ID30116A - Turunan-turunan piridopiranoazepin, pembuatannya dan penggunaan terapinya - Google Patents

Turunan-turunan piridopiranoazepin, pembuatannya dan penggunaan terapinya

Info

Publication number
ID30116A
ID30116A IDW00200101796A ID20011796A ID30116A ID 30116 A ID30116 A ID 30116A ID W00200101796 A IDW00200101796 A ID W00200101796A ID 20011796 A ID20011796 A ID 20011796A ID 30116 A ID30116 A ID 30116A
Authority
ID
Indonesia
Prior art keywords
piridopiranoazepin
therapy
decreases
production
piridopiranoazepin decreases
Prior art date
Application number
IDW00200101796A
Other languages
English (en)
Indonesian (id)
Inventor
Frederic Galli
Samir Jegham
Alistair Lochead
Axelle Samsom
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of ID30116A publication Critical patent/ID30116A/id

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IDW00200101796A 1999-03-05 2000-03-01 Turunan-turunan piridopiranoazepin, pembuatannya dan penggunaan terapinya ID30116A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9902784A FR2790474B1 (fr) 1999-03-05 1999-03-05 Derives de pyridopyranoazepines, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
ID30116A true ID30116A (id) 2001-11-08

Family

ID=9542888

Family Applications (1)

Application Number Title Priority Date Filing Date
IDW00200101796A ID30116A (id) 1999-03-05 2000-03-01 Turunan-turunan piridopiranoazepin, pembuatannya dan penggunaan terapinya

Country Status (37)

Country Link
US (2) US6538003B1 (ru)
EP (1) EP1161434B1 (ru)
JP (1) JP4806123B2 (ru)
KR (2) KR20070086359A (ru)
CN (1) CN1137894C (ru)
AR (1) AR022820A1 (ru)
AT (1) ATE231869T1 (ru)
AU (1) AU764625B2 (ru)
BG (1) BG65211B1 (ru)
BR (1) BR0008763A (ru)
CA (1) CA2372063C (ru)
CO (1) CO5160250A1 (ru)
CZ (1) CZ302259B6 (ru)
DE (1) DE60001307T2 (ru)
DK (1) DK1161434T3 (ru)
EE (1) EE04497B1 (ru)
ES (1) ES2191611T3 (ru)
FR (1) FR2790474B1 (ru)
HK (1) HK1040398B (ru)
HR (1) HRP20010655B1 (ru)
HU (1) HU228671B1 (ru)
ID (1) ID30116A (ru)
IL (2) IL145150A0 (ru)
MX (1) MXPA01008972A (ru)
NO (1) NO327119B1 (ru)
NZ (1) NZ513561A (ru)
PE (1) PE20001543A1 (ru)
PL (1) PL201683B1 (ru)
RS (1) RS49997B (ru)
RU (1) RU2238273C2 (ru)
SK (1) SK284339B6 (ru)
TR (1) TR200102403T2 (ru)
TW (1) TWI222975B (ru)
UA (1) UA61164C2 (ru)
UY (1) UY26048A1 (ru)
WO (1) WO2000053608A1 (ru)
ZA (1) ZA200106811B (ru)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10164139A1 (de) 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
NZ537003A (en) 2002-07-18 2008-03-28 Cytos Biotechnology Ag Hapten-carrier conjugates comprising virus like particles and uses thereof
US7238715B2 (en) * 2002-12-06 2007-07-03 The Feinstein Institute For Medical Research Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists
ATE378048T1 (de) * 2002-12-06 2007-11-15 The Feinstein Inst Medical Res Hemmung von entzündungen unter verwendungvon alpha-7-rezeptor verbindenden cholinergen agonisten
US8580842B2 (en) 2003-09-30 2013-11-12 Abbott Gmbh & Co. Kg Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
US8316104B2 (en) 2005-11-15 2012-11-20 California Institute Of Technology Method and apparatus for collaborative system
US20080167286A1 (en) * 2006-12-12 2008-07-10 Abbott Laboratories Pharmaceutical compositions and their methods of use
US8486979B2 (en) * 2006-12-12 2013-07-16 Abbvie Inc. 1,2,4 oxadiazole compounds and methods of use thereof
UY30846A1 (es) 2006-12-30 2008-07-31 Abbott Gmbh & Amp Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos
US20080255203A1 (en) * 2007-04-12 2008-10-16 Abbott Laboratories Heterocyclic compounds and their methods of use
US20090076059A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched dianicline
MX2010006206A (es) * 2007-12-07 2011-03-04 Abbott Gmbh & Co Kg Derivados de oxindol substituidos por 5-halogeno y el uso de los mismos para el tratamiento de enfermedades dependientes de la vasopresina.
US8703775B2 (en) * 2007-12-07 2014-04-22 AbbVie Deutschland GmbH & Co. KG Amidomethyl-substituted oxindole derivatives and the use thereof for the treatment of vasopressin-dependent illnesses
US8703774B2 (en) * 2007-12-07 2014-04-22 AbbVie Deutschland GmbH & Co. KG Carbamate-substituted oxindole derivatives and use thereof for the treatment of vasopressin-dependent diseases
JP5645217B2 (ja) 2007-12-07 2014-12-24 アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー ５，６−二置換オキシンドール誘導体およびバソプレッシン依存性疾患を治療するためのこれらの使用
US20090221648A1 (en) * 2007-12-21 2009-09-03 Abbott Laboratories Compositions for treatment of cognitive disorders
US8383657B2 (en) * 2007-12-21 2013-02-26 Abbott Laboratories Thiazolylidine urea and amide derivatives and methods of use thereof
US9463190B2 (en) * 2008-03-31 2016-10-11 University Of South Florida Methods of treating disease-induced ataxia and non-ataxic imbalance
PT2889033T (pt) 2008-11-19 2018-06-18 Forum Pharmaceuticals Inc Tratamento de sintomas negativos da esquizofrenia com (r)-7-cloro-n-(-quinuclidin-3-il)benzo[b]tiofeno-2-carboxamida e sais farmacêuticos resultantes da mesma
TW201031664A (en) 2009-01-26 2010-09-01 Targacept Inc Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
RU2011150248A (ru) * 2009-05-11 2013-06-20 Энвиво Фармасьютикалз, Инк. Лечение когнитивных расстройств с определенными рецепторами альфа-7 никотиновой кислоты в комбинации с ингибиторами ацетилхолинэстеразы
EP2435080A2 (en) * 2009-05-29 2012-04-04 Abbott Laboratories Pharmaceutical compositions for the treatment of pain
EP2571874B1 (en) 2010-05-17 2016-03-30 Forum Pharmaceuticals Inc. A crystalline form of (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate
AU2013259871A1 (en) 2012-05-08 2014-11-20 Forum Pharmaceuticals Inc. Methods of maintaining, treating or improving cognitive function
US9585867B2 (en) 2015-08-06 2017-03-07 Charles Everett Ankner Cannabinod formulation for the sedation of a human or animal

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9301660D0 (en) * 1993-01-28 1993-03-17 Smithkline Beecham Plc Pharmaceuticals
JPH11512443A (ja) * 1995-09-22 1999-10-26 ノボ ノルディスク アクティーゼルスカブ 新規な置換アザ環式またはアザ二環式化合物
FR2761072B1 (fr) * 1997-03-20 1999-04-23 Synthelabo Derives de 2,3-dihydrofuro[3,2-b]pyridine, leur preparation et leur application en therapeutique
DE69819891T2 (de) * 1997-05-30 2004-08-26 Neurosearch A/S Spiro chinuclidin-derivate, ihre herstellung und verwendung
AR013184A1 (es) * 1997-07-18 2000-12-13 Astrazeneca Ab Aminas heterociclicas espiroazobiciclicas, composicion farmaceutica, uso de dichas aminas para preparar medicamentos y metodo de tratamiento o profilaxis
SE9900100D0 (sv) * 1999-01-15 1999-01-15 Astra Ab New compounds

Also Published As

Publication number Publication date
YU59601A (sh) 2004-03-12
PE20001543A1 (es) 2001-03-18
NO20014270D0 (no) 2001-09-03
HU228671B1 (en) 2013-05-28
AR022820A1 (es) 2002-09-04
AU764625B2 (en) 2003-08-28
HK1040398B (zh) 2003-07-18
RS49997B (sr) 2008-09-29
UY26048A1 (es) 2000-09-29
US6538003B1 (en) 2003-03-25
TR200102403T2 (tr) 2001-12-21
AU2922600A (en) 2000-09-28
BG65211B1 (bg) 2007-07-31
JP2002539129A (ja) 2002-11-19
ES2191611T3 (es) 2003-09-16
KR20070086359A (ko) 2007-08-27
BG105828A (bg) 2002-03-29
EP1161434B1 (fr) 2003-01-29
SK12422001A3 (sk) 2002-04-04
HRP20010655B1 (en) 2003-06-30
CZ302259B6 (cs) 2011-01-19
SK284339B6 (sk) 2005-02-04
CZ20013102A3 (cs) 2002-01-16
NO327119B1 (no) 2009-04-27
NO20014270L (no) 2001-11-05
DK1161434T3 (da) 2003-05-26
EP1161434A1 (fr) 2001-12-12
WO2000053608A1 (fr) 2000-09-14
US20030187012A1 (en) 2003-10-02
IL145150A0 (en) 2002-06-30
HUP0201753A3 (en) 2004-12-28
NZ513561A (en) 2003-06-30
UA61164C2 (ru) 2003-11-17
IL145150A (en) 2007-06-03
JP4806123B2 (ja) 2011-11-02
KR20010102492A (ko) 2001-11-15
CN1343208A (zh) 2002-04-03
ATE231869T1 (de) 2003-02-15
TWI222975B (en) 2004-11-01
CN1137894C (zh) 2004-02-11
MXPA01008972A (es) 2002-03-27
CA2372063C (en) 2011-01-11
BR0008763A (pt) 2002-01-02
US6908927B2 (en) 2005-06-21
PL201683B1 (pl) 2009-04-30
FR2790474B1 (fr) 2001-04-06
DE60001307T2 (de) 2003-12-11
ZA200106811B (en) 2002-08-19
HUP0201753A2 (en) 2002-09-28
HRP20010655A2 (en) 2002-08-31
PL352330A1 (en) 2003-08-11
KR100768355B1 (ko) 2007-10-17
EE04497B1 (et) 2005-06-15
CO5160250A1 (es) 2002-05-30
CA2372063A1 (en) 2000-09-14
DE60001307D1 (de) 2003-03-06
RU2238273C2 (ru) 2004-10-20
HK1040398A1 (en) 2002-06-07
EE200100470A (et) 2002-12-16
FR2790474A1 (fr) 2000-09-08

Similar Documents

Publication Publication Date Title
ID30116A (id) Turunan-turunan piridopiranoazepin, pembuatannya dan penggunaan terapinya
ID30393A (id) Senyawa tienopirimidina, pembuatan dan penggunaannya
ID26351A (id) Isosianat-isosianat oligomerik tersumbat, pembuatan dan penggunaannya
NO995135D0 (no) Fremstilling av höyaktive katalysatorer, katalysatorene og deres anvendelse
ID23600A (id) Turunan tiazolidin dan oksazolidin, pembuatan dan penggunaannya untuk pengobatan (pecahan dari p-950453)
HK1078266A1 (en) Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and the use of the same
DE69836514D1 (de) Elektrodenkörper, mit diesem versehener Akkumulator, sowie Herstellung des Elektrodenkörpers und des Akkumulators
ID28787A (id) 2-fenilbenzimidazol tersubstitusi, pembuatannya dan penggunaannya
DE60002526D1 (de) Herstellung von Tricyclodecandicarbaldehyd, Pentacyclopentadecandicarbaldehyd und der entsprechenden Dimethanole
ID26612A (id) Turunan-turunan siklobutena, pembuatannya dan penggunaan-penggunaan terapinya
EE200200175A (et) Asendatud 2-tio-3,5-ditsüano-4-arüül-6-aminopüridiinid ja nende kasutamine
ATE313317T1 (de) Herstellung von therapeutischem mikroschaum
ID26305A (id) Benzamida tersubstitusi baru, pembuatan dan penggunaannya
PL347885A1 (en) Azepinoindole derivatives, the production and use thereof
HUP0203225A3 (en) Benzodiazepin derivatives, the production and use thereof
EE200100370A (et) Teraapias kasutatavad spirofuropüridiinide uued aralküülamiinid
ID28997A (id) Kedok sekali pakai, dan proses pembuatannya
NO20014963L (no) Cycloalkyl-substituerte benzimidazoler, samt fremstilling og anvendelse derav
LV12624B (lv) Tienilazolilalkosietanamini to iegusanas panemiens un pielietojums medikamentu legusana
ID26728A (id) Amida-amida baru dengan pensubstitusi heterosiklik, pembuatan dan penggunaannya
ID26611A (id) Turunan-turunan pirol tersubstitusi heteroaril, pembuatannya dan kegunaan-kegunaan terapetiknya
DE69941825D1 (de) Arzneistoffhaltiger kaugummi, dessen herstellungsverfahren und so erhaltene tablette
NO20013337L (no) Ny behandling
ID30562A (id) Senyawa-senyawa amina aromatik tersubstitusi ribosa baru, metode pembuatannya dan penggunaannya sebagai obat
HK1047048A1 (en) Therapeutic use of melatonin.