HUP9900947A3 - Process for the preparation of piperidine derivatives, intermediates and preparation thereof - Google Patents

Process for the preparation of piperidine derivatives, intermediates and preparation thereof

Info

Publication number
HUP9900947A3
HUP9900947A3 HU9900947A HUP9900947A HUP9900947A3 HU P9900947 A3 HUP9900947 A3 HU P9900947A3 HU 9900947 A HU9900947 A HU 9900947A HU P9900947 A HUP9900947 A HU P9900947A HU P9900947 A3 HUP9900947 A3 HU P9900947A3
Authority
HU
Hungary
Prior art keywords
preparation
intermediates
piperidine derivatives
piperidine
derivatives
Prior art date
Application number
HU9900947A
Other languages
English (en)
Hungarian (hu)
Original Assignee
Amr Technology Inc Manchester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amr Technology Inc Manchester filed Critical Amr Technology Inc Manchester
Publication of HUP9900947A2 publication Critical patent/HUP9900947A2/hu
Publication of HUP9900947A3 publication Critical patent/HUP9900947A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
HU9900947A 1995-12-21 1996-12-19 Process for the preparation of piperidine derivatives, intermediates and preparation thereof HUP9900947A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/575,344 US6201124B1 (en) 1995-12-21 1995-12-21 Process for production of piperidine derivatives

Publications (2)

Publication Number Publication Date
HUP9900947A2 HUP9900947A2 (hu) 1999-07-28
HUP9900947A3 true HUP9900947A3 (en) 2000-12-28

Family

ID=24299941

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900947A HUP9900947A3 (en) 1995-12-21 1996-12-19 Process for the preparation of piperidine derivatives, intermediates and preparation thereof

Country Status (16)

Country Link
US (7) US6201124B1 (cg-RX-API-DMAC7.html)
EP (2) EP0877733B1 (cg-RX-API-DMAC7.html)
JP (2) JP4865113B2 (cg-RX-API-DMAC7.html)
KR (2) KR100591212B1 (cg-RX-API-DMAC7.html)
AT (1) ATE335726T1 (cg-RX-API-DMAC7.html)
AU (1) AU723759B2 (cg-RX-API-DMAC7.html)
BR (1) BR9612099A (cg-RX-API-DMAC7.html)
CA (1) CA2240735C (cg-RX-API-DMAC7.html)
DE (1) DE69636439T2 (cg-RX-API-DMAC7.html)
DK (1) DK0877733T3 (cg-RX-API-DMAC7.html)
ES (1) ES2268715T3 (cg-RX-API-DMAC7.html)
HU (1) HUP9900947A3 (cg-RX-API-DMAC7.html)
NO (1) NO311718B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ326228A (cg-RX-API-DMAC7.html)
PT (1) PT877733E (cg-RX-API-DMAC7.html)
WO (1) WO1997022344A1 (cg-RX-API-DMAC7.html)

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HU226037B1 (en) * 1993-06-25 2008-03-28 Aventis Inc Process for producing antihistaminic 4-diphenylmethyl/diphenylmethoxy piperidine derivatives and novel intermediates
US6153754A (en) * 1995-12-21 2000-11-28 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US6201124B1 (en) * 1995-12-21 2001-03-13 Albany Molecular Research, Inc. Process for production of piperidine derivatives
ES2151442B1 (es) * 1999-01-11 2001-07-01 Espanola Prod Quimicos Nuevo derivado del bencenoetanol.
US20030021849A1 (en) * 2001-04-09 2003-01-30 Ben-Zion Dolitzky Polymorphs of fexofenadine hydrochloride
KR20040012747A (ko) * 2001-04-09 2004-02-11 테바 파마슈티컬 인더스트리즈 리미티드 펙소페나딘 염산염의 다형체
ITRM20010260A1 (it) 2001-05-17 2002-11-18 Dinamite Dipharma S P A In For Processo per la preparazione della fexofenadina o acido 4 1-idrossi-4-4- (idrossidifenilmetil)-1-piperidinil|-butil|-alfa,alfa-dimetilbenz
EP1453509A2 (en) * 2001-11-08 2004-09-08 Teva Pharmaceutical Industries Ltd. Polymorphs of fexofenadine base
JP2005532356A (ja) * 2002-06-10 2005-10-27 テバ ファーマシューティカル インダストリーズ リミティド 塩酸フェキソフェナジンの多型体ｘｖｉ
US6949765B2 (en) 2002-11-05 2005-09-27 Chartered Semiconductor Manufacturing Ltd. Padless structure design for easy identification of bridging defects in lines by passive voltage contrast
TW200517114A (en) 2003-10-15 2005-06-01 Combinatorx Inc Methods and reagents for the treatment of immunoinflammatory disorders
EP1628959A2 (en) * 2004-04-26 2006-03-01 Teva Pharmaceutical Industries Ltd Crystalline forms of fexofenadine hydrochloride and processes for their preparation
US7498443B2 (en) * 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of carebastine
US7498345B2 (en) 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of piperidine derivatives
WO2006037042A1 (en) * 2004-09-28 2006-04-06 Teva Pharmaceutical Industries Ltd. Fexofenadine crystal form and processes for its preparation thereof
RU2008122978A (ru) 2005-11-09 2009-12-20 Комбинаторкс, Инкорпорейтед (Us) Способы, композиции и наборы для лечения медицинских состояний
CN100443470C (zh) * 2006-07-21 2008-12-17 杭州保灵有限公司 一种依巴斯汀的制备方法
ITMI20061492A1 (it) * 2006-07-27 2008-01-28 Archimica Srl Processo per la preparazione di fexofenadina.
ITMI20061491A1 (it) * 2006-07-27 2008-01-28 Archimica Srl Processo per la preparazione di fexofenadina.
ITMI20070987A1 (it) 2007-05-16 2008-11-17 Dipharma Francis Srl Procedimento per la preparazione di composti chetonici
US20100092479A1 (en) * 2008-08-18 2010-04-15 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
US20110130711A1 (en) * 2009-11-19 2011-06-02 Follica, Inc. Hair growth treatment
EP2371817A1 (en) * 2010-04-01 2011-10-05 Arevipharma GmbH Process for the preparation of 1-[4-(1,1-dimethylethyl)phenyl]-4-[4-(diphenylmethoxy)-1-piperidinyl]-1-butanone and acid addition salts thereof
CN105254579A (zh) * 2015-09-19 2016-01-20 万全万特制药江苏有限公司 一种一锅法制备比拉斯汀中间体的方法
CN114621083A (zh) * 2022-03-30 2022-06-14 西安万隆制药股份有限公司 一种抗组胺药物盐酸非索非那定杂质及其合成方法和应用
CN114671802B (zh) * 2022-04-14 2024-05-17 江苏联环药业股份有限公司 一种高纯度依巴斯汀的制备方法
EP4647423A1 (en) * 2023-01-03 2025-11-12 Chengdu Shibeikang Biomedical Technology Co., Ltd. Crystal form and amorphous form of carebastine p-toluenesulfonate

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DE4034218A1 (de) 1990-10-27 1992-04-30 Merck Patent Gmbh Verfahren zur herstellung von carebastin
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KR100387348B1 (ko) * 1993-06-24 2003-06-12 알바니 몰레큘라 리써치, 인크. 피페리딘 유도체의 제조 방법
US20020007068A1 (en) * 1999-07-16 2002-01-17 D'ambra Thomas E. Piperidine derivatives and process for their production
HU226037B1 (en) * 1993-06-25 2008-03-28 Aventis Inc Process for producing antihistaminic 4-diphenylmethyl/diphenylmethoxy piperidine derivatives and novel intermediates
US6201124B1 (en) * 1995-12-21 2001-03-13 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US6153754A (en) * 1995-12-21 2000-11-28 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US5925761A (en) * 1997-02-04 1999-07-20 Sepracor Inc. Synthesis of terfenadine and derivatives
US7498345B2 (en) * 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of piperidine derivatives

Also Published As

Publication number Publication date
US6448406B1 (en) 2002-09-10
NO311718B1 (no) 2002-01-14
KR20050086753A (ko) 2005-08-30
EP0877733A4 (en) 1999-03-31
KR100516869B1 (ko) 2005-11-25
CA2240735C (en) 2006-08-29
NO982806D0 (no) 1998-06-18
NZ326228A (en) 2000-02-28
US6201124B1 (en) 2001-03-13
PT877733E (pt) 2006-12-29
US7560561B2 (en) 2009-07-14
EP1362849A2 (en) 2003-11-19
US20050272771A1 (en) 2005-12-08
EP0877733B1 (en) 2006-08-09
DE69636439T2 (de) 2007-03-29
JP2009019059A (ja) 2009-01-29
DK0877733T3 (da) 2006-12-11
US8022220B2 (en) 2011-09-20
AU723759B2 (en) 2000-09-07
CA2240735A1 (en) 1997-06-26
NO982806L (no) 1998-08-12
JP2000502105A (ja) 2000-02-22
DE69636439D1 (de) 2006-09-21
WO1997022344A1 (en) 1997-06-26
EP0877733A1 (en) 1998-11-18
US6974872B2 (en) 2005-12-13
ATE335726T1 (de) 2006-09-15
BR9612099A (pt) 1999-12-28
KR100591212B1 (ko) 2006-06-22
US20100010227A1 (en) 2010-01-14
HUP9900947A2 (hu) 1999-07-28
US20030171590A1 (en) 2003-09-11
US6452011B1 (en) 2002-09-17
US20110295014A1 (en) 2011-12-01
AU1354797A (en) 1997-07-14
EP1362849A3 (en) 2003-11-26
ES2268715T3 (es) 2007-03-16
JP4865113B2 (ja) 2012-02-01
KR20000064507A (ko) 2000-11-06

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Legal Events

Date Code Title Description
GB9A Succession in title

Owner name: ALBANY MOLECULAR RESEARCH, INC., US

Free format text: FORMER OWNER(S): AMR TECHNOLOGY, INC., US; ALBANY MOLECULAR RESEARCH, INC., US

FH91 Appointment of a representative

Free format text: FORMER REPRESENTATIVE(S): IFJ. SZENTPETERI ADAM, S.B.G. & K. BUDAPESTI NEMZETKOEZI SZABADALMI IRODA, HU

Representative=s name: DANUBIA SZABADALMI ES JOGI IRODA KFT., HU

FH92 Termination of representative

Representative=s name: IFJ. SZENTPETERI ADAM, S.B.G. & K. BUDAPESTI N, HU

FD9A Lapse of provisional protection due to non-payment of fees