GB1312956A - Process for liberating free hydroxyl groups in steroid ethers - Google Patents

Process for liberating free hydroxyl groups in steroid ethers

Info

Publication number
GB1312956A
GB1312956A GB2240470A GB2240470A GB1312956A GB 1312956 A GB1312956 A GB 1312956A GB 2240470 A GB2240470 A GB 2240470A GB 2240470 A GB2240470 A GB 2240470A GB 1312956 A GB1312956 A GB 1312956A
Authority
GB
United Kingdom
Prior art keywords
ethers
methyl
steroid
hydroxyl groups
free hydroxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2240470A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of GB1312956A publication Critical patent/GB1312956A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

1312956 Cleavage of steroid ethers SCHERING AG 8 May 1970 [8 May 1969] 22404/70 Heading C2U An alkyl ether of a phenolic steroid is cleaved by treatment at 100‹ C. or below with a hydrogen halide in the presence of a C 1-5 aliphatic carboxylic acid. Preferably HBr in acetic or propionic acid is used at 80-100‹ C. Estrone, estradiol, 18-methyl-estradiol, 17#-acetoxy-18- methyl - #<SP>1,3,5(10)</SP> - estratrien - 3 - ol, 3 - hydroxy- #<SP>1,3,5(10)</SP> - 19 - norpregnatrien - 20 - one, 3- hydroxy - 18 - methyl - #<SP>1,3,5,(10),6,8</SP> - estrapentaen-17-one, equilenin and 9(11)-dehydroestrone may thus be prepared by cleavage of their ethers, e.g. methyl ethers.
GB2240470A 1969-05-08 1970-05-08 Process for liberating free hydroxyl groups in steroid ethers Expired GB1312956A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19691924222 DE1924222A1 (en) 1969-05-08 1969-05-08 Cleavage of aromatic steroidal alkyl ethers

Publications (1)

Publication Number Publication Date
GB1312956A true GB1312956A (en) 1973-04-11

Family

ID=5733999

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2240470A Expired GB1312956A (en) 1969-05-08 1970-05-08 Process for liberating free hydroxyl groups in steroid ethers

Country Status (8)

Country Link
JP (1) JPS5037662B1 (en)
BE (1) BE750162A (en)
CH (1) CH544079A (en)
DE (1) DE1924222A1 (en)
DK (1) DK126777B (en)
FR (1) FR2047463A5 (en)
GB (1) GB1312956A (en)
NL (1) NL7006657A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52106359U (en) * 1976-02-05 1977-08-12
JPS5319477U (en) * 1976-07-27 1978-02-18
JPH06182007A (en) * 1992-12-15 1994-07-05 Bridgestone Corp Golf club shaft

Also Published As

Publication number Publication date
BE750162A (en) 1970-11-09
NL7006657A (en) 1970-11-10
FR2047463A5 (en) 1971-03-12
DE1924222A1 (en) 1970-11-19
CH544079A (en) 1973-11-15
JPS5037662B1 (en) 1975-12-04
DK126777B (en) 1973-08-20

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees