AR004402A1 - Sulfonas ciclicas, procedimiento para prepararlas, preparaciones farmaceuticas que las contienen y empleo de las mismas para combatir enfermedades. - Google Patents
Sulfonas ciclicas, procedimiento para prepararlas, preparaciones farmaceuticas que las contienen y empleo de las mismas para combatir enfermedades.Info
- Publication number
- AR004402A1 AR004402A1 ARP960105800A ARP960105800A AR004402A1 AR 004402 A1 AR004402 A1 AR 004402A1 AR P960105800 A ARP960105800 A AR P960105800A AR P960105800 A ARP960105800 A AR P960105800A AR 004402 A1 AR004402 A1 AR 004402A1
- Authority
- AR
- Argentina
- Prior art keywords
- same
- pharmaceutical preparations
- prepare
- procedure
- containing pharmaceutical
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/66—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
El invento se refiere a las sulfonas cíclicas de fórmula (I) en la que R1, R2, R8, R9, X, Y y n tienen los significados indicados en la reivindicación 1,y a sus sales aceptables desde el punto de vista fisiológico. También se refiere a unpro cedimiento para preparar dichos compuestos, a preparacionesfarmacéuticas que los contienen y al empleo de los mismos para el tratamiento de las arritmias, de la angina de pecho, infartos y también para el tratamientopreventivo de estasenfermedades . Los nuevos compuestos del invento poseen propiedades antiarrítmicas y un efecto inhibidor del mecanismo de intercambiode Na+/H+ de las células.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19548708A DE19548708A1 (de) | 1995-12-23 | 1995-12-23 | Cyclische Sulfone |
Publications (1)
Publication Number | Publication Date |
---|---|
AR004402A1 true AR004402A1 (es) | 1998-11-04 |
Family
ID=7781400
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP960105800A AR004402A1 (es) | 1995-12-23 | 1996-10-20 | Sulfonas ciclicas, procedimiento para prepararlas, preparaciones farmaceuticas que las contienen y empleo de las mismas para combatir enfermedades. |
Country Status (18)
Country | Link |
---|---|
US (1) | US6028069A (es) |
EP (1) | EP0873335A1 (es) |
JP (1) | JP2000502663A (es) |
KR (1) | KR19990076675A (es) |
AR (1) | AR004402A1 (es) |
AU (1) | AU710048B2 (es) |
BR (1) | BR9612200A (es) |
CA (1) | CA2241143A1 (es) |
CZ (1) | CZ199798A3 (es) |
DE (1) | DE19548708A1 (es) |
HU (1) | HUP9802920A3 (es) |
NO (1) | NO982906D0 (es) |
PL (1) | PL327186A1 (es) |
RU (1) | RU2161616C2 (es) |
SK (1) | SK81598A3 (es) |
TW (1) | TW381091B (es) |
WO (1) | WO1997023476A1 (es) |
ZA (1) | ZA9610724B (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4328352A1 (de) | 1993-08-24 | 1995-03-02 | Hoechst Ag | Substituierte N,N'-Di-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
JP2002502414A (ja) * | 1997-06-02 | 2002-01-22 | 藤沢薬品工業株式会社 | 細胞中のNa▲上+▼/H▲上+▼交換の阻害剤としてのグアニジン誘導体 |
US6730697B2 (en) * | 2002-02-07 | 2004-05-04 | Aventis Pharma Deutschland Gmbh | Dihydrothiaphenanthrenecarbonylguanidines: composition, process of making, and use as medicament or diagnostic aid |
TW200614995A (en) * | 2004-11-10 | 2006-05-16 | Nicholas Piramal India Ltd | Tricyclic guanidine derivatives as sodium-proton exchange inhibitors |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3929582A1 (de) * | 1989-09-06 | 1991-03-07 | Hoechst Ag | Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament |
ATE147375T1 (de) * | 1992-09-22 | 1997-01-15 | Hoechst Ag | Benzoylguanidine, verfahren zu ihrer herstellung, sowie ihre verwendung als antiarrhythmika |
DE69329787T2 (de) * | 1992-09-28 | 2001-06-13 | Hoechst Ag | Antiarrhythmische und cardioprotektive substituierte 1(2H)-Isochinoline, Verfahren zu deren Herstellung, diese enthaltende Arzneimittel und ihre Anwendung für die Herstellung eines Arzneimittels zur Behandlung von Herzinsuffizienzen |
US5514801A (en) * | 1992-12-29 | 1996-05-07 | Monsanto Company | Cyclic sulfone containing retroviral protease inhibitors |
CA2121391A1 (en) * | 1993-04-28 | 1994-10-29 | Atsuyuki Kojima | Indoloylguanidine derivatives |
DE4317076A1 (de) * | 1993-05-21 | 1994-11-24 | Bayer Ag | Benzthiophencarbonsäureamid-S-oxide |
US5607898A (en) * | 1993-08-02 | 1997-03-04 | Idemitsu Kosan Company, Ltd. | Pyrazole derivatives |
EP0639573A1 (de) * | 1993-08-03 | 1995-02-22 | Hoechst Aktiengesellschaft | Benzokondensierte 5-Ringheterocyclen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, ihre Verwendung als Diagnostikum, sowie sie enthaltendes Medikament |
US5627194A (en) * | 1993-11-17 | 1997-05-06 | Allelix Biopharmaceuticals Inc. | Anti-viral guanidino-substituted compounds |
DE4344550A1 (de) * | 1993-12-24 | 1995-06-29 | Hoechst Ag | Substituierte 1-Oxo-1,2-dihydro-isochinolinoyl- und 1,1-Dioxo-2H-1,2-benzothiazinoylguanidine, Verfahrenzu ihrer Herstellung, ihre Verwendung als Medikamentt oder Diagnostikum sowie sie enthaltendes Medikamen |
EP0791589B1 (en) * | 1994-04-11 | 2002-03-06 | Chugai Seiyaku Kabushiki Kaisha | 4,6-DI-t-BUTYL-2,3-DIHYDROBENZOTHIOPHENES WHICH INHIBIT LDL OXIDATION |
DE4412334A1 (de) * | 1994-04-11 | 1995-10-19 | Hoechst Ag | Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
US5863936A (en) * | 1995-04-18 | 1999-01-26 | Geron Corporation | Telomerase inhibitors |
US5821250A (en) * | 1996-02-01 | 1998-10-13 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
FR2762598A1 (fr) * | 1997-04-25 | 1998-10-30 | Adir | Nouveaux composes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennnent |
-
1995
- 1995-12-23 DE DE19548708A patent/DE19548708A1/de not_active Withdrawn
-
1996
- 1996-10-20 AR ARP960105800A patent/AR004402A1/es unknown
- 1996-11-19 TW TW085114208A patent/TW381091B/zh active
- 1996-12-16 RU RU98114077/04A patent/RU2161616C2/ru active
- 1996-12-16 BR BR9612200A patent/BR9612200A/pt not_active Application Discontinuation
- 1996-12-16 PL PL96327186A patent/PL327186A1/xx unknown
- 1996-12-16 JP JP9523281A patent/JP2000502663A/ja active Pending
- 1996-12-16 HU HU9802920A patent/HUP9802920A3/hu unknown
- 1996-12-16 WO PCT/EP1996/005645 patent/WO1997023476A1/de not_active Application Discontinuation
- 1996-12-16 EP EP96943131A patent/EP0873335A1/de not_active Withdrawn
- 1996-12-16 CZ CZ981997A patent/CZ199798A3/cs unknown
- 1996-12-16 AU AU11960/97A patent/AU710048B2/en not_active Ceased
- 1996-12-16 CA CA002241143A patent/CA2241143A1/en not_active Abandoned
- 1996-12-16 US US09/091,652 patent/US6028069A/en not_active Expired - Fee Related
- 1996-12-16 KR KR1019980704787A patent/KR19990076675A/ko not_active Application Discontinuation
- 1996-12-16 SK SK815-98A patent/SK81598A3/sk unknown
- 1996-12-19 ZA ZA9610724A patent/ZA9610724B/xx unknown
-
1998
- 1998-06-22 NO NO982906A patent/NO982906D0/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2000502663A (ja) | 2000-03-07 |
TW381091B (en) | 2000-02-01 |
MX9804972A (es) | 1998-09-30 |
CA2241143A1 (en) | 1997-07-03 |
HUP9802920A3 (en) | 2000-12-28 |
HUP9802920A2 (hu) | 2000-05-28 |
DE19548708A1 (de) | 1997-06-26 |
NO982906L (no) | 1998-06-22 |
AU1196097A (en) | 1997-07-17 |
AU710048B2 (en) | 1999-09-09 |
RU2161616C2 (ru) | 2001-01-10 |
BR9612200A (pt) | 1999-07-13 |
NO982906D0 (no) | 1998-06-22 |
US6028069A (en) | 2000-02-22 |
PL327186A1 (en) | 1998-11-23 |
EP0873335A1 (de) | 1998-10-28 |
KR19990076675A (ko) | 1999-10-15 |
WO1997023476A1 (de) | 1997-07-03 |
CZ199798A3 (cs) | 1998-10-14 |
ZA9610724B (en) | 1997-06-26 |
SK81598A3 (en) | 1999-01-11 |
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