HUP9901684A3 - Lipoprotein (a) lowering activity aminophosphonate derivatives, preparation and use thereof, pharmaceutical compositions containing these compounds - Google Patents
Lipoprotein (a) lowering activity aminophosphonate derivatives, preparation and use thereof, pharmaceutical compositions containing these compoundsInfo
- Publication number
- HUP9901684A3 HUP9901684A3 HU9901684A HUP9901684A HUP9901684A3 HU P9901684 A3 HUP9901684 A3 HU P9901684A3 HU 9901684 A HU9901684 A HU 9901684A HU P9901684 A HUP9901684 A HU P9901684A HU P9901684 A3 HUP9901684 A3 HU P9901684A3
- Authority
- HU
- Hungary
- Prior art keywords
- lipoprotein
- compounds
- preparation
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
- 102000057248 Lipoprotein(a) Human genes 0.000 title 1
- 108010033266 Lipoprotein(a) Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- PTMHPRAIXMAOOB-UHFFFAOYSA-N phosphoramidic acid Chemical class NP(O)(O)=O PTMHPRAIXMAOOB-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4056—Esters of arylalkanephosphonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH01920/95A CH690264A5 (fr) | 1995-06-30 | 1995-06-30 | Dérivés aminophosphonates substitués, leur procédé de préparation et leur utilisation pour la préparation de compositions pharmaceutiques. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9901684A2 HUP9901684A2 (hu) | 1999-09-28 |
| HUP9901684A3 true HUP9901684A3 (en) | 2000-04-28 |
Family
ID=4221681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9901684A HUP9901684A3 (en) | 1995-06-30 | 1996-06-26 | Lipoprotein (a) lowering activity aminophosphonate derivatives, preparation and use thereof, pharmaceutical compositions containing these compounds |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US6060464A (hu) |
| EP (1) | EP0835116A1 (hu) |
| JP (1) | JPH11508576A (hu) |
| KR (1) | KR19990028542A (hu) |
| CN (1) | CN1113654C (hu) |
| AP (1) | AP778A (hu) |
| AR (1) | AR004498A1 (hu) |
| AU (1) | AU705206B2 (hu) |
| BG (1) | BG102215A (hu) |
| BR (1) | BR9609653A (hu) |
| CA (1) | CA2225391A1 (hu) |
| CH (1) | CH690264A5 (hu) |
| CZ (1) | CZ422097A3 (hu) |
| EA (1) | EA199800106A1 (hu) |
| HU (1) | HUP9901684A3 (hu) |
| IL (1) | IL122717A0 (hu) |
| MA (1) | MA24340A1 (hu) |
| MX (1) | MX9800189A (hu) |
| NO (1) | NO976128L (hu) |
| NZ (1) | NZ312696A (hu) |
| OA (1) | OA10554A (hu) |
| PL (1) | PL187024B1 (hu) |
| SK (1) | SK178397A3 (hu) |
| TR (1) | TR199701700T1 (hu) |
| TW (1) | TW413681B (hu) |
| WO (1) | WO1997002037A1 (hu) |
| ZA (1) | ZA965505B (hu) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6548084B2 (en) | 1995-07-20 | 2003-04-15 | Smithkline Beecham Plc | Controlled release compositions |
| GB9626616D0 (en) * | 1996-12-20 | 1997-02-05 | Symphar Sa | Novel compounds |
| GB9626615D0 (en) | 1996-12-20 | 1997-02-05 | Symphar Sa | Novel compounds |
| GB9626536D0 (en) * | 1996-12-20 | 1997-02-05 | Symphar Sa | Novel compounds |
| DE19748659A1 (de) * | 1997-11-04 | 1999-05-06 | Hoechst Ag | Aminophosphoniumgruppen enthaltende vernetzte Copolymere für medizinische Verwendungen |
| US6017918A (en) * | 1998-08-06 | 2000-01-25 | Warner-Lambert Company | Phenyl glycine compounds and methods of treating atherosclerosis and restenosis |
| US6284795B1 (en) | 1998-09-04 | 2001-09-04 | Warner-Lambert Company | Sulfonamide compounds and methods of treating atherosclerosis and restenosis |
| DE60029131T2 (de) | 1999-10-27 | 2007-01-18 | Teva Pharmaceutical Industries Ltd. | Verwendung von 1-aminoindanderivaten zur behandlung der manie in verbindung mit manisch-depressiver erkrankung |
| NZ520752A (en) | 2000-02-16 | 2004-03-26 | Smithkline Beecham P | Pyrimidine-4-one derivatives as LDL-PLA2 inhibitors |
| AU9479201A (en) | 2000-09-27 | 2002-04-08 | Ilex Oncology Res S A | Alpha-substituted beta-aminoethyl phosphonates |
| US20030114421A1 (en) * | 2000-09-27 | 2003-06-19 | Phan Hieu Trung | Alpha-substituted beta-aminoethyl phosphonate derivatives |
| GB0024808D0 (en) | 2000-10-10 | 2000-11-22 | Smithkline Beecham Plc | Novel compounds |
| GB0025849D0 (en) * | 2000-10-23 | 2000-12-06 | Smithkline Beecham Plc | Novel compounds |
| MXPA04007797A (es) * | 2002-02-11 | 2005-09-08 | Ilex Products Inc | Derivados de fosfonato heteroarilalquilo a-sustituidos. |
| AU2003228990A1 (en) * | 2002-05-11 | 2003-11-11 | Ilex Products, Inc. | Hydroxyphosphonates and phosphonophosphates as apolipoprotein e modulators |
| US20040122061A1 (en) * | 2002-08-30 | 2004-06-24 | Biostratum, Inc. | Inhibitors of post-amadori advanced glycation end products |
| ES2559224T3 (es) | 2010-12-06 | 2016-02-11 | Glaxo Group Limited | Compuestos de pirimidinona para uso en el tratamiento de enfermedades o condiciones mediadas por Lp-PLA2 |
| JP2014521611A (ja) | 2011-07-27 | 2014-08-28 | グラクソ グループ リミテッド | Ｌｐ−ＰＬＡ２阻害剤としての２，３−ジヒドロイミダゾ［１，２−ｃ］ピリミジン−５（１Ｈ）−オン化合物の使用 |
| JP2014521625A (ja) | 2011-07-27 | 2014-08-28 | グラクソ グループ リミテッド | 二環式ピリミドン化合物 |
| PE20141411A1 (es) | 2011-09-01 | 2014-10-29 | Glaxo Group Ltd | Nueva forma de cristal |
| EP2948452B1 (en) | 2013-01-25 | 2017-08-09 | GlaxoSmithKline Intellectual Property Development Limited | 2,3-dihydroimidazol[1,2-c]pyrimidin-5(1h)-one based lipoprotein-associated phospholipase a2 (lp-pla2) inhibitors |
| CA2899124A1 (en) | 2013-01-25 | 2014-07-31 | Glaxosmithkline Intellectual Property Development Limited | Compounds |
| CA2899143A1 (en) | 2013-01-25 | 2014-07-31 | Glaxosmithkline Intellectual Property Development Limited | Bicyclic pyrimidone compounds as inhibitors of lp-pla2 |
| WO2016012917A1 (en) | 2014-07-22 | 2016-01-28 | Glaxosmithkline Intellectual Property Development Limited | 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2 |
| WO2016012916A1 (en) | 2014-07-22 | 2016-01-28 | Glaxosmithkline Intellectual Property Development Limited | 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2 |
| WO2021089032A1 (zh) | 2019-11-09 | 2021-05-14 | 上海赛默罗生物科技有限公司 | 三环二氢咪唑并嘧啶酮衍生物、其制备方法、药物组合物和用途 |
| CN115304620A (zh) | 2021-05-07 | 2022-11-08 | 上海赛默罗生物科技有限公司 | 嘧啶酮衍生物、其制备方法、药物组合物和用途 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH683996A5 (fr) * | 1992-03-05 | 1994-06-30 | Symphar Sa | Dérivés aminophosphonates substitués, leur procédé de préparation et compositions pharmaceutiques les contenant. |
| DE4433244A1 (de) * | 1994-09-19 | 1996-03-28 | Hoechst Ag | Aminomethylphosphon- und Aminomethylphosphinsäure-Derivate und deren Verwendung zur Behandlung von degenerativen Gelenkserkrankungen |
-
1995
- 1995-06-30 CH CH01920/95A patent/CH690264A5/fr not_active IP Right Cessation
-
1996
- 1996-06-26 EP EP96923971A patent/EP0835116A1/en not_active Withdrawn
- 1996-06-26 AP APAP/P/1997/001160A patent/AP778A/en active
- 1996-06-26 CN CN96196395A patent/CN1113654C/zh not_active Expired - Fee Related
- 1996-06-26 JP JP9504801A patent/JPH11508576A/ja not_active Withdrawn
- 1996-06-26 CZ CZ974220A patent/CZ422097A3/cs unknown
- 1996-06-26 WO PCT/EP1996/002842 patent/WO1997002037A1/en not_active Application Discontinuation
- 1996-06-26 IL IL12271796A patent/IL122717A0/xx unknown
- 1996-06-26 BR BR9609653-5A patent/BR9609653A/pt not_active Application Discontinuation
- 1996-06-26 NZ NZ312696A patent/NZ312696A/en unknown
- 1996-06-26 EA EA199800106A patent/EA199800106A1/ru unknown
- 1996-06-26 PL PL96324341A patent/PL187024B1/pl unknown
- 1996-06-26 HU HU9901684A patent/HUP9901684A3/hu unknown
- 1996-06-26 MX MX9800189A patent/MX9800189A/es unknown
- 1996-06-26 KR KR1019970709860A patent/KR19990028542A/ko not_active Application Discontinuation
- 1996-06-26 CA CA002225391A patent/CA2225391A1/en not_active Abandoned
- 1996-06-26 AU AU64185/96A patent/AU705206B2/en not_active Ceased
- 1996-06-26 TR TR97/01700T patent/TR199701700T1/xx unknown
- 1996-06-26 SK SK1783-97A patent/SK178397A3/sk unknown
- 1996-06-26 US US08/973,669 patent/US6060464A/en not_active Expired - Fee Related
- 1996-06-28 ZA ZA9605505A patent/ZA965505B/xx unknown
- 1996-06-28 AR ARP960103399A patent/AR004498A1/es unknown
- 1996-06-28 MA MA24297A patent/MA24340A1/fr unknown
- 1996-07-01 TW TW085107922A patent/TW413681B/zh not_active IP Right Cessation
-
1997
- 1997-12-29 NO NO976128A patent/NO976128L/no not_active Application Discontinuation
- 1997-12-30 OA OA70171A patent/OA10554A/en unknown
-
1998
- 1998-01-28 BG BG102215A patent/BG102215A/xx unknown
-
2000
- 2000-04-03 US US09/541,217 patent/US6660724B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ZA965505B (en) | 1998-03-30 |
| AP9701160A0 (en) | 1998-01-31 |
| SK178397A3 (en) | 1998-06-03 |
| US6060464A (en) | 2000-05-09 |
| EP0835116A1 (en) | 1998-04-15 |
| TW413681B (en) | 2000-12-01 |
| AP778A (en) | 1999-10-29 |
| AU6418596A (en) | 1997-02-05 |
| CZ422097A3 (cs) | 1998-10-14 |
| EA199800106A1 (ru) | 1998-08-27 |
| KR19990028542A (ko) | 1999-04-15 |
| JPH11508576A (ja) | 1999-07-27 |
| CN1193913A (zh) | 1998-09-23 |
| CA2225391A1 (en) | 1997-01-23 |
| BG102215A (en) | 1998-09-30 |
| MA24340A1 (fr) | 1998-07-01 |
| MX9800189A (es) | 1998-04-30 |
| NZ312696A (en) | 1999-10-28 |
| PL187024B1 (pl) | 2004-04-30 |
| CH690264A5 (fr) | 2000-06-30 |
| US6660724B1 (en) | 2003-12-09 |
| IL122717A0 (en) | 1998-08-16 |
| NO976128D0 (no) | 1997-12-29 |
| NO976128L (no) | 1998-02-10 |
| AU705206B2 (en) | 1999-05-20 |
| PL324341A1 (en) | 1998-05-25 |
| AR004498A1 (es) | 1998-12-16 |
| WO1997002037A1 (en) | 1997-01-23 |
| TR199701700T1 (xx) | 1998-03-21 |
| OA10554A (en) | 2002-05-29 |
| CN1113654C (zh) | 2003-07-09 |
| HUP9901684A2 (hu) | 1999-09-28 |
| BR9609653A (pt) | 1999-12-21 |
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