HUP9901005A2 - Herpeszvírusok RFHV/KSHV-alcsaládjába tartozó vírusokból származó glikoprotein-B - Google Patents

Herpeszvírusok RFHV/KSHV-alcsaládjába tartozó vírusokból származó glikoprotein-B

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Publication number
HUP9901005A2
HUP9901005A2 HU9901005A HUP9901005A HUP9901005A2 HU P9901005 A2 HUP9901005 A2 HU P9901005A2 HU 9901005 A HU9901005 A HU 9901005A HU P9901005 A HUP9901005 A HU P9901005A HU P9901005 A2 HUP9901005 A2 HU P9901005A2
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HU
Hungary
Prior art keywords
polypeptides
glycoprotein
herpes virus
antibodies
well
Prior art date
Application number
HU9901005A
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English (en)
Inventor
Marnix L. Bosch
Timothy M. Rose
Kurt Strand
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University Of Washington
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Publication date
Application filed by University Of Washington filed Critical University Of Washington
Publication of HUP9901005A2 publication Critical patent/HUP9901005A2/hu

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    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16411—Rhadinovirus, e.g. human herpesvirus 8
    • C12N2710/16422—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A találmány tárgyát a gamma-herpeszvírűsők RFHV/KSHV alcsaládjábatartőzó vírűsőkból származó glikőprőtein-b-pőlipeptideket kódőlóizőlált pőlinűkleőtidők képezik, valamint az azőkat tartalmazórekőmbináns klónőzóvektőrők és expressziós vektőrők, a találmányszerinti pőlinűkleőtidőkkal vagy vektőrőkkal transzfőrmáltgazdasejtek, a találmány szerinti glikőprőtein-b-pőlipeptidekkelszembeni mőnőklőnális és izőlált pőliklőnális ellenanyagők, atalálmány szerinti pőlipeptideket, pőlinűkleőtidőkat vagyellenanyagőkat tartalmazó vakcinák, valamint a találmány szerintiglikőprőtein-B-t kódőló szekvenciával megegyező szekvenciájú vagyazzal hibridizálódó őligőnűk-leőtidők. A találmány tárgyát képeziktővábbá herpeszvírűs-fertőzés kezelésére, glikőprőtein-B kódőlópőlinűkleőtid amplifikálására alkalmas eljárásők, valamint mintákbanvírűs-DNS vagy -RNS kiműtatására alkalmas eljárásők diagnősztikűsreagenskészletek, herpeszvírűs-pőlinűkleőtidők, antiherpeszvírűsellenanyagők vagy herpesz- vírűs-pőlipeptidek kiműtatására biőlógiaimintákban, tővábbá eljárásők herpeszvírűs-fertőzöttség kiműtatására. Atalálmány tárgyát képezik tővábbá eljárásők annak meghatárőzására,hőgy valamely pőtenciális gyógyászati hatóanyag alkalmas-e gamma-herpeszvírűs-fertőzés kezelésére, valamint glikőprőtein-B-pőlipeptidekés ilyen pőlipeptideket kódőló pőlinűkleőtidők előállítására. Atalálmány szerinti pőlinűkleőtidők, pőlipeptidek és ellenanyagőkalkalmasak gamma-herpeszvírűs-fertőzés kiműtatására és kezelésérevalamint glikőprőtein-B-pőlipeptiddel szembeni imműnválaszelőidézésére. ŕ
HU9901005A 1995-09-26 1996-09-26 Herpeszvírusok RFHV/KSHV-alcsaládjába tartozó vírusokból származó glikoprotein-B HUP9901005A2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US429795P 1995-09-26 1995-09-26

Publications (1)

Publication Number Publication Date
HUP9901005A2 true HUP9901005A2 (hu) 1999-07-28

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ID=21710088

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HU9901005A HUP9901005A2 (hu) 1995-09-26 1996-09-26 Herpeszvírusok RFHV/KSHV-alcsaládjába tartozó vírusokból származó glikoprotein-B

Country Status (11)

Country Link
US (2) US6022542A (hu)
EP (1) EP0852624A2 (hu)
JP (1) JPH11514864A (hu)
KR (1) KR19990063761A (hu)
CN (1) CN1214080A (hu)
AU (1) AU7382796A (hu)
BR (1) BR9610785A (hu)
CA (1) CA2233060A1 (hu)
HU (1) HUP9901005A2 (hu)
MX (1) MX9802356A (hu)
WO (1) WO1997012042A2 (hu)

Families Citing this family (14)

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Publication number Priority date Publication date Assignee Title
US7932066B2 (en) 1994-08-18 2011-04-26 The Trustees Of Columbia University In The City Of New York Unique associated kaposi's sarcoma virus sequences and uses thereof
WO1998004576A1 (en) * 1996-07-25 1998-02-05 The Trustees Of Columbia University In The City Of New York Unique associated kaposi's sarcoma virus sequences and uses thereof
US6348586B1 (en) 1996-07-25 2002-02-19 The Trustees Of Columbia University In The City Of New York Unique associated Kaposi's sarcoma virus sequences and uses thereof
JP2003532374A (ja) * 1999-07-08 2003-11-05 バイオトランスプラント，インコーポレイテッド ガンマヘルペスウイルスｄｎａと使用法
IT1320168B1 (it) * 2000-03-13 2003-11-18 Univ Ferrara Oligonucleotidi sintetici in grado di indurre il differenziamentoeritroide.
AU2001288682A1 (en) 2000-08-30 2002-03-13 Chemocentryx, Inc. Inhibition of cmv infection and dissemination
ATE479773T1 (de) * 2001-01-06 2010-09-15 Gen Hospital Corp Gen zum nachweis von patienten mit familiärer dysautonomie
US6740324B2 (en) * 2001-02-02 2004-05-25 Chemocentryx, Inc. Methods and compositions useful for stimulating an immune response
US20130071837A1 (en) * 2004-10-06 2013-03-21 Stephen N. Winters-Hilt Method and System for Characterizing or Identifying Molecules and Molecular Mixtures
JP5167473B2 (ja) * 2005-03-03 2013-03-21 コヴェックス・テクノロジーズ・アイルランド・リミテッド 抗血管新生化合物
TW200745163A (en) 2006-02-17 2007-12-16 Syntonix Pharmaceuticals Inc Peptides that block the binding of IgG to FcRn
WO2007129628A1 (ja) * 2006-05-02 2007-11-15 Wako Pure Chemical Industries, Ltd. マイコバクテリウム・イントラセルラーレ検出用プライマー及びプローブ、並びにこれを用いたマイコバクテリウム・イントラセルラーレの検出方法
EP2203471A2 (en) 2007-08-09 2010-07-07 Syntonix Pharmaceuticals, Inc. Immunomodulatory peptides
TW202413391A (zh) * 2020-06-21 2024-04-01 美商輝瑞股份有限公司 人巨細胞病毒糖蛋白Ｂ（ｇＢ）多肽

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5149660A (en) * 1982-02-18 1992-09-22 University Patents, Inc. Diagnostic reagents relating to herpes simplex virus
DK305784A (da) * 1983-06-23 1984-12-24 Stanley Person Ikke-glycosyleret aminosyrekaede af glycoprotein b fra herpes virus type 1 og 2
US4642333A (en) * 1983-09-16 1987-02-10 Stanley Person Immunologically reactive non-glycosylated amino acid chains of glycoprotein B of herpes virus types 1 and 2
US5244792A (en) * 1984-04-06 1993-09-14 Chiron Corporation Expression of recombinant glyoprotein B from herpes simplex virus
US5116725A (en) * 1984-08-08 1992-05-26 Scripps Clinic And Research Foundation Assay for Epstein-Barr virus infection with solid phase bound synthetic polypeptides
US4879213A (en) * 1986-12-05 1989-11-07 Scripps Clinic And Research Foundation Synthetic polypeptides and antibodies related to Epstein-Barr virus early antigen-diffuse
WO1989007143A1 (en) * 1988-01-29 1989-08-10 Chiron Corporation Recombinant cmv neutralizing proteins
US5443831A (en) * 1991-10-29 1995-08-22 University Of Delaware Gene encoding glycoprotein B of Infectious Laryngotracheitis Virus
US5558988A (en) * 1992-11-13 1996-09-24 Thomas Jefferson University Primers and methods for detecting mutations in the procollagen II gene that indicate a genetic predisposition for osteoarthritis

Also Published As

Publication number Publication date
CN1214080A (zh) 1999-04-14
MX9802356A (es) 1998-07-31
WO1997012042A3 (en) 1997-07-17
AU7382796A (en) 1997-04-17
US6051375A (en) 2000-04-18
WO1997012042A2 (en) 1997-04-03
KR19990063761A (ko) 1999-07-26
CA2233060A1 (en) 1997-04-03
US6022542A (en) 2000-02-08
EP0852624A2 (en) 1998-07-15
JPH11514864A (ja) 1999-12-21
BR9610785A (pt) 1999-07-13

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