HUP0401977A2 - Anyagcsere szabályozott fermentálás a karbamoil-tobramycin előállítására - Google Patents
Anyagcsere szabályozott fermentálás a karbamoil-tobramycin előállításáraInfo
- Publication number
- HUP0401977A2 HUP0401977A2 HU0401977A HUP0401977A HUP0401977A2 HU P0401977 A2 HUP0401977 A2 HU P0401977A2 HU 0401977 A HU0401977 A HU 0401977A HU P0401977 A HUP0401977 A HU P0401977A HU P0401977 A2 HUP0401977 A2 HU P0401977A2
- Authority
- HU
- Hungary
- Prior art keywords
- production
- fermentation process
- controlled fermentation
- tobramycin
- carbamoyl
- Prior art date
Links
- 238000000855 fermentation Methods 0.000 title abstract 2
- 230000004151 fermentation Effects 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- YPPFEJHOHNPKLT-PBSUHMDJSA-N nebramycin 5' Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](COC(N)=O)O2)O)[C@H](N)C[C@@H]1N YPPFEJHOHNPKLT-PBSUHMDJSA-N 0.000 title abstract 2
- 230000002503 metabolic effect Effects 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 241000187178 Streptoalloteichus tenebrarius Species 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
A találmány tárgya anyagcsere szabályozott fermentálási eljáráskarbamoil-tobramicin előállítására különféle Streptomyces tenebrariustörzsek segítségével, süllyesztett tenyészetben, 37-41 °C közöttihőmérsékleten, asszimilálható szén, nitrogénforrásokat, ásványi sókattartalmazó táptalajon, adagolás segítségével: ily módon a termék jókihozatallal és nagy tisztaságban kapható meg. Ó
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26054201P | 2001-01-09 | 2001-01-09 | |
| US33712701P | 2001-12-04 | 2001-12-04 | |
| PCT/US2002/001843 WO2002055490A2 (en) | 2001-01-09 | 2002-01-09 | Metabolic controlled fermentation process for carbamoyl tobramycin production |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0401977A2 true HUP0401977A2 (hu) | 2004-12-28 |
| HUP0401977A3 HUP0401977A3 (en) | 2008-03-28 |
Family
ID=26948059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0401977A HUP0401977A3 (en) | 2001-01-09 | 2002-01-09 | Metabolic controlled fermentation process for carbamoyl tobramycin production |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20020197683A1 (hu) |
| EP (1) | EP1357918A2 (hu) |
| JP (1) | JP2004524018A (hu) |
| KR (1) | KR20040004486A (hu) |
| CN (1) | CN1527715A (hu) |
| CA (1) | CA2433813A1 (hu) |
| CZ (1) | CZ20032058A3 (hu) |
| DE (1) | DE02717362T1 (hu) |
| ES (1) | ES2208147T1 (hu) |
| HU (1) | HUP0401977A3 (hu) |
| IL (1) | IL156834A0 (hu) |
| IS (1) | IS6864A (hu) |
| MX (1) | MXPA03006118A (hu) |
| NO (1) | NO20033126L (hu) |
| PL (1) | PL368609A1 (hu) |
| SK (1) | SK9692003A3 (hu) |
| TR (1) | TR200400060T3 (hu) |
| WO (1) | WO2002055490A2 (hu) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4895507B2 (ja) * | 2005-02-04 | 2012-03-14 | 株式会社ヤクルト本社 | ストレプトマイセス属細菌の培養方法及びこれを利用する有用物質の製造方法 |
| CN109593807B (zh) * | 2018-12-06 | 2021-09-03 | 浙江普洛生物科技有限公司 | 一种发酵生产安普霉素的方法 |
| CN114381384B (zh) * | 2020-10-22 | 2023-09-15 | 上海医药工业研究院 | 一种提高安普霉素发酵单位的种子培养基及其应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4032404A (en) * | 1976-07-14 | 1977-06-28 | Bristol-Myers Company | Fermentation process for producing apramycin and nebramycin factor V' |
-
2002
- 2002-01-09 PL PL02368609A patent/PL368609A1/xx unknown
- 2002-01-09 SK SK969-2003A patent/SK9692003A3/sk unknown
- 2002-01-09 WO PCT/US2002/001843 patent/WO2002055490A2/en not_active Application Discontinuation
- 2002-01-09 IL IL15683402A patent/IL156834A0/xx unknown
- 2002-01-09 CZ CZ20032058A patent/CZ20032058A3/cs unknown
- 2002-01-09 KR KR10-2003-7009073A patent/KR20040004486A/ko not_active Application Discontinuation
- 2002-01-09 DE DE0001357918T patent/DE02717362T1/de active Pending
- 2002-01-09 TR TR2004/00060T patent/TR200400060T3/xx unknown
- 2002-01-09 HU HU0401977A patent/HUP0401977A3/hu unknown
- 2002-01-09 ES ES02717362T patent/ES2208147T1/es active Pending
- 2002-01-09 EP EP02717362A patent/EP1357918A2/en not_active Withdrawn
- 2002-01-09 CA CA002433813A patent/CA2433813A1/en not_active Abandoned
- 2002-01-09 US US10/047,693 patent/US20020197683A1/en not_active Abandoned
- 2002-01-09 JP JP2002556163A patent/JP2004524018A/ja active Pending
- 2002-01-09 CN CNA028035585A patent/CN1527715A/zh active Pending
- 2002-01-09 MX MXPA03006118A patent/MXPA03006118A/es not_active Application Discontinuation
-
2003
- 2003-07-03 IS IS6864A patent/IS6864A/is unknown
- 2003-07-08 NO NO20033126A patent/NO20033126L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004524018A (ja) | 2004-08-12 |
| CA2433813A1 (en) | 2002-07-18 |
| IL156834A0 (en) | 2004-02-08 |
| PL368609A1 (en) | 2005-04-04 |
| WO2002055490A3 (en) | 2003-05-30 |
| NO20033126L (no) | 2003-09-08 |
| TR200400060T3 (tr) | 2004-02-23 |
| EP1357918A2 (en) | 2003-11-05 |
| KR20040004486A (ko) | 2004-01-13 |
| DE02717362T1 (de) | 2004-05-19 |
| IS6864A (is) | 2003-07-03 |
| US20020197683A1 (en) | 2002-12-26 |
| NO20033126D0 (no) | 2003-07-08 |
| SK9692003A3 (en) | 2003-11-04 |
| CN1527715A (zh) | 2004-09-08 |
| WO2002055490A2 (en) | 2002-07-18 |
| CZ20032058A3 (cs) | 2003-11-12 |
| ES2208147T1 (es) | 2004-06-16 |
| HUP0401977A3 (en) | 2008-03-28 |
| MXPA03006118A (es) | 2005-02-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HC9A | Change of name, address |
Owner name: TEVA GYOGYSZERGYAR ZRT., HU Free format text: FORMER OWNER(S): BIOGAL GYOGYSZERGYAR RT., HU |
|
| FD9A | Lapse of provisional protection due to non-payment of fees |