CY1113564T1 - Διαδικασια παρασκευης κυκλικων πολυαμινων που περιεχουν ν-1 προστατευμενα ν ατομα αζωτου στον δακτυλιο και των προϊοντων αυτων - Google Patents

Διαδικασια παρασκευης κυκλικων πολυαμινων που περιεχουν ν-1 προστατευμενα ν ατομα αζωτου στον δακτυλιο και των προϊοντων αυτων

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Publication number
CY1113564T1
CY1113564T1 CY20131100084T CY131100084T CY1113564T1 CY 1113564 T1 CY1113564 T1 CY 1113564T1 CY 20131100084 T CY20131100084 T CY 20131100084T CY 131100084 T CY131100084 T CY 131100084T CY 1113564 T1 CY1113564 T1 CY 1113564T1
Authority
CY
Cyprus
Prior art keywords
ring
polyamins
persons
procedure
products
Prior art date
Application number
CY20131100084T
Other languages
English (en)
Inventor
Christen M Giandomenico
Wen Yang
Original Assignee
Genzyme Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corporation filed Critical Genzyme Corporation
Publication of CY1113564T1 publication Critical patent/CY1113564T1/el

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D255/00Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
    • C07D255/02Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D257/00Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Abstract

Κυκλικές πολυαμίνες, οι οποίες περιέχουν Ν άτομα αζώτου στον δακτύλιο προστατεύονται με υψηλές αποδόσεις με έναν Ν-1 τρόπο, π.χ. όλες προστατεύονται εκτός από μια, χρησιμοποιώντας συγκεκριμένους παράγοντες που περιέχουν φθόριο, οι οποίοι προσφέρουν εύκολη αποπροστασία. Κατά προτίμηση, περιγράφεται μια νέα διαδικασία παρασκευής του 1,1'-[1,4-φαινυλενεδις (μεθυλενο)]-δις-1,4,8,11- τετρααζακυκλοδεκατετρανίου του χημικού τύπου XII.
CY20131100084T 2000-09-29 2013-01-30 Διαδικασια παρασκευης κυκλικων πολυαμινων που περιεχουν ν-1 προστατευμενα ν ατομα αζωτου στον δακτυλιο και των προϊοντων αυτων CY1113564T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23700200P 2000-09-29 2000-09-29
EP08163998A EP2022787B1 (en) 2000-09-29 2001-09-28 Process for the preparation of N-1 protected N ring nitrogen containing cyclic polyamines and products thereof

Publications (1)

Publication Number Publication Date
CY1113564T1 true CY1113564T1 (el) 2016-06-22

Family

ID=22891923

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20131100084T CY1113564T1 (el) 2000-09-29 2013-01-30 Διαδικασια παρασκευης κυκλικων πολυαμινων που περιεχουν ν-1 προστατευμενα ν ατομα αζωτου στον δακτυλιο και των προϊοντων αυτων

Country Status (24)

Country Link
US (1) US6489472B2 (el)
EP (2) EP1322626B1 (el)
JP (2) JP5335171B2 (el)
KR (1) KR100808385B1 (el)
CN (1) CN1273455C (el)
AT (1) ATE413391T1 (el)
AU (2) AU1139302A (el)
BR (1) BR0114246A (el)
CA (1) CA2419631A1 (el)
CY (1) CY1113564T1 (el)
DE (1) DE60136476D1 (el)
DK (1) DK2022787T3 (el)
ES (2) ES2320323T3 (el)
HK (1) HK1058035A1 (el)
HU (1) HUP0301176A3 (el)
IL (3) IL154400A0 (el)
MX (1) MXPA03002772A (el)
NO (1) NO20031401D0 (el)
NZ (1) NZ524580A (el)
PL (1) PL359292A1 (el)
PT (1) PT2022787E (el)
RU (2) RU2311413C2 (el)
WO (1) WO2002026721A1 (el)
ZA (1) ZA200301012B (el)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1411918E (pt) 2001-07-31 2012-03-06 Genzyme Global S A R L Métodos para mobilizar células progenitoras/estaminais
US7169750B2 (en) 2001-07-31 2007-01-30 Anormed, Inc. Methods to mobilize progenitor/stem cells
CN100418957C (zh) * 2003-07-08 2008-09-17 香港大学 三-n-烷基化的1,4,7,10-四氮杂环十二烷的合成
DE102004038134B4 (de) * 2004-08-05 2013-07-25 Johann Wolfgang Goethe-Universität Frankfurt am Main Multivalente Chelatoren zum Modifizieren und Organisieren von Zielmolekülen, Verfahren zu ihrer Herstellung sowie ihre Verwendung
US20060035829A1 (en) * 2004-08-13 2006-02-16 Anormed Inc. Chemokine combinations to mobilize progenitor/stem cells
US7306785B2 (en) * 2004-09-23 2007-12-11 General Electric Company Multifunctional cross-bridged tetraaza macrocyclic compounds and methods of making and using
KR20090014164A (ko) * 2006-04-19 2009-02-06 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 세포 영상화 및 치료를 위한 조성물 및 방법
US8758723B2 (en) 2006-04-19 2014-06-24 The Board Of Regents Of The University Of Texas System Compositions and methods for cellular imaging and therapy
AU2007281090A1 (en) * 2006-08-02 2008-02-07 Genzyme Corporation Combination therapy
RU2009108289A (ru) * 2006-08-07 2010-09-20 Джензим Корпорейшн (Us) Комбинированная терапия
MX365242B (es) 2011-05-16 2019-05-28 Genzyme Corp El uso del antagonista cxcr4: 1,1´-[1,4-fenileno-bis-(metileno)-bi s-1, 4, 8, 11-tetraazaciclotetradecano (plerixaflor) para el tratamiento del síndrome de whim.
US9439984B2 (en) * 2012-05-31 2016-09-13 The Regents Of The University Of California Macrocycles
WO2014125499A1 (en) 2013-02-13 2014-08-21 Natco Pharma Limited Improved and commercially viable process for the preparation of high pure plerixafor base
CN104211652B (zh) * 2014-08-27 2016-09-07 吉林大学 一种制备普乐沙福的方法
US10544109B2 (en) 2015-09-02 2020-01-28 Fresenius Kabi Oncology Ltd. Process for the preparation of xylene linked cyclam compounds

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4885363A (en) 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
US5132409A (en) 1987-01-12 1992-07-21 Bracco Industria Chimica S.P.A. Macrocyclic chelating agents and chelates thereof
FR2609985B1 (fr) 1987-01-26 1989-04-14 Rhone Poulenc Chimie Procede de n-o trifluoroacetylation des a, o diaminoacides monocarboxyliques aliphatiques satures
US5064956A (en) 1987-06-24 1991-11-12 The Dow Chemical Company Process for preparing mono-n-alkylated polyazamacrocycles
US5012625A (en) * 1988-06-17 1991-05-07 Propst Robert L Building enclosure system and method
US5144290A (en) * 1988-10-31 1992-09-01 Kabushiki Kaisha Toshiba Display unit attachment device
FR2644453A1 (fr) 1989-03-20 1990-09-21 Centre Nat Rech Scient Procede de preparation de tetramines cycliques monofonctionnalisees
US6001826A (en) 1989-12-21 1999-12-14 Anormed, Inc. Chemical compounds
US5021409A (en) 1989-12-21 1991-06-04 Johnson Matthey Plc Antiviral cyclic polyamines
GB2250198B (en) * 1990-04-18 1994-06-22 Celltech Ltd Tetra-aza macrocycles,processes for their preparation and their use in magnetic resonance imaging
DE4035760A1 (de) 1990-11-08 1992-05-14 Schering Ag Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
FR2672051B1 (fr) * 1991-01-24 1993-05-21 Guerbet Sa Nouveaux ligands macrocycliques azotes, procede de preparation, complexes polymetalliques, composition de diagnostic et therapeutique.
US5410043A (en) 1991-12-06 1995-04-25 Schering Aktiengesellschaft Process for the production of mono-N-substituted tetraaza macrocycles
GB9126677D0 (en) 1991-12-16 1992-02-12 Johnson Matthey Plc Improvements in chemical compounds
US5684149A (en) * 1993-01-22 1997-11-04 Research Foundation Of State University Of New York Metal complexes for promoting catalytic cleavage of RNA by transesterification
JP2504713B2 (ja) * 1993-03-09 1996-06-05 タキゲン製造株式会社 引出し回転型扉用ロックハンドル装置
DE4340809C2 (de) 1993-11-24 2000-08-03 Schering Ag 1.4,7,10-Tetraazacyclododecan-Derivate, diese enthaltende pharmazeutische Mittel und Verfahren zu deren Herstellung
GB9400411D0 (en) 1994-01-11 1994-03-09 Johnson Matthey Plc Improvements in chemical compounds
US5583735A (en) * 1994-01-18 1996-12-10 Hollingsead International, Inc. Aircraft video monitor deployment and retraction apparatus
FR2725449B1 (fr) * 1994-10-05 1996-12-27 Air Liquide Derives de polyazacycloalcanes, leurs complexes metalliques et produits pharmaceutiques incorporant ces complexes
GB9504910D0 (en) 1995-03-10 1995-04-26 Nycomed Imaging As Compounds
US5612478A (en) 1995-03-30 1997-03-18 Johnson Matthey Plc Process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane
US5606053A (en) 1995-05-02 1997-02-25 Johnson Matthey Plc Process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane
US5705689A (en) * 1995-06-19 1998-01-06 Associated Universities, Inc. Aza compounds as anion receptors
US5874573A (en) * 1995-06-26 1999-02-23 Concat, Inc. Compounds with chelation affinity and selectivity for first transition series elements: use in medical therapy
DE19601060C2 (de) 1996-01-04 2002-04-25 Schering Ag Neue monofunktionalisierte EDTA-, DTPA- und TTHA-Derivate und deren Verwendung in der medizinischen Diagnostik und Therapie
JP3293740B2 (ja) * 1996-06-24 2002-06-17 矢崎総業株式会社 自動車用ルーフモジュール
US5946055A (en) * 1996-08-16 1999-08-31 Rosen Product Development, Inc. Display unit
US6059255A (en) * 1996-08-16 2000-05-09 Rosen Products Llc Stowable display apparatus
DE19724186C2 (de) 1997-06-02 2002-07-18 Schering Ag Verfahren zur Mono- und 1,7-Bis-N-ß-Hydroxyalkylierung von Cyclen und die entsprechenden N-ß-Hydroxyalkyl-1,4,7,10-tetraazacyclododecan-Li-Salz-Komplexe
DE19729013A1 (de) * 1997-07-03 1999-02-04 Schering Ag Oligomere, perfluoralkylhaltige Verbindungen, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
US6007036A (en) * 1997-09-23 1999-12-28 Rosen Products Llc Stowable support apparatus
US6062623A (en) * 1998-05-18 2000-05-16 Prince Corporation Latch for vehicle overhead storage bin
US6135528A (en) * 1998-10-20 2000-10-24 Prince Corporation Combined storage compartment and garage door opening transmitter storage and actuating compartment
JP2002529502A (ja) * 1998-11-17 2002-09-10 スミスクライン・ビーチャム・コーポレイション 血小板減少症の治療法
US6365583B1 (en) 1999-02-02 2002-04-02 Anormed, Inc. Methods to enhance white blood cell count
US6412848B1 (en) * 1999-11-02 2002-07-02 Rosen Products Llc Vehicle display monitor system
US6400560B1 (en) * 2000-11-08 2002-06-04 Yue-Hui Chian Engaging device for a computer screen in a car
US6633347B2 (en) * 2001-01-02 2003-10-14 Alpine Electronics, Inc. Display assembly having display supported on casing to be controllable in attitude
US6575528B2 (en) * 2001-10-19 2003-06-10 Lear Corporation Modular overhead console assembly

Also Published As

Publication number Publication date
ES2320323T3 (es) 2009-05-21
KR20030031195A (ko) 2003-04-18
EP1322626B1 (en) 2008-11-05
CA2419631A1 (en) 2002-04-04
ZA200301012B (en) 2004-03-08
CN1466579A (zh) 2004-01-07
RU2311413C2 (ru) 2007-11-27
PL359292A1 (en) 2004-08-23
US20020058807A1 (en) 2002-05-16
PT2022787E (pt) 2013-01-25
MXPA03002772A (es) 2003-07-28
US6489472B2 (en) 2002-12-03
HK1058035A1 (en) 2004-04-30
HUP0301176A2 (hu) 2003-12-29
KR100808385B1 (ko) 2008-03-07
ES2398399T3 (es) 2013-03-15
AU1139302A (en) 2002-04-08
NO20031401L (no) 2003-03-27
BR0114246A (pt) 2003-10-07
JP2004509951A (ja) 2004-04-02
WO2002026721A1 (en) 2002-04-04
NO20031401D0 (no) 2003-03-27
IL217872A0 (en) 2012-03-29
EP1322626A1 (en) 2003-07-02
IL154400A (en) 2012-03-29
JP2012056967A (ja) 2012-03-22
IL154400A0 (en) 2003-09-17
NZ524580A (en) 2004-10-29
HUP0301176A3 (en) 2007-03-28
DK2022787T3 (da) 2013-02-25
EP2022787A1 (en) 2009-02-11
CN1273455C (zh) 2006-09-06
DE60136476D1 (de) 2008-12-18
RU2007121719A (ru) 2008-12-20
EP2022787B1 (en) 2012-11-28
ATE413391T1 (de) 2008-11-15
JP5335171B2 (ja) 2013-11-06
AU2002211393B2 (en) 2007-06-28

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