|
ID26987A
(id)
*
|
1998-07-06 |
2001-02-22 |
Janssen Pharmaceutica Nv |
Inhibitor-inhibitor transferase protein farnesil dengan sifat-sifat peka terhadap sinar radiasi in vivo
|
|
PL349839A1
(en)
*
|
1999-02-11 |
2002-09-23 |
Pfizer Prod Inc |
Heteroaryl-substituted quinolin-2-one derivatives useful as anticancer agents
|
|
ATE260269T1
(de)
|
1999-11-05 |
2004-03-15 |
Cytovia Inc |
Substituierte 4h-chromene und ähnliche verbindungen als kaspasis aktivatoren und apoptosis induktoren und deren verwendung
|
|
PT1106612E
(pt)
*
|
1999-11-30 |
2004-06-30 |
Pfizer Prod Inc |
Derivados de quinolina uteis para inibir a farnesil-proteina-transferase
|
|
HN2000000266A
(es)
*
|
2000-01-21 |
2001-05-21 |
Pfizer Prod Inc |
Compuesto anticanceroso y metodo de separacion de enantiomeros util para sintetizar dicho compuesto.
|
|
AU3653301A
(en)
*
|
2000-01-28 |
2001-08-07 |
Merck & Co., Inc. |
Treatment or prevention of prostate cancer with a cox-2 selective inhibiting drug
|
|
JO2361B1
(en)
*
|
2000-06-22 |
2006-12-12 |
جانسين فارماسيوتيكا ان. في |
Enaniumer 1,2-anylated quinoline inhibitor for the transporter - farnesyl
|
|
EP1170011A1
(en)
*
|
2000-07-06 |
2002-01-09 |
Boehringer Ingelheim International GmbH |
Novel use of inhibitors of the epidermal growth factor receptor
|
|
US7067531B2
(en)
|
2000-09-25 |
2006-06-27 |
Angibaud Patrick Rene |
Farnesyl transferase inhibiting 6-heterocyclylmethyl quinolinone derivatives
|
|
WO2002024682A1
(en)
|
2000-09-25 |
2002-03-28 |
Janssen Pharmaceutica N.V. |
Farnesyl transferase inhibiting quinoline and quinazoline derivatives as farnesyl transferase inhibitors
|
|
WO2002024686A2
(en)
*
|
2000-09-25 |
2002-03-28 |
Janssen Pharmaceutica N.V. |
Farnesyl transferase inhibiting 6-heterocyclylmethyl quinoline and quinazoline derivatives
|
|
US7173040B2
(en)
|
2000-09-25 |
2007-02-06 |
Janssen Pharmaceutica N.V. |
Farnesyl transferase inhibiting 6-[(substituted phenyl)methyl]-quinoline and quinazoline derinazoline derivatives
|
|
CZ20031145A3
(cs)
*
|
2000-10-02 |
2003-12-17 |
Janssen Pharmaceutica N.V. |
Antagonisté metabotropního glutamátového receptoru
|
|
JP4348080B2
(ja)
|
2000-11-21 |
2009-10-21 |
ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ |
ファルネシルトランスフェラーゼを阻害するベンゾ複素環誘導体
|
|
JP4351444B2
(ja)
*
|
2000-12-27 |
2009-10-28 |
ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ |
ファルネシルトランスフェラーゼを阻害する4−ヘテロシクリル−キノリンおよびキナゾリン誘導体
|
|
ES2260316T3
(es)
|
2000-12-27 |
2006-11-01 |
Janssen Pharmaceutica N.V. |
Derivados de quinazolina y quinolina 4-sustituidos que inhiben la farnesil transferasa.
|
|
WO2002092594A1
(en)
*
|
2001-05-16 |
2002-11-21 |
Cytovia, Inc. |
Substituted 4h-chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof
|
|
WO2002092076A1
(en)
*
|
2001-05-16 |
2002-11-21 |
Cytovia, Inc. |
Substituted coumarins and quinolines as caspases activators
|
|
US6858607B1
(en)
|
2001-05-16 |
2005-02-22 |
Cytovia, Inc. |
7,8-fused 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof
|
|
WO2003006006A1
(en)
*
|
2001-07-09 |
2003-01-23 |
The Regents Of The University Of California |
Use of matrix metalloproteinase inhibitors to mitigate nerve damage
|
|
ATE425978T1
(de)
|
2001-12-19 |
2009-04-15 |
Janssen Pharmaceutica Nv |
Durch c-verbundene imidazole substituierte 1,8- annellierten chinolon-derivate als farnesyl transferase inhibitoren
|
|
JP4450628B2
(ja)
*
|
2002-03-22 |
2010-04-14 |
ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ |
ファルネシルトランスフェラーゼインヒビターとして使用するためのベンジルイミダゾリル置換2−キノリンおよびキナゾリン誘導体
|
|
CA2479109C
(en)
*
|
2002-03-29 |
2011-08-02 |
Janssen Pharmaceutica N.V. |
Radiolabelled quinoline and quinolinone derivatives and their use as metabotropic glutamate receptor ligands
|
|
ATE336496T1
(de)
|
2002-04-15 |
2006-09-15 |
Janssen Pharmaceutica Nv |
Farnesyl transferase hemmende tricyclische quinazolinederivate substitutiert mit kohlenstoff-gebundenen imidazolen oder triazolen
|
|
EP1513515A2
(en)
|
2002-05-16 |
2005-03-16 |
Cytovia, Inc. |
Substituted 4h-chromenes, 2h-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof
|
|
CN100349887C
(zh)
|
2002-05-16 |
2007-11-21 |
西托维亚公司 |
取代的4-芳基-4h-吡咯并[2,3-h]色烯和类似物及其药物组合物和用途
|
|
US20040186160A1
(en)
*
|
2002-12-13 |
2004-09-23 |
Sugen, Inc. |
Hexahydro-cyclohepta-pyrrole oxindole as potent kinase inhibitors
|
|
WO2004056806A1
(en)
*
|
2002-12-19 |
2004-07-08 |
Pfizer Inc. |
2-(1h-indazol-6-ylamino)-benzamide compounds as protein kinases inhibitors useful for the treatment of ophtalmic diseases
|
|
DK1603570T5
(da)
|
2003-02-26 |
2013-12-09 |
Sugen Inc |
Aminoheteroarylforbindelser som proteinkinaseinhibitorer
|
|
WO2004076446A1
(ja)
*
|
2003-02-27 |
2004-09-10 |
Chugai Seiyaku Kabushiki Kaisha |
ベンゾチオフェン誘導体
|
|
EP1660087A2
(en)
*
|
2003-07-22 |
2006-05-31 |
Janssen Pharmaceutica N.V. |
Quinolinone derivatives as inhibitors of c-fms kinase
|
|
JP4691041B2
(ja)
|
2003-11-20 |
2011-06-01 |
チルドレンズ ホスピタル メディカル センター |
Gtpアーゼ阻害剤および使用方法
|
|
US20070293539A1
(en)
*
|
2004-03-18 |
2007-12-20 |
Lansbury Peter T |
Methods for the treatment of synucleinopathies
|
|
US20060106060A1
(en)
*
|
2004-03-18 |
2006-05-18 |
The Brigham And Women's Hospital, Inc. |
Methods for the treatment of synucleinopathies (Lansbury)
|
|
US20050272722A1
(en)
*
|
2004-03-18 |
2005-12-08 |
The Brigham And Women's Hospital, Inc. |
Methods for the treatment of synucleinopathies
|
|
JP2007529555A
(ja)
*
|
2004-03-18 |
2007-10-25 |
ザ ブライハム アンド ウイメンズ ホスピタル, インコーポレイテッド |
シヌクレイノパチーを治療する方法
|
|
CA2559285A1
(en)
*
|
2004-03-18 |
2005-09-29 |
Brigham And Women's Hospital, Inc. |
Methods for the treatment of synucleinopathies
|
|
WO2005094830A1
(en)
*
|
2004-03-30 |
2005-10-13 |
Pfizer Products Inc. |
Combinations of signal transduction inhibitors
|
|
EP1786777A1
(en)
*
|
2004-08-26 |
2007-05-23 |
Pfizer, Inc. |
Aminoheteroaryl compounds as protein tyrosine kinase inhibitors
|
|
DE602005020465D1
(de)
|
2004-08-26 |
2010-05-20 |
Pfizer |
Enantiomerenreine aminoheteroaryl-verbindungen als proteinkinasehemmer
|
|
ES2355923T3
(es)
*
|
2004-08-26 |
2011-04-01 |
Pfizer, Inc. |
Compuestos de aminoheteroarilo sustituidos con pirazol como inhibidores de proteina quinasa.
|
|
EP1807426A2
(en)
*
|
2004-10-07 |
2007-07-18 |
Cytovia, Inc. |
SUBSTITUTED N-ARYL-1H-PYRAZOLOÝ3,4-b¨QUINOLIN-4-AMINES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS
|
|
US7826982B2
(en)
|
2005-07-29 |
2010-11-02 |
Children's Hospital Medical Center |
Method of identifying inhibitors using a 3-D structure of RAC-1 GTPASE
|
|
NZ566774A
(en)
|
2005-09-07 |
2011-11-25 |
Pfizer |
Human monoclonal antibodies to activin receptor-like kinase-1
|
|
CA2623125A1
(en)
|
2005-09-20 |
2007-03-29 |
Osi Pharmaceuticals, Inc. |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
|
CA2634598A1
(en)
|
2005-12-23 |
2007-07-05 |
Link Medicine Corporation |
Treatment of synucleinopathies
|
|
TW200812615A
(en)
|
2006-03-22 |
2008-03-16 |
Hoffmann La Roche |
Tumor therapy with an antibody for vascular endothelial growth factor and an antibody for human epithelial growth factor receptor type 2
|
|
EP2258700A1
(en)
|
2006-05-09 |
2010-12-08 |
Pfizer Products Inc. |
Cycloalkylamino acid derivatives and pharmaceutical compositions thereof
|
|
CL2007002404A1
(es)
|
2006-08-21 |
2008-04-18 |
Hoffmann La Roche |
Uso de un anticuerpo anti-vegf (factor de crecimiento endotelial vascular) para el tratamiento de un paciente que padece una recaida de cancer her2 positivo durante o despues del tratamiento con un anticuerpo anti-her2.
|
|
BRPI0812385A2
(pt)
*
|
2007-05-23 |
2019-09-24 |
Allergan Inc |
lactamas cíclicas para o tratamento de glaucoma ou pressão intraocular elevada
|
|
CA2687973C
(en)
*
|
2007-05-23 |
2015-04-07 |
Allergan, Inc. |
((bicylicheteroaryl) imidazolyl)methylheteroaryl compounds as adrenergic receptor agonists
|
|
US8129356B2
(en)
*
|
2007-10-01 |
2012-03-06 |
Vanderbilt University |
Bmx mediated signal transduction in irradiated vascular endothelium
|
|
WO2009151683A2
(en)
*
|
2008-03-12 |
2009-12-17 |
Link Medicine Corporation |
Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
|
|
DE102008022221A1
(de)
*
|
2008-05-06 |
2009-11-12 |
Universität des Saarlandes |
Inhibitoren der humanen Aldosteronsynthase CYP11B2
|
|
US20100331363A1
(en)
*
|
2008-11-13 |
2010-12-30 |
Link Medicine Corporation |
Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
|
|
NZ593090A
(en)
*
|
2008-11-13 |
2013-06-28 |
Link Medicine Corp |
Azaquinolinone derivatives and uses thereof
|
|
US20110060005A1
(en)
*
|
2008-11-13 |
2011-03-10 |
Link Medicine Corporation |
Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
|
|
TW201041892A
(en)
|
2009-02-09 |
2010-12-01 |
Supergen Inc |
Pyrrolopyrimidinyl Axl kinase inhibitors
|
|
WO2010099139A2
(en)
|
2009-02-25 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
Combination anti-cancer therapy
|
|
JP2012519170A
(ja)
|
2009-02-26 |
2012-08-23 |
オーエスアイ・ファーマシューティカルズ,エルエルシー |
生体内の腫瘍細胞のemtステータスをモニターするためのinsitu法
|
|
WO2010099363A1
(en)
|
2009-02-27 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
|
WO2010098866A1
(en)
|
2009-02-27 |
2010-09-02 |
Supergen, Inc. |
Cyclopentathiophene/cyclohexathiophene dna methyltransferase inhibitors
|
|
WO2010099138A2
(en)
|
2009-02-27 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
|
WO2010099364A2
(en)
|
2009-02-27 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
|
WO2011109572A2
(en)
|
2010-03-03 |
2011-09-09 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
|
CA2783665A1
(en)
|
2010-03-03 |
2011-09-09 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
|
WO2012116040A1
(en)
|
2011-02-22 |
2012-08-30 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors in hepatocellular carcinoma
|
|
WO2012149014A1
(en)
|
2011-04-25 |
2012-11-01 |
OSI Pharmaceuticals, LLC |
Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment
|
|
EP3812387A1
(en)
|
2011-07-21 |
2021-04-28 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Heterocyclic protein kinase inhibitors
|
|
WO2013152252A1
(en)
|
2012-04-06 |
2013-10-10 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
|
US9980942B2
(en)
|
2012-05-02 |
2018-05-29 |
Children's Hospital Medical Center |
Rejuvenation of precursor cells
|
|
CN104884448A
(zh)
|
2012-10-16 |
2015-09-02 |
詹森药业有限公司 |
Rorγt的杂芳基连接的喹啉基调节剂
|
|
CN105073729A
(zh)
|
2012-10-16 |
2015-11-18 |
詹森药业有限公司 |
RORγt的苯基连接的喹啉基调节剂
|
|
US9290476B2
(en)
|
2012-10-16 |
2016-03-22 |
Janssen Pharmaceutica Nv |
Methylene linked quinolinyl modulators of RORγt
|
|
US9260426B2
(en)
|
2012-12-14 |
2016-02-16 |
Arrien Pharmaceuticals Llc |
Substituted 1H-pyrrolo [2, 3-b] pyridine and 1H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors
|
|
AR094403A1
(es)
|
2013-01-11 |
2015-07-29 |
Hoffmann La Roche |
Terapia de combinación de anticuerpos anti-her3
|
|
MX394360B
(es)
|
2013-03-14 |
2025-03-24 |
Sumitomo Pharma Oncology Inc |
Inhibidores de jak2 y alk2 y metodos para su uso.
|
|
US9206188B2
(en)
|
2013-04-18 |
2015-12-08 |
Arrien Pharmaceuticals Llc |
Substituted pyrrolo[2,3-b]pyridines as ITK and JAK inhibitors
|
|
BR112016008258A2
(pt)
|
2013-10-15 |
2017-10-10 |
Janssen Pharmaceutica Nv |
moduladores de ror?t de quinolinila
|
|
US9403816B2
(en)
|
2013-10-15 |
2016-08-02 |
Janssen Pharmaceutica Nv |
Phenyl linked quinolinyl modulators of RORγt
|
|
US9328095B2
(en)
|
2013-10-15 |
2016-05-03 |
Janssen Pharmaceutica Nv |
Heteroaryl linked quinolinyl modulators of RORgammat
|
|
US9284308B2
(en)
|
2013-10-15 |
2016-03-15 |
Janssen Pharmaceutica Nv |
Methylene linked quinolinyl modulators of RORγt
|
|
BR112016008215A2
(pt)
|
2013-10-15 |
2017-09-26 |
Janssen Pharmaceutica Nv |
moduladores de quinolinila ligados por alquila de roryt
|
|
US10555941B2
(en)
|
2013-10-15 |
2020-02-11 |
Janssen Pharmaceutica Nv |
Alkyl linked quinolinyl modulators of RORγt
|
|
US9221804B2
(en)
|
2013-10-15 |
2015-12-29 |
Janssen Pharmaceutica Nv |
Secondary alcohol quinolinyl modulators of RORγt
|
|
US10028503B2
(en)
|
2014-06-18 |
2018-07-24 |
Children's Hospital Medical Center |
Platelet storage methods and compositions for same
|
|
WO2017096165A1
(en)
|
2015-12-03 |
2017-06-08 |
Agios Pharmaceuticals, Inc. |
Mat2a inhibitors for treating mtap null cancer
|
|
CN108003150A
(zh)
*
|
2016-10-31 |
2018-05-08 |
河南工业大学 |
4-杂芳基喹啉酮衍生物的制备方法及其应用
|
|
AU2019310590A1
(en)
|
2018-07-26 |
2021-01-14 |
Sumitomo Pharma Oncology, Inc. |
Methods for treating diseases associated with abnormal acvr1 expression and acvr1 inhibitors for use in the same
|
|
KR20260008165A
(ko)
|
2019-02-12 |
2026-01-15 |
스미토모 파마 아메리카, 인크. |
헤테로시클릭 단백질 키나제 억제제를 포함하는 제제
|
|
CN114450027A
(zh)
|
2019-08-16 |
2022-05-06 |
儿童医院医疗中心 |
用cdc42特异性抑制剂治疗受试者的方法
|
|
WO2021155006A1
(en)
|
2020-01-31 |
2021-08-05 |
Les Laboratoires Servier Sas |
Inhibitors of cyclin-dependent kinases and uses thereof
|