HUT74091A - 1,5-benzodiazepine derivatives having cck and/or gastrin antagonistic activity - Google Patents

1,5-benzodiazepine derivatives having cck and/or gastrin antagonistic activity Download PDF

Info

Publication number
HUT74091A
HUT74091A HU9502977A HU9502977A HUT74091A HU T74091 A HUT74091 A HU T74091A HU 9502977 A HU9502977 A HU 9502977A HU 9502977 A HU9502977 A HU 9502977A HU T74091 A HUT74091 A HU T74091A
Authority
HU
Hungary
Prior art keywords
formula
compound
phenyl
compounds
alkyl
Prior art date
Application number
HU9502977A
Other languages
English (en)
Hungarian (hu)
Other versions
HU9502977D0 (en
Inventor
Robin Arthur Ellis Carr
Harry Finch
Pritom Shah
Original Assignee
Glaxo Wellcome Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939307833A external-priority patent/GB9307833D0/en
Priority claimed from GB9406037A external-priority patent/GB9406037D0/en
Application filed by Glaxo Wellcome Inc filed Critical Glaxo Wellcome Inc
Publication of HU9502977D0 publication Critical patent/HU9502977D0/hu
Publication of HUT74091A publication Critical patent/HUT74091A/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HU9502977A 1993-04-15 1994-04-13 1,5-benzodiazepine derivatives having cck and/or gastrin antagonistic activity HUT74091A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939307833A GB9307833D0 (en) 1993-04-15 1993-04-15 Modulators of cholecystokinin and gastrin
GB9406037A GB9406037D0 (en) 1994-03-29 1994-03-29 1,5 Benzodiazepine derivatives

Publications (2)

Publication Number Publication Date
HU9502977D0 HU9502977D0 (en) 1995-12-28
HUT74091A true HUT74091A (en) 1996-11-28

Family

ID=26302765

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9502977A HUT74091A (en) 1993-04-15 1994-04-13 1,5-benzodiazepine derivatives having cck and/or gastrin antagonistic activity

Country Status (14)

Country Link
EP (1) EP0694040A1 (ja)
JP (1) JPH08508743A (ja)
CN (1) CN1120845A (ja)
AU (1) AU688316B2 (ja)
CA (1) CA2158972A1 (ja)
CZ (1) CZ267695A3 (ja)
FI (1) FI954852A0 (ja)
HU (1) HUT74091A (ja)
NO (1) NO954091L (ja)
NZ (1) NZ265271A (ja)
OA (1) OA10236A (ja)
PL (1) PL311083A1 (ja)
SK (1) SK125495A3 (ja)
WO (1) WO1994024151A1 (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2173167T3 (es) * 1993-12-28 2002-10-16 Shionogi & Co Derivados de benzodiazepina.
PT945445E (pt) * 1996-12-10 2004-01-30 Zeria Pharm Co Ltd Derivados de 1,5-benzodiazepina
US6444849B1 (en) 1997-06-25 2002-09-03 Mitsubishi Chemical Corporation Amide derivatives
JP2000026434A (ja) 1998-06-05 2000-01-25 Zeria Pharmaceut Co Ltd 新規１，５−ベンゾジアゼピン誘導体
WO2000037434A1 (fr) * 1998-12-22 2000-06-29 Mitsubishi Chemical Corporation Derives d'amide
GB201414116D0 (en) 2014-08-08 2014-09-24 Trio Medicines Ltd Benzodiazepine derivatives
GB201513979D0 (en) 2015-08-07 2015-09-23 Trio Medicines Ltd Synthesis of benzodiazepine derivatives
KR20220150270A (ko) 2019-10-07 2022-11-10 칼리오페, 인크. Gpr119 효능제

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2641280B1 (fr) * 1988-12-29 1994-01-21 Roussel Uclaf Nouveaux derives de la 2,4-dioxo 2,3,4,5-tetrahydro 1h-1,5-benzodiazepine, leur procede de preparation et leur application comme medicaments
FR2659653B1 (fr) * 1990-03-13 1992-05-22 Rhone Poulenc Sante Derives de l'uree, leur preparation et les medicaments les contenant.
US5206234A (en) * 1990-10-22 1993-04-27 Merck & Co., Inc. Benzolactam analogs as antagonists of cck
GEP20001968B (en) * 1992-01-21 2000-03-05 Glaxo Spa Arilthio Compounds as Antibacterial and Antiviral Agents

Also Published As

Publication number Publication date
NO954091L (no) 1995-12-13
FI954852A (fi) 1995-10-12
OA10236A (en) 1997-10-07
NO954091D0 (no) 1995-10-13
CA2158972A1 (en) 1994-10-27
AU688316B2 (en) 1998-03-12
NZ265271A (en) 1997-06-24
FI954852A0 (fi) 1995-10-12
SK125495A3 (en) 1996-06-05
WO1994024151A1 (en) 1994-10-27
EP0694040A1 (en) 1996-01-31
JPH08508743A (ja) 1996-09-17
AU6567594A (en) 1994-11-08
HU9502977D0 (en) 1995-12-28
CZ267695A3 (en) 1996-04-17
CN1120845A (zh) 1996-04-17
PL311083A1 (en) 1996-02-05

Similar Documents

Publication Publication Date Title
US5585376A (en) 1,5-benzodiazepine derivatives having CCK and/or gastrin antagonistic activity
FI111632B (fi) Menetelmä CCK-B-antagonistisesti vaikuttavien 1,5-bentsodiatsepiinijohdannaisten valmistamiseksi
US5618812A (en) Benzodiazepine derivatives
US4820834A (en) Benzodiazepine analogs
US5004741A (en) Methods of antagonizing CCK or gastrin with benzodiazepine analogs
US20040024203A1 (en) Benzodiazepine derivatives as inhibitors of gamma secretase
IE904562A1 (en) Benzodiazepine analogs for treating panic syndrome and for¹directly inducing analgesia
BG99696A (bg) Производни на 1,4-бензодиазепин,методи за тяхното получаване, съдържащи ги фармацевтични състави,използването им като сск- модулатори и метод за лечение на състояния,модулирани от сск
US5521175A (en) Benzodiazepine derivatives
US6344452B1 (en) 1,5-benzodiazepine derivatives
US5686449A (en) 1,5-benzodiazepines useful as gastrinor CCK-antagonists
HUT74091A (en) 1,5-benzodiazepine derivatives having cck and/or gastrin antagonistic activity
HUT76135A (en) Cholecystokinin and gastrin modulating 5-heterocyclic-1,5-benzodiazepines
JPH0680650A (ja) コレシストキニン拮抗薬
JP2004502677A (ja) バソプレシン拮抗質としての非ペプチド系置換スピロベンゾアゼピン
US5641775A (en) 3-phenylureido-1,5-benzodiazepine-diones useful as gastrin or antagonists
US5486514A (en) Carbamate derivatives
SI9300328A (sl) Derivati 1,5-benzodiazepina

Legal Events

Date Code Title Description
DFD9 Temporary protection cancelled due to non-payment of fee