HUT64353A - Process for preparing boronic acid conjugates and marking agents containing said compounds - Google Patents
Process for preparing boronic acid conjugates and marking agents containing said compoundsInfo
- Publication number
- HUT64353A HUT64353A HU9301408A HU140893A HUT64353A HU T64353 A HUT64353 A HU T64353A HU 9301408 A HU9301408 A HU 9301408A HU 140893 A HU140893 A HU 140893A HU T64353 A HUT64353 A HU T64353A
- Authority
- HU
- Hungary
- Prior art keywords
- pct
- boronic acid
- haemoglobin
- acid conjugates
- compounds
- Prior art date
Links
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000003550 marker Substances 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 238000002372 labelling Methods 0.000 abstract 3
- 238000010521 absorption reaction Methods 0.000 abstract 2
- BCHZICNRHXRCHY-UHFFFAOYSA-N 2h-oxazine Chemical compound N1OC=CC=C1 BCHZICNRHXRCHY-UHFFFAOYSA-N 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- 238000000862 absorption spectrum Methods 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 239000001007 phthalocyanine dye Substances 0.000 abstract 1
- 238000011002 quantification Methods 0.000 abstract 1
- 239000001016 thiazine dye Substances 0.000 abstract 1
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 abstract 1
- AAAQKTZKLRYKHR-UHFFFAOYSA-N triphenylmethane Chemical compound C1=CC=CC=C1C(C=1C=CC=CC=1)C1=CC=CC=C1 AAAQKTZKLRYKHR-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
- G01N33/587—Nanoparticles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Organic Chemistry (AREA)
- Nanotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Thermal Transfer Or Thermal Recording In General (AREA)
- Inks, Pencil-Leads, Or Crayons (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Cosmetics (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Luminescent Compositions (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909024775A GB9024775D0 (en) | 1990-11-14 | 1990-11-14 | Chemical compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU9301408D0 HU9301408D0 (en) | 1993-09-28 |
| HUT64353A true HUT64353A (en) | 1993-12-28 |
| HU216635B HU216635B (hu) | 1999-07-28 |
Family
ID=10685377
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9301408A HU216635B (hu) | 1990-11-14 | 1991-11-13 | Eljárás boronsav-konjugátum jelzőanyagok előállítására |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5739318A (hu) |
| EP (1) | EP0557357B1 (hu) |
| JP (1) | JP2761494B2 (hu) |
| AT (1) | ATE120195T1 (hu) |
| AU (1) | AU666294B2 (hu) |
| CA (1) | CA2096251C (hu) |
| DE (1) | DE69108403T2 (hu) |
| DK (1) | DK0557357T3 (hu) |
| ES (1) | ES2069914T3 (hu) |
| FI (1) | FI105549B (hu) |
| GB (1) | GB9024775D0 (hu) |
| HU (1) | HU216635B (hu) |
| NO (1) | NO304691B1 (hu) |
| PL (1) | PL176747B1 (hu) |
| RU (1) | RU2076127C1 (hu) |
| WO (1) | WO1992008722A1 (hu) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0596700A1 (en) * | 1992-11-03 | 1994-05-11 | Hewlett-Packard Company | Cis-diol detection method and solid supports |
| EP0617288B1 (en) * | 1993-03-19 | 2002-05-02 | Novartis AG | Long emission wavelength chemiluminescent compounds and their use in test assays |
| US5395752A (en) * | 1993-03-19 | 1995-03-07 | Ciba Corning Diagnostics Corp. | Long emission wavelength chemiluminescent compounds and their use in test assays |
| US5623055A (en) * | 1994-01-28 | 1997-04-22 | Prolinx, Inc. | Phenylboronic acid complexes derived from aminosalicylic acid for bioconjugate preparation |
| US5852178A (en) * | 1994-01-28 | 1998-12-22 | Prolinx, Inc. | Phenylboronic acid complexing reagents for conjugating biologically active molecules |
| US5594151A (en) * | 1994-01-28 | 1997-01-14 | Prolinx, Inc. | Phenylboronic acid complexing reagents derived from aminosalicylic acid |
| US5594111A (en) * | 1994-01-28 | 1997-01-14 | Prolinx, Inc. | Phenylboronic acid complexes for bioconjugate preparation |
| US5847192A (en) * | 1994-01-28 | 1998-12-08 | Prolinx, Inc. | Boronic compound complexing reagents and complexes |
| CA2181252A1 (en) * | 1994-01-28 | 1995-08-03 | Mark L. Stolowitz | Phenylboronic acid complexes |
| US5777148A (en) * | 1994-01-28 | 1998-07-07 | Prolinx, Inc. | Boronic compound complexing reagents and highly stable complexes |
| US5744627A (en) * | 1994-01-28 | 1998-04-28 | Prolinx, Inc. | Boronic compound complexing reagents and complexes |
| US5837878A (en) * | 1994-01-28 | 1998-11-17 | Prolinx, Inc. | Boronic compound complexing reagents and highly stable complexes |
| US5880279A (en) * | 1995-07-31 | 1999-03-09 | Chevron U.S.A. Inc. | Cobalt dihalodihydroxydisulfophthalocyanines |
| US6075126A (en) | 1996-08-05 | 2000-06-13 | Prolinx, Inc. | Phenyldiboronic acid reagents and complexes |
| US6156884A (en) | 1996-08-05 | 2000-12-05 | Prolinx, Inc. | Bifunctional boronic compound complexing reagents and complexes |
| DE19721399A1 (de) * | 1997-05-22 | 1998-11-26 | Basf Ag | Phthalocyanine und ihre Verwendung als Markierungsmittel |
| DE19843094A1 (de) * | 1998-09-21 | 2000-03-23 | Roche Diagnostics Gmbh | Verfahren zur Bestimmung von glykiertem Hämoglobin |
| AU4024500A (en) * | 1999-03-24 | 2000-10-09 | Princeton Separations | Chemically reactive plane-rigidized cyanine dyes and their derivatives |
| RU2183635C2 (ru) * | 1999-11-26 | 2002-06-20 | Федеральное государственное унитарное предприятие Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" | Сульфозамещенные фталоцианины как фотосенсибилизаторы для фотодинамической терапии |
| CA2419238A1 (en) * | 2000-08-16 | 2002-02-21 | University Of Alberta | Non-pressurized methods for the preparation of conjugated solid supports for boronic acids |
| ATE287430T1 (de) * | 2000-09-06 | 2005-02-15 | Evotec Ag | Oxazinderivate |
| EP1213328A1 (de) * | 2000-12-08 | 2002-06-12 | Evotec OAI AG | Oxazinderivate |
| US7470420B2 (en) | 2000-12-05 | 2008-12-30 | The Regents Of The University Of California | Optical determination of glucose utilizing boronic acid adducts |
| US6627177B2 (en) * | 2000-12-05 | 2003-09-30 | The Regents Of The University Of California | Polyhydroxyl-substituted organic molecule sensing optical in vivo method utilizing a boronic acid adduct and the device thereof |
| US6653141B2 (en) | 2000-12-05 | 2003-11-25 | The Regents Of The University Of California | Polyhydroxyl-substituted organic molecule sensing method and device |
| US7195923B2 (en) * | 2001-01-31 | 2007-03-27 | Scripps Laboratories, Inc. | Ratiometric determination of glycated protein |
| GB0110053D0 (en) * | 2001-04-24 | 2001-06-13 | Axis Shield Asa | Assay |
| WO2002099077A2 (en) * | 2001-06-06 | 2002-12-12 | Proteologics, Inc. | Methods and compositions related to tagging of membrane surface proteins |
| US6858592B2 (en) * | 2001-06-29 | 2005-02-22 | Genzyme Corporation | Aryl boronic acids for treating obesity |
| US7041280B2 (en) * | 2001-06-29 | 2006-05-09 | Genzyme Corporation | Aryl boronate functionalized polymers for treating obesity |
| US7390670B2 (en) * | 2003-02-20 | 2008-06-24 | Lumigen, Inc. | Signalling compounds and methods for detecting hydrogen peroxide |
| US7427129B2 (en) * | 2004-02-04 | 2008-09-23 | Hewlett-Packard Development Company, L.P. | Boronic acid containing dyes to improve permanence of images |
| EP2099807B1 (en) * | 2006-11-30 | 2014-01-01 | Senseonics, Incorporated | Oxidation resistant indicator molecules |
| GB0903348D0 (en) * | 2009-02-27 | 2009-04-08 | Pharmalucia Ltd | Compounds and methods relating thereto |
| CN107421796B (zh) | 2011-06-17 | 2021-05-04 | 罗氏血液诊断股份有限公司 | 用于生物样品的组织加工的溶液 |
| GB201215571D0 (en) | 2012-08-31 | 2012-10-17 | Axis Shield Asa | Assay method |
| EP3375777A1 (en) * | 2017-03-15 | 2018-09-19 | MIKROCHEM spol. s.r.o. | Method for preparation of 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride or bromide |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4496722A (en) * | 1981-05-01 | 1985-01-29 | The Children's Medical Center Corporation | Reporter compounds |
| EP0319620A1 (en) * | 1987-12-10 | 1989-06-14 | Viomedics Inc. | Novel oxazines-ureas and thiazine urea chromophors |
| US4830786A (en) * | 1986-02-27 | 1989-05-16 | Syntex (U.S.A.) Inc. | Squaraine dyes |
| DE3720736A1 (de) * | 1987-06-23 | 1989-01-05 | Erwin Dr Schleicher | Verfahren, reagenzien und ausruestung zur einfachen bestimmung von nicht-enzymatisch glykosylierten proteinen in koerperfluessigkeiten |
| US4861728A (en) * | 1987-07-24 | 1989-08-29 | Becton, Dickinson And Company | Immunoassay of glycosylated hemoglobin using a labeled boron reagent |
| EP0310361A3 (en) * | 1987-09-30 | 1989-05-24 | Beckman Instruments, Inc. | Tridentate conjugate and method of use thereof |
| DE3827340A1 (de) * | 1988-08-12 | 1990-02-15 | Hoechst Ag | Verwendung von (alpha)-aminoboronsaeure-derivaten zur prophylaxe und behandlung von viruserkrankungen |
| DE3840452A1 (de) * | 1988-12-01 | 1990-06-07 | Hoechst Ag | (beta)-amino-boronsaeure-derivate |
| DE3843605A1 (de) * | 1988-12-23 | 1990-06-28 | Hoechst Ag | Wasserloesliche faserreaktive farbstoffe, verfahren zu ihrer herstellung und ihre verwendung |
| NO890029D0 (no) * | 1989-01-04 | 1989-01-04 | Axis Research | Nye modifiserte peptider og proteiner for in vitro diagnoser (diabetes). |
| JPH02226070A (ja) * | 1989-02-27 | 1990-09-07 | Fuji Photo Film Co Ltd | 糖タンパク質の定量方法 |
| US5071531A (en) * | 1989-05-01 | 1991-12-10 | Soane Technologies, Inc. | Casting of gradient gels |
| WO1990013604A1 (de) * | 1989-05-10 | 1990-11-15 | Hoechst Aktiengesellschaft | Wasserlösliche faserreaktive farbstoffe, verfahren zu ihrer herstellung und ihre verwendung |
| DE69108439T2 (de) * | 1990-05-01 | 1995-07-27 | Nacalai Tesque Inc | Verfahren zur Bestimmung des Glykationsprozentsatzes eines bestimmten Proteins. |
-
1990
- 1990-11-14 GB GB909024775A patent/GB9024775D0/en active Pending
-
1991
- 1991-11-13 WO PCT/EP1991/002160 patent/WO1992008722A1/en not_active Ceased
- 1991-11-13 ES ES91920019T patent/ES2069914T3/es not_active Expired - Lifetime
- 1991-11-13 AU AU89092/91A patent/AU666294B2/en not_active Ceased
- 1991-11-13 RU RU9193043620A patent/RU2076127C1/ru not_active IP Right Cessation
- 1991-11-13 PL PL91299064A patent/PL176747B1/pl not_active IP Right Cessation
- 1991-11-13 JP JP3518099A patent/JP2761494B2/ja not_active Expired - Lifetime
- 1991-11-13 US US08/050,275 patent/US5739318A/en not_active Expired - Lifetime
- 1991-11-13 EP EP91920019A patent/EP0557357B1/en not_active Expired - Lifetime
- 1991-11-13 CA CA002096251A patent/CA2096251C/en not_active Expired - Lifetime
- 1991-11-13 AT AT91920019T patent/ATE120195T1/de not_active IP Right Cessation
- 1991-11-13 DE DE69108403T patent/DE69108403T2/de not_active Expired - Lifetime
- 1991-11-13 DK DK91920019.6T patent/DK0557357T3/da active
- 1991-11-13 HU HU9301408A patent/HU216635B/hu unknown
-
1993
- 1993-05-12 FI FI932149A patent/FI105549B/fi not_active IP Right Cessation
- 1993-05-13 NO NO931746A patent/NO304691B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US5739318A (en) | 1998-04-14 |
| AU8909291A (en) | 1992-06-11 |
| PL176747B1 (pl) | 1999-07-30 |
| EP0557357A1 (en) | 1993-09-01 |
| CA2096251A1 (en) | 1992-05-15 |
| FI105549B (fi) | 2000-09-15 |
| NO931746D0 (no) | 1993-05-13 |
| GB9024775D0 (en) | 1991-01-02 |
| CA2096251C (en) | 1999-08-17 |
| AU666294B2 (en) | 1996-02-08 |
| JPH06502170A (ja) | 1994-03-10 |
| FI932149A0 (fi) | 1993-05-12 |
| EP0557357B1 (en) | 1995-03-22 |
| HU216635B (hu) | 1999-07-28 |
| NO931746L (no) | 1993-07-13 |
| ATE120195T1 (de) | 1995-04-15 |
| HU9301408D0 (en) | 1993-09-28 |
| ES2069914T3 (es) | 1995-05-16 |
| RU2076127C1 (ru) | 1997-03-27 |
| DE69108403T2 (de) | 1995-08-17 |
| DE69108403D1 (de) | 1995-04-27 |
| WO1992008722A1 (en) | 1992-05-29 |
| FI932149L (fi) | 1993-06-10 |
| DK0557357T3 (da) | 1995-06-12 |
| JP2761494B2 (ja) | 1998-06-04 |
| NO304691B1 (no) | 1999-02-01 |
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