FR2142398A5 - Water-soluble coupling products - from active amino-cpds and carbonyl-polymers by solubilisation of residual carbonyl - Google Patents

Water-soluble coupling products - from active amino-cpds and carbonyl-polymers by solubilisation of residual carbonyl

Info

Publication number
FR2142398A5
FR2142398A5 FR7221077A FR7221077A FR2142398A5 FR 2142398 A5 FR2142398 A5 FR 2142398A5 FR 7221077 A FR7221077 A FR 7221077A FR 7221077 A FR7221077 A FR 7221077A FR 2142398 A5 FR2142398 A5 FR 2142398A5
Authority
FR
France
Prior art keywords
carbonyl
solubilisation
polymers
water
cpds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR7221077A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akademie der Wissenschaften der DDR
Original Assignee
Akademie der Wissenschaften der DDR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akademie der Wissenschaften der DDR filed Critical Akademie der Wissenschaften der DDR
Application granted granted Critical
Publication of FR2142398A5 publication Critical patent/FR2142398A5/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Biologically active cpds. contg. amino-groups are converted into water-soluble products by coupling with polymers contg. carbonyl groups using part of the latter groups for coupling and modifying another for solubilisation. This is done by coupling with simple amino or sulphonic acids or as an after-treatment by a disproportionation or partial reducn. of the residual carbonyl groups. Products are soluble in a neutral-aq. medium and have a high content of active agent. In an example 3.1g (68%) product contg. 11% noradrenaline (twice the amt. obtainable without solubilisers) is obtd. from 1.1g glycine, 40 ml of a 10% oxydextran-soln. and 3.34 g noradrenaline bitartrate.
FR7221077A 1971-06-14 1972-06-12 Water-soluble coupling products - from active amino-cpds and carbonyl-polymers by solubilisation of residual carbonyl Expired FR2142398A5 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DD15574071 1971-06-14

Publications (1)

Publication Number Publication Date
FR2142398A5 true FR2142398A5 (en) 1973-01-26

Family

ID=5483945

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7221077A Expired FR2142398A5 (en) 1971-06-14 1972-06-12 Water-soluble coupling products - from active amino-cpds and carbonyl-polymers by solubilisation of residual carbonyl

Country Status (3)

Country Link
DE (1) DE2223618A1 (en)
FR (1) FR2142398A5 (en)
HU (1) HU166985B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0491644A2 (en) * 1990-12-17 1992-06-24 Industria Farmaceutica Cantabria S.A. Process for obtaining polymers with antiviral activity
WO1999007744A1 (en) * 1997-08-08 1999-02-18 Behringwerke Aktiengesellschaft Polysaccharide conjugates of biomolecules
CN109387622A (en) * 2018-03-02 2019-02-26 国家纳米科学中心 A kind of polymer surface method of modifying and its application

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0491644A2 (en) * 1990-12-17 1992-06-24 Industria Farmaceutica Cantabria S.A. Process for obtaining polymers with antiviral activity
EP0491644A3 (en) * 1990-12-17 1993-06-02 Laboratorios Andromaco S.A. Process for obtaining polymers with antiviral activity
WO1999007744A1 (en) * 1997-08-08 1999-02-18 Behringwerke Aktiengesellschaft Polysaccharide conjugates of biomolecules
CN109387622A (en) * 2018-03-02 2019-02-26 国家纳米科学中心 A kind of polymer surface method of modifying and its application

Also Published As

Publication number Publication date
DE2223618A1 (en) 1973-01-04
HU166985B (en) 1975-07-28

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