IE33075B1 - Benzodiazepine derivatives and a process for the manufacture thereof - Google Patents
Benzodiazepine derivatives and a process for the manufacture thereofInfo
- Publication number
- IE33075B1 IE33075B1 IE630/69A IE63069A IE33075B1 IE 33075 B1 IE33075 B1 IE 33075B1 IE 630/69 A IE630/69 A IE 630/69A IE 63069 A IE63069 A IE 63069A IE 33075 B1 IE33075 B1 IE 33075B1
- Authority
- IE
- Ireland
- Prior art keywords
- added
- evapd
- stirred
- phh
- nh4oh
- Prior art date
Links
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 title 1
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 abstract 2
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
- 235000011114 ammonium hydroxide Nutrition 0.000 abstract 2
- 235000019439 ethyl acetate Nutrition 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 2
- FALRKNHUBBKYCC-UHFFFAOYSA-N 2-(chloromethyl)pyridine-3-carbonitrile Chemical compound ClCC1=NC=CC=C1C#N FALRKNHUBBKYCC-UHFFFAOYSA-N 0.000 abstract 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 abstract 1
- 239000012267 brine Substances 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 229910052681 coesite Inorganic materials 0.000 abstract 1
- 229910052906 cristobalite Inorganic materials 0.000 abstract 1
- DZGCGKFAPXFTNM-UHFFFAOYSA-N ethanol;hydron;chloride Chemical compound Cl.CCO DZGCGKFAPXFTNM-UHFFFAOYSA-N 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940125723 sedative agent Drugs 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 239000000377 silicon dioxide Substances 0.000 abstract 1
- 235000012239 silicon dioxide Nutrition 0.000 abstract 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 abstract 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 abstract 1
- 229910052682 stishovite Inorganic materials 0.000 abstract 1
- 229940014800 succinic anhydride Drugs 0.000 abstract 1
- 229910052905 tridymite Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72735668A | 1968-05-07 | 1968-05-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE33075L IE33075L (en) | 1969-11-07 |
| IE33075B1 true IE33075B1 (en) | 1974-03-06 |
Family
ID=24922333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE630/69A IE33075B1 (en) | 1968-05-07 | 1969-05-05 | Benzodiazepine derivatives and a process for the manufacture thereof |
Country Status (17)
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT224121B (de) * | 1959-12-10 | 1962-11-12 | Hoffmann La Roche | Verfahren zur Herstellung von neuen 1,4-Benzodiazepin-Derivaten |
| AT256114B (de) * | 1964-08-13 | 1967-08-10 | Hoffmann La Roche | Verfahren zur Herstellung von neuen Benzodiazepinderivaten |
-
1969
- 1969-04-22 IL IL32059A patent/IL32059A/xx unknown
- 1969-04-23 CH CH614169A patent/CH512476A/de not_active IP Right Cessation
- 1969-04-30 DK DK239669AA patent/DK120440B/da not_active IP Right Cessation
- 1969-05-05 CS CS317969A patent/CS154270B2/cs unknown
- 1969-05-05 IE IE630/69A patent/IE33075B1/xx unknown
- 1969-05-05 BR BR208524/69A patent/BR6908524D0/pt unknown
- 1969-05-05 GB GB22779/69A patent/GB1192729A/en not_active Expired
- 1969-05-06 FR FR6914419A patent/FR2007969A1/fr not_active Withdrawn
- 1969-05-06 BE BE732557D patent/BE732557A/xx not_active IP Right Cessation
- 1969-05-06 YU YU1104/69A patent/YU33274B/xx unknown
- 1969-05-06 NO NO1864/69A patent/NO122654B/no unknown
- 1969-05-06 ES ES366840A patent/ES366840A1/es not_active Expired
- 1969-05-07 FI FI691348A patent/FI49039C/fi active
- 1969-05-07 DE DE1923250A patent/DE1923250C3/de not_active Expired
- 1969-05-07 NL NL6906970.A patent/NL164557C/xx not_active IP Right Cessation
- 1969-05-07 SE SE06467/69A patent/SE351646B/xx unknown
-
1971
- 1971-12-31 MY MY197156A patent/MY7100056A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL32059A (en) | 1972-08-30 |
| IE33075L (en) | 1969-11-07 |
| YU33274B (en) | 1976-08-31 |
| CH512476A (de) | 1971-09-15 |
| NL6906970A (enrdf_load_html_response) | 1969-11-11 |
| FR2007969A1 (en) | 1970-01-16 |
| GB1192729A (en) | 1970-05-20 |
| IL32059A0 (en) | 1969-06-25 |
| MY7100056A (en) | 1971-12-31 |
| FI49039B (enrdf_load_html_response) | 1974-12-02 |
| DE1923250A1 (de) | 1969-11-20 |
| NL164557B (nl) | 1980-08-15 |
| NO122654B (enrdf_load_html_response) | 1971-07-26 |
| BR6908524D0 (pt) | 1973-01-04 |
| DK120440B (da) | 1971-06-01 |
| ES366840A1 (es) | 1971-04-01 |
| YU110469A (en) | 1976-03-31 |
| DE1923250B2 (de) | 1980-07-24 |
| NL164557C (nl) | 1981-01-15 |
| BE732557A (enrdf_load_html_response) | 1969-11-06 |
| DE1923250C3 (de) | 1981-04-02 |
| SE351646B (enrdf_load_html_response) | 1972-12-04 |
| FI49039C (fi) | 1975-03-10 |
| CS154270B2 (enrdf_load_html_response) | 1974-03-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1527131A (en) | Benzo or heterocyclic fused imidazodiazepines and pharmaceutical compositions containing them | |
| IE33075B1 (en) | Benzodiazepine derivatives and a process for the manufacture thereof | |
| Abraham et al. | 159. The proton magnetic resonance spectra of porphyrins. Part III. meso-Substituted porphyrins | |
| US3250809A (en) | 6-deoxy-6-demethyl-6-halomethylene tetracyclines and their 11a-chloro and fluoro derivatives | |
| Sakuragi et al. | Conformations and competitive [2+ 2] cycloadditions of intramolecular exciplexes of some anisylalkenyl 9-phenanthrenecarboxylates | |
| GB1434517A (en) | Triazolo-1,5-a-pyridine processes for its preparation and compositions incorporating it | |
| LEONARD et al. | Unsaturated Amines. VI. Introduction of α, β-Unsaturation by Means of Mercuric Acetate: Bicyclic Tertiary Amines1, 2 | |
| Iwai et al. | Studies on Acetylenic Compounds. XXXV. The Cyclization Reaction of some Propargylammonium Derivatives.(1). | |
| GB1413814A (en) | Process for the preparation of a readily dispersible pigment | |
| Harada et al. | Absolute stereostructure of novel chiral troponoid spiro compounds as determined by theoretical calculation of CD spectra | |
| ES444144A1 (es) | Un procedimiento para la preparacion de un acido 6,11-dihi- dro-11-oxo-dibenz (b, e) oxepin-alcanoico. | |
| SE384026B (sv) | Forfarande for framstellning av nya derivat av 5,6-dihydro-pyrrolo(3,4-b)pyridin | |
| Clar et al. | 5. 2: 3–5: 6–8: 9-Tribenzoperinaphthene | |
| Kakimoto et al. | Antituberclous Compounds. XXVII. Synthesis of 7, 8-Dihydropyrido-[2.3d] pyridazin-(6H)-one | |
| Huebner et al. | Rauwolfia alkaloids XXVI. Stereochemistry at C-17 | |
| Jones et al. | Stereochemistry and absolute configuration of tecomanine and alkaloid C, an oxygenated skytanthine, two monoterpene alkaloids from Tecoma stans | |
| DE591120C (de) | Verfahren zur Herstellung loeslicher Celluloseester | |
| SU463323A1 (ru) | Способ получени замещенных лактонов 2-(2-оксиэтил)-никотиновой кислоты или их @ -окисей | |
| JPS51141895A (en) | Process for preparing 1,4-diaza-bicyclo(2,2,2)octane | |
| JPS5241245A (en) | Sugarrcrystallizingmethod for finish process of automatic crystallization with crystallizing evaporator | |
| AT326839B (de) | Verfahren zur halbsynthetischen herstellung von vincristin | |
| Cameron et al. | Tautomeric benz [de] anthracene derivatives and related systems | |
| Jones et al. | Conformational interconversions in acyclic and cyclic tetra-alkyl hydrazines | |
| Giller et al. | Ethylenimine chemistry: VII. Pyramidal stability of N-aminoethylenimine derivatives | |
| ES251415A1 (es) | Procedimiento para la preparacion de derivados de diimidazol |