HUP9900913A2 - Eljárás N-monoszubsztituált és N,N'-diszubsztituált aszimmetrikus 7-tagú ciklusos karbamidok előállítására - Google Patents

Eljárás N-monoszubsztituált és N,N'-diszubsztituált aszimmetrikus 7-tagú ciklusos karbamidok előállítására

Info

Publication number
HUP9900913A2
HUP9900913A2 HU9900913A HUP9900913A HUP9900913A2 HU P9900913 A2 HUP9900913 A2 HU P9900913A2 HU 9900913 A HU9900913 A HU 9900913A HU P9900913 A HUP9900913 A HU P9900913A HU P9900913 A2 HUP9900913 A2 HU P9900913A2
Authority
HU
Hungary
Prior art keywords
monosubstituted
preparing
cyclic ureas
membered cyclic
unsymmetrical
Prior art date
Application number
HU9900913A
Other languages
English (en)
Inventor
James David Rodgers
Jung-Hui Sun
Original Assignee
Dupont Pharmaceuticals Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dupont Pharmaceuticals Company filed Critical Dupont Pharmaceuticals Company
Publication of HUP9900913A2 publication Critical patent/HUP9900913A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

A találmány tárgya új eljárás aszimmetrikűsan szűbsztitűált (VIa) és(VIb) általánős képletű ciklűsős karbamidők előállítására, amelyekhasznős HIV prőteáz inhibitőrők. Az eljárást izőkarbamid intermedierenkeresztül hajtják végre. A képletekben R4, R7 és R22 előnyös jelentésebenzilcsőpőrt, R23 előnyösen aminő-indazől-metil vagy piridil-metil-csőpőrt. ŕ
HU9900913A 1995-06-07 1996-06-06 Eljárás N-monoszubsztituált és N,N'-diszubsztituált aszimmetrikus 7-tagú ciklusos karbamidok előállítására HUP9900913A2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/481,683 US5532357A (en) 1995-06-07 1995-06-07 Method for preparing N-monosubstituted and N,N'-disubstituted unsymmetrical cyclic ureas

Publications (1)

Publication Number Publication Date
HUP9900913A2 true HUP9900913A2 (hu) 1999-09-28

Family

ID=23912954

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900913A HUP9900913A2 (hu) 1995-06-07 1996-06-06 Eljárás N-monoszubsztituált és N,N'-diszubsztituált aszimmetrikus 7-tagú ciklusos karbamidok előállítására

Country Status (26)

Country Link
US (1) US5532357A (hu)
EP (2) EP1029859A1 (hu)
JP (1) JPH11506779A (hu)
KR (1) KR19990022467A (hu)
CN (1) CN1192209A (hu)
AR (1) AR002384A1 (hu)
AU (1) AU704535B2 (hu)
BR (1) BR9609493A (hu)
CA (1) CA2223391A1 (hu)
CZ (1) CZ381997A3 (hu)
EA (1) EA000363B1 (hu)
EE (1) EE9700330A (hu)
HR (1) HRP960259A2 (hu)
HU (1) HUP9900913A2 (hu)
IL (1) IL122424A0 (hu)
LT (1) LT4381B (hu)
LV (1) LV12045B (hu)
MX (1) MX9709652A (hu)
NO (1) NO975679L (hu)
NZ (1) NZ309648A (hu)
PL (1) PL323993A1 (hu)
SI (1) SI9620077A (hu)
SK (1) SK164397A3 (hu)
TW (1) TW358091B (hu)
WO (1) WO1996040652A1 (hu)
ZA (1) ZA964847B (hu)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5466797A (en) * 1994-06-30 1995-11-14 The Du Pont Merck Pharmaceutical Company Intermediates for the preparation of cyclic urea
US6054597A (en) * 1995-11-14 2000-04-25 Dupont Pharmaceuticals Processes and intermediates for the preparation of cyclic urea HIV protease inhibitors
US6218386B1 (en) 1996-11-08 2001-04-17 Dupont Pharmaceuticals A1-(3-aminoindazol-5-yl)-3 butyl-cyclic urea useful as a HIV protease inhibitor
US5932570A (en) * 1996-11-08 1999-08-03 Dupont Pharmaceuticals Company 1-(3-aminoindazol-5-yl)-3-phenylmethyl-cyclic ureas useful as HIV protease inhibitors
WO1998020008A1 (en) * 1996-11-08 1998-05-14 Du Pont Pharmaceuticals Company 1-(3-aminoindazol-5-yl)-3-phenylmethyl-cyclic ureas useful as hiv protease inhibitors
AU6870098A (en) * 1997-03-31 1998-10-22 Du Pont Merck Pharmaceutical Company, The Indazoles of cyclic ureas useful as hiv protease inhibitors
US6218534B1 (en) 1997-10-06 2001-04-17 Dupont Pharmaceuticals Company Preparation of asymmetric cyclic ureas through a monoacylated diamine intermediate
EP1091944A1 (en) * 1998-06-30 2001-04-18 Du Pont Pharmaceuticals Company 1,3-benzodiazepin-2-ones and 1,3-benzoxazepin-2-ones useful as hiv reverse transcriptase inhibitors
CA2370141A1 (en) 1999-05-26 2000-12-07 James D. Rodgers 1,4-benzodiazepin-2-ones useful as hiv reverse transcriptase inhibitors
US6313110B1 (en) * 1999-06-02 2001-11-06 Dupont Pharmaceuticals Company Substituted 2H-1,3-diazapin-2-one useful as an HIV protease inhibitor
FR2810039B1 (fr) * 2000-06-13 2007-05-25 Centre Nat Rech Scient Composes urees cycliques et leur procede de preparation
AU2002258633A1 (en) * 2001-03-28 2002-10-15 Bristol-Myers Squibb Company Cyanamide, alkoxyamino, and urea derivatives of 1,3-benzodiazapines as hiv reverse transcriptase inhibitors
US20080033167A1 (en) * 2005-12-29 2008-02-07 Gilles Guichard Compositions and methods for synthesizing heterocyclic therapeutic compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610294A (en) * 1991-10-11 1997-03-11 The Du Pont Merck Pharmaceutical Company Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors
ATE216371T1 (de) * 1991-10-11 2002-05-15 Du Pont Pharm Co Cyclische harnstoffe und analoga verwendbar als retrovirale proteasehemmer
US5430043A (en) * 1993-08-24 1995-07-04 G. D. Searle & Co. Platelet aggregation inhibitors
US5466797A (en) * 1994-06-30 1995-11-14 The Du Pont Merck Pharmaceutical Company Intermediates for the preparation of cyclic urea
US5530124A (en) * 1994-06-30 1996-06-25 The Dupont Merck Pharmaceutical Company Method for preparing cyclic ureas and their use for the synthesis of HIV protease inhibitors
US5532356A (en) * 1995-06-06 1996-07-02 The Dupont Merck Pharmaceutical Company Method for preparing N,N'-disubstituted cyclic ureas
US7344671B2 (en) 2003-11-26 2008-03-18 Glopak Inc. Optical sealing clamp and a method for sealing and cutting polymeric sheets with a laser
US7369013B2 (en) 2005-04-06 2008-05-06 Avago Technologies Wireless Ip Pte Ltd Acoustic resonator performance enhancement using filled recessed region

Also Published As

Publication number Publication date
TW358091B (en) 1999-05-11
EA000363B1 (ru) 1999-06-24
BR9609493A (pt) 1999-03-02
NZ309648A (en) 1998-09-24
HRP960259A2 (en) 1997-10-31
EE9700330A (et) 1998-06-15
EA199800034A1 (ru) 1998-08-27
LV12045B (en) 1998-09-20
PL323993A1 (en) 1998-04-27
AU5986896A (en) 1996-12-30
SK164397A3 (en) 2000-04-10
NO975679L (no) 1998-02-02
ZA964847B (en) 1997-12-08
JPH11506779A (ja) 1999-06-15
LT4381B (lt) 1998-09-25
EP1029859A1 (en) 2000-08-23
IL122424A0 (en) 1998-06-15
SI9620077A (sl) 1998-08-31
LT97188A (en) 1998-04-27
US5532357A (en) 1996-07-02
EP0837855A4 (en) 1998-09-02
AU704535B2 (en) 1999-04-29
CA2223391A1 (en) 1996-12-19
KR19990022467A (ko) 1999-03-25
CN1192209A (zh) 1998-09-02
CZ381997A3 (cs) 1999-01-13
LV12045A (lv) 1998-05-20
MX9709652A (es) 1998-03-29
AR002384A1 (es) 1998-03-11
NO975679D0 (no) 1997-12-05
EP0837855A1 (en) 1998-04-29
WO1996040652A1 (en) 1996-12-19

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