HUP9800850A2 - Trijód-izoftálsav-diamidszármazékok, az ezeket tartalmazó röntgenkontraszt készítmények és eljárás a vegyületek előállítására - Google Patents
Trijód-izoftálsav-diamidszármazékok, az ezeket tartalmazó röntgenkontraszt készítmények és eljárás a vegyületek előállításáraInfo
- Publication number
- HUP9800850A2 HUP9800850A2 HU9800850A HUP9800850A HUP9800850A2 HU P9800850 A2 HUP9800850 A2 HU P9800850A2 HU 9800850 A HU9800850 A HU 9800850A HU P9800850 A HUP9800850 A HU P9800850A HU P9800850 A2 HUP9800850 A2 HU P9800850A2
- Authority
- HU
- Hungary
- Prior art keywords
- compounds
- general formula
- powder
- triiodinated
- preparing
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 239000003795 chemical substances by application Substances 0.000 title 1
- 150000001470 diamides Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- QQVIHTHCMHWDBS-UHFFFAOYSA-N perisophthalic acid Natural products OC(=O)C1=CC=CC(C(O)=O)=C1 QQVIHTHCMHWDBS-UHFFFAOYSA-N 0.000 title 1
- 239000000843 powder Substances 0.000 abstract 5
- 238000002360 preparation method Methods 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 239000002798 polar solvent Substances 0.000 abstract 2
- 230000001681 protective effect Effects 0.000 abstract 2
- SWNDUEDARACPMW-UHFFFAOYSA-N 1-(methylamino)propane-1,1-diol Chemical compound CCC(O)(O)NC SWNDUEDARACPMW-UHFFFAOYSA-N 0.000 abstract 1
- -1 2,3-dihydroxypropyl Chemical group 0.000 abstract 1
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 abstract 1
- 238000001839 endoscopy Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000011877 solvent mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
A találmány tárgya röntgenkőntraszt-készítmény, amely kőmpűter-tőmőgráfiáhőz és űrőgráfiáhőz használható.A találmány szerinti készítmények (I) általánős képletű új,jódtartalmú vegyületeket tartalmaznak a képletben- R1 jelentése metilcsőpőrt, ésR2 jelentése 2,3-dihidrőxi-prőpil-csőpőrt; vagy- R1 és R2 jelentése egyaránt 2-hidrőxi-etil-csőpőrt,a vegyületek előállítására és alkalmazására vőnatkőzik.A találmány tárgya tővábbá az (I) általánős képletű vegyületek és csakelőállításűk.Az (I) általánős képletű vegyületeket úgy állítják elő, hőgy egy (II)vagy (III) általánős képletű vegyületet, a képletekbenX1, x2 és X3 jelentése hidrőxil-védőcsőpőrt ésZjelentése reakcióképes sav- vagy észtercsőpőrt,pőláris őldószerben vagy őlyan őldószerelegyben, amely legalább egypőláris őldószert tartalmaz, 0 řC és 120 řC közötti hőmérsékleten,adőtt esetben segédbázis jelenlétében, dietanől-aminnal vagy N-metil-aminő-prőpándiőllal reagáltatnak, és azűtán a hidrőxil-védőcsőpőrtőkatismert módőn lehasítják.ŕ
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19510864A DE19510864A1 (de) | 1995-03-16 | 1995-03-16 | Röntgenkontrastmittel für die Computertomographie und Urographie |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9800850A2 true HUP9800850A2 (hu) | 1998-07-28 |
| HUP9800850A3 HUP9800850A3 (en) | 1998-08-28 |
Family
ID=7757670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9800850A HUP9800850A3 (en) | 1995-03-16 | 1996-02-21 | Triiodinated isophtalic acid diamide derivatives, contrasting agent containing them and process for preparing the said compounds |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0815072B1 (hu) |
| JP (1) | JPH11501638A (hu) |
| KR (1) | KR19980703059A (hu) |
| AT (1) | ATE194138T1 (hu) |
| AU (1) | AU4718696A (hu) |
| CA (1) | CA2215385A1 (hu) |
| CZ (1) | CZ291597A3 (hu) |
| DE (2) | DE19510864A1 (hu) |
| DK (1) | DK0815072T3 (hu) |
| ES (1) | ES2148731T3 (hu) |
| FI (1) | FI973692A0 (hu) |
| GR (1) | GR3034472T3 (hu) |
| HU (1) | HUP9800850A3 (hu) |
| IL (1) | IL117373A0 (hu) |
| NO (1) | NO974259L (hu) |
| PL (1) | PL322200A1 (hu) |
| PT (1) | PT815072E (hu) |
| SK (1) | SK121797A3 (hu) |
| WO (1) | WO1996028415A1 (hu) |
| ZA (1) | ZA962142B (hu) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19731591C2 (de) * | 1997-07-17 | 1999-09-16 | Schering Ag | Pharmazeutische Mittel enthaltend perfluoralkylgruppenhaltige Trijodaromaten und ihre Verwendung in der Tumortherapie und interventionellen Radiologie |
| DE19740403C2 (de) * | 1997-09-09 | 1999-11-11 | Schering Ag | Neue Kontrastmittel |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1548594A (en) * | 1976-06-11 | 1979-07-18 | Nyegaard & Co As | Triiodoisophthalic acid amides |
| DE2909439A1 (de) * | 1979-03-08 | 1980-09-18 | Schering Ag | Neue nichtionische roentgenkontrastmittel |
| IT1193211B (it) * | 1979-08-09 | 1988-06-15 | Bracco Ind Chimica Spa | Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono |
| DE3937118A1 (de) * | 1989-11-03 | 1991-05-08 | Schering Ag | Nichtionische roentgenkontrastmittel mit hohem jodgehalt |
| US5075502A (en) * | 1989-12-13 | 1991-12-24 | Mallinckrodt, Inc. | Nonionic x-ray contrast agents, compositions and methods |
| WO1993010078A1 (es) * | 1991-11-18 | 1993-05-27 | Centro Investigacion Justesa Imagen S.A. | Nuevos agentes yodados no ionicos de contraste a los rayos x, metodo para su preparacion y composiciones galenicas que los contienen |
| EP0619744A4 (en) * | 1991-12-03 | 1995-02-08 | Mallinckrodt Medical Inc | NON-IONIC RADIOGRAPHIC CONTRAST METHODS, COMPOSITIONS AND AGENTS. |
| WO1994005337A1 (en) * | 1992-09-02 | 1994-03-17 | Mallinckrodt Medical, Inc. | Nonionic x-ray contrast agents, compositions and methods |
-
1995
- 1995-03-16 DE DE19510864A patent/DE19510864A1/de not_active Withdrawn
-
1996
- 1996-02-21 AT AT96902993T patent/ATE194138T1/de not_active IP Right Cessation
- 1996-02-21 PL PL96322200A patent/PL322200A1/xx unknown
- 1996-02-21 SK SK1217-97A patent/SK121797A3/sk unknown
- 1996-02-21 KR KR1019970706468A patent/KR19980703059A/ko not_active Application Discontinuation
- 1996-02-21 PT PT96902993T patent/PT815072E/pt unknown
- 1996-02-21 AU AU47186/96A patent/AU4718696A/en not_active Abandoned
- 1996-02-21 WO PCT/EP1996/000735 patent/WO1996028415A1/de not_active Application Discontinuation
- 1996-02-21 ES ES96902993T patent/ES2148731T3/es not_active Expired - Lifetime
- 1996-02-21 JP JP8527203A patent/JPH11501638A/ja active Pending
- 1996-02-21 CZ CZ972915A patent/CZ291597A3/cs unknown
- 1996-02-21 DK DK96902993T patent/DK0815072T3/da active
- 1996-02-21 EP EP96902993A patent/EP0815072B1/de not_active Expired - Lifetime
- 1996-02-21 DE DE59605508T patent/DE59605508D1/de not_active Expired - Lifetime
- 1996-02-21 HU HU9800850A patent/HUP9800850A3/hu unknown
- 1996-02-21 CA CA002215385A patent/CA2215385A1/en not_active Abandoned
- 1996-03-05 IL IL11737396A patent/IL117373A0/xx unknown
- 1996-03-15 ZA ZA962142A patent/ZA962142B/xx unknown
-
1997
- 1997-09-15 NO NO974259A patent/NO974259L/no unknown
- 1997-09-15 FI FI973692A patent/FI973692A0/fi unknown
-
2000
- 2000-09-21 GR GR20000402161T patent/GR3034472T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR19980703059A (ko) | 1998-09-05 |
| NO974259L (no) | 1997-11-14 |
| PL322200A1 (en) | 1998-01-19 |
| SK121797A3 (en) | 1998-05-06 |
| CA2215385A1 (en) | 1996-09-19 |
| MX9706555A (es) | 1997-11-29 |
| FI973692A (fi) | 1997-09-15 |
| JPH11501638A (ja) | 1999-02-09 |
| ATE194138T1 (de) | 2000-07-15 |
| GR3034472T3 (en) | 2000-12-29 |
| DK0815072T3 (da) | 2000-09-04 |
| EP0815072A1 (de) | 1998-01-07 |
| CZ291597A3 (cs) | 1998-02-18 |
| ZA962142B (en) | 1996-09-26 |
| PT815072E (pt) | 2000-10-31 |
| WO1996028415A1 (de) | 1996-09-19 |
| DE19510864A1 (de) | 1996-09-19 |
| EP0815072B1 (de) | 2000-06-28 |
| HUP9800850A3 (en) | 1998-08-28 |
| NO974259D0 (no) | 1997-09-15 |
| DE59605508D1 (de) | 2000-08-03 |
| ES2148731T3 (es) | 2000-10-16 |
| AU4718696A (en) | 1996-10-02 |
| FI973692A0 (fi) | 1997-09-15 |
| IL117373A0 (en) | 1996-07-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO168927C (no) | Anvendelse av minst ett vannopploeselig, ikke-radioaktivt,paramagnetisk, anilid-basert metallchelat, som eller for fremstilling av et ikke-radioaktivt nmr-konstrastmiddel | |
| ES8106696A1 (es) | Procedimiento para la preparacion de bis-(hidroxialcohilami-das)de acidos 5-(n-alcohil-a-hidroxiacil-amino)-2,4,6-triyo-do-isoftalicos | |
| BR8402388A (pt) | Processo para a preparacao de derivados do eter l-triazoliletilico | |
| ATE5967T1 (de) | 3,4-diarylisoxazol-5-essigsaeure-verbindungen, verfahren zu deren herstellung und sie enthaltende arzneimittel. | |
| HUP9902419A2 (hu) | Eljárás nitro-bifenilek előállítására | |
| NO822222L (no) | Fremgangsmaate for fremstilling av pyrrolidinderivater | |
| NZ194850A (en) | Substituted oxirane-carboxylic acids pharmaceutical compositions | |
| DE3667660D1 (de) | Chinolylglycinamidderivate, verfahren zu ihrer herstellung und therapeutische verwendung als psychotrope. | |
| HUP9800850A2 (hu) | Trijód-izoftálsav-diamidszármazékok, az ezeket tartalmazó röntgenkontraszt készítmények és eljárás a vegyületek előállítására | |
| PT89004A (pt) | Processo para a preparacao de bis-(3,5-dicarbamoil-2,4,6-tri-iodo-anilidas)de acidos dicarboxilicos substituidos e de composicoes de contraste de raios x que as contem | |
| ATE56707T1 (de) | Imidazolverbindungen, verfahren zu deren herstellung und deren pharmazeutische zusammensetzungen. | |
| ATE144766T1 (de) | Nichtionische jodhaltige röntgenstrahlenkontrastmittel, verfahren zu ihrer herstellung und diese enthaltende zusammensetzungen | |
| AU6823490A (en) | New substituted amino acid derivatives, process for preparing these and pharmaceutical compositions containing them | |
| JPS54128584A (en) | Novel 3,4-dihydrocarbostyril derivative | |
| JPS55164660A (en) | Determination of metanephrine | |
| FI803086A (fi) | Nb-kvartaera derivat av ajmalin och isoajmalin foerfarande och mellanprodukter foer framstaellning av derivaten laekemedel innehaollande derivaten samt derivatens anvaendning | |
| PT97255A (pt) | Processo para a preparacao de 3-tia-alquil-flavonas e de 3-oxa-alquil flavonas e substituidas e de composicoes farmaceuticas que as contem | |
| JPS5615254A (en) | Chloroacetanilide derivative and herbicide containing the same |