GB1192729A - Benzodiazepine Derivatives and a Process for the Manufacture Thereof - Google Patents
Benzodiazepine Derivatives and a Process for the Manufacture ThereofInfo
- Publication number
- GB1192729A GB1192729A GB22779/69A GB2277969A GB1192729A GB 1192729 A GB1192729 A GB 1192729A GB 22779/69 A GB22779/69 A GB 22779/69A GB 2277969 A GB2277969 A GB 2277969A GB 1192729 A GB1192729 A GB 1192729A
- Authority
- GB
- United Kingdom
- Prior art keywords
- benzodiazepine derivatives
- manufacture
- compounds
- haloethanol
- benzodiazepin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 title abstract 2
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001557 benzodiazepines Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940125723 sedative agent Drugs 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
1,192,729. Benzodiazepine derivatives. F. HOFFMANN-LA ROCHE & CO. A.G. 5 May, 1969 [7 May, 1968], No. 22779/69. Heading C2C. Compounds of the general formula (R = H or alkanoyl containing up to 7 carbon atoms) and their acid addition salts are prepared by reacting the 1-sodio derivative of 7- chloro - 5 - (o - fluorophenyl) - 1,3 - dihydro- 2H - 1,4 - benzodiazepin - 2 - one with a 2- haloethanol or ethylene oxide, optionally followed by esterification and/or salt formation. The above compounds are sedatives, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72735668A | 1968-05-07 | 1968-05-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1192729A true GB1192729A (en) | 1970-05-20 |
Family
ID=24922333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB22779/69A Expired GB1192729A (en) | 1968-05-07 | 1969-05-05 | Benzodiazepine Derivatives and a Process for the Manufacture Thereof |
Country Status (17)
| Country | Link |
|---|---|
| BE (1) | BE732557A (en) |
| BR (1) | BR6908524D0 (en) |
| CH (1) | CH512476A (en) |
| CS (1) | CS154270B2 (en) |
| DE (1) | DE1923250C3 (en) |
| DK (1) | DK120440B (en) |
| ES (1) | ES366840A1 (en) |
| FI (1) | FI49039C (en) |
| FR (1) | FR2007969A1 (en) |
| GB (1) | GB1192729A (en) |
| IE (1) | IE33075B1 (en) |
| IL (1) | IL32059A (en) |
| MY (1) | MY7100056A (en) |
| NL (1) | NL164557C (en) |
| NO (1) | NO122654B (en) |
| SE (1) | SE351646B (en) |
| YU (1) | YU33274B (en) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT224121B (en) * | 1959-12-10 | 1962-11-12 | Hoffmann La Roche | Process for the preparation of new 1,4-benzodiazepine derivatives |
| AT256114B (en) * | 1964-08-13 | 1967-08-10 | Hoffmann La Roche | Process for the preparation of new benzodiazepine derivatives |
-
1969
- 1969-04-22 IL IL32059A patent/IL32059A/en unknown
- 1969-04-23 CH CH614169A patent/CH512476A/en not_active IP Right Cessation
- 1969-04-30 DK DK239669AA patent/DK120440B/en not_active IP Right Cessation
- 1969-05-05 BR BR208524/69A patent/BR6908524D0/en unknown
- 1969-05-05 GB GB22779/69A patent/GB1192729A/en not_active Expired
- 1969-05-05 CS CS317969A patent/CS154270B2/cs unknown
- 1969-05-05 IE IE630/69A patent/IE33075B1/en unknown
- 1969-05-06 YU YU1104/69A patent/YU33274B/en unknown
- 1969-05-06 FR FR6914419A patent/FR2007969A1/en not_active Withdrawn
- 1969-05-06 BE BE732557D patent/BE732557A/xx not_active IP Right Cessation
- 1969-05-06 NO NO1864/69A patent/NO122654B/no unknown
- 1969-05-06 ES ES366840A patent/ES366840A1/en not_active Expired
- 1969-05-07 SE SE06467/69A patent/SE351646B/xx unknown
- 1969-05-07 FI FI691348A patent/FI49039C/en active
- 1969-05-07 DE DE1923250A patent/DE1923250C3/en not_active Expired
- 1969-05-07 NL NL6906970.A patent/NL164557C/en not_active IP Right Cessation
-
1971
- 1971-12-31 MY MY197156A patent/MY7100056A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SE351646B (en) | 1972-12-04 |
| ES366840A1 (en) | 1971-04-01 |
| MY7100056A (en) | 1971-12-31 |
| BE732557A (en) | 1969-11-06 |
| NO122654B (en) | 1971-07-26 |
| YU110469A (en) | 1976-03-31 |
| DE1923250B2 (en) | 1980-07-24 |
| FI49039B (en) | 1974-12-02 |
| NL164557B (en) | 1980-08-15 |
| BR6908524D0 (en) | 1973-01-04 |
| FR2007969A1 (en) | 1970-01-16 |
| YU33274B (en) | 1976-08-31 |
| DK120440B (en) | 1971-06-01 |
| IL32059A0 (en) | 1969-06-25 |
| NL6906970A (en) | 1969-11-11 |
| DE1923250A1 (en) | 1969-11-20 |
| IL32059A (en) | 1972-08-30 |
| IE33075B1 (en) | 1974-03-06 |
| IE33075L (en) | 1969-11-07 |
| FI49039C (en) | 1975-03-10 |
| DE1923250C3 (en) | 1981-04-02 |
| NL164557C (en) | 1981-01-15 |
| CS154270B2 (en) | 1974-03-29 |
| CH512476A (en) | 1971-09-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |