HUP0401890A2 - Inhalálható kompozíció, amely hatóanyagként triciklusos 5,6-dihidro-9H-pirazolo (3,4-C)-1,2,4-triazolo (4,3-alfa) piridineket tartalmaz - Google Patents

Inhalálható kompozíció, amely hatóanyagként triciklusos 5,6-dihidro-9H-pirazolo (3,4-C)-1,2,4-triazolo (4,3-alfa) piridineket tartalmaz

Info

Publication number
HUP0401890A2
HUP0401890A2 HU0401890A HUP0401890A HUP0401890A2 HU P0401890 A2 HUP0401890 A2 HU P0401890A2 HU 0401890 A HU0401890 A HU 0401890A HU P0401890 A HUP0401890 A HU P0401890A HU P0401890 A2 HUP0401890 A2 HU P0401890A2
Authority
HU
Hungary
Prior art keywords
triazolo
pyrazolo
pyridines
dihydro
tryciclic
Prior art date
Application number
HU0401890A
Other languages
English (en)
Inventor
Michael John Humphrey
Paul Robert Miller
Michael Trevor Shepherd
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of HUP0401890A2 publication Critical patent/HUP0401890A2/hu
Publication of HUP0401890A3 publication Critical patent/HUP0401890A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M13/00—Insufflators for therapeutic or disinfectant purposes, i.e. devices for blowing a gas, powder or vapour into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Otolaryngology (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

A jelen találmány tárgya egy inhalálható készítmény, amely egy, az5,6-dihidro-9H-pirazolo[3,4-c]-1,2,4-triazolo[4,3-a]piridinek egybizonyos osztályába tartozó vegyületet tartalmaz; amelyet képes finomszilárd részecskék formájában a tüdőbe juttatni, valamint ezenkészítmény alkalmazása bizonyos betegségek, mint pl. légzőszervimegbetegedések kezelésére. Az ilyen készítmények alkalmazásávallehetségessé válik az említett vegyületek oldatadagolósinhalálókészülékkel történő beadásakor fellépő nemkívánatos köhögésireakció elkerülése, amely reakció megakadályozhatja a hatékonyterápiához szükséges adag beadását. Ó
HU0401890A 2001-09-12 2002-09-02 Inhalation compositions comprising tryciclic 5,6-dihydro-9h-pyrazolo (3,4-c)-1,2,4-triazolo (4,3-alpha)pyridines as active ingredient HUP0401890A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0122031.8A GB0122031D0 (en) 2001-09-12 2001-09-12 Use of pde4 inhibitors in a dry powder inhaler
PCT/IB2002/003599 WO2003022275A1 (en) 2001-09-12 2002-09-02 Inhalation compositions comprising tricyclic 5,6-dihydro-9h-pyrazolo (3,4-c)-1,2,4-triazolo (4,3-alpha) pyridines

Publications (2)

Publication Number Publication Date
HUP0401890A2 true HUP0401890A2 (hu) 2004-12-28
HUP0401890A3 HUP0401890A3 (en) 2008-03-28

Family

ID=9921954

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0401890A HUP0401890A3 (en) 2001-09-12 2002-09-02 Inhalation compositions comprising tryciclic 5,6-dihydro-9h-pyrazolo (3,4-c)-1,2,4-triazolo (4,3-alpha)pyridines as active ingredient

Country Status (34)

Country Link
US (3) US20030064031A1 (hu)
EP (1) EP1427414A1 (hu)
JP (1) JP2005505560A (hu)
KR (1) KR20040036940A (hu)
CN (1) CN1553801A (hu)
AP (2) AP2002002623A0 (hu)
AR (2) AR036473A1 (hu)
BG (1) BG108569A (hu)
BR (1) BR0212449A (hu)
CA (1) CA2457717A1 (hu)
CZ (1) CZ2004310A3 (hu)
EA (1) EA006742B1 (hu)
EC (1) ECSP045018A (hu)
EE (1) EE200400078A (hu)
GB (1) GB0122031D0 (hu)
HN (2) HN2002000253A (hu)
HR (1) HRP20040162A2 (hu)
HU (1) HUP0401890A3 (hu)
IL (1) IL160380A0 (hu)
IS (1) IS7151A (hu)
MA (1) MA27062A1 (hu)
MX (1) MXPA04002354A (hu)
NO (1) NO20041011L (hu)
NZ (1) NZ530929A (hu)
OA (1) OA12660A (hu)
PA (2) PA8554601A1 (hu)
PE (2) PE20030443A1 (hu)
PL (1) PL368736A1 (hu)
SK (1) SK1272004A3 (hu)
SV (2) SV2004001227A (hu)
TN (1) TNSN04040A1 (hu)
TW (1) TW200602054A (hu)
WO (2) WO2003022275A1 (hu)
ZA (1) ZA200401002B (hu)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7931022B2 (en) 2001-10-19 2011-04-26 Respirks, Inc. Method and apparatus for dispensing inhalator medicament
JP2006513235A (ja) * 2002-12-31 2006-04-20 ネクター セラピューティクス 真菌感染症療法のためのエアゾール化可能な医薬製剤
GB0315889D0 (en) 2003-07-08 2003-08-13 Aventis Pharma Ltd Stable pharmaceutical products
US20060009435A1 (en) * 2004-06-23 2006-01-12 Joseph Kaspi Synthesis and powder preparation of fluticasone propionate
CA2623882A1 (en) * 2005-09-28 2007-04-05 Merck Frosst Canada Ltd. Aerosol powder formulation comprising sieved lactose
GB0801876D0 (en) * 2008-02-01 2008-03-12 Vectura Group Plc Suspension formulations
US8834931B2 (en) 2009-12-25 2014-09-16 Mahmut Bilgic Dry powder formulation containing tiotropium for inhalation
TR200909788A2 (tr) * 2009-12-25 2011-07-21 Bi̇lgi̇ç Mahmut Tiotropyum içeren inhalasyona uygun kuru toz formülasyonu
CN105121439A (zh) 2013-02-19 2015-12-02 辉瑞公司 作为pde4亚型抑制剂用于治疗cns和其他病症的氮杂苯并咪唑化合物
KR20150076005A (ko) 2013-12-26 2015-07-06 삼성디스플레이 주식회사 액정 표시 장치
EP3172210B1 (en) 2014-07-24 2020-01-15 Pfizer Inc Pyrazolopyrimidine compounds
KR102061952B1 (ko) 2014-08-06 2020-01-02 화이자 인코포레이티드 이미다조피리다진 화합물
RS58897B1 (sr) * 2014-09-15 2019-08-30 Verona Pharma Plc Tečna inhalaciona formulacija koja sadrži rpl554

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK282167B6 (sk) * 1995-06-06 2001-11-06 Pfizer Inc. Tricyklické 5,6-dihydro-9h-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-a] pyridíny a farmaceutický prostriedok na ich báze
US5985309A (en) * 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
DE19835346A1 (de) * 1998-08-05 2000-02-10 Boehringer Ingelheim Pharma Zweiteilige Kapsel zur Aufnahme von pharmazeutischen Zubereitungen für Pulverinhalatoren

Also Published As

Publication number Publication date
PA8554701A1 (es) 2003-09-17
TNSN04040A1 (fr) 2006-06-01
MA27062A1 (fr) 2004-12-20
SV2004001227A (es) 2004-02-24
CA2457717A1 (en) 2003-03-20
PA8554601A1 (es) 2003-09-17
CN1553801A (zh) 2004-12-08
ZA200401002B (en) 2005-02-07
HUP0401890A3 (en) 2008-03-28
WO2003022275A1 (en) 2003-03-20
NZ530929A (en) 2006-08-31
MXPA04002354A (es) 2004-06-29
BG108569A (bg) 2005-02-28
EE200400078A (et) 2004-06-15
PE20030509A1 (es) 2003-06-23
SK1272004A3 (sk) 2005-03-04
IL160380A0 (en) 2004-07-25
JP2005505560A (ja) 2005-02-24
AP2002002623A0 (en) 2002-09-30
HN2002000254A (es) 2003-04-07
EA200400301A1 (ru) 2004-06-24
TW200602054A (en) 2006-01-16
AR036473A1 (es) 2004-09-08
SV2004001226A (es) 2004-02-24
HRP20040162A2 (en) 2004-08-31
HN2002000253A (es) 2003-04-07
BR0212449A (pt) 2004-08-17
US20050232871A1 (en) 2005-10-20
OA12660A (en) 2006-06-19
KR20040036940A (ko) 2004-05-03
EA006742B1 (ru) 2006-04-28
US20030064031A1 (en) 2003-04-03
CZ2004310A3 (cs) 2005-02-16
ECSP045018A (es) 2004-04-28
IS7151A (is) 2004-02-13
AP2002002624A0 (en) 2002-09-30
GB0122031D0 (en) 2001-10-31
WO2003022279A1 (en) 2003-03-20
PL368736A1 (en) 2005-04-04
NO20041011L (no) 2004-03-10
EP1427414A1 (en) 2004-06-16
AR036474A1 (es) 2004-09-08
PE20030443A1 (es) 2003-05-17
US20030064034A1 (en) 2003-04-03

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Legal Events

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FD9A Lapse of provisional protection due to non-payment of fees