HUT48904A - Process for production of derivatives of 2-substituated adenosin and medical preparatives containing these substances - Google Patents

Process for production of derivatives of 2-substituated adenosin and medical preparatives containing these substances

Info

Publication number
HUT48904A
HUT48904A HU8933A HU3389A HUT48904A HU T48904 A HUT48904 A HU T48904A HU 8933 A HU8933 A HU 8933A HU 3389 A HU3389 A HU 3389A HU T48904 A HUT48904 A HU T48904A
Authority
HU
Hungary
Prior art keywords
substituated
adenosin
derivatives
substances
production
Prior art date
Application number
HU8933A
Other languages
English (en)
Other versions
HU202550B (en
Inventor
Alan J Hutchison
John E Francis
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of HUT48904A publication Critical patent/HUT48904A/hu
Publication of HU202550B publication Critical patent/HU202550B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
HU8933A 1988-01-07 1989-01-05 Process for producing 2-substituted adenosyl derivatives and pharmaceutical compositions comprising such compounds HU202550B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14205588A 1988-01-07 1988-01-07
US07/193,968 US5034381A (en) 1988-01-07 1988-05-13 2-(substituted amino) adenosines as antihypertensives

Publications (2)

Publication Number Publication Date
HUT48904A true HUT48904A (en) 1989-07-28
HU202550B HU202550B (en) 1991-03-28

Family

ID=26839719

Family Applications (1)

Application Number Title Priority Date Filing Date
HU8933A HU202550B (en) 1988-01-07 1989-01-05 Process for producing 2-substituted adenosyl derivatives and pharmaceutical compositions comprising such compounds

Country Status (17)

Country Link
US (1) US5034381A (hu)
EP (1) EP0323807A3 (hu)
JP (1) JPH01265100A (hu)
KR (1) KR890011903A (hu)
AU (1) AU618055B2 (hu)
CA (1) CA1325209C (hu)
DD (1) DD283402A5 (hu)
DK (1) DK5089A (hu)
FI (1) FI90430C (hu)
HU (1) HU202550B (hu)
IL (1) IL88877A0 (hu)
MX (1) MX14446A (hu)
NO (1) NO169843C (hu)
NZ (1) NZ227542A (hu)
PH (1) PH26672A (hu)
PT (1) PT89392B (hu)
ZA (1) ZA8984B (hu)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7157442B2 (en) 1999-08-20 2007-01-02 Sankyo Company, Limited Antibacterial compound

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3820989A (en) * 1988-08-02 1990-02-08 Ciba-Geigy Ag 7-amino-3-beta-d-ribofuranosyl-3h-imidazo(4,5-b) pyridin-5-amine derivatives
US4977144A (en) * 1988-08-02 1990-12-11 Ciba-Geigy Corporation Imidazo[4,5-b]pyridine derivatives as cardiovascular agents
US5189027A (en) 1990-11-30 1993-02-23 Yamasa Shoyu Kabushiki Kaisha 2-substituted adenosine derivatives and pharmaceutical compositions for circulatory diseases
US5206222A (en) * 1991-05-22 1993-04-27 Vanderbilt University Methods for the reduction of myocardial reperfusion injury
IT1254915B (it) * 1992-04-24 1995-10-11 Gloria Cristalli Derivati di adenosina ad attivita' a2 agonista
IL107101A0 (en) * 1992-09-30 1993-12-28 Merrell Dow Pharma 2-substituted adenosines with a-2 receptor affinity
US5426101A (en) * 1992-09-30 1995-06-20 Merrell Dow Pharmaceuticals Inc. 2-substituted adenosines with A-2 receptor affinity
WO1994023723A1 (en) * 1993-04-15 1994-10-27 New York University Adenosine receptor agonists for the promotion of wound healing
US5817641A (en) * 1994-07-21 1998-10-06 Thomas Jefferson University Treatment of enterotoxigenic diarrhea with 2-substituted adenosine derivatives
WO1998057651A1 (en) 1997-06-18 1998-12-23 Discovery Therapeutics, Inc. Compositions and methods for preventing restenosis following revascularization procedures
WO1999017784A1 (en) 1997-10-07 1999-04-15 Regents Of The University Of California Corporation Treating occlusive peripheral vascular disease and coronary disease with combinations of heparin and an adenoside a2 agonist, or with adenosine
US5972903A (en) * 1997-10-07 1999-10-26 Regents Of The University Of California Corporation Method for promoting angiogenesis using heparin and adenosine
CN1181087C (zh) * 1998-07-09 2004-12-22 三共株式会社 新的抗菌化合物
AU4343500A (en) 1999-04-16 2000-11-02 Schering Corporation Use of azetidinone compounds
US20050033044A1 (en) 2003-05-19 2005-02-10 Bristol-Myers Squibb Pharma Company Methods for preparing 2-alkynyladenosine derivatives
WO2006089053A2 (en) 2005-02-17 2006-08-24 Wyeth Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives
US20090136460A1 (en) * 2007-07-10 2009-05-28 Vanderbilt University Use of adenosine receptor ligands to promote cell adhesion in cell-based therapies
RU2695358C2 (ru) * 2013-10-23 2019-07-23 Академия Синика Соединения для предотвращения и лечения нейродегенеративных заболеваний и боли

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670265A1 (de) * 1967-08-25 1971-01-28 Boehringer Mannheim Gmbh 2-Amino-Adenosinderivate und Verfahren zu deren Herstellung
NL7203984A (hu) * 1971-04-10 1972-10-12
US3917583A (en) * 1972-08-04 1975-11-04 Icn Pharmaceuticals 2-Substituted cyclic AMP derivatives
AR205247A1 (es) * 1973-02-07 1976-04-21 Icn Pharmaceuticals Procedimiento para preparar derivados de amp 2-substituidos
JPS5630355B2 (hu) * 1974-01-21 1981-07-14
AU5118979A (en) * 1978-10-16 1980-04-24 Takeda Chemical Industries Ltd. 2,6-diaminoebularines
JPS55139399A (en) * 1979-04-12 1980-10-31 Asahi Chem Ind Co Ltd Novel adenosine derivative substituted in the 2-position
JPS56152437U (hu) * 1980-04-14 1981-11-14
US4501735A (en) * 1983-12-05 1985-02-26 Warner-Lambert Company N6-(1- and 2-benzocycloalkyl) adenosines
DE3406533A1 (de) * 1984-02-23 1985-08-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verwendung von adenosin-derivaten als antiallergica und arzneimittel, die diese enthalten
ATE50777T1 (de) * 1984-04-18 1990-03-15 Whitby Research Inc Cardio-vasodilatatore n-6-substituierte adenosine.
US4594350A (en) * 1984-07-30 1986-06-10 Reagents Of University Of Minnesota (3-ethoxypropionate) esters of cyclaradine
US4683223A (en) * 1985-09-09 1987-07-28 Warner-Lambert Company N6 -Benzopyrano-and benzothiopyrano adenosines and methods of use
US4791103A (en) * 1985-02-08 1988-12-13 Warner-Lambert Company 2,N6 -disubstituted adenosines, derivatives and methods of use
US4593019A (en) * 1984-10-26 1986-06-03 Warner-Lambert Company N6 -tricyclic adenosines
US4600707A (en) * 1985-01-25 1986-07-15 Warner-Lambert Company Benzothien-3-yl adenosine; benzothien-3-yl adenosine, S-oxide; and benzothien-3-yl, S,S-dioxide adenosine compounds
US4755594A (en) * 1986-01-31 1988-07-05 Warner-Lambert Company N6 -substituted adenosines
US4843066A (en) * 1986-11-27 1989-06-27 Nippon Zoki Pharmaceutical Co., Ltd. Novel adenosine derivatives and pharmaceutical composition containing them as an active ingredient
EP0277917A3 (en) * 1987-02-04 1990-03-28 Ciba-Geigy Ag Certain adenosine 5'-carboxamide derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7157442B2 (en) 1999-08-20 2007-01-02 Sankyo Company, Limited Antibacterial compound

Also Published As

Publication number Publication date
ZA8984B (en) 1989-08-30
FI890028A (fi) 1989-07-08
DK5089D0 (da) 1989-01-06
HU202550B (en) 1991-03-28
EP0323807A2 (en) 1989-07-12
EP0323807A3 (en) 1990-06-20
FI890028A0 (fi) 1989-01-04
IL88877A0 (en) 1989-08-15
NO885821D0 (no) 1988-12-30
MX14446A (es) 1994-01-31
KR890011903A (ko) 1989-08-23
PH26672A (en) 1992-09-15
AU618055B2 (en) 1991-12-12
NO169843C (no) 1992-08-12
PT89392B (pt) 1993-09-30
DD283402A5 (de) 1990-10-10
NO885821L (no) 1989-07-10
NZ227542A (en) 1992-03-26
PT89392A (pt) 1990-02-08
DK5089A (da) 1989-07-08
NO169843B (no) 1992-05-04
US5034381A (en) 1991-07-23
CA1325209C (en) 1993-12-14
AU2776789A (en) 1989-07-13
FI90430C (fi) 1994-02-10
FI90430B (fi) 1993-10-29
JPH01265100A (ja) 1989-10-23

Similar Documents

Publication Publication Date Title
HUT48903A (en) Process for production of derivatives of adenosin and medical preparatives containing these substances
HUT51272A (en) Process for producing thiadiazin derivatives and pharmaceutical composirions containing them
HUT64746A (en) Process for the production of 1-cycloalkyl-piperidines and medical preparations containing them
HUT44027A (en) Process for production of derivatives of phenil-piperisin with antiarithmical effect and medical compouns containing them
HUT48904A (en) Process for production of derivatives of 2-substituated adenosin and medical preparatives containing these substances
HUT44489A (en) Process for production of derivatives of benzosulphonamid-indanyl and medical preparatives containing them as active substance
HUT44787A (en) Process for production of derivatives of nitrofurane and medical preparatives containing these compounds
HUT48587A (en) Process for production of derivatives of piperidin and medical preparatives containing these substances
HUT52747A (en) Process for production of derivatives of cycloalcanon and/or cycloalcanol
HUT48581A (en) Process for production of derivatives of substituated pirrol and medical preparatives containing them as active substance
HUT46907A (en) Process for production of derivatives of 1,4-dihydropiridine and medical preparatives containing such substances
HUT45971A (en) Process for production of new alkon-sulphon-anilid and medical preparatives containing such substances
HU911443D0 (en) Process for the production of medical preparations containing pravastaine and fibrinous-acid derivatives
HUT51247A (en) Process for production of aryl-zyanguananidins and medical compositions containing them
YU236989A (en) Derivatives of 2-iminobenzothiazoline and process for obtaining thereof
HUT44483A (en) Process for production of derivatives of 2n (benzolsulphonil)-antranil-acid-amid and medical preparatives containing them
HUT50167A (en) Process for production of derivatives of tetrasole and medical compositions containing them
HU892651D0 (en) Process for the production of flavoxate derivatives and medical preparations containing thereof
HUT46910A (en) Process for production of new /benzofurane-2-il/-imidasole derivatives and their salts and medical preparatives containing such substances
HUT48579A (en) Process for production of derivatives of pirrolidine and medical preparatives containing these substances
HUT48278A (en) Process for production of rhenin-hindering dipeptides and medical preparatives containing them
HUT37414A (en) Process for production of derivatives of diamine and medical preparatives consisting of such substances
HU912213D0 (en) Process for the production of amino-diol derivatives and medical preparations containing them
HUT44013A (en) Process for production of of derivatives of heteroaromatic acetilene and medical preparatives containing them
HUT43844A (en) Process for production of derivatives of benzamid and medical preparatives containing thereof

Legal Events

Date Code Title Description
HMM4 Cancellation of final prot. due to non-payment of fee