TW358091B - Method for preparing N-monosubstituted and N, N'-disubstituted unsymmetrical cyclic ureas - Google Patents

Method for preparing N-monosubstituted and N, N'-disubstituted unsymmetrical cyclic ureas

Info

Publication number
TW358091B
TW358091B TW085108193A TW85108193A TW358091B TW 358091 B TW358091 B TW 358091B TW 085108193 A TW085108193 A TW 085108193A TW 85108193 A TW85108193 A TW 85108193A TW 358091 B TW358091 B TW 358091B
Authority
TW
Taiwan
Prior art keywords
compound
alkyl
formula
same
substituted
Prior art date
Application number
TW085108193A
Other languages
English (en)
Inventor
James David Rodgers
Jung-Hui Sun
Original Assignee
Du Pont Merck Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma
Application granted granted Critical
Publication of TW358091B publication Critical patent/TW358091B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Enzymes And Modification Thereof (AREA)
TW085108193A 1995-06-07 1996-07-06 Method for preparing N-monosubstituted and N, N'-disubstituted unsymmetrical cyclic ureas TW358091B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/481,683 US5532357A (en) 1995-06-07 1995-06-07 Method for preparing N-monosubstituted and N,N'-disubstituted unsymmetrical cyclic ureas

Publications (1)

Publication Number Publication Date
TW358091B true TW358091B (en) 1999-05-11

Family

ID=23912954

Family Applications (1)

Application Number Title Priority Date Filing Date
TW085108193A TW358091B (en) 1995-06-07 1996-07-06 Method for preparing N-monosubstituted and N, N'-disubstituted unsymmetrical cyclic ureas

Country Status (26)

Country Link
US (1) US5532357A (zh)
EP (2) EP0837855A4 (zh)
JP (1) JPH11506779A (zh)
KR (1) KR19990022467A (zh)
CN (1) CN1192209A (zh)
AR (1) AR002384A1 (zh)
AU (1) AU704535B2 (zh)
BR (1) BR9609493A (zh)
CA (1) CA2223391A1 (zh)
CZ (1) CZ381997A3 (zh)
EA (1) EA000363B1 (zh)
EE (1) EE9700330A (zh)
HR (1) HRP960259A2 (zh)
HU (1) HUP9900913A2 (zh)
IL (1) IL122424A0 (zh)
LT (1) LT4381B (zh)
LV (1) LV12045B (zh)
MX (1) MX9709652A (zh)
NO (1) NO975679L (zh)
NZ (1) NZ309648A (zh)
PL (1) PL323993A1 (zh)
SI (1) SI9620077A (zh)
SK (1) SK164397A3 (zh)
TW (1) TW358091B (zh)
WO (1) WO1996040652A1 (zh)
ZA (1) ZA964847B (zh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5466797A (en) * 1994-06-30 1995-11-14 The Du Pont Merck Pharmaceutical Company Intermediates for the preparation of cyclic urea
US6054597A (en) * 1995-11-14 2000-04-25 Dupont Pharmaceuticals Processes and intermediates for the preparation of cyclic urea HIV protease inhibitors
CA2270966A1 (en) * 1996-11-08 1998-05-14 Du Pont Pharmaceuticals Company 1-(3-aminoindazol-5-yl)-3-phenylmethyl-cyclic ureas useful as hiv protease inhibitors
US5932570A (en) * 1996-11-08 1999-08-03 Dupont Pharmaceuticals Company 1-(3-aminoindazol-5-yl)-3-phenylmethyl-cyclic ureas useful as HIV protease inhibitors
US6218386B1 (en) 1996-11-08 2001-04-17 Dupont Pharmaceuticals A1-(3-aminoindazol-5-yl)-3 butyl-cyclic urea useful as a HIV protease inhibitor
JP2001518094A (ja) * 1997-03-31 2001-10-09 デュポン ファーマシューティカルズ カンパニー Ｈｉｖプロテアーゼ阻害剤として有用なインダゾール−環式尿素
US6218534B1 (en) * 1997-10-06 2001-04-17 Dupont Pharmaceuticals Company Preparation of asymmetric cyclic ureas through a monoacylated diamine intermediate
EP1091944A1 (en) 1998-06-30 2001-04-18 Du Pont Pharmaceuticals Company 1,3-benzodiazepin-2-ones and 1,3-benzoxazepin-2-ones useful as hiv reverse transcriptase inhibitors
WO2000073284A2 (en) 1999-05-26 2000-12-07 Du Pont Pharmaceuticals Company 1,4-benzodiazepin-2-ones useful as hiv reverse transcriptase inhibitors
US6313110B1 (en) * 1999-06-02 2001-11-06 Dupont Pharmaceuticals Company Substituted 2H-1,3-diazapin-2-one useful as an HIV protease inhibitor
FR2810039B1 (fr) * 2000-06-13 2007-05-25 Centre Nat Rech Scient Composes urees cycliques et leur procede de preparation
US7015214B2 (en) * 2001-03-28 2006-03-21 Bristol-Myers Squibb Pharma Company Cyanamide, alkoxyamino, and urea derivatives of 1,3-benzodiazepine as HIV reverse transcriptase inhibitors
US7777030B2 (en) 2005-12-29 2010-08-17 Centre National de la Recherge Scientifique (CNRS) Compositions and methods for the treatment and prevention of disease

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2131420C1 (ru) * 1991-10-11 1999-06-10 Дзе Дюпон Мерк Фармасьютикал Компани Циклические мочевины, способ ингибирования роста ретровирусов и фармацевтическая композиция
US5610294A (en) * 1991-10-11 1997-03-11 The Du Pont Merck Pharmaceutical Company Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors
US5430043A (en) * 1993-08-24 1995-07-04 G. D. Searle & Co. Platelet aggregation inhibitors
US5530124A (en) * 1994-06-30 1996-06-25 The Dupont Merck Pharmaceutical Company Method for preparing cyclic ureas and their use for the synthesis of HIV protease inhibitors
US5466797A (en) * 1994-06-30 1995-11-14 The Du Pont Merck Pharmaceutical Company Intermediates for the preparation of cyclic urea
US5532356A (en) * 1995-06-06 1996-07-02 The Dupont Merck Pharmaceutical Company Method for preparing N,N'-disubstituted cyclic ureas
US7344671B2 (en) 2003-11-26 2008-03-18 Glopak Inc. Optical sealing clamp and a method for sealing and cutting polymeric sheets with a laser
US7369013B2 (en) 2005-04-06 2008-05-06 Avago Technologies Wireless Ip Pte Ltd Acoustic resonator performance enhancement using filled recessed region

Also Published As

Publication number Publication date
IL122424A0 (en) 1998-06-15
LV12045B (en) 1998-09-20
EP0837855A4 (en) 1998-09-02
MX9709652A (es) 1998-03-29
CA2223391A1 (en) 1996-12-19
US5532357A (en) 1996-07-02
NZ309648A (en) 1998-09-24
LT97188A (en) 1998-04-27
HRP960259A2 (en) 1997-10-31
EA000363B1 (ru) 1999-06-24
AR002384A1 (es) 1998-03-11
AU704535B2 (en) 1999-04-29
EP0837855A1 (en) 1998-04-29
WO1996040652A1 (en) 1996-12-19
CZ381997A3 (cs) 1999-01-13
HUP9900913A2 (hu) 1999-09-28
NO975679L (no) 1998-02-02
EE9700330A (et) 1998-06-15
NO975679D0 (no) 1997-12-05
LT4381B (lt) 1998-09-25
BR9609493A (pt) 1999-03-02
EA199800034A1 (ru) 1998-08-27
CN1192209A (zh) 1998-09-02
PL323993A1 (en) 1998-04-27
SI9620077A (sl) 1998-08-31
EP1029859A1 (en) 2000-08-23
AU5986896A (en) 1996-12-30
LV12045A (lv) 1998-05-20
JPH11506779A (ja) 1999-06-15
KR19990022467A (ko) 1999-03-25
SK164397A3 (en) 2000-04-10
ZA964847B (en) 1997-12-08

Similar Documents

Publication Publication Date Title
IE810392L (en) Hydropyridine derivatives.
TW358091B (en) Method for preparing N-monosubstituted and N, N'-disubstituted unsymmetrical cyclic ureas
ATE15660T1 (de) Dihydropyridine als anti-ischaemische und antihypertensive mittel, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
IE812273L (en) Cephalosporin derivatives
DE69722027D1 (de) Kristalle von benzimidazolderivate und verfahren zu ihrer herstellung
NO20012411L (no) Pyrrolidin-derivater-CCR-3-reseptorantagonister
NO990227L (no) Heterocykliske forbindelser som farmas°ytika
CA2324418A1 (en) Novel opiate compounds, methods of making and methods of use
DE3873612D1 (de) Dithioacetal-verbindungen, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
IE41539L (en) Chroman derivatives.
KR920002555A (ko) 앤지오텐신 ii 수용체 길항질인 신규한 피리미딘 유도체, 그 제조방법 및 그를 포함하는 제약학적 조성물
HUP9800087A2 (hu) Alkoxi-imino-ecetsav-amidok, e vegyületeket tartalmazó növényvédő szerek, valamint eljárás kártevők leküzdésére, továbbá e vegyületek előállítására
HUT36113A (en) Process for preparing dihydro-pyridibes with anti-ischaemic activity and blood pressure decreasing effect and pharmaceutical compositions containing such compounds
EP0335979A4 (en) Thienopyrimidine derivatives
HUP0100453A1 (hu) Eljárás izokarbamidok előállítására
DE3480839D1 (de) Benzimidazol-derivat, verfahren zu seiner herstellung und pharmazeutische zusammensetzung.
CA2267800A1 (en) Tricyclic compounds having activity as ras-fpt inhibitors
ES2128960A1 (es) Derivados de fluorofenil-triazinas y pirimidinas compuestos farmacologicamente activos en el sistema nervioso central.
ATE117997T1 (de) 4-(hetero)arylmethyloxy-phenyl-diazolderivate, verfahren zu deren herstellung und ihre therapeutische verwendung.
ATE346845T1 (de) Ein verfahren zur herstellung substituierter alkylamin-derivate
ATE67194T1 (de) Thiadiazolylacetamid-derivate, verfahren zu ihrer herstellung und ihre verwendung.
ATE258545T1 (de) Antioxidantien, verfahren zu ihrer herstellung und ihre verwendungen
JPS6429359A (en) 1,4-dihydropyridine derivative and production thereof
KR870010047A (ko) 티에닐티아졸 화합물의 제조방법
TH9467B (th) อนุพันธุ์ต่าง ๆ ของควิโนลีนชนิดใหม่และกรรมวิธีสำหรับการเตรียมของสารประกอบนั้น