HUT73760A - Process for preparing intermediates for the synthesis of antifungal agents - Google Patents
Process for preparing intermediates for the synthesis of antifungal agentsInfo
- Publication number
- HUT73760A HUT73760A HU9503084A HU9503084A HUT73760A HU T73760 A HUT73760 A HU T73760A HU 9503084 A HU9503084 A HU 9503084A HU 9503084 A HU9503084 A HU 9503084A HU T73760 A HUT73760 A HU T73760A
- Authority
- HU
- Hungary
- Prior art keywords
- synthesis
- image
- antifungal agents
- preparing intermediates
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/62—Halogen-containing esters
- C07C69/63—Halogen-containing esters of saturated acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/62—Halogen-containing esters
- C07C69/65—Halogen-containing esters of unsaturated acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Furan Compounds (AREA)
- Saccharide Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/055,268 US5403937A (en) | 1993-04-30 | 1993-04-30 | Process for preparing intermediates for the synthesis of antifungal agents |
| PCT/US1994/004355 WO1994025452A1 (en) | 1993-04-30 | 1994-04-28 | Process for preparing intermediates for the synthesis of antifungal agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU9503084D0 HU9503084D0 (en) | 1995-12-28 |
| HUT73760A true HUT73760A (en) | 1996-09-30 |
| HU219143B HU219143B (hu) | 2001-02-28 |
Family
ID=21996778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9503084A HU219143B (hu) | 1993-04-30 | 1994-04-28 | Eljárás gombaellenes szerek szintézisében alkalmazható intermedierek előállítására |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5403937A (hu) |
| EP (1) | EP0696282B1 (hu) |
| JP (1) | JP3411283B2 (hu) |
| KR (1) | KR100313650B1 (hu) |
| CN (1) | CN1057089C (hu) |
| AT (1) | ATE182146T1 (hu) |
| AU (1) | AU681659B2 (hu) |
| CA (1) | CA2161662C (hu) |
| CZ (1) | CZ284395A3 (hu) |
| DE (1) | DE69419505T2 (hu) |
| DK (1) | DK0696282T3 (hu) |
| ES (1) | ES2133559T3 (hu) |
| FI (1) | FI955119A0 (hu) |
| GR (1) | GR3030881T3 (hu) |
| HK (1) | HK1008822A1 (hu) |
| HU (1) | HU219143B (hu) |
| IL (1) | IL109465A (hu) |
| NO (1) | NO308606B1 (hu) |
| NZ (1) | NZ266074A (hu) |
| PH (1) | PH31511A (hu) |
| PL (1) | PL182328B1 (hu) |
| SG (1) | SG42883A1 (hu) |
| SK (1) | SK281091B6 (hu) |
| TW (1) | TW284763B (hu) |
| WO (1) | WO1994025452A1 (hu) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5703236A (en) * | 1993-12-21 | 1997-12-30 | Schering Corporation | Tetrahydrofuran antifungals |
| US5486625A (en) * | 1994-07-08 | 1996-01-23 | Schering Corporation | Process for the preparation of chiral intermediates useful for the synthesis of antifungal agents |
| ES2112151B1 (es) * | 1995-03-17 | 1999-09-16 | Menarini Lab | Nuevos compuestos homoquirales para la preparacion de ketoconazol, terconazol y antifungicos relacionados, procedimiento para su fabricacion y utilizacion de los mismos. |
| US5625064A (en) * | 1995-04-19 | 1997-04-29 | Schering Corporation | Process for the preparation of triazolones |
| US5616777A (en) * | 1995-04-19 | 1997-04-01 | Schering Corporation | Chiral hydrazine derivatives |
| US5756830A (en) * | 1995-12-20 | 1998-05-26 | Schering Corporation | Process for preparing intermediates for the synthesis of antifungal agents |
| ES2187684T3 (es) * | 1995-12-20 | 2003-06-16 | Schering Corp | Procedimiento para preparar productos intermedios para la sintesis de agentes antifungicos. |
| KR100326276B1 (ko) * | 1999-12-14 | 2002-03-08 | 정명식 | 테트라하이드로푸란 유도체, 이의 제조방법 및 이를포함하는 항진균제 |
| AU2011254658B2 (en) * | 2010-05-19 | 2016-02-18 | Sandoz Ag | Purification of posaconazole and of posaconazole intermediates |
| WO2011144656A1 (en) | 2010-05-19 | 2011-11-24 | Sandoz Ag | Preparation of posaconazole intermediates |
| CN102892750B (zh) | 2010-05-19 | 2016-03-02 | 桑多斯股份公司 | 制备手性酰肼的方法 |
| WO2011144653A1 (en) | 2010-05-19 | 2011-11-24 | Sandoz Ag | Process for the preparation of chiral triazolones |
| CA2838051C (en) | 2011-06-16 | 2019-09-24 | Sandoz Ag | Process for the preparation of a chiral compound |
| EP2758385B1 (en) * | 2011-09-19 | 2018-03-28 | MSN Laboratories Limited | Process for the preparation of triazole antifungal drug, its intermediates and polymorphs thereof |
| CN102643194B (zh) * | 2012-03-27 | 2014-03-12 | 福州大学 | 一种泊沙康唑中间体的制备方法 |
| EP2789610A1 (en) | 2013-04-10 | 2014-10-15 | Sandoz Ag | Purification of Posaconazole Intermediates |
| CN104119302B (zh) * | 2013-07-03 | 2017-01-18 | 郑州裕昌有机硅化工有限公司 | 手性四氢呋喃类化合物及其制备方法和脱水产物 |
| IN2013CH04757A (hu) * | 2013-10-22 | 2015-04-24 | Msn Lab Private Ltd | |
| CN105503765B (zh) * | 2014-09-26 | 2019-03-12 | 浙江奥翔药业股份有限公司 | 泊沙康唑、组合物、中间体及其制备方法和用途 |
| WO2016087878A1 (en) * | 2014-12-05 | 2016-06-09 | Pulmocide Limited | Antimycotic compound |
| ES2893793T3 (es) | 2016-03-04 | 2022-02-10 | Zhejiang Ausun Pharmaceutical Co Ltd | Posaconazol, composición, producto intermedio, método de preparación para el mismo y usos del mismo |
| CN106565639B (zh) * | 2016-10-14 | 2018-09-21 | 宁波大学 | 一种四氢呋喃类化合物及其制备方法和用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0318214B1 (en) * | 1987-11-20 | 1994-12-14 | Schering Corporation | Tri- and tetra-substituted-oxetanes and -tetrahydrofurans and intermediates thereof |
| US5039676A (en) * | 1990-05-11 | 1991-08-13 | Schering Corporation | Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof |
| TW211006B (hu) * | 1990-08-24 | 1993-08-11 | Mochida Pharm Co Ltd | |
| IL103558A0 (en) * | 1991-10-30 | 1993-03-15 | Schering Corp | Tri-substituted tetrahydrofuran antifungals |
-
1993
- 1993-04-30 US US08/055,268 patent/US5403937A/en not_active Expired - Lifetime
-
1994
- 1994-04-28 NZ NZ266074A patent/NZ266074A/xx unknown
- 1994-04-28 KR KR1019950704755A patent/KR100313650B1/ko not_active IP Right Cessation
- 1994-04-28 CN CN94191958A patent/CN1057089C/zh not_active Expired - Fee Related
- 1994-04-28 IL IL109465A patent/IL109465A/en not_active IP Right Cessation
- 1994-04-28 DK DK94915399T patent/DK0696282T3/da active
- 1994-04-28 CZ CZ952843A patent/CZ284395A3/cs unknown
- 1994-04-28 EP EP94915399A patent/EP0696282B1/en not_active Expired - Lifetime
- 1994-04-28 TW TW083103830A patent/TW284763B/zh active
- 1994-04-28 SK SK1342-95A patent/SK281091B6/sk unknown
- 1994-04-28 AU AU66671/94A patent/AU681659B2/en not_active Ceased
- 1994-04-28 PH PH48183A patent/PH31511A/en unknown
- 1994-04-28 CA CA002161662A patent/CA2161662C/en not_active Expired - Fee Related
- 1994-04-28 SG SG1996000427A patent/SG42883A1/en unknown
- 1994-04-28 WO PCT/US1994/004355 patent/WO1994025452A1/en not_active Application Discontinuation
- 1994-04-28 DE DE69419505T patent/DE69419505T2/de not_active Expired - Lifetime
- 1994-04-28 HU HU9503084A patent/HU219143B/hu not_active IP Right Cessation
- 1994-04-28 JP JP52437894A patent/JP3411283B2/ja not_active Expired - Fee Related
- 1994-04-28 ES ES94915399T patent/ES2133559T3/es not_active Expired - Lifetime
- 1994-04-28 AT AT94915399T patent/ATE182146T1/de not_active IP Right Cessation
- 1994-04-28 PL PL94311267A patent/PL182328B1/pl unknown
-
1995
- 1995-10-27 NO NO954314A patent/NO308606B1/no not_active IP Right Cessation
- 1995-10-27 FI FI955119A patent/FI955119A0/fi unknown
-
1998
- 1998-07-29 HK HK98109521A patent/HK1008822A1/xx not_active IP Right Cessation
-
1999
- 1999-07-30 GR GR990401962T patent/GR3030881T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HMM4 | Cancellation of final prot. due to non-payment of fee |