EE9700330A - N-üksikasendatud ja N,N'-kaksikasendatud ebasümmeetriliste tsükliliste uureade valmistamise meetod - Google Patents

N-üksikasendatud ja N,N'-kaksikasendatud ebasümmeetriliste tsükliliste uureade valmistamise meetod

Info

Publication number
EE9700330A
EE9700330A EE9700330A EE9700330A EE9700330A EE 9700330 A EE9700330 A EE 9700330A EE 9700330 A EE9700330 A EE 9700330A EE 9700330 A EE9700330 A EE 9700330A EE 9700330 A EE9700330 A EE 9700330A
Authority
EE
Estonia
Prior art keywords
preparing
detailed
cyclic ureas
asymmetric cyclic
disubstituted asymmetric
Prior art date
Application number
EE9700330A
Other languages
English (en)
Inventor
David Rodgers James
Sun Jung-Hui
Original Assignee
The Du Pont Merck Pharmaceutical Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Du Pont Merck Pharmaceutical Company filed Critical The Du Pont Merck Pharmaceutical Company
Publication of EE9700330A publication Critical patent/EE9700330A/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
EE9700330A 1995-06-07 1996-06-06 N-üksikasendatud ja N,N'-kaksikasendatud ebasümmeetriliste tsükliliste uureade valmistamise meetod EE9700330A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/481,683 US5532357A (en) 1995-06-07 1995-06-07 Method for preparing N-monosubstituted and N,N'-disubstituted unsymmetrical cyclic ureas
PCT/US1996/009021 WO1996040652A1 (en) 1995-06-07 1996-06-06 Method for preparing n-monosubstituted and n,n'-disubstituted unsymmetrical cyclic ureas

Publications (1)

Publication Number Publication Date
EE9700330A true EE9700330A (et) 1998-06-15

Family

ID=23912954

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9700330A EE9700330A (et) 1995-06-07 1996-06-06 N-üksikasendatud ja N,N'-kaksikasendatud ebasümmeetriliste tsükliliste uureade valmistamise meetod

Country Status (26)

Country Link
US (1) US5532357A (et)
EP (2) EP1029859A1 (et)
JP (1) JPH11506779A (et)
KR (1) KR19990022467A (et)
CN (1) CN1192209A (et)
AR (1) AR002384A1 (et)
AU (1) AU704535B2 (et)
BR (1) BR9609493A (et)
CA (1) CA2223391A1 (et)
CZ (1) CZ381997A3 (et)
EA (1) EA000363B1 (et)
EE (1) EE9700330A (et)
HR (1) HRP960259A2 (et)
HU (1) HUP9900913A2 (et)
IL (1) IL122424A0 (et)
LT (1) LT4381B (et)
LV (1) LV12045B (et)
MX (1) MX9709652A (et)
NO (1) NO975679L (et)
NZ (1) NZ309648A (et)
PL (1) PL323993A1 (et)
SI (1) SI9620077A (et)
SK (1) SK164397A3 (et)
TW (1) TW358091B (et)
WO (1) WO1996040652A1 (et)
ZA (1) ZA964847B (et)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5466797A (en) * 1994-06-30 1995-11-14 The Du Pont Merck Pharmaceutical Company Intermediates for the preparation of cyclic urea
US6054597A (en) * 1995-11-14 2000-04-25 Dupont Pharmaceuticals Processes and intermediates for the preparation of cyclic urea HIV protease inhibitors
US6218386B1 (en) 1996-11-08 2001-04-17 Dupont Pharmaceuticals A1-(3-aminoindazol-5-yl)-3 butyl-cyclic urea useful as a HIV protease inhibitor
EE9900188A (et) * 1996-11-08 1999-12-15 Dupont Pharmaceuticals Company HIV proteaasi inhibiitoritena kasulikud 1-(3-aminoindasool-5-üül)-3-fenüülmetüül-tsüklilised uuread
US5932570A (en) * 1996-11-08 1999-08-03 Dupont Pharmaceuticals Company 1-(3-aminoindazol-5-yl)-3-phenylmethyl-cyclic ureas useful as HIV protease inhibitors
WO1998043969A1 (en) * 1997-03-31 1998-10-08 Dupont Pharmaceuticals Company Indazoles of cyclic ureas useful as hiv protease inhibitors
US6218534B1 (en) * 1997-10-06 2001-04-17 Dupont Pharmaceuticals Company Preparation of asymmetric cyclic ureas through a monoacylated diamine intermediate
EP1091944A1 (en) * 1998-06-30 2001-04-18 Du Pont Pharmaceuticals Company 1,3-benzodiazepin-2-ones and 1,3-benzoxazepin-2-ones useful as hiv reverse transcriptase inhibitors
CA2370141A1 (en) 1999-05-26 2000-12-07 James D. Rodgers 1,4-benzodiazepin-2-ones useful as hiv reverse transcriptase inhibitors
US6313110B1 (en) * 1999-06-02 2001-11-06 Dupont Pharmaceuticals Company Substituted 2H-1,3-diazapin-2-one useful as an HIV protease inhibitor
FR2810039B1 (fr) * 2000-06-13 2007-05-25 Centre Nat Rech Scient Composes urees cycliques et leur procede de preparation
AU2002258633A1 (en) * 2001-03-28 2002-10-15 Bristol-Myers Squibb Company Cyanamide, alkoxyamino, and urea derivatives of 1,3-benzodiazapines as hiv reverse transcriptase inhibitors
US7777030B2 (en) 2005-12-29 2010-08-17 Centre National de la Recherge Scientifique (CNRS) Compositions and methods for the treatment and prevention of disease

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610294A (en) * 1991-10-11 1997-03-11 The Du Pont Merck Pharmaceutical Company Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors
AU2871592A (en) * 1991-10-11 1993-05-03 Du Pont Merck Pharmaceutical Company, The Cyclic ureas and analogues useful as retroviral protease inhibitiors
US5430043A (en) * 1993-08-24 1995-07-04 G. D. Searle & Co. Platelet aggregation inhibitors
US5530124A (en) * 1994-06-30 1996-06-25 The Dupont Merck Pharmaceutical Company Method for preparing cyclic ureas and their use for the synthesis of HIV protease inhibitors
US5466797A (en) * 1994-06-30 1995-11-14 The Du Pont Merck Pharmaceutical Company Intermediates for the preparation of cyclic urea
US5532356A (en) * 1995-06-06 1996-07-02 The Dupont Merck Pharmaceutical Company Method for preparing N,N'-disubstituted cyclic ureas
US7344671B2 (en) 2003-11-26 2008-03-18 Glopak Inc. Optical sealing clamp and a method for sealing and cutting polymeric sheets with a laser
US7369013B2 (en) 2005-04-06 2008-05-06 Avago Technologies Wireless Ip Pte Ltd Acoustic resonator performance enhancement using filled recessed region

Also Published As

Publication number Publication date
PL323993A1 (en) 1998-04-27
CZ381997A3 (cs) 1999-01-13
HUP9900913A2 (hu) 1999-09-28
AU5986896A (en) 1996-12-30
IL122424A0 (en) 1998-06-15
EA000363B1 (ru) 1999-06-24
AU704535B2 (en) 1999-04-29
EP0837855A4 (en) 1998-09-02
CA2223391A1 (en) 1996-12-19
CN1192209A (zh) 1998-09-02
BR9609493A (pt) 1999-03-02
EP0837855A1 (en) 1998-04-29
ZA964847B (en) 1997-12-08
NZ309648A (en) 1998-09-24
LV12045B (en) 1998-09-20
HRP960259A2 (en) 1997-10-31
US5532357A (en) 1996-07-02
LT4381B (lt) 1998-09-25
SK164397A3 (en) 2000-04-10
EA199800034A1 (ru) 1998-08-27
WO1996040652A1 (en) 1996-12-19
JPH11506779A (ja) 1999-06-15
NO975679D0 (no) 1997-12-05
SI9620077A (sl) 1998-08-31
LV12045A (lv) 1998-05-20
AR002384A1 (es) 1998-03-11
EP1029859A1 (en) 2000-08-23
TW358091B (en) 1999-05-11
KR19990022467A (ko) 1999-03-25
MX9709652A (es) 1998-03-29
NO975679L (no) 1998-02-02
LT97188A (en) 1998-04-27

Similar Documents

Publication Publication Date Title
BR9607083A (pt) Processos para preparar sulfeto ciclico de 1,1-ciclo-propano-dimetanol 1-hidróxi-metil-cciclo-propano-acetonitrila e ácido 1-tío-metíl-ciclo propano-acético
EE03921B1 (et) N-(3-bensofuranüül)karbamiidderivaadid, nende valmistamismeetod ja kasutamine
EE03482B1 (et) Kinasoliiniderivaadid, nende valmistamismeetod ja kasutamine
KR970001343A (ko) 나프탈렌 유도체,그의 제조 방법,및그의 중간체
DE69006290T2 (de) N-Substituierte Benzyloxyiminderivate, Verfahren zu deren Herstellung und deren Verwendung.
FI945166A0 (fi) Katalyttejä, niiden käyttömenetelmä ja menetelmä niiden valmistamiseksi
EE9700330A (et) N-üksikasendatud ja N,N'-kaksikasendatud ebasümmeetriliste tsükliliste uureade valmistamise meetod
IL122457A0 (en) Method for preparing n,n'-disubstituted cyclic ureas
DE59602230D1 (de) Verfahren zur Herstellung von 2,2-Difluorbenzo[1.3]dioxolcarbaldehyden
DE3674582D1 (de) (s)-(-)-1-propyl-2',6'-pipecoloxylidid-hydrochloridmonohydrat, verfahren zu seiner herstellung und es enthaltendes pharmazeutisches praeparat.
EE9800145A (et) Fenüülamidiini derivaadid, meetodid nende valmistamiseks ja nende kasutamine arstimitena
ATA36995A (de) Verfahren zur herstellung und reinigung von l-5-(2-hydroxypropionylamino)-2,4,6-
DE3783199T2 (de) Verfahren zur herstellung von 4,4' diaminodiphenylmethan und derivaten davon.
NO953321D0 (no) 2,3 cyklisk kondenserte 1,4-dihydropyridiner, fremgangsmåte for fremstilling derav og deres anvendelse som legemidler
DE69318181T2 (de) Papierblock, streifen und verfahren zu deren herstellung
EE04117B1 (et) Karboksüasendatud tsüklilised karboksamiidi derivaadid, nende valmistamise meetod ja kasutamine
DE3765628D1 (de) N,n'-disubstituierte harnstoffe und verfahren zu ihrer herstellung.
DE69021127D1 (de) Polyisocyanatoalkylphenyl-isocyanurates, Verfahren zu deren Herstellung und deren Verwendung.
KR960701075A (ko) 신규 2'-메틸리덴 뉴클레오티드 화합물, 그의 제조 방법 및 그의 약학적 용도[novel 2'-methylidenenucleotide compound, process for producing the same, and pharmaceutical use thereof]
DE58902684D1 (de) Verfahren zur herstellung von cyclischen n,n'-dimethylharnstoffen.
DE69506944T2 (de) 1-Phenyl-1-cyano-C5-C7-Alkane, ihre organoleptische Verwendung und Verfahren zu deren Herstellung
FR2733230B1 (fr) Nouveaux derives d'ornithine, procede de preparation, utilisation et composition les comprenant
DE59603908D1 (de) Verfahren zur Herstellung von N',N'-disubstituierten 1,4-Diaminoanthrachinonen
ATA141090A (de) Verfahren zur herstellung von 3-azido-2,3didesoxy-d-erythro-pentose sowie von substituierten und unsubstituierten 3-azido-2,3- didesoxy-d-erythro-pentofuranosen und deren verwendung
ATE57527T1 (de) N,n'-disubstituierte harnstoffe und verfahren zu ihrer herstellung.