HUP9901711A2 - Nemszteroid gyulladáscsökkentők alkalmazása vastagbél-adenómák kezelésére használható gyógyszerek előállítására - Google Patents

Nemszteroid gyulladáscsökkentők alkalmazása vastagbél-adenómák kezelésére használható gyógyszerek előállítására

Info

Publication number
HUP9901711A2
HUP9901711A2 HU9901711A HUP9901711A HUP9901711A2 HU P9901711 A2 HUP9901711 A2 HU P9901711A2 HU 9901711 A HU9901711 A HU 9901711A HU P9901711 A HUP9901711 A HU P9901711A HU P9901711 A2 HUP9901711 A2 HU P9901711A2
Authority
HU
Hungary
Prior art keywords
pghs
steroidal anti
preparation
pharmaceutical compositions
inflammatory agents
Prior art date
Application number
HU9901711A
Other languages
English (en)
Inventor
Jilly Evans
Stacia Kargman
Thomas J. Simon
Original Assignee
Merck & Co. Inc.
Merck Frosst Canada Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603470.7A external-priority patent/GB9603470D0/en
Application filed by Merck & Co. Inc., Merck Frosst Canada Inc. filed Critical Merck & Co. Inc.
Publication of HUP9901711A2 publication Critical patent/HUP9901711A2/hu
Publication of HUP9901711A3 publication Critical patent/HUP9901711A3/hu
Publication of HU225506B1 publication Critical patent/HU225506B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/603—Salicylic acid; Derivatives thereof having further aromatic rings, e.g. diflunisal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Lasers (AREA)
  • Harvester Elements (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Soil Working Implements (AREA)

Abstract

A találmány prősztaglandin G/H szintáz (PGHS) enzim 2-es izőfőrmját az1-es izőfőrmmal szemben szelektíven gátló hatású, nem-szterőidgyűlladáscsökkentő szerek (NSAID-k) alkalmazására vőnatkőzik őlyangyógyszerek előállítására, amelyek örökletes adenómás pőlipózis (FAP)kórtörténettel vagy egy vagy több vastagbél-adenómával rendelkezőbetegben megelőzik vagy késleltetik az adenómák adenőkarcinómávátörténő átalakűlását, illetve az adenómasejtek azőn képességénekkialakűlását, hőgy a vastagbél nyálkahártya alatti szöveténekalapmembránjára ráterjedjenek. A specifikűs PGHS-2 inhibitőrőknakazőkat az NSAID-ket tekintik, amelyek PGHS-2-t gátló aktivitása aPGHS-1-et gátló aktivitáshőz viszőnyítva legalább 50-szeres. ŕ
HU9901711A 1995-07-19 1996-07-15 Use of 4-(4-methylsulfonyl-phenyl)-3-phenyl-2-(5h)-furanone for the preparation of medicaments treating colonic adenomas HU225506B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US124095P 1995-07-19 1995-07-19
GBGB9603470.7A GB9603470D0 (en) 1996-02-19 1996-02-19 Method of treating colonic adenomas
PCT/US1996/011761 WO1997003667A1 (en) 1995-07-19 1996-07-15 Method of treating colonic adenomas

Publications (3)

Publication Number Publication Date
HUP9901711A2 true HUP9901711A2 (hu) 1999-09-28
HUP9901711A3 HUP9901711A3 (en) 2001-02-28
HU225506B1 HU225506B1 (en) 2007-01-29

Family

ID=26308761

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9901711A HU225506B1 (en) 1995-07-19 1996-07-15 Use of 4-(4-methylsulfonyl-phenyl)-3-phenyl-2-(5h)-furanone for the preparation of medicaments treating colonic adenomas

Country Status (17)

Country Link
EP (1) EP0839034B1 (hu)
KR (1) KR100454624B1 (hu)
CN (1) CN1196679A (hu)
AT (1) ATE268176T1 (hu)
AU (1) AU706089B2 (hu)
CA (1) CA2227238C (hu)
CZ (1) CZ294516B6 (hu)
DE (1) DE69632632T2 (hu)
EA (1) EA005073B1 (hu)
ES (1) ES2220983T3 (hu)
HU (1) HU225506B1 (hu)
IL (1) IL122960A (hu)
MX (1) MX9800568A (hu)
NO (1) NO980221L (hu)
NZ (1) NZ312997A (hu)
SK (1) SK5298A3 (hu)
WO (1) WO1997003667A1 (hu)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6166024A (en) 1995-03-30 2000-12-26 Mayo Foundation For Medical Education And Research Use of topical azathioprine and thioguanine to treat colorectal adenomas
WO1999009988A1 (en) * 1997-08-27 1999-03-04 Hexal Ag New pharmaceutical compositions of meloxicam with improved solubility and bioavailability
NZ509376A (en) * 1998-07-09 2003-10-31 Francis A Nardella Indole or carbazole derivatives for the treatment of chronic lyphocytic leukemia
US7105560B1 (en) * 1999-07-23 2006-09-12 The Regents Of The University Of California Use of etodolac in the treatment of multiple myeloma
US20020035107A1 (en) 2000-06-20 2002-03-21 Stefan Henke Highly concentrated stable meloxicam solutions
AR038957A1 (es) 2001-08-15 2005-02-02 Pharmacia Corp Terapia de combinacion para el tratamiento del cancer
DE10161077A1 (de) 2001-12-12 2003-06-18 Boehringer Ingelheim Vetmed Hochkonzentrierte stabile Meloxicamlösungen zur nadellosen Injektion
US7232821B2 (en) 2002-04-08 2007-06-19 Glaxo Group Limited (2-((2-alkoxy)-phenyl) -cyclopent-1enyl) aromatic carbo and heterocyclic acid and derivatives
US8992980B2 (en) 2002-10-25 2015-03-31 Boehringer Ingelheim Vetmedica Gmbh Water-soluble meloxicam granules
GB0225548D0 (en) 2002-11-01 2002-12-11 Glaxo Group Ltd Compounds
EP1568369A1 (en) 2004-02-23 2005-08-31 Boehringer Ingelheim Vetmedica Gmbh Use of meloxicam for the treatment of respiratory diseases in pigs
AR047894A1 (es) 2004-02-25 2006-03-01 Wyeth Corp Derivados de tiofeno como inhibidores de la proteina tirosina fosfatasa 1b (ptpasa 1b); metodos para su preparacion, composiciones farmaceuticas que los contienen y su uso en el tratamiento de enfermedades mediadas por ptpasa 1b
TW200735866A (en) * 2005-11-18 2007-10-01 Synta Pharmaceuticals Corp Compounds for the treatment of proliferative disorders
WO2008089459A1 (en) * 2007-01-19 2008-07-24 Ardea Biosciences, Inc. Inhibitors of mek
CN102647971B (zh) 2009-10-12 2016-03-16 贝林格尔.英格海姆维特梅迪卡有限公司 用于包含美洛昔康的组合物的容器
WO2011107150A1 (en) 2010-03-03 2011-09-09 Boehringer Ingelheim Vetmedica Gmbh Use of meloxicam for the long-term treatment of musculoskeletal disorders in cats
US9795568B2 (en) 2010-05-05 2017-10-24 Boehringer Ingelheim Vetmedica Gmbh Low concentration meloxicam tablets

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0739340A1 (en) * 1994-01-10 1996-10-30 Merck Frosst Canada Inc. Phenyl heterocycles as cox-2 inhibitors
JPH10511089A (ja) * 1994-12-21 1998-10-27 メルク フロスト カナダ インコーポレーテツド Ｃｏｘ−２阻害剤としてのジアリール−２−（５ｈ）−フラノン

Also Published As

Publication number Publication date
CA2227238C (en) 2003-10-28
AU706089B2 (en) 1999-06-10
EP0839034B1 (en) 2004-06-02
EA199800139A1 (ru) 1998-08-27
CZ15698A3 (cs) 1998-09-16
ATE268176T1 (de) 2004-06-15
NZ312997A (en) 2000-07-28
EA005073B1 (ru) 2004-10-28
WO1997003667A1 (en) 1997-02-06
IL122960A (en) 2006-07-05
CA2227238A1 (en) 1997-02-06
EP0839034A1 (en) 1998-05-06
IL122960A0 (en) 1998-08-16
AU6496096A (en) 1997-02-18
MX9800568A (es) 1998-04-30
NO980221L (no) 1998-03-18
SK5298A3 (en) 1998-12-02
KR19990029066A (ko) 1999-04-15
CN1196679A (zh) 1998-10-21
KR100454624B1 (ko) 2004-12-31
DE69632632T2 (de) 2005-05-25
EP0839034A4 (en) 2002-06-19
HUP9901711A3 (en) 2001-02-28
DE69632632D1 (de) 2004-07-08
HU225506B1 (en) 2007-01-29
CZ294516B6 (cs) 2005-01-12
NO980221D0 (no) 1998-01-16
ES2220983T3 (es) 2004-12-16

Similar Documents

Publication Publication Date Title
HUP9901711A2 (hu) Nemszteroid gyulladáscsökkentők alkalmazása vastagbél-adenómák kezelésére használható gyógyszerek előállítására
Browatzki et al. Angiotensin II stimulates matrix metalloproteinase secretion in human vascular smooth muscle cells via nuclear factor-κB and activator protein 1 in a redox-sensitive manner
NO20015462L (no) Anvendelse av fthalazinderivater
TR200101858T2 (tr) JNK protein kinaz inhibitörleri olarak 4-ariloksindoller
MA26491A1 (fr) Composes inhibiteurs selectifs de cox-2, anti-inflammatoires et compositions pharmaceutiques les contenant .
Al‐Swayeh et al. Nitroparacetamol exhibits anti‐inflammatory and anti‐nociceptive activity
WO2002010137A3 (en) Indazole derivatives as JNK inhibitors
AU1718400A (en) Method for treating pain
BR9707081A (pt) Soluções de injeção e infusão concentradas aperfeiçoadas para aplicação intravasal
AR027656A1 (es) Composiciones farmaceuticas de inhibidores de la glucogeno-fosforilasa
NO20004053L (no) Glukokortikoid-selektive antiinflammatoriske midler
TR200200606T2 (tr) Lipaz inhibitörleri içeren dispersiyon terkipleri.
ATE296283T1 (de) Zelladhäsion- und entzündungshemmende immunosuppressive verbindungen
NO996443L (no) Stedsrettet kjemoterapi av metastaser
DK0847755T3 (da) Anvendelse af en ekstrakt af cimicifuga racemosa
TR200200319T2 (tr) Sulama düzeni.
FR2801204B1 (fr) Composition cosmetique comprenant au moins un polymere filmogene et au moins un agent regulateur
TR200100455T2 (tr) Nimesulid içeren topikal farmasötik bileşimler
TR200101756T2 (tr) Protein kinaz inhibitörleri olarak 4,5-pirazinoksindoller.
NO20005883L (no) Anvendelse av <alfa>1<beta>1-integrinreseptorinhibitorer og TGF-<beta>1-inhibitorer i behandling av nyresykdom
BR9814207A (pt) Adesivos de cianoacrilato estabilizados
TR200101547T2 (tr) Askomisinleri içeren topik kompozisyonlar
BR9710143A (pt) Matriz para aplicador aperfeiçoado
DK0900212T3 (da) Chirale phenyldihydrofuranoner som PDE-IV inhibitorer
DE69821228D1 (de) Selektive mmp inhibitoren mit verringerten nebenwirkungen

Legal Events

Date Code Title Description
GB9A Succession in title

Owner name: MERCK FROSST COMPANY, CA

Free format text: FORMER OWNER(S): MERCK & CO., INC., US; MERCK FROSST CANADA INC., CA

Owner name: MERCK & CO., INC., US

Free format text: FORMER OWNER(S): MERCK & CO., INC., US; MERCK FROSST CANADA INC., CA

GB9A Succession in title

Owner name: MERCK FROSST COMPANY, CA

Free format text: FORMER OWNER(S): MERCK & CO., INC., US; MERCK & CO., INC., US; MERCK FROSST CANADA INC., CA

Owner name: MERCK SHARP & DOHME CORP., US

Free format text: FORMER OWNER(S): MERCK & CO., INC., US; MERCK & CO., INC., US; MERCK FROSST CANADA INC., CA

MM4A Lapse of definitive patent protection due to non-payment of fees