ID25880A - Turunan-turunan amonium bis-kuartener sebagai obat pengurang ketegangan pada saraf/otot - Google Patents
Turunan-turunan amonium bis-kuartener sebagai obat pengurang ketegangan pada saraf/ototInfo
- Publication number
- ID25880A ID25880A IDW20000761A ID20000761A ID25880A ID 25880 A ID25880 A ID 25880A ID W20000761 A IDW20000761 A ID W20000761A ID 20000761 A ID20000761 A ID 20000761A ID 25880 A ID25880 A ID 25880A
- Authority
- ID
- Indonesia
- Prior art keywords
- quarterer
- damages
- nerve
- muscle
- bis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/957,240 US5990124A (en) | 1997-10-24 | 1997-10-24 | Neuromuscular relaxants |
Publications (1)
Publication Number | Publication Date |
---|---|
ID25880A true ID25880A (id) | 2000-11-09 |
Family
ID=25499282
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IDW20000761A ID25880A (id) | 1997-10-24 | 1998-09-24 | Turunan-turunan amonium bis-kuartener sebagai obat pengurang ketegangan pada saraf/otot |
Country Status (17)
Country | Link |
---|---|
US (3) | US5990124A (id) |
EP (1) | EP1025099A1 (id) |
JP (1) | JP2001521032A (id) |
KR (1) | KR20010024558A (id) |
CN (1) | CN1280578A (id) |
AU (1) | AU760009B2 (id) |
BR (1) | BR9814100A (id) |
CA (1) | CA2306878A1 (id) |
HU (1) | HUP0100400A3 (id) |
ID (1) | ID25880A (id) |
IL (1) | IL135703A0 (id) |
NO (1) | NO20002024L (id) |
NZ (1) | NZ504086A (id) |
PL (1) | PL340216A1 (id) |
RU (1) | RU2199539C2 (id) |
TR (1) | TR200001691T2 (id) |
WO (1) | WO1999021854A1 (id) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6376510B1 (en) * | 1997-10-24 | 2002-04-23 | Newlaxant Llc | Neuromuscular relaxants |
US5990124A (en) * | 1997-10-24 | 1999-11-23 | Gyermek; Laszlo | Neuromuscular relaxants |
JP2002535366A (ja) * | 1999-02-01 | 2002-10-22 | ニユーラクサント・エル・エル・シー | モノアシルオキシアラルキル神経筋弛緩薬 |
WO2013049013A2 (en) * | 2011-09-26 | 2013-04-04 | Board Of Regents, University Of Texas System | Preparation of bromomethylated derivatives via protection with trihaloacetic anhydride |
CN110776481B (zh) * | 2018-07-24 | 2023-06-16 | 四川大学华西医院 | 一类双阳离子化合物及其制备方法和用途 |
CN108727248B (zh) * | 2018-07-25 | 2021-05-25 | 四川大学华西医院 | 一类双季铵化合物及其制备方法和用途 |
CN112939896B (zh) * | 2019-11-26 | 2023-04-14 | 四川大学华西医院 | 一种双季铵化合物及其制备方法和用途 |
CN112876408B (zh) * | 2019-11-29 | 2022-05-17 | 四川大学华西医院 | 一类短效双季铵化合物及其制备方法和用途 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2734062A (en) * | 1956-02-07 | Method of making them | ||
US2746964A (en) * | 1953-11-02 | 1956-05-22 | Lakeside Lab Inc | Dicarboxylic acid esters of nu-alkyl-3-hydroxypiperidine and salts thereof |
CH327915A (de) * | 1954-01-22 | 1958-02-15 | Sandoz Ag | Verfahren zur Herstellung quartärer Ammoniumsalze veresterter 6-Alkoxy-tropine |
GB886183A (en) * | 1958-11-25 | 1962-01-03 | T & H Smith Ltd | Quaternary salts of tropine compounds |
NL295726A (id) * | 1962-07-25 | |||
DE1287588B (de) * | 1962-12-01 | 1969-01-23 | Munnes | Neue curarewirksame bisquartaere Verbindungen |
GB1223130A (en) * | 1967-04-12 | 1971-02-24 | Egyt Gyogyszervegyeszeti Gyar | Tropine ester salts |
DE1933478A1 (de) * | 1969-07-02 | 1971-01-21 | Asta Werke Ag Chem Fab | Neue bis-quartaere Ammoniumverbindungen und diese enthaltende pharmazeutische Praeparate |
JPS4919012A (id) * | 1972-06-12 | 1974-02-20 | ||
HU168431B (id) * | 1972-07-27 | 1976-04-28 | ||
IE50675B1 (en) * | 1979-12-12 | 1986-06-11 | Akzo Nv | Bis-and mono-quaternary ammonium derivatives of 2beta,16beta-dipiperidino-5alpha-androstanes,processes for their preparation and pharmaceutical preparations |
SU1048382A1 (ru) * | 1982-06-24 | 1983-10-15 | Пятигорский фармацевтический институт | Способ качественного определени квалидила |
US5494898A (en) * | 1991-02-13 | 1996-02-27 | Ohmeda Pharmaceutical Products Division Inc. | Peptide skeletal muscle relaxants |
US5510355A (en) * | 1994-09-06 | 1996-04-23 | Bencherif; Merouane | Depolarizing skeletal muscle relaxants |
US5990124A (en) * | 1997-10-24 | 1999-11-23 | Gyermek; Laszlo | Neuromuscular relaxants |
-
1997
- 1997-10-24 US US08/957,240 patent/US5990124A/en not_active Expired - Fee Related
-
1998
- 1998-09-24 RU RU2000112878/04A patent/RU2199539C2/ru not_active IP Right Cessation
- 1998-09-24 WO PCT/US1998/019848 patent/WO1999021854A1/en not_active Application Discontinuation
- 1998-09-24 CN CN98811702A patent/CN1280578A/zh active Pending
- 1998-09-24 EP EP98947208A patent/EP1025099A1/en not_active Withdrawn
- 1998-09-24 KR KR1020007004408A patent/KR20010024558A/ko not_active Application Discontinuation
- 1998-09-24 CA CA002306878A patent/CA2306878A1/en not_active Abandoned
- 1998-09-24 HU HU0100400A patent/HUP0100400A3/hu unknown
- 1998-09-24 TR TR2000/01691T patent/TR200001691T2/xx unknown
- 1998-09-24 ID IDW20000761A patent/ID25880A/id unknown
- 1998-09-24 NZ NZ504086A patent/NZ504086A/en unknown
- 1998-09-24 AU AU94039/98A patent/AU760009B2/en not_active Ceased
- 1998-09-24 BR BR9814100-7A patent/BR9814100A/pt not_active IP Right Cessation
- 1998-09-24 JP JP2000517964A patent/JP2001521032A/ja not_active Withdrawn
- 1998-09-24 IL IL13570398A patent/IL135703A0/xx unknown
- 1998-09-24 PL PL98340216A patent/PL340216A1/xx unknown
-
1999
- 1999-10-25 US US09/426,673 patent/US6274623B1/en not_active Expired - Fee Related
- 1999-10-29 US US09/429,998 patent/US6274757B1/en not_active Expired - Fee Related
-
2000
- 2000-04-18 NO NO20002024A patent/NO20002024L/no unknown
Also Published As
Publication number | Publication date |
---|---|
CA2306878A1 (en) | 1999-05-06 |
NO20002024L (no) | 2000-06-19 |
WO1999021854A1 (en) | 1999-05-06 |
BR9814100A (pt) | 2000-10-03 |
US6274757B1 (en) | 2001-08-14 |
TR200001691T2 (tr) | 2001-01-22 |
PL340216A1 (en) | 2001-01-15 |
RU2199539C2 (ru) | 2003-02-27 |
AU9403998A (en) | 1999-05-17 |
HUP0100400A2 (hu) | 2001-08-28 |
AU760009B2 (en) | 2003-05-08 |
US6274623B1 (en) | 2001-08-14 |
NZ504086A (en) | 2001-12-21 |
CN1280578A (zh) | 2001-01-17 |
IL135703A0 (en) | 2001-05-20 |
NO20002024D0 (no) | 2000-04-18 |
US5990124A (en) | 1999-11-23 |
JP2001521032A (ja) | 2001-11-06 |
HUP0100400A3 (en) | 2001-09-28 |
EP1025099A1 (en) | 2000-08-09 |
KR20010024558A (ko) | 2001-03-26 |
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