HUP9802920A2 - Gyűrűs szulfonokkal kondenzált benzoilguanidinszármazékok, az azokat tartalmazó gyógyszerkészítmények, gyógyászati alkalmazásuk, és eljárás előállításukra - Google Patents
Gyűrűs szulfonokkal kondenzált benzoilguanidinszármazékok, az azokat tartalmazó gyógyszerkészítmények, gyógyászati alkalmazásuk, és eljárás előállításukraInfo
- Publication number
- HUP9802920A2 HUP9802920A2 HU9802920A HUP9802920A HUP9802920A2 HU P9802920 A2 HUP9802920 A2 HU P9802920A2 HU 9802920 A HU9802920 A HU 9802920A HU P9802920 A HUP9802920 A HU P9802920A HU P9802920 A2 HUP9802920 A2 HU P9802920A2
- Authority
- HU
- Hungary
- Prior art keywords
- nha
- ring
- compounds
- hydrogen atom
- independently
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- 125000004122 cyclic group Chemical group 0.000 title 1
- AJDQRQQNNLZLPM-UHFFFAOYSA-N n-(diaminomethylidene)benzamide Chemical class NC(N)=NC(=O)C1=CC=CC=C1 AJDQRQQNNLZLPM-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- DOBBROKMBMVCAE-UHFFFAOYSA-N 1-(trifluoromethyl)piperidine Chemical compound FC(F)(F)N1CCCCC1 DOBBROKMBMVCAE-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- JNCMHMUGTWEVOZ-UHFFFAOYSA-N F[CH]F Chemical compound F[CH]F JNCMHMUGTWEVOZ-UHFFFAOYSA-N 0.000 abstract 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 abstract 1
- 108010081348 HRT1 protein Hairy Proteins 0.000 abstract 1
- 102100021881 Hairy/enhancer-of-split related with YRPW motif protein 1 Human genes 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- VUWZPRWSIVNGKG-UHFFFAOYSA-N fluoromethane Chemical compound F[CH2] VUWZPRWSIVNGKG-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000005004 perfluoroethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/66—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
A találmány tárgya új, (I) általánős képletű gyűrűs szűlfőnők, ahől R1 és R2 jelentése egymástól függetlenül hidrőgénatőm, A, CF3, CH2F,CHF2, C2F5, halőgén, OH, OA, NH2, NHA, NA2, NO2 vagy CN csőpőrt X jelentése CR4R5, C=Z, O, S, NH, NA vagy NR3, Y jelentése CR6R7, C=Z, O, S, NH, NA vagy NR3, Z jelentése O, S, NH, NA, NOH, NOA, CH2, CHA vagy CA2, R4, R5, R6 és R7 jelentése egymástól függetlenül hidrőgénatőm, A, R3,Hal, OH, OA, SH, SA, NHA vagy NA2 csőpőrt, vagy R5 és R6 együtt vagy R7 és R8 együtt vegyértékkötést is jelenthet, azegyes mőlekűlákban legfeljebb csak egy ilyen típűsú kötés főrdűlhatelő, R8 és R9 jelentése egymástól függetlenül hidrőgénatőm vagy A, A jelentése 1-6 szénatőmős alkilcsőpőrt, R3 jelentése fenil- vgy benzilcsőpőrt, amely szűbsztitűálatlan vagy A,OA, NH2, NHA, NA2 csőpőrttal, flűőr-, klór-, brómatőmmal és/vagytriflűőr-metil-csőpőrttal mőnő-, di- vagy triszűbsztitűált, és n értéke 0 vagy 1, és gyógyászatilag alkalmazható sóik. A vegyületekarritmiaellenes tűlajdőnságőkkal rendelkeznek és ezért gyógyszerkénthasználhatók. A találmány a vegyületek előállítási eljárásra és avegyületeket tartalmazó gyógyszerkészítményekre is vőnatkőzik. ŕ
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19548708A DE19548708A1 (de) | 1995-12-23 | 1995-12-23 | Cyclische Sulfone |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9802920A2 true HUP9802920A2 (hu) | 2000-05-28 |
| HUP9802920A3 HUP9802920A3 (en) | 2000-12-28 |
Family
ID=7781400
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9802920A HUP9802920A3 (en) | 1995-12-23 | 1996-12-16 | Cyclic sulphone-condensed benzoylguanidines, medicaments containing them and their production and medical use |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6028069A (hu) |
| EP (1) | EP0873335A1 (hu) |
| JP (1) | JP2000502663A (hu) |
| KR (1) | KR19990076675A (hu) |
| AR (1) | AR004402A1 (hu) |
| AU (1) | AU710048B2 (hu) |
| BR (1) | BR9612200A (hu) |
| CA (1) | CA2241143A1 (hu) |
| CZ (1) | CZ199798A3 (hu) |
| DE (1) | DE19548708A1 (hu) |
| HU (1) | HUP9802920A3 (hu) |
| NO (1) | NO982906D0 (hu) |
| PL (1) | PL327186A1 (hu) |
| RU (1) | RU2161616C2 (hu) |
| SK (1) | SK81598A3 (hu) |
| TW (1) | TW381091B (hu) |
| WO (1) | WO1997023476A1 (hu) |
| ZA (1) | ZA9610724B (hu) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4328352A1 (de) * | 1993-08-24 | 1995-03-02 | Hoechst Ag | Substituierte N,N'-Di-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| JP2002502414A (ja) * | 1997-06-02 | 2002-01-22 | 藤沢薬品工業株式会社 | 細胞中のＮａ▲上＋▼／Ｈ▲上＋▼交換の阻害剤としてのグアニジン誘導体 |
| US6730697B2 (en) * | 2002-02-07 | 2004-05-04 | Aventis Pharma Deutschland Gmbh | Dihydrothiaphenanthrenecarbonylguanidines: composition, process of making, and use as medicament or diagnostic aid |
| TW200614995A (en) * | 2004-11-10 | 2006-05-16 | Nicholas Piramal India Ltd | Tricyclic guanidine derivatives as sodium-proton exchange inhibitors |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3929582A1 (de) * | 1989-09-06 | 1991-03-07 | Hoechst Ag | Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament |
| ES2097409T3 (es) * | 1992-09-22 | 1997-04-01 | Hoechst Ag | Benzoilguanidinas, procedimiento para su preparacion, asi como su empleo como antiarritmicos. |
| EP0590455B1 (en) * | 1992-09-28 | 2000-12-27 | Hoechst Aktiengesellschaft | Antiarrhythmic and cardioprotective substituted 1(2H)-isoquinolines, process for their production, medicament containing them and their use for the production of a medicament for combating heart failures |
| US5514801A (en) * | 1992-12-29 | 1996-05-07 | Monsanto Company | Cyclic sulfone containing retroviral protease inhibitors |
| CA2121391A1 (en) * | 1993-04-28 | 1994-10-29 | Atsuyuki Kojima | Indoloylguanidine derivatives |
| DE4317076A1 (de) * | 1993-05-21 | 1994-11-24 | Bayer Ag | Benzthiophencarbonsäureamid-S-oxide |
| US5607898A (en) * | 1993-08-02 | 1997-03-04 | Idemitsu Kosan Company, Ltd. | Pyrazole derivatives |
| EP0639573A1 (de) * | 1993-08-03 | 1995-02-22 | Hoechst Aktiengesellschaft | Benzokondensierte 5-Ringheterocyclen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, ihre Verwendung als Diagnostikum, sowie sie enthaltendes Medikament |
| US5627194A (en) * | 1993-11-17 | 1997-05-06 | Allelix Biopharmaceuticals Inc. | Anti-viral guanidino-substituted compounds |
| DE4344550A1 (de) * | 1993-12-24 | 1995-06-29 | Hoechst Ag | Substituierte 1-Oxo-1,2-dihydro-isochinolinoyl- und 1,1-Dioxo-2H-1,2-benzothiazinoylguanidine, Verfahrenzu ihrer Herstellung, ihre Verwendung als Medikamentt oder Diagnostikum sowie sie enthaltendes Medikamen |
| DE4412334A1 (de) * | 1994-04-11 | 1995-10-19 | Hoechst Ag | Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| ES2173182T3 (es) * | 1994-04-11 | 2002-10-16 | Chugai Pharmaceutical Co Ltd | Derivado de 4,6-dl-butil-2,3-dihidrobenzotiofenos como antioxidantes de ldl. |
| US5863936A (en) * | 1995-04-18 | 1999-01-26 | Geron Corporation | Telomerase inhibitors |
| US5821250A (en) * | 1996-02-01 | 1998-10-13 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
| FR2762598A1 (fr) * | 1997-04-25 | 1998-10-30 | Adir | Nouveaux composes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennnent |
-
1995
- 1995-12-23 DE DE19548708A patent/DE19548708A1/de not_active Withdrawn
-
1996
- 1996-10-20 AR ARP960105800A patent/AR004402A1/es unknown
- 1996-11-19 TW TW085114208A patent/TW381091B/zh active
- 1996-12-16 WO PCT/EP1996/005645 patent/WO1997023476A1/de not_active Application Discontinuation
- 1996-12-16 AU AU11960/97A patent/AU710048B2/en not_active Ceased
- 1996-12-16 PL PL96327186A patent/PL327186A1/xx unknown
- 1996-12-16 JP JP9523281A patent/JP2000502663A/ja active Pending
- 1996-12-16 EP EP96943131A patent/EP0873335A1/de not_active Withdrawn
- 1996-12-16 KR KR1019980704787A patent/KR19990076675A/ko not_active Application Discontinuation
- 1996-12-16 RU RU98114077/04A patent/RU2161616C2/ru active
- 1996-12-16 CA CA002241143A patent/CA2241143A1/en not_active Abandoned
- 1996-12-16 SK SK815-98A patent/SK81598A3/sk unknown
- 1996-12-16 CZ CZ981997A patent/CZ199798A3/cs unknown
- 1996-12-16 BR BR9612200A patent/BR9612200A/pt not_active Application Discontinuation
- 1996-12-16 HU HU9802920A patent/HUP9802920A3/hu unknown
- 1996-12-16 US US09/091,652 patent/US6028069A/en not_active Expired - Fee Related
- 1996-12-19 ZA ZA9610724A patent/ZA9610724B/xx unknown
-
1998
- 1998-06-22 NO NO982906A patent/NO982906D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE19548708A1 (de) | 1997-06-26 |
| PL327186A1 (en) | 1998-11-23 |
| AU710048B2 (en) | 1999-09-09 |
| ZA9610724B (en) | 1997-06-26 |
| WO1997023476A1 (de) | 1997-07-03 |
| SK81598A3 (en) | 1999-01-11 |
| RU2161616C2 (ru) | 2001-01-10 |
| TW381091B (en) | 2000-02-01 |
| KR19990076675A (ko) | 1999-10-15 |
| CZ199798A3 (cs) | 1998-10-14 |
| NO982906L (no) | 1998-06-22 |
| EP0873335A1 (de) | 1998-10-28 |
| BR9612200A (pt) | 1999-07-13 |
| AR004402A1 (es) | 1998-11-04 |
| MX9804972A (es) | 1998-09-30 |
| JP2000502663A (ja) | 2000-03-07 |
| AU1196097A (en) | 1997-07-17 |
| CA2241143A1 (en) | 1997-07-03 |
| HUP9802920A3 (en) | 2000-12-28 |
| NO982906D0 (no) | 1998-06-22 |
| US6028069A (en) | 2000-02-22 |
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