MX9802356A - Glicoproteina b de la subfamilia rfhv/kshv de virus de herpes. - Google Patents

Glicoproteina b de la subfamilia rfhv/kshv de virus de herpes.

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Publication number
MX9802356A
MX9802356A MX9802356A MX9802356A MX9802356A MX 9802356 A MX9802356 A MX 9802356A MX 9802356 A MX9802356 A MX 9802356A MX 9802356 A MX9802356 A MX 9802356A MX 9802356 A MX9802356 A MX 9802356A
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MX
Mexico
Prior art keywords
kshv
glycoprotein
herpes viruses
rfhv
percent identical
Prior art date
Application number
MX9802356A
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English (en)
Inventor
Timothy M Rose
Marnix L Bosch
Kurt Strand
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Univ Washington
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Publication date
Application filed by Univ Washington filed Critical Univ Washington
Publication of MX9802356A publication Critical patent/MX9802356A/es

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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
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    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
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    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16411—Rhadinovirus, e.g. human herpesvirus 8
    • C12N2710/16422—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Genetics & Genomics (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Communicable Diseases (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invencion se refiere a polinucleotidos que codifican la glicoproteína B de la sub-familia RFHV/KSHV de los virus de herpes gama, cuyos tres miembros son caracterizados en detalle. Extractos de ADN fueron obtenidos de monos Macaque nemestrina y Macaque mulatta afectados por fibromatosis retroperitoeal (RF) y pacientes humanos de SIDA afectados por sarcoma de Kaposi (KS). Los extractos fueron amplificados usando sondas de oligonucleotidos degenerados en el consenso diseñadas a partir de proteínas y secuencias de ADN conocidas de virus de herpes gama. Las secuencias de nucleotidos de un fragmento de 319 pares de bases son alrededor de 76% idénticas entre RHFV1 y KSHV, y alrededor de 60-63% idénticas a los virus de herpes gama más estrechamente relacionados fuera de la sub-familia RFHV/KSHV. Secuencias de proteínas codificadas dentro de estos fragmentos son alrededor de 91% idénticas entre RFHV1/KSHV, y menos o aproximadamente 65% idénticas a las de otros virus de herpes gama. Las secuencias de proteínas codificadas dentro de estos fragmentos son alrededor de 91% idénticas a las de otro virus de herpes gama. La secuencia de la glicoproteína B de KSHV de longitud completa comprende un dominio de transmembrana cerca del término N, y una pluralidad de sitios potencialmente antigénicos en el dominio extracelular. Se proporcionan materiales y métodos para caracterizar las regiones que codifican la glicoproteína B de miembros de la sub-familia RFHV/KSHV, incluyendo pero sin limitarse a RFhV1, RFHV2 y KSHV. Péptidos, polinucleotidos y anticuerpos de esta invencion pueden ser usados para diagnosticar infeccion y para estimular una respuesta inmune contra la glicoproteína B.
MX9802356A 1995-09-26 1996-09-26 Glicoproteina b de la subfamilia rfhv/kshv de virus de herpes. MX9802356A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US429795P 1995-09-26 1995-09-26
PCT/US1996/015702 WO1997012042A2 (en) 1995-09-26 1996-09-26 Glycoprotein b of the rfhv/kshv subfamily of herpes viruses

Publications (1)

Publication Number Publication Date
MX9802356A true MX9802356A (es) 1998-07-31

Family

ID=21710088

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9802356A MX9802356A (es) 1995-09-26 1996-09-26 Glicoproteina b de la subfamilia rfhv/kshv de virus de herpes.

Country Status (11)

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US (2) US6022542A (es)
EP (1) EP0852624A2 (es)
JP (1) JPH11514864A (es)
KR (1) KR19990063761A (es)
CN (1) CN1214080A (es)
AU (1) AU7382796A (es)
BR (1) BR9610785A (es)
CA (1) CA2233060A1 (es)
HU (1) HUP9901005A2 (es)
MX (1) MX9802356A (es)
WO (1) WO1997012042A2 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7932066B2 (en) 1994-08-18 2011-04-26 The Trustees Of Columbia University In The City Of New York Unique associated kaposi's sarcoma virus sequences and uses thereof
US6348586B1 (en) 1996-07-25 2002-02-19 The Trustees Of Columbia University In The City Of New York Unique associated Kaposi's sarcoma virus sequences and uses thereof
CA2261164A1 (en) * 1996-07-25 1998-02-05 The Trustees Of Columbia University In The City Of New York Unique associated kaposi's sarcoma virus sequences and uses thereof
EP1210111A4 (en) * 1999-07-08 2004-07-21 Biotransplant Inc DNA OF GAMMA HERPESVIRUS AND METHODS OF USE THEREOF
IT1320168B1 (it) * 2000-03-13 2003-11-18 Univ Ferrara Oligonucleotidi sintetici in grado di indurre il differenziamentoeritroide.
WO2002018954A2 (en) 2000-08-30 2002-03-07 Chemocentryx, Inc. Inhibition of cmv infection and dissemination
DE60237509D1 (de) * 2001-01-06 2010-10-14 Gen Hospital Corp Gen zum nachweis von patienten mit familiärer dysautonomie
WO2002062296A2 (en) * 2001-02-02 2002-08-15 Chemocentryx, Inc. Methods and compositions useful for stimulating an immune response
US20130071837A1 (en) * 2004-10-06 2013-03-21 Stephen N. Winters-Hilt Method and System for Characterizing or Identifying Molecules and Molecular Mixtures
EP1853294A4 (en) * 2005-03-03 2010-01-27 Covx Technologies Ireland Ltd ANTIANGIOGENIC COMPOUNDS
TW200745163A (en) 2006-02-17 2007-12-16 Syntonix Pharmaceuticals Inc Peptides that block the binding of IgG to FcRn
JPWO2007129628A1 (ja) * 2006-05-02 2009-09-17 和光純薬工業株式会社 マイコバクテリウム・イントラセルラーレ検出用プライマー及びプローブ、並びにこれを用いたマイコバクテリウム・イントラセルラーレの検出方法
BRPI0814763A2 (pt) 2007-08-09 2015-03-03 Syntonix Pharmaceuticals Inc Peptídeos imunomoduladores
US11857622B2 (en) * 2020-06-21 2024-01-02 Pfizer Inc. Human cytomegalovirus GB polypeptide

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5149660A (en) * 1982-02-18 1992-09-22 University Patents, Inc. Diagnostic reagents relating to herpes simplex virus
DE3461928D1 (en) * 1983-06-23 1987-02-12 Person Stanley Immunologically reactive non-glycosylated amino acid chains of glycoprotein b of herpes virus types 1 and 2
US4642333A (en) * 1983-09-16 1987-02-10 Stanley Person Immunologically reactive non-glycosylated amino acid chains of glycoprotein B of herpes virus types 1 and 2
US5244792A (en) * 1984-04-06 1993-09-14 Chiron Corporation Expression of recombinant glyoprotein B from herpes simplex virus
US5116725A (en) * 1984-08-08 1992-05-26 Scripps Clinic And Research Foundation Assay for Epstein-Barr virus infection with solid phase bound synthetic polypeptides
US4879213A (en) * 1986-12-05 1989-11-07 Scripps Clinic And Research Foundation Synthetic polypeptides and antibodies related to Epstein-Barr virus early antigen-diffuse
JP2607712B2 (ja) * 1988-01-29 1997-05-07 カイロン コーポレイション 組換えｃｍｖ中和タンパク
US5443831A (en) * 1991-10-29 1995-08-22 University Of Delaware Gene encoding glycoprotein B of Infectious Laryngotracheitis Virus
US5558988A (en) * 1992-11-13 1996-09-24 Thomas Jefferson University Primers and methods for detecting mutations in the procollagen II gene that indicate a genetic predisposition for osteoarthritis

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Publication number Publication date
JPH11514864A (ja) 1999-12-21
US6051375A (en) 2000-04-18
US6022542A (en) 2000-02-08
CN1214080A (zh) 1999-04-14
CA2233060A1 (en) 1997-04-03
WO1997012042A3 (en) 1997-07-17
AU7382796A (en) 1997-04-17
BR9610785A (pt) 1999-07-13
KR19990063761A (ko) 1999-07-26
HUP9901005A2 (hu) 1999-07-28
WO1997012042A2 (en) 1997-04-03
EP0852624A2 (en) 1998-07-15

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