ag | Verfahren zur herstellung von insulin, insulin-analogen und -derivaten |
| NL7314766A (enExample) * | 1972-10-31 | 1974-05-02 | ||
| US4175122A (en) * | 1975-04-15 | 1979-11-20 | Burroughs Wellcome Co. | Biologically active amides |
| US4223017A (en) * | 1975-04-15 | 1980-09-16 | Burroughs Wellcome Co. | Biologically active amides |
| GB1560933A (en) * | 1975-04-15 | 1980-02-13 | Wellcome Found | Biologically activy polypeptides |
| DK179286D0 (da) * | 1986-04-18 | 1986-04-18 | Nordisk Gentofte | Insulinpraeparat |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3528960A (en) * | 1968-10-07 | 1970-09-15 | Lilly Co Eli | N-carboxyaroyl insulins |
-
1972
- 1972-01-12 IE IE4672A patent/IE36225B1/xx unknown
- 1972-01-24 AU AU38213/72A patent/AU472582B2/en not_active Expired
- 1972-01-26 BE BE778538A patent/BE778538A/xx unknown
- 1972-01-27 SE SE94972A patent/SE382452B/xx unknown
- 1972-01-28 DE DE19722204053 patent/DE2204053A1/de active Pending
- 1972-01-28 NL NL7201179A patent/NL7201179A/xx unknown
- 1972-01-28 FR FR7202946A patent/FR2123524A1/fr active Granted
- 1972-01-28 CH CH125672A patent/CH547777A/fr not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8309123B2 (en) | 2007-12-19 | 2012-11-13 | Farid Bennis | Pharmaceutical compositions and methods for the oral delivery of insulin |
Also Published As
| Publication number | Publication date |
|---|---|
| NL7201179A (enExample) | 1972-08-01 |
| FR2123524B1 (enExample) | 1975-12-26 |
| AU3821372A (en) | 1973-07-26 |
| IE36225L (en) | 1972-07-28 |
| BE778538A (fr) | 1972-07-26 |
| SE382452B (sv) | 1976-02-02 |
| FR2123524A1 (en) | 1972-09-08 |
| AU472582B2 (en) | 1976-05-27 |
| CH547777A (fr) | 1974-04-11 |
| DE2204053A1 (de) | 1972-08-17 |
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