IE32768B1 - Ethers of 1alpha,2alpha-methylene-19-nor-testosterone and of its 18-methyl homologues - Google Patents
Ethers of 1alpha,2alpha-methylene-19-nor-testosterone and of its 18-methyl homologuesInfo
- Publication number
- IE32768B1 IE32768B1 IE443/69A IE44369A IE32768B1 IE 32768 B1 IE32768 B1 IE 32768B1 IE 443/69 A IE443/69 A IE 443/69A IE 44369 A IE44369 A IE 44369A IE 32768 B1 IE32768 B1 IE 32768B1
- Authority
- IE
- Ireland
- Prior art keywords
- methyl
- methylene
- estran
- prepared
- acetoxy
- Prior art date
Links
- 150000002170 ethers Chemical class 0.000 title 1
- 229960004719 nandrolone Drugs 0.000 title 1
- 150000003431 steroids Chemical class 0.000 abstract 3
- PVFOHMXILQEIHX-UHFFFAOYSA-N 8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9-[2-(2-bromophenyl)ethyl]purin-6-amine Chemical compound C=1C=2OCOC=2C=C(Br)C=1SC1=NC=2C(N)=NC=NC=2N1CCC1=CC=CC=C1Br PVFOHMXILQEIHX-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- QENZOBLYOJSARN-GSNZFIHSSA-N (8r,9r,10s,13s,14s)-13-methyl-2,4,5,6,7,8,9,10,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-3-one Chemical compound C1CC2CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CCC[C@@]1(C)CC2 QENZOBLYOJSARN-GSNZFIHSSA-N 0.000 abstract 1
- BUDQDWGNQVEFAC-UHFFFAOYSA-N Dihydropyran Chemical compound C1COC=CC1 BUDQDWGNQVEFAC-UHFFFAOYSA-N 0.000 abstract 1
- 238000006640 acetylation reaction Methods 0.000 abstract 1
- 229940100198 alkylating agent Drugs 0.000 abstract 1
- 239000002168 alkylating agent Substances 0.000 abstract 1
- 229940124325 anabolic agent Drugs 0.000 abstract 1
- 239000003263 anabolic agent Substances 0.000 abstract 1
- 230000031709 bromination Effects 0.000 abstract 1
- 238000005893 bromination reaction Methods 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000006704 dehydrohalogenation reaction Methods 0.000 abstract 1
- QGXBDMJGAMFCBF-XRJZGPCZSA-N epietiocholanolone Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC[C@@H]21 QGXBDMJGAMFCBF-XRJZGPCZSA-N 0.000 abstract 1
- 230000026030 halogenation Effects 0.000 abstract 1
- 238000005658 halogenation reaction Methods 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 230000011987 methylation Effects 0.000 abstract 1
- 238000007069 methylation reaction Methods 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19681768161 DE1768161B2 (de) | 1968-04-05 | 1968-04-05 | Aether des 1 alpha, 2 alpha-methylen-19-nor-testosterons und seiner 18- alkylhomologen, verfahren zu ihrer herstellung, diese enthaltende arzneimittel sowie entsprechende 5 alpha-oestran-zwischenprodukte |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE32768L IE32768L (en) | 1969-10-05 |
| IE32768B1 true IE32768B1 (en) | 1973-11-28 |
Family
ID=5699619
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE443/69A IE32768B1 (en) | 1968-04-05 | 1969-04-01 | Ethers of 1alpha,2alpha-methylene-19-nor-testosterone and of its 18-methyl homologues |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US3590033A (enExample) |
| AT (2) | AT290743B (enExample) |
| BE (1) | BE731081A (enExample) |
| CH (1) | CH535219A (enExample) |
| CS (3) | CS162679B2 (enExample) |
| DE (1) | DE1768161B2 (enExample) |
| DK (1) | DK119109B (enExample) |
| ES (1) | ES365404A1 (enExample) |
| FI (1) | FI45320C (enExample) |
| FR (1) | FR2007402A1 (enExample) |
| GB (1) | GB1265393A (enExample) |
| IE (1) | IE32768B1 (enExample) |
| IL (1) | IL31926A (enExample) |
| NL (1) | NL160571C (enExample) |
| NO (1) | NO129348B (enExample) |
| SE (1) | SE344063B (enExample) |
-
1968
- 1968-04-05 DE DE19681768161 patent/DE1768161B2/de active Granted
-
1969
- 1969-03-11 CH CH366869A patent/CH535219A/de not_active IP Right Cessation
- 1969-03-17 DK DK143669AA patent/DK119109B/da unknown
- 1969-03-21 AT AT282269A patent/AT290743B/de not_active IP Right Cessation
- 1969-03-21 AT AT922969A patent/AT289308B/de not_active IP Right Cessation
- 1969-03-24 CS CS741409A patent/CS162679B2/cs unknown
- 1969-03-24 CS CS741410A patent/CS162680B2/cs unknown
- 1969-03-24 CS CS2074A patent/CS162678B2/cs unknown
- 1969-03-28 ES ES365404A patent/ES365404A1/es not_active Expired
- 1969-03-30 IL IL31926A patent/IL31926A/en unknown
- 1969-03-31 GB GB1265393D patent/GB1265393A/en not_active Expired
- 1969-03-31 SE SE4540/69A patent/SE344063B/xx unknown
- 1969-04-01 IE IE443/69A patent/IE32768B1/xx unknown
- 1969-04-01 FI FI690958A patent/FI45320C/fi active
- 1969-04-01 NO NO01365/69A patent/NO129348B/no unknown
- 1969-04-03 NL NL6905323.A patent/NL160571C/xx not_active IP Right Cessation
- 1969-04-04 BE BE731081D patent/BE731081A/xx unknown
- 1969-04-04 FR FR6910486A patent/FR2007402A1/fr not_active Withdrawn
- 1969-04-04 US US815259A patent/US3590033A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IE32768L (en) | 1969-10-05 |
| SE344063B (enExample) | 1972-03-27 |
| NL160571B (nl) | 1979-06-15 |
| AT290743B (de) | 1971-06-11 |
| AT289308B (de) | 1971-04-13 |
| DE1768161B2 (de) | 1977-06-23 |
| CH535219A (de) | 1973-03-31 |
| NL6905323A (enExample) | 1969-10-07 |
| BE731081A (enExample) | 1969-10-06 |
| FI45320C (fi) | 1972-05-10 |
| CS162679B2 (en) | 1975-07-15 |
| FR2007402A1 (enExample) | 1970-01-09 |
| DK119109B (da) | 1970-11-16 |
| DE1768161A1 (de) | 1971-11-18 |
| US3590033A (en) | 1971-06-29 |
| ES365404A1 (es) | 1971-01-01 |
| NO129348B (enExample) | 1974-04-01 |
| NL160571C (nl) | 1979-11-15 |
| FI45320B (enExample) | 1972-01-31 |
| IL31926A0 (en) | 1969-05-28 |
| IL31926A (en) | 1973-06-29 |
| GB1265393A (enExample) | 1972-03-01 |
| CS162678B2 (enExample) | 1975-07-15 |
| CS162680B2 (en) | 1975-07-15 |
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