HUT71345A - Bis(amidinobenzimidazolyl)alkanes and pharmaceutical compositions containing them - Google Patents

Bis(amidinobenzimidazolyl)alkanes and pharmaceutical compositions containing them Download PDF

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Publication number
HUT71345A
HUT71345A HU9501811A HU9501811A HUT71345A HU T71345 A HUT71345 A HU T71345A HU 9501811 A HU9501811 A HU 9501811A HU 9501811 A HU9501811 A HU 9501811A HU T71345 A HUT71345 A HU T71345A
Authority
HU
Hungary
Prior art keywords
formula
mmol
compound
alkyl
hydrogen
Prior art date
Application number
HU9501811A
Other languages
English (en)
Hungarian (hu)
Other versions
HU9501811D0 (en
Inventor
Darryl Gene Cleary
Michael Cory
Paula Ann Sherman
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of HU9501811D0 publication Critical patent/HU9501811D0/hu
Publication of HUT71345A publication Critical patent/HUT71345A/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HU9501811A 1993-09-22 1994-09-21 Bis(amidinobenzimidazolyl)alkanes and pharmaceutical compositions containing them HUT71345A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12546693A 1993-09-22 1993-09-22
US23291594A 1994-04-25 1994-04-25

Publications (2)

Publication Number Publication Date
HU9501811D0 HU9501811D0 (en) 1995-08-28
HUT71345A true HUT71345A (en) 1995-11-28

Family

ID=26823613

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9501811A HUT71345A (en) 1993-09-22 1994-09-21 Bis(amidinobenzimidazolyl)alkanes and pharmaceutical compositions containing them

Country Status (6)

Country Link
EP (1) EP0720603A1 (fr)
JP (1) JPH09506335A (fr)
AU (1) AU7661594A (fr)
HU (1) HUT71345A (fr)
IL (1) IL111011A0 (fr)
WO (1) WO1995008540A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6815461B1 (en) * 1994-01-20 2004-11-09 The University Of North Carolina At Chapel Hill Method of inhibiting retroviral integrase
US6562854B2 (en) 1994-12-14 2003-05-13 Axys Pharmaceuticals, Inc. Compositions comprising a substituted benzimidazole useful for treating immunomediated inflammatory disorders
US5693515A (en) * 1995-04-28 1997-12-02 Arris Pharmaceutical Corporation Metal complexed serine protease inhibitors
US6255091B1 (en) 1995-04-28 2001-07-03 Axys Pharmaceuticals, Inc. Potentiating metal mediated serine protease inhibitors with cobalt or zinc ions
US5723495A (en) * 1995-11-16 1998-03-03 The University Of North Carolina At Chapel Hill Benzamidoxime prodrugs as antipneumocystic agents
US6369235B1 (en) 1997-02-25 2002-04-09 The United States Of America As Represented By The Department Of Health And Human Services Substituted benzimidazoles, and methods of use thereof, for the inhibition of HIV reverse transcription and for the treatment of HIV infection
US5935982A (en) * 1997-02-28 1999-08-10 The University Of North Carolina At Chapel Hill Methods of treating retroviral infection and compounds useful therefor
EP1019382A1 (fr) * 1997-04-07 2000-07-19 Axys Pharmaceuticals, Inc. Composes et compositions pour traitement de maladies associees a une serine protease, en particulier une activite de tryptase
US5886191A (en) * 1997-08-18 1999-03-23 Dupont Pharmaceuticals Company Amidinoindoles, amidinoazoles, and analogs thereof
WO1999026933A1 (fr) * 1997-11-26 1999-06-03 Axys Pharmaceuticals, Inc. Derives d'amidinoaryle substitue et leur utilisation comme anticoagulants
US6150379A (en) * 1997-11-26 2000-11-21 Axys Pharmaceuticals, Inc. Compounds and compositions as anticoagulants
HUP0101137A3 (en) 1998-04-10 2003-03-28 Japan Tobacco Inc Anticoagulant amidines and their pharmaceutical use
GT199900167A (es) * 1998-10-01 2001-03-21 Nuevos bis-benzimidazoles.
CA2375843A1 (fr) * 1999-06-04 2000-12-14 Qi Zhao Compositions et methodes permettant d'inhiber la mort cellulaire
DE60032022T2 (de) * 1999-12-20 2007-05-16 The University Of North Carolina At Chapel Hill Diamidin verbindungen als dna nebenrillebinder
IT1317925B1 (it) * 2000-11-03 2003-07-15 Sigma Tau Ind Farmaceuti Bis-eterocicli ad attivita' antitumorale e chemosensibilizzante.
WO2009043902A1 (fr) * 2007-10-05 2009-04-09 Universite De Mons Hainaut Bisbenzimidazoles en tant qu'agents antipaludiques
AR091156A1 (es) 2012-05-25 2015-01-14 Jansen R & D Ireland Nucleosidos de espirooxetano de uracilo
PT2935303T (pt) 2012-12-21 2021-04-30 Alios Biopharma Inc 4'-fluoro-nucleósidos, 4'-fluoro-nucleótidos e seus análogos para o tratamento de hcv

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4324794A (en) * 1980-08-26 1982-04-13 Research Triangle Institute Inhibition of respiratory syncytial virus-induced cell fusion by amidino compounds
US5428051A (en) * 1992-10-13 1995-06-27 University Of North Carolina Methods of combating pneumocystis carinii pneumonia and compounds useful therefor

Also Published As

Publication number Publication date
HU9501811D0 (en) 1995-08-28
WO1995008540A1 (fr) 1995-03-30
JPH09506335A (ja) 1997-06-24
EP0720603A1 (fr) 1996-07-10
IL111011A0 (en) 1994-11-28
AU7661594A (en) 1995-04-10

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Legal Events

Date Code Title Description
DFD9 Temporary protection cancelled due to non-payment of fee