IE32334B1 - Glyceryl esters and their analgesic anti-inflammatory use - Google Patents
Glyceryl esters and their analgesic anti-inflammatory useInfo
- Publication number
- IE32334B1 IE32334B1 IE418/68A IE41868A IE32334B1 IE 32334 B1 IE32334 B1 IE 32334B1 IE 418/68 A IE418/68 A IE 418/68A IE 41868 A IE41868 A IE 41868A IE 32334 B1 IE32334 B1 IE 32334B1
- Authority
- IE
- Ireland
- Prior art keywords
- formula
- compound
- group
- carbamoyl
- vinyl
- Prior art date
Links
- 230000000202 analgesic effect Effects 0.000 title abstract 2
- 230000003110 anti-inflammatory effect Effects 0.000 title abstract 2
- 125000005908 glyceryl ester group Chemical group 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 7
- -1 cyclic acetals Chemical class 0.000 abstract 5
- 150000002148 esters Chemical class 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 3
- 229920002554 vinyl polymer Polymers 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 230000007062 hydrolysis Effects 0.000 abstract 2
- 238000006460 hydrolysis reaction Methods 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- UUMMTMQODCACRH-UHFFFAOYSA-N 2-anilinopyridine-3-carboxylic acid Chemical class OC(=O)C1=CC=CN=C1NC1=CC=CC=C1 UUMMTMQODCACRH-UHFFFAOYSA-N 0.000 abstract 1
- IBRSSZOHCGUTHI-UHFFFAOYSA-N 2-chloropyridine-3-carboxylic acid Chemical compound OC(=O)C1=CC=CN=C1Cl IBRSSZOHCGUTHI-UHFFFAOYSA-N 0.000 abstract 1
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N N-phenyl amine Natural products NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 abstract 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001448 anilines Chemical class 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 239000002221 antipyretic Substances 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000006575 electron-withdrawing group Chemical group 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 150000004702 methyl esters Chemical class 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
- 238000005809 transesterification reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62938267A | 1967-04-10 | 1967-04-10 | |
| US62938367A | 1967-04-10 | 1967-04-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE32334L IE32334L (en) | 1968-10-10 |
| IE32334B1 true IE32334B1 (en) | 1973-06-27 |
Family
ID=27090926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE418/68A IE32334B1 (en) | 1967-04-10 | 1968-04-09 | Glyceryl esters and their analgesic anti-inflammatory use |
Country Status (19)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3852333A (en) * | 1967-10-23 | 1974-12-03 | Parke Davis & Co | New anthranilic acid{60 -monoglycerides |
| DE1939111C3 (de) * | 1969-08-01 | 1974-04-18 | Troponwerke Dinklage & Co, 5000 Koeln | Derivate der N- eckige Klammer auf 3-Trifluormethylphenyl eckige Klammer zu -anthranilsäure, Verfahren zu ihrer Herstellung und pharmakologisch wirksame Zubereitungen derselben |
| FR2154330A1 (en) * | 1971-09-30 | 1973-05-11 | Crt | 2'-(3'-trifluoromethylthio-aniline)-glycerol nicotinate - anti -anflammatory and antipyretic |
| JPS53105445A (en) * | 1977-02-26 | 1978-09-13 | Hokuriku Pharmaceutical | Nn*33trifluoromethylphenyl* anthranylate alklyester derivative and process for preparing same |
| DE2806597A1 (de) * | 1978-02-16 | 1979-08-30 | Bosch Gmbh Robert | Schaltungsanordnung zur verbesserung der selbsterregung von generatoren |
| US4168313A (en) * | 1978-02-21 | 1979-09-18 | Sebastian Bago | Phthalidyl 2-(3'-trifluoromethyl-anilino)-pyridine-3-carboxylate and its salts |
| JPS5545615A (en) * | 1978-09-27 | 1980-03-31 | Nissan Chem Ind Ltd | Derivative of (n-allyl-o-(2,6-dichloroanilino) phenyl) acetic acid |
| US4255581A (en) * | 1979-08-13 | 1981-03-10 | Laboratories Bago, S.A. | Process for the preparation of alkyl and aryl esters of 3'-substituted and 2', 3'-disubstituted 2-anilino-3-pyridinecarboxylic acids |
| FR2546885B1 (fr) * | 1983-06-06 | 1986-02-07 | Fabre Sa Pierre | Oxamates d'anthranilates fonctionnalises utiles comme medicaments dans le traitement des dermatoses inflammatoires |
| DK8502611A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1985-08-08 | 1986-12-12 | ||
| EP4021449A4 (en) * | 2019-08-30 | 2023-11-01 | University of South Florida | STING MODULATORS, COMPOSITIONS AND METHODS OF USE |
| CN118234498A (zh) * | 2021-09-03 | 2024-06-21 | 南佛罗里达大学 | Sting调节剂、组合物及其使用方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2408905A (en) * | 1941-11-29 | 1946-10-08 | Ind Patents Corp | Preparation of synthetic glycerides |
| US3390172A (en) * | 1964-03-27 | 1968-06-25 | Parke Davis & Co | Nu-(3-trifluoromethylphenyl)-anthranilic acids |
-
1967
- 1967-04-10 US US629382A patent/US3511872A/en not_active Expired - Lifetime
- 1967-04-10 US US629383A patent/US3478040A/en not_active Expired - Lifetime
-
1968
- 1968-04-04 CH CH502968A patent/CH534130A/de not_active IP Right Cessation
- 1968-04-04 PL PL1968126222A patent/PL79312B1/pl unknown
- 1968-04-05 GB GB06477/68A patent/GB1220468A/en not_active Expired
- 1968-04-08 JP JP43022917A patent/JPS4940705B1/ja active Pending
- 1968-04-08 IL IL29775A patent/IL29775A/en unknown
- 1968-04-08 AT AT342068A patent/AT284842B/de not_active IP Right Cessation
- 1968-04-09 NO NO1382/68A patent/NO132093C/no unknown
- 1968-04-09 DE DE19681770163 patent/DE1770163A1/de active Pending
- 1968-04-09 OA OA53245A patent/OA03854A/xx unknown
- 1968-04-09 DK DK159968AA patent/DK127725B/da unknown
- 1968-04-09 IE IE418/68A patent/IE32334B1/xx unknown
- 1968-04-09 SE SE04778/68A patent/SE364273B/xx unknown
- 1968-04-09 ES ES0352582A patent/ES352582A1/es not_active Expired
- 1968-04-10 BE BE713499D patent/BE713499A/xx unknown
- 1968-04-10 FR FR147685A patent/FR7472M/fr not_active Expired
- 1968-04-10 NL NL6805079A patent/NL6805079A/xx unknown
-
1974
- 1974-02-13 CY CY72174A patent/CY721A/xx unknown
- 1974-12-31 MY MY197456A patent/MY7400056A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US3511872A (en) | 1970-05-12 |
| IE32334L (en) | 1968-10-10 |
| US3478040A (en) | 1969-11-11 |
| PL79312B1 (en) | 1975-06-30 |
| SE364273B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-02-18 |
| BE713499A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1968-10-10 |
| NO132093C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-09-17 |
| NO132093B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-06-09 |
| CH534130A (de) | 1973-02-28 |
| DE1770163A1 (de) | 1972-03-09 |
| AT284842B (de) | 1970-09-25 |
| FR7472M (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1969-12-01 |
| ES352582A1 (es) | 1969-07-01 |
| GB1220468A (en) | 1971-01-27 |
| IL29775A (en) | 1972-04-27 |
| OA03854A (fr) | 1971-12-24 |
| NL6805079A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1968-10-11 |
| CY721A (en) | 1974-02-13 |
| DK127725B (da) | 1973-12-24 |
| MY7400056A (en) | 1974-12-31 |
| JPS4940705B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-11-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IE32334B1 (en) | Glyceryl esters and their analgesic anti-inflammatory use | |
| SE7608037L (sv) | 2-substituerade oxazolopyridiner | |
| GB1455524A (en) | Aryl-substituted oxo-alkanoic and oxo-alkenoic acids and derivatives of such acids | |
| GB1271132A (en) | Improvements in or relating to naphthyl alkanols and derivatives thereof | |
| ES8105254A1 (es) | Un procedimiento para la preparacion de acido 2-(4-dimetil- vinilfenil) propionico | |
| IE35234L (en) | 2-(substituted phenyl) propionic acids | |
| IE31869L (en) | Glyceryl esters of acetylsalicylic acid | |
| JPS556A (en) | Biochemical resolution | |
| JPS5283436A (en) | Preparation of intermediates for synthesis of prostaglandin | |
| JPS55133327A (en) | Preparation of alpha,beta-unsaturated aldehyde | |
| GB1488905A (en) | 2-(4-biphenyl-yl)-propionic acids and esters and compositions thereof | |
| JPS5527161A (en) | Production of alcohol or its ether derivative | |
| SU1051087A1 (ru) | Способ получени 2- @ -5-(оксигексафторизопропил)-фуранов | |
| JPS5476513A (en) | Polyprenyl alcohol ester and hypotensives containing it | |
| JPS56113736A (en) | Preparation of 2-arylalkanoic acid | |
| JPS55105643A (en) | Novel cyclohexanecarboxylic acid derivative | |
| JPS54154754A (en) | Beta-lactone derivative of antiesterase active substance delta-hydroxymicolic acid and its preparation | |
| JPS57158778A (en) | 2,2,4-trimethyl-5-hydroxymethyl-1,3-dioxolane | |
| JPS5334718A (en) | Preparation of optical active gamma,delta-unsaturated-alpha-oxyvaleric acids | |
| JPS5493A (en) | Preparation of oligomer having low skin irritating property | |
| JPS5436286A (en) | Novel cephalosporanic acid derivative, its optically active isomer, and its preparation | |
| JPS549214A (en) | Preparation of carboxylic acid ester of secondary or tertiary alcohol | |
| JPS5242855A (en) | Process for preparation of 7_(2-alkoxycarbonylcyclopentyl+)-5-heptenoi c acid | |
| JPS5576900A (en) | 24-fluoro-25-hydroxycholestene or its hydroxyl-protected derivative and their preparation | |
| JPS5699445A (en) | Preparation of novel pyruvic acid derivative |