HUP9900458A2 - Közeli infravörös diagnosztika céljára alkalmas kontrasztanyag - Google Patents

Közeli infravörös diagnosztika céljára alkalmas kontrasztanyag

Info

Publication number
HUP9900458A2
HUP9900458A2 HU9900458A HUP9900458A HUP9900458A2 HU P9900458 A2 HUP9900458 A2 HU P9900458A2 HU 9900458 A HU9900458 A HU 9900458A HU P9900458 A HUP9900458 A HU P9900458A HU P9900458 A2 HUP9900458 A2 HU P9900458A2
Authority
HU
Hungary
Prior art keywords
near infrared
contrasting agents
infrared diagnosis
diagnosis
contrasting
Prior art date
Application number
HU9900458A
Other languages
English (en)
Inventor
Dieter Heldmann
Kai Licha
Björn Riefke
Violetta Sudmann
Werner Weitschiess
Original Assignee
Institut für Diagnostikforschung GmbH. an der Freien Universität Berlin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut für Diagnostikforschung GmbH. an der Freien Universität Berlin filed Critical Institut für Diagnostikforschung GmbH. an der Freien Universität Berlin
Publication of HUP9900458A2 publication Critical patent/HUP9900458A2/hu
Publication of HUP9900458A3 publication Critical patent/HUP9900458A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0076—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0076—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion
    • A61K49/0078—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion microemulsion, nanoemulsion

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Nanotechnology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

A találmány pőlimetin színezőanyagőkkal telített megfelelő főtőfizikaiés farmakőlógiai tűlajdőnságőkkal rendelkező kőllőidális rendszerekre,azők flűőreszcencia- és transzillűminációs diagnősztikában a közeliinfravörös spektrűmtartőmányban használatős kőntrasztanyagként történőalkalmazására, tővábbá azők előállítására szőlgáló eljárásravőnatkőzik. ŕ
HU9900458A 1995-10-11 1996-09-26 Contrasting agents for near infrared diagnosis HUP9900458A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19539409A DE19539409C2 (de) 1995-10-11 1995-10-11 Kontrastmittel für die Nahinfrarot-Diagnostik

Publications (2)

Publication Number Publication Date
HUP9900458A2 true HUP9900458A2 (hu) 1999-06-28
HUP9900458A3 HUP9900458A3 (en) 1999-11-29

Family

ID=7775535

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900458A HUP9900458A3 (en) 1995-10-11 1996-09-26 Contrasting agents for near infrared diagnosis

Country Status (13)

Country Link
US (2) US6319488B1 (hu)
EP (1) EP0854732A2 (hu)
JP (1) JPH11504656A (hu)
KR (1) KR100290240B1 (hu)
CN (1) CN1075951C (hu)
AU (1) AU711266B2 (hu)
CA (1) CA2233995A1 (hu)
DE (1) DE19539409C2 (hu)
HU (1) HUP9900458A3 (hu)
IL (1) IL119365A (hu)
NO (1) NO981586D0 (hu)
WO (1) WO1997013490A2 (hu)
ZA (1) ZA968229B (hu)

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DE4445065A1 (de) * 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
DE19717904A1 (de) * 1997-04-23 1998-10-29 Diagnostikforschung Inst Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
WO1998048838A1 (en) * 1997-04-29 1998-11-05 Nycomed Imaging As Compounds
US6083486A (en) * 1998-05-14 2000-07-04 The General Hospital Corporation Intramolecularly-quenched near infrared fluorescent probes
CN1323224A (zh) 1998-09-17 2001-11-21 日本化药株式会社 光化学疗法治疗剂
US7547721B1 (en) 1998-09-18 2009-06-16 Bayer Schering Pharma Ag Near infrared fluorescent contrast agent and fluorescence imaging
JP2000095758A (ja) * 1998-09-18 2000-04-04 Schering Ag 近赤外蛍光造影剤および蛍光造影方法
US20030180221A1 (en) * 1998-09-18 2003-09-25 Schering Ag Near infrared fluorescent contrast agent and fluorescence imaging
WO2001037630A2 (en) * 1999-11-22 2001-05-31 Epix Medical, Inc. Imaging sexual response
US7897140B2 (en) 1999-12-23 2011-03-01 Health Research, Inc. Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents
DE10046215B4 (de) * 2000-09-19 2004-04-15 Institut für Chemo- und Biosensorik Münster e.V. i.Ins. Fluorochrome und deren Verwendung
US7139122B1 (en) * 2000-10-17 2006-11-21 Lucid, Inc. System and method for enhancing confocal reflectance images of tissue specimens
US7003345B1 (en) * 2000-10-17 2006-02-21 Lucid, Inc. System and method for enhancing microscope images of tissue using citric acid and agents of the like
TWI240632B (en) 2001-07-30 2005-10-01 Epix Medical Inc Purified peptides for peptide-based multimeric targeted contrast agents
JP2003261464A (ja) * 2002-03-07 2003-09-16 Fuji Photo Film Co Ltd 近赤外蛍光造影剤および蛍光造影法
US20040133112A1 (en) * 2002-03-08 2004-07-08 Milind Rajadhyaksha System and method for macroscopic and confocal imaging of tissue
DE60328496D1 (en) 2002-06-27 2009-09-03 Health Research Inc Fluorinierte chlorin und bacteriochlorin photosensitizer für fotodynamische therapie
ES2431520T3 (es) * 2003-01-25 2013-11-26 Seno Medical Instruments, Inc. Procedimiento de formación de imágenes optoacústicas de contraste elevado utilizando nanopartículas no esféricas
JP2004269439A (ja) * 2003-03-10 2004-09-30 Motohiro Takeda センチネルリンパ節検出剤及び検出方法
WO2005082423A2 (en) * 2003-11-18 2005-09-09 Beth Israel Deaconess Medical Center Serum albumin conjugated to fluorescent substances for imaging
JP2005145921A (ja) * 2003-11-19 2005-06-09 Konica Minolta Medical & Graphic Inc 診断用蛍光造影剤及び蛍光造影診断方法
AU2005265048B2 (en) 2004-06-18 2011-06-16 Elamleh, David R. Intravascular imaging device and uses thereof
US8227621B2 (en) * 2005-06-30 2012-07-24 Li-Cor, Inc. Cyanine dyes and methods of use
JP2008043396A (ja) * 2006-08-11 2008-02-28 Olympus Corp 内視鏡システム
GB2440910A (en) * 2006-08-18 2008-02-20 Robert Charles Wilson A marker for studying drug dynamics in vivo
KR100825939B1 (ko) * 2006-08-28 2008-04-29 한국과학기술연구원 근적외선 형광체가 결합된 양친성 고분자의 나노 입자를포함하는 암 진단용 조영제
JP2008148791A (ja) * 2006-12-14 2008-07-03 Olympus Corp 内視鏡システム
CN101723874B (zh) * 2008-10-31 2013-09-11 深圳迈瑞生物医疗电子股份有限公司 花菁类化合物及其在生物样品染色中的用途
CN101750476B (zh) * 2008-12-08 2015-06-03 深圳迈瑞生物医疗电子股份有限公司 血液分析试剂及其使用方法
EP2419478B1 (en) * 2009-04-17 2018-02-28 Li-Cor, Inc. Fluorescent imaging with substituted cyanine dyes
CN102115456B (zh) * 2009-12-30 2014-08-20 深圳迈瑞生物医疗电子股份有限公司 花菁类化合物，包含所述化合物的组合物及其在细胞检测中的用途
WO2012054784A1 (en) 2010-10-20 2012-04-26 Li-Cor, Inc. Fluorescent imaging with substituted cyanine dyes
US9138492B2 (en) 2012-02-23 2015-09-22 Canon Kabushiki Kaisha Particle containing hydrophobic dye having cyanine structure, and contrast agent containing the particle
KR102132885B1 (ko) * 2018-09-03 2020-07-10 (주)씨바이오멕스 생체물질과 연결될 수 있는 양쪽성 형광물질
CN114149693B (zh) * 2021-11-14 2022-10-25 华中科技大学 一种用于血管网络标记成像的染料工作液、其制备和应用

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US3916069A (en) * 1973-04-02 1975-10-28 Minnesota Mining & Mfg Reduced styryl/cyanine dye
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4859584A (en) * 1986-10-31 1989-08-22 Smithkline Beckman Corporation Cell growth rate determination by measurement of changes in cyanine dye levels in plasma membranes
US4762701A (en) * 1986-10-31 1988-08-09 Smithkline Beckman Corporation In vivo cellular tracking
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EP0430968B1 (en) * 1988-05-02 1996-11-20 PHANOS TECHNOLOGIES, Inc. Compounds, compositions and method for binding bio-affecting substances to surface membranes of bio-particles
AU642396B2 (en) * 1988-09-08 1993-10-21 British Technology Group Usa, Inc. Red-shifted phthalocyanine and tetrabenztriazaporphyrin reagents
US5208336A (en) * 1990-10-19 1993-05-04 Sterling Drug Inc. Selenomerocyanines and processes for preparation and methods of use and compositions thereof
US5433531A (en) * 1993-09-21 1995-07-18 Federal-Mogul Corporation Engine bearing surface treatment
US6238931B1 (en) * 1993-09-24 2001-05-29 Biosite Diagnostics, Inc. Fluorescence energy transfer in particles
DE4445065A1 (de) * 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung

Also Published As

Publication number Publication date
US6319488B1 (en) 2001-11-20
WO1997013490A2 (de) 1997-04-17
AU1589297A (en) 1997-04-30
CN1199341A (zh) 1998-11-18
ZA968229B (en) 1997-05-14
EP0854732A2 (de) 1998-07-29
CA2233995A1 (en) 1997-04-17
NO981586L (no) 1998-04-07
AU711266B2 (en) 1999-10-07
HUP9900458A3 (en) 1999-11-29
IL119365A0 (en) 1997-01-10
CN1075951C (zh) 2001-12-12
NO981586D0 (no) 1998-04-07
DE19539409C2 (de) 1999-02-18
IL119365A (en) 2000-07-26
JPH11504656A (ja) 1999-04-27
KR100290240B1 (ko) 2001-05-15
DE19539409A1 (de) 1997-04-17
US20020022004A1 (en) 2002-02-21
WO1997013490A3 (de) 1997-10-23
KR19990044581A (ko) 1999-06-25

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