ID25880A - Turunan-turunan amonium bis-kuartener sebagai obat pengurang ketegangan pada saraf/otot - Google Patents

Turunan-turunan amonium bis-kuartener sebagai obat pengurang ketegangan pada saraf/otot

Info

Publication number
ID25880A
ID25880A IDW20000761A ID20000761A ID25880A ID 25880 A ID25880 A ID 25880A ID W20000761 A IDW20000761 A ID W20000761A ID 20000761 A ID20000761 A ID 20000761A ID 25880 A ID25880 A ID 25880A
Authority
ID
Indonesia
Prior art keywords
quarterer
damages
nerve
muscle
bis
Prior art date
Application number
IDW20000761A
Other languages
English (en)
Inventor
Laszlo Gyermex
Chingmuh Lee
Young Moon Cho
Original Assignee
Newlaxant Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Newlaxant Llc filed Critical Newlaxant Llc
Publication of ID25880A publication Critical patent/ID25880A/id

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
IDW20000761A 1997-10-24 1998-09-24 Turunan-turunan amonium bis-kuartener sebagai obat pengurang ketegangan pada saraf/otot ID25880A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/957,240 US5990124A (en) 1997-10-24 1997-10-24 Neuromuscular relaxants

Publications (1)

Publication Number Publication Date
ID25880A true ID25880A (id) 2000-11-09

Family

ID=25499282

Family Applications (1)

Application Number Title Priority Date Filing Date
IDW20000761A ID25880A (id) 1997-10-24 1998-09-24 Turunan-turunan amonium bis-kuartener sebagai obat pengurang ketegangan pada saraf/otot

Country Status (17)

Country Link
US (3) US5990124A (id)
EP (1) EP1025099A1 (id)
JP (1) JP2001521032A (id)
KR (1) KR20010024558A (id)
CN (1) CN1280578A (id)
AU (1) AU760009B2 (id)
BR (1) BR9814100A (id)
CA (1) CA2306878A1 (id)
HU (1) HUP0100400A3 (id)
ID (1) ID25880A (id)
IL (1) IL135703A0 (id)
NO (1) NO20002024L (id)
NZ (1) NZ504086A (id)
PL (1) PL340216A1 (id)
RU (1) RU2199539C2 (id)
TR (1) TR200001691T2 (id)
WO (1) WO1999021854A1 (id)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6376510B1 (en) * 1997-10-24 2002-04-23 Newlaxant Llc Neuromuscular relaxants
US5990124A (en) * 1997-10-24 1999-11-23 Gyermek; Laszlo Neuromuscular relaxants
CZ20012780A3 (cs) * 1999-02-01 2002-01-16 Newlaxant, L. L. C. Deriváty cyklických alkanoldiesterů
WO2013049013A2 (en) * 2011-09-26 2013-04-04 Board Of Regents, University Of Texas System Preparation of bromomethylated derivatives via protection with trihaloacetic anhydride
CN110776481B (zh) * 2018-07-24 2023-06-16 四川大学华西医院 一类双阳离子化合物及其制备方法和用途
CN108727248B (zh) * 2018-07-25 2021-05-25 四川大学华西医院 一类双季铵化合物及其制备方法和用途
CN112939896B (zh) * 2019-11-26 2023-04-14 四川大学华西医院 一种双季铵化合物及其制备方法和用途
CN112876408B (zh) * 2019-11-29 2022-05-17 四川大学华西医院 一类短效双季铵化合物及其制备方法和用途

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2734062A (en) * 1956-02-07 Method of making them
US2746964A (en) * 1953-11-02 1956-05-22 Lakeside Lab Inc Dicarboxylic acid esters of nu-alkyl-3-hydroxypiperidine and salts thereof
CH327915A (de) * 1954-01-22 1958-02-15 Sandoz Ag Verfahren zur Herstellung quartärer Ammoniumsalze veresterter 6-Alkoxy-tropine
GB886183A (en) * 1958-11-25 1962-01-03 T & H Smith Ltd Quaternary salts of tropine compounds
BE635304A (id) * 1962-07-25
DE1287588B (de) * 1962-12-01 1969-01-23 Munnes Neue curarewirksame bisquartaere Verbindungen
GB1223130A (en) * 1967-04-12 1971-02-24 Egyt Gyogyszervegyeszeti Gyar Tropine ester salts
DE1933478A1 (de) * 1969-07-02 1971-01-21 Asta Werke Ag Chem Fab Neue bis-quartaere Ammoniumverbindungen und diese enthaltende pharmazeutische Praeparate
JPS4919012A (id) * 1972-06-12 1974-02-20
HU168431B (id) * 1972-07-27 1976-04-28
IE50675B1 (en) * 1979-12-12 1986-06-11 Akzo Nv Bis-and mono-quaternary ammonium derivatives of 2beta,16beta-dipiperidino-5alpha-androstanes,processes for their preparation and pharmaceutical preparations
SU1048382A1 (ru) * 1982-06-24 1983-10-15 Пятигорский фармацевтический институт Способ качественного определени квалидила
US5494898A (en) * 1991-02-13 1996-02-27 Ohmeda Pharmaceutical Products Division Inc. Peptide skeletal muscle relaxants
US5510355A (en) * 1994-09-06 1996-04-23 Bencherif; Merouane Depolarizing skeletal muscle relaxants
US5990124A (en) * 1997-10-24 1999-11-23 Gyermek; Laszlo Neuromuscular relaxants

Also Published As

Publication number Publication date
IL135703A0 (en) 2001-05-20
US5990124A (en) 1999-11-23
HUP0100400A2 (hu) 2001-08-28
BR9814100A (pt) 2000-10-03
AU9403998A (en) 1999-05-17
US6274757B1 (en) 2001-08-14
RU2199539C2 (ru) 2003-02-27
CA2306878A1 (en) 1999-05-06
US6274623B1 (en) 2001-08-14
NZ504086A (en) 2001-12-21
NO20002024D0 (no) 2000-04-18
HUP0100400A3 (en) 2001-09-28
PL340216A1 (en) 2001-01-15
WO1999021854A1 (en) 1999-05-06
EP1025099A1 (en) 2000-08-09
AU760009B2 (en) 2003-05-08
JP2001521032A (ja) 2001-11-06
NO20002024L (no) 2000-06-19
TR200001691T2 (tr) 2001-01-22
CN1280578A (zh) 2001-01-17
KR20010024558A (ko) 2001-03-26

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