HUT62901A - Process for producing cefalosporing antibiotic - Google Patents

Process for producing cefalosporing antibiotic

Info

Publication number
HUT62901A
HUT62901A HU929202884A HU9202884A HUT62901A HU T62901 A HUT62901 A HU T62901A HU 929202884 A HU929202884 A HU 929202884A HU 9202884 A HU9202884 A HU 9202884A HU T62901 A HUT62901 A HU T62901A
Authority
HU
Hungary
Prior art keywords
antibiotic
isomer
cefalosporing
producing
methyl
Prior art date
Application number
HU929202884A
Other languages
English (en)
Other versions
HU9202884D0 (en
HU212782B (en
Inventor
Gary M F Lim
John M Roubie
Elizabeth Ann Garofalo
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of HU9202884D0 publication Critical patent/HU9202884D0/hu
Publication of HUT62901A publication Critical patent/HUT62901A/hu
Publication of HU212782B publication Critical patent/HU212782B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Revetment (AREA)
  • Artificial Fish Reefs (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
HU9202884A 1991-09-10 1992-09-09 Water-free acylating process for stereospecifical producing antibioticum cephepim-dihydrochloride-hydrate HU212782B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75710491A 1991-09-10 1991-09-10

Publications (3)

Publication Number Publication Date
HU9202884D0 HU9202884D0 (en) 1992-11-30
HUT62901A true HUT62901A (en) 1993-06-28
HU212782B HU212782B (en) 1996-11-28

Family

ID=25046366

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9202884A HU212782B (en) 1991-09-10 1992-09-09 Water-free acylating process for stereospecifical producing antibioticum cephepim-dihydrochloride-hydrate

Country Status (29)

Country Link
EP (1) EP0531981B1 (hu)
JP (1) JP3434840B2 (hu)
KR (1) KR0178280B1 (hu)
CN (2) CN1036587C (hu)
AT (1) ATE209209T1 (hu)
AU (1) AU655838B2 (hu)
BG (1) BG61189B1 (hu)
CA (1) CA2077836A1 (hu)
CZ (2) CZ282160B6 (hu)
DE (1) DE69232216T2 (hu)
DK (1) DK0531981T3 (hu)
EG (1) EG20184A (hu)
ES (1) ES2165351T3 (hu)
FI (2) FI109127B (hu)
HU (1) HU212782B (hu)
IL (1) IL103109A (hu)
MX (1) MX9205147A (hu)
NO (1) NO301930B1 (hu)
NZ (1) NZ244295A (hu)
OA (1) OA09764A (hu)
PH (1) PH31206A (hu)
PL (1) PL174820B1 (hu)
PT (1) PT531981E (hu)
RO (1) RO109651B1 (hu)
RU (1) RU2042681C1 (hu)
SK (2) SK280934B6 (hu)
UY (1) UY23475A1 (hu)
YU (1) YU81692A (hu)
ZA (1) ZA926866B (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL103110A (en) * 1991-09-10 1997-04-15 Bristol Myers Squibb Co Anhydrous process for preparing cefepime dihydrochloride hydrate
CA2101571A1 (en) * 1992-09-08 1994-03-09 Elizabeth A. Garofalo Crystalline dihydrate of a cephalosporin dihydrate salt and injectable compositions thereof
KR19980019860A (ko) * 1996-09-04 1998-06-25 김윤배 세팔로스포린 중간체의 신규한 제조방법
US7847093B2 (en) 2003-04-16 2010-12-07 Sandoz Ag Processes for the preparations of cefepime
DE602004028111D1 (de) * 2003-04-16 2010-08-26 Sandoz Ag Verfahren zur herstellung von cefepim
GB0416379D0 (en) * 2004-07-22 2004-08-25 Sandoz Ag Organic compounds
ITMI20051684A1 (it) * 2005-09-13 2007-03-14 Harvest Lodge Ltd Procedimento per la produzione del dicloridrato di amminoacidi
RU2469040C1 (ru) * 2011-12-07 2012-12-10 Общество с ограниченной ответственностью "КОМПАНИЯ "ДЕКО" Способ получения 7-[2-(2-аминотиазол-4-ил)-2(z)-метоксииминоацетамидо]-3-[(1-метил-1-пирролидино)метил]-цеф-3-ем-4-карбоксилата дигидрохлорида моногидрата (цефепима дигидрохлорида моногидрата)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1213882A (en) * 1982-03-04 1986-11-12 Jun Okumura Cephalosporins
DE3419015A1 (de) * 1984-05-22 1985-11-28 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von cephalosporinen
GB2165245B (en) * 1984-10-01 1988-05-25 Glaxo Group Ltd Chemical compounds
US4910301A (en) * 1985-08-05 1990-03-20 Bristol-Myers Company Cefepime cephalosporin salts
US4714760A (en) * 1985-08-20 1987-12-22 Bristol-Myers Company Cephalosporin intermediates
IL103110A (en) * 1991-09-10 1997-04-15 Bristol Myers Squibb Co Anhydrous process for preparing cefepime dihydrochloride hydrate

Also Published As

Publication number Publication date
PL295873A1 (en) 1993-05-04
JP3434840B2 (ja) 2003-08-11
NO923495L (no) 1993-03-11
FI924031A0 (fi) 1992-09-09
UY23475A1 (es) 1992-10-08
CZ282160B6 (cs) 1997-05-14
SK33698A3 (en) 2000-09-12
ZA926866B (en) 1993-03-09
PL174820B1 (pl) 1998-09-30
CZ71996A3 (en) 1997-06-11
CN1059438C (zh) 2000-12-13
DK0531981T3 (da) 2002-05-21
HU9202884D0 (en) 1992-11-30
SK280933B6 (sk) 2000-09-12
KR930006032A (ko) 1993-04-20
AU655838B2 (en) 1995-01-12
IL103109A (en) 1997-07-13
IL103109A0 (en) 1993-02-21
ES2165351T3 (es) 2002-03-16
NO923495D0 (no) 1992-09-09
CN1036587C (zh) 1997-12-03
SK280934B6 (sk) 2000-09-12
DE69232216T2 (de) 2002-06-27
PH31206A (en) 1998-05-05
CA2077836A1 (en) 1993-03-11
FI924031A (fi) 1993-03-11
EG20184A (en) 1997-09-30
EP0531981A1 (en) 1993-03-17
RU2042681C1 (ru) 1995-08-27
CZ282315B6 (cs) 1997-06-11
NZ244295A (en) 1995-08-28
FI20011921A (fi) 2001-10-01
CN1158333A (zh) 1997-09-03
BG96859A (bg) 1993-12-24
MX9205147A (es) 1993-03-01
RO109651B1 (ro) 1995-04-28
EP0531981B1 (en) 2001-11-21
SK278092A3 (en) 2000-09-12
YU81692A (sh) 1995-03-27
PT531981E (pt) 2002-05-31
NO301930B1 (no) 1997-12-29
ATE209209T1 (de) 2001-12-15
CN1070398A (zh) 1993-03-31
DE69232216D1 (de) 2002-01-03
CZ278092A3 (en) 1993-03-17
KR0178280B1 (ko) 1999-03-20
HU212782B (en) 1996-11-28
BG61189B1 (bg) 1997-02-28
OA09764A (fr) 1993-11-30
AU2284492A (en) 1993-03-11
JPH05194532A (ja) 1993-08-03
FI119811B (fi) 2009-03-31
FI109127B (fi) 2002-05-31

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Legal Events

Date Code Title Description
MM4A Lapse of definitive patent protection due to non-payment of fees