HUP0500645A2 - Terc-Butil-taxán-származékok enzimes rezolválása - Google Patents

Terc-Butil-taxán-származékok enzimes rezolválása

Info

Publication number
HUP0500645A2
HUP0500645A2 HU0500645A HUP0500645A HUP0500645A2 HU P0500645 A2 HUP0500645 A2 HU P0500645A2 HU 0500645 A HU0500645 A HU 0500645A HU P0500645 A HUP0500645 A HU P0500645A HU P0500645 A2 HUP0500645 A2 HU P0500645A2
Authority
HU
Hungary
Prior art keywords
butyl
enzymatic resolution
taxane derivatives
mixture
carboxyl ester
Prior art date
Application number
HU0500645A
Other languages
English (en)
Inventor
Ramesh N. Patel
Original Assignee
Bristol-Myers Squibb Co.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Co., filed Critical Bristol-Myers Squibb Co.,
Publication of HUP0500645A2 publication Critical patent/HUP0500645A2/hu
Publication of HUP0500645A3 publication Critical patent/HUP0500645A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A találmány tárgya eljárás az általános képletű vegyület - amelyképletében R1 jelentése -O-C(O)alkil-, -O-C(O)aril- vagy -O-C(O)cikloalkil-csoport - cisz- és transz-enantiomereit tartalmazóelegy rezolválására, amely szerint az enantiomerelegyet az említettelegy sztereoszelektív hidrolízisét katalizáló karboxil-észter-hidroláz enzimmel vagy mikroorganizmusból származó karboxil-észter-hidroláz enzimmel hozzák érintkezésbe. A találmány értelmében az ígykapott enantiomereket olyan daganatellenes szerek előállításáraalkalmazzák, amelyek különösen alkalmasak orális adagolásra.
HU0500645A 2001-08-21 2002-08-21 Enzymatic resolution of t-butyl taxane derivatives HUP0500645A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31375701P 2001-08-21 2001-08-21
PCT/US2002/026810 WO2003016543A2 (en) 2001-08-21 2002-08-21 Enzymatic resolution of t-butyl taxane derivatives

Publications (2)

Publication Number Publication Date
HUP0500645A2 true HUP0500645A2 (hu) 2005-09-28
HUP0500645A3 HUP0500645A3 (en) 2009-03-02

Family

ID=23217015

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0500645A HUP0500645A3 (en) 2001-08-21 2002-08-21 Enzymatic resolution of t-butyl taxane derivatives

Country Status (13)

Country Link
US (1) US7063977B2 (hu)
EP (1) EP1425407A4 (hu)
JP (1) JP2007503201A (hu)
KR (1) KR20040053114A (hu)
CN (1) CN1294274C (hu)
AU (1) AU2002323346B2 (hu)
BR (1) BR0211999A (hu)
CZ (1) CZ2004254A3 (hu)
HU (1) HUP0500645A3 (hu)
IL (1) IL160061A0 (hu)
MX (1) MXPA04001631A (hu)
PL (1) PL374278A1 (hu)
WO (1) WO2003016543A2 (hu)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108084126A (zh) * 2016-11-21 2018-05-29 山东国际生物科技园发展有限公司 化合物FuramycinsⅠ和Ⅱ及其制备方法和应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY110249A (en) 1989-05-31 1998-03-31 Univ Florida State Method for preparation of taxol using beta lactam
US5175315A (en) 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5274124A (en) 1991-09-23 1993-12-28 Florida State University Metal alkoxides
US5284865A (en) 1991-09-23 1994-02-08 Holton Robert A Cyclohexyl substituted taxanes and pharmaceutical compositions containing them
US5243045A (en) 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5229526A (en) 1991-09-23 1993-07-20 Florida State University Metal alkoxides
US5227400A (en) 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
CA2087359A1 (en) * 1992-01-15 1993-07-16 Ramesh N. Patel Enzymatic processes for resolution of enantiomeric mixtures of compoundsuseful as intermediates in the preparation of taxanes
US5939561A (en) * 1992-03-10 1999-08-17 Rhone-Poulence Rorer S.A. Process for the preparation of β-phenylisoserine and β-lactam and their analogues
US5254580A (en) 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
US5294637A (en) 1992-07-01 1994-03-15 Bristol-Myers Squibb Company Fluoro taxols
CA2100808A1 (en) 1992-10-01 1994-04-02 Vittorio Farina Deoxy paclitaxels
US5420337A (en) * 1992-11-12 1995-05-30 E. R. Squibb & Sons, Inc. Enzymatic reduction method for the preparation of compounds useful for preparing taxanes
US5973160A (en) 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
ATE309229T1 (de) 1992-12-23 2005-11-15 Bristol Myers Squibb Co Seitenkette tragende taxanen und deren zwischenprodukten
US5840929A (en) 1995-04-14 1998-11-24 Bristol-Myers Squibb Company C4 methoxy ether derivatives of paclitaxel
TW354293B (en) 1995-06-06 1999-03-11 Bristol Myers Squibb Co Prodrugs of paclitaxel derivatives
DE69832173T2 (de) 1997-05-27 2006-08-03 IVAX RESEARCH, INC., Miami Zusammensetzungen zur oralen verabreichung von taxanen und deren verwendung
US6916942B2 (en) 2000-02-03 2005-07-12 Bristol-Myers Squibb Company Process for the preparation of C-4 carbonate taxanes
US6750246B1 (en) 2000-02-03 2004-06-15 Bristol-Myers Squibb Company C-4 carbonate taxanes
US20050020685A1 (en) * 2003-06-12 2005-01-27 Skonezny Paul M. Process for recovery of 6-aminopenicillanic acid from an aqueous discharge stream

Also Published As

Publication number Publication date
WO2003016543A3 (en) 2003-07-24
AU2002323346B2 (en) 2007-09-20
JP2007503201A (ja) 2007-02-22
US7063977B2 (en) 2006-06-20
US20030069415A1 (en) 2003-04-10
PL374278A1 (en) 2005-10-03
KR20040053114A (ko) 2004-06-23
CN1545555A (zh) 2004-11-10
WO2003016543A2 (en) 2003-02-27
MXPA04001631A (es) 2004-07-08
HUP0500645A3 (en) 2009-03-02
IL160061A0 (en) 2004-06-20
EP1425407A4 (en) 2007-02-21
CZ2004254A3 (cs) 2004-10-13
EP1425407A2 (en) 2004-06-09
CN1294274C (zh) 2007-01-10
BR0211999A (pt) 2005-08-02

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