HUP9602469A2 - Eljárás fluoxetin előállítására - Google Patents

Eljárás fluoxetin előállítására

Info

Publication number
HUP9602469A2
HUP9602469A2 HU9602469A HUP9602469A HUP9602469A2 HU P9602469 A2 HUP9602469 A2 HU P9602469A2 HU 9602469 A HU9602469 A HU 9602469A HU P9602469 A HUP9602469 A HU P9602469A HU P9602469 A2 HUP9602469 A2 HU P9602469A2
Authority
HU
Hungary
Prior art keywords
formula
compound
phenoxy
trifluoromethyl
phenyl
Prior art date
Application number
HU9602469A
Other languages
English (en)
Inventor
Zoltán Budai
Józsefné Reiter
János Imre
Gyula Simig
Gábor Blaskó
Kálmán Nagy
Tibor Mezei
László Ladányi
Péter Tömpe
Original Assignee
EGIS Gyógyszergyár Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EGIS Gyógyszergyár Rt. filed Critical EGIS Gyógyszergyár Rt.
Priority to HU9602469A priority Critical patent/HU226690B1/hu
Publication of HU9602469D0 publication Critical patent/HU9602469D0/hu
Priority to SK290-99A priority patent/SK29099A3/sk
Priority to PCT/HU1997/000050 priority patent/WO1998011054A1/en
Priority to EP97943082A priority patent/EP0929514A1/en
Priority to AU44689/97A priority patent/AU4468997A/en
Priority to PL97332141A priority patent/PL332141A1/xx
Priority to CZ99752A priority patent/CZ75299A3/cs
Publication of HUP9602469A2 publication Critical patent/HUP9602469A2/hu
Publication of HUP9602469A3 publication Critical patent/HUP9602469A3/hu
Publication of HU226690B1 publication Critical patent/HU226690B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A találmány tárgya eljárás az (I) képletű N-metil-{3-fenil-3-[4-(triflűőr-metil)-fenőxi]-prőpil}-amin és gyógyászatilag alkalmassavaddíciós sói előállítására, a (III) képletű N,N-dimetil -{3-fenil-3-[4-(triflűőr-metil)-fenőx]-prőpil-amin és klór-hangyasav-etil-észterreakciója, majd a kapőtt (II) képletű N-metil-N-etőxikarbőnil-{3-fenil-3-[(4-(triflűőr-metil-fenőxi]-prőpil}-amin hidrőlízise ésdekarbőxilezése, és kívánt esetben a kapőtt (I) képletű vegyületgyógyászatilag alkalmas savaddíciós sóvá történő átalakítása útján őlymódőn, hőgy a (III) képletű vegyület és a klór-hangyasav-etil-észterreakcióját tőlűőlban vagy xilőlban vagy ezek elegyében, 90 řC-nálalacsőnyab hőmérsékleten végzik el, a reakcióelegyből a szennyezéseketés melléktermékeket híg savval történő kezeléssel eltávőlítják; a (II)képletű űretán-származékőt tartalmazó szerves fázist elválasztják és a(II) képletű űretán-származék izőlálása nélkül alkálifém-hidrőxiddal,a reakcióelegy főrráspőntján, víz és adőtt esetben n-bűtil-alkőhőljelenlétében reagáltatják, a szervetlen vegyületeket eltávőlítják,majd a kapőtt (I) képletű bázist kívánt esetben gyógyászatilagalkalmas savaddíciós sóvá alakítják. Az (I) képletű vegyület ismertantidepresszív hatású vegyület. Az eljárás előnye, hőgy iparikörülmények között egyszerűen megvalósítható módőn nagytisztaságúterméket biztősít. ŕ
HU9602469A 1996-09-10 1996-09-10 Process for producing fluoxetin HU226690B1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
HU9602469A HU226690B1 (en) 1996-09-10 1996-09-10 Process for producing fluoxetin
SK290-99A SK29099A3 (en) 1996-09-10 1997-09-10 Process for the preparation of fluoxetine
PCT/HU1997/000050 WO1998011054A1 (en) 1996-09-10 1997-09-10 Process for the preparation of fluoxetine
EP97943082A EP0929514A1 (en) 1996-09-10 1997-09-10 Process for the preparation of fluoxetine
AU44689/97A AU4468997A (en) 1996-09-10 1997-09-10 Process for the preparation of fluoxetine
PL97332141A PL332141A1 (en) 1996-09-10 1997-09-10 Method of obtaining fluoxetin
CZ99752A CZ75299A3 (cs) 1996-09-10 1997-09-10 Způsob přípravy fluoxetinu

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9602469A HU226690B1 (en) 1996-09-10 1996-09-10 Process for producing fluoxetin

Publications (4)

Publication Number Publication Date
HU9602469D0 HU9602469D0 (en) 1996-10-28
HUP9602469A2 true HUP9602469A2 (hu) 1998-09-28
HUP9602469A3 HUP9602469A3 (en) 1999-06-28
HU226690B1 HU226690B1 (en) 2009-06-29

Family

ID=89994255

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9602469A HU226690B1 (en) 1996-09-10 1996-09-10 Process for producing fluoxetin

Country Status (7)

Country Link
EP (1) EP0929514A1 (hu)
AU (1) AU4468997A (hu)
CZ (1) CZ75299A3 (hu)
HU (1) HU226690B1 (hu)
PL (1) PL332141A1 (hu)
SK (1) SK29099A3 (hu)
WO (1) WO1998011054A1 (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6025517A (en) * 1998-08-03 2000-02-15 Sepracor Inc. Fluoxetine process from benzoylacetonitrile
US6313350B1 (en) 2001-01-31 2001-11-06 Grayson Walker Stowell Form a of fluoxetine hydrochloride
US6258853B1 (en) 2001-01-31 2001-07-10 Grayson Walker Stowell Form a of fluoxetine hydrochloride
US6316672B1 (en) 2001-01-31 2001-11-13 Grayson Walker Stowell Form a of fluoxetine hydrochloride
US6310251B1 (en) 2001-01-31 2001-10-30 Grayson Walker Stowell Form a of fluoxetine hydrochloride
US6310250B1 (en) 2001-01-31 2001-10-30 Grayson Walker Stowell Form A of fluoxetine hydrochloride
US6846957B2 (en) 2002-11-22 2005-01-25 Board Of Regents, The University Of Texas System Synthesis of 3-aminomethyl-1-propanol, a fluoxetine precursor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4018895A (en) * 1974-01-10 1977-04-19 Eli Lilly And Company Aryloxyphenylpropylamines in treating depression
IL99316A (en) * 1991-08-27 1995-03-15 Teva Pharma Production of fluoxetine and new intermediates
US5618968A (en) * 1993-02-05 1997-04-08 Pliva Farmaceutska Kemijska, Prehrambena I Kozmeticka Industrija, Dionicko Drustvo N-substituted derivatives of N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine and the procedure for their preparation

Also Published As

Publication number Publication date
CZ75299A3 (cs) 1999-09-15
HU9602469D0 (en) 1996-10-28
HUP9602469A3 (en) 1999-06-28
HU226690B1 (en) 2009-06-29
WO1998011054A1 (en) 1998-03-19
PL332141A1 (en) 1999-08-30
SK29099A3 (en) 1999-08-06
AU4468997A (en) 1998-04-02
EP0929514A1 (en) 1999-07-21

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Legal Events

Date Code Title Description
HC9A Change of name, address

Owner name: EGIS GYOGYSZERGYAR NYILVANOSAN MUEKOEDOE RESZV, HU

Free format text: FORMER OWNER(S): EGIS GYOGYSZERGYAR RT., HU