FR2123524A1 - N-blocked insulin derivs - with high water solubility, and the corresp o-blocked cpds - Google Patents

N-blocked insulin derivs - with high water solubility, and the corresp o-blocked cpds

Info

Publication number
FR2123524A1
FR2123524A1 FR7202946A FR7202946A FR2123524A1 FR 2123524 A1 FR2123524 A1 FR 2123524A1 FR 7202946 A FR7202946 A FR 7202946A FR 7202946 A FR7202946 A FR 7202946A FR 2123524 A1 FR2123524 A1 FR 2123524A1
Authority
FR
France
Prior art keywords
blocked
derivs
insulin
cpds
corresp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7202946A
Other languages
French (fr)
Other versions
FR2123524B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Research Development Corp UK
Original Assignee
National Research Development Corp UK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB338771A external-priority patent/GB1381273A/en
Priority claimed from GB338871A external-priority patent/GB1381274A/en
Application filed by National Research Development Corp UK filed Critical National Research Development Corp UK
Publication of FR2123524A1 publication Critical patent/FR2123524A1/en
Application granted granted Critical
Publication of FR2123524B1 publication Critical patent/FR2123524B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C07K14/625—Extraction from natural sources
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Therepeutic prepns. contg. insulin derivs., in which at least one of the NH2 gps. of the A1(glycine), B1 (phenylalanine) and B29 (lysine) amino acid elements is blocked by a substituent capable of forming an anion, and in which opt. at least one tyrosine OH gp. is blocked by a substit. easily removable in vivo, have a large proportion of the hypoglycaemic activity of normal insulin prepns. while being more sol. in H2O and having acceptable immunological properties. The OH-blocked cpds. extend the duration of hypoglycaemic activity. Pref. N-blocking gps. are succinyl and glutaryl, and OH-blocking gps. are pref. opt. N-substd. carbamoyl. The N-blocked derivs. may be prepd. by acylation with a suitable dicarboxylic acid or functional deriv.
FR7202946A 1971-01-28 1972-01-28 N-blocked insulin derivs - with high water solubility, and the corresp o-blocked cpds Granted FR2123524A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB338771A GB1381273A (en) 1971-01-28 1971-01-28 Insulin derivatives
GB338871A GB1381274A (en) 1971-01-28 1971-01-28 Insulin derivatives

Publications (2)

Publication Number Publication Date
FR2123524A1 true FR2123524A1 (en) 1972-09-08
FR2123524B1 FR2123524B1 (en) 1975-12-26

Family

ID=26238276

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7202946A Granted FR2123524A1 (en) 1971-01-28 1972-01-28 N-blocked insulin derivs - with high water solubility, and the corresp o-blocked cpds

Country Status (8)

Country Link
AU (1) AU472582B2 (en)
BE (1) BE778538A (en)
CH (1) CH547777A (en)
DE (1) DE2204053A1 (en)
FR (1) FR2123524A1 (en)
IE (1) IE36225B1 (en)
NL (1) NL7201179A (en)
SE (1) SE382452B (en)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2160619A1 (en) * 1971-11-18 1973-06-29 Nat Res Dev
FR2161063A1 (en) * 1971-11-27 1973-07-06 Schering Ag
FR2181778A1 (en) * 1972-03-01 1973-12-07 Bayer Ag
FR2181779A1 (en) * 1972-03-01 1973-12-07 Bayer Ag
FR2204618A1 (en) * 1972-10-31 1974-05-24 Hoechst Ag
FR2204617A2 (en) * 1972-10-31 1974-05-24 Hoechst Ag
FR2204616A1 (en) * 1972-10-25 1974-05-24 Hoechst Ag
FR2307541A1 (en) * 1975-04-15 1976-11-12 Wellcome Found MEDICINAL PRODUCT BASED ON A POLYPEPTIDE
US4175122A (en) * 1975-04-15 1979-11-20 Burroughs Wellcome Co. Biologically active amides
US4223017A (en) * 1975-04-15 1980-09-16 Burroughs Wellcome Co. Biologically active amides
FR2925333A1 (en) * 2007-12-19 2009-06-26 Farid Bennis PHARMACEUTICAL COMPOSITIONS COMPRISING AT LEAST ONE PROTEIN ACTIVE INGREDIENT PROTECTS DIGESTIVE ENZYMES

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK179286D0 (en) * 1986-04-18 1986-04-18 Nordisk Gentofte INSULIN PREPARATION

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3528960A (en) * 1968-10-07 1970-09-15 Lilly Co Eli N-carboxyaroyl insulins

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3528960A (en) * 1968-10-07 1970-09-15 Lilly Co Eli N-carboxyaroyl insulins

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2160619A1 (en) * 1971-11-18 1973-06-29 Nat Res Dev
FR2161063A1 (en) * 1971-11-27 1973-07-06 Schering Ag
FR2181778A1 (en) * 1972-03-01 1973-12-07 Bayer Ag
FR2181779A1 (en) * 1972-03-01 1973-12-07 Bayer Ag
FR2204616A1 (en) * 1972-10-25 1974-05-24 Hoechst Ag
FR2204617A2 (en) * 1972-10-31 1974-05-24 Hoechst Ag
FR2204618A1 (en) * 1972-10-31 1974-05-24 Hoechst Ag
FR2307541A1 (en) * 1975-04-15 1976-11-12 Wellcome Found MEDICINAL PRODUCT BASED ON A POLYPEPTIDE
US4175122A (en) * 1975-04-15 1979-11-20 Burroughs Wellcome Co. Biologically active amides
US4223017A (en) * 1975-04-15 1980-09-16 Burroughs Wellcome Co. Biologically active amides
US4355025A (en) * 1975-04-15 1982-10-19 Burroughs Wellcome Co. Biologically active amides
FR2925333A1 (en) * 2007-12-19 2009-06-26 Farid Bennis PHARMACEUTICAL COMPOSITIONS COMPRISING AT LEAST ONE PROTEIN ACTIVE INGREDIENT PROTECTS DIGESTIVE ENZYMES
WO2009083686A1 (en) * 2007-12-19 2009-07-09 Farid Bennis Pharmaceutical compositions containing at least one proteinaceous active ingredient protected against digestive enzymes
AP3573A (en) * 2007-12-19 2016-02-08 Farid Bennis Pharmaceutical compositions containing at least one proteinaceous active ingredient protected against digestive enzymes
EA023107B1 (en) * 2007-12-19 2016-04-29 Фарид Беннис Pharmaceutical compositions containing at least one proteinaceous active ingredient protected against digestive enzymes

Also Published As

Publication number Publication date
AU3821372A (en) 1973-07-26
IE36225B1 (en) 1976-09-15
BE778538A (en) 1972-07-26
FR2123524B1 (en) 1975-12-26
AU472582B2 (en) 1976-05-27
NL7201179A (en) 1972-08-01
SE382452B (en) 1976-02-02
CH547777A (en) 1974-04-11
DE2204053A1 (en) 1972-08-17
IE36225L (en) 1972-07-28

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none THE SOCIETY FOR ITALIAN STUDIES: EXECUTIVE COMMITTEE, 1972
Mathur et al. Synthetic substitute enzymes. IV. Glycosidase activity of a copolymer of L-phenylalanine & L-glutamic acid & synthesis of poly-L-phenylalanyl, poly-L-alanyl, poly-L-valyl & poly-L-valyl-L-alanyl, L-asparaginyl-L-lysyl-L-histidyl-L-arginine as ribonuclease substitutes

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