HUP0401863A2 - Autoimmun-betegségek szuppresszálására szolgáló aminosav-kopolimerek és alkalmazási eljárások - Google Patents

Autoimmun-betegségek szuppresszálására szolgáló aminosav-kopolimerek és alkalmazási eljárások

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Publication number
HUP0401863A2
HUP0401863A2 HU0401863A HUP0401863A HUP0401863A2 HU P0401863 A2 HUP0401863 A2 HU P0401863A2 HU 0401863 A HU0401863 A HU 0401863A HU P0401863 A HUP0401863 A HU P0401863A HU P0401863 A2 HUP0401863 A2 HU P0401863A2
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Hungary
Prior art keywords
copolymers
mbp
membered
hla
plp
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HU0401863A
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English (en)
Inventor
Jack L. Strominger
Masha Fridkis-Hareli
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President And Fellows Of Harvard College
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Publication of HUP0401863A2 publication Critical patent/HUP0401863A2/hu
Publication of HUP0401863A3 publication Critical patent/HUP0401863A3/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2026—IL-4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2066—IL-10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/215—IFN-beta
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)

Abstract

A találmány tárgyát 14, 35 és 50 tagú, 3 és 4 aminosavból álló randomaminosav-kopolimerek képezik. Az 50-tagú FEAK hatásos inhibitora azMBP 85-99 vagy proteolipid protein (PLP) 40-60-ra specifikus HLA-DR-2-korlátozott T-sejt-klónoknak. Ezek a kopolimerek hatásosanszuppresszálták az érzékeny SJL/J (H-2s) egértörzsekben a teljesgerincvelő homogenizátummal (WSCH) vagy a PLP 139-151enkefalitogenikus epitóppal indukált EAE-t. Az 50 tagú YFAK - amelyneka mólaránya körülbelül Y 0,8:F 0,2 - hatékonyabban gátolta abiotinilált MBP 85-99 epitóp kötődését a HLA-DR-2 molekulákhoz, mint ajelöletlen MBP 85-99 vagy a Copaxone<<. Az YFAK és FAK kopolimerekhatékonyan szuppresszálták az SJL/J (H-2s) egerekben a PLP 139-151enkefalitogenikus epitóppal indukált EAE-t. Az YFK, VYAK és atriptofánt tartalmazó VWAK kopolimerek hatásosak voltak az MBP 85-99peptiddel indukált EAE súlyosságának és a tünetek időtartamának azenyhítésére olyan humanizált egérmodellben, amely egyaránt expresszáltszklerózis multiplexszel (MS) kapcsolatos HLA-DR-2 géneket és egy MS-páciensből származó T-sejt-receptort. Ó
HU0401863A 2001-10-03 2002-10-03 Amino acid-copolymers for suppression of autoimmune diseases, and methods of use HUP0401863A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32670501P 2001-10-03 2001-10-03
PCT/US2002/031399 WO2003029276A2 (en) 2001-10-03 2002-10-03 Copolymers for suppression of autoimmune diseases, and methods of use

Publications (2)

Publication Number Publication Date
HUP0401863A2 true HUP0401863A2 (hu) 2004-12-28
HUP0401863A3 HUP0401863A3 (en) 2012-09-28

Family

ID=23273317

Family Applications (1)

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HU0401863A HUP0401863A3 (en) 2001-10-03 2002-10-03 Amino acid-copolymers for suppression of autoimmune diseases, and methods of use

Country Status (12)

Country Link
US (3) US7381790B2 (hu)
EP (2) EP2123669A1 (hu)
JP (3) JP5010798B2 (hu)
AU (1) AU2002362445B2 (hu)
CA (1) CA2462459C (hu)
DE (1) DE02800437T1 (hu)
HU (1) HUP0401863A3 (hu)
IL (2) IL161121A0 (hu)
NO (2) NO20041345L (hu)
NZ (1) NZ532199A (hu)
WO (1) WO2003029276A2 (hu)
ZA (1) ZA200402601B (hu)

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AU2002240057A1 (en) * 2001-01-24 2002-08-06 President And Fellows Of Harvard College Therapeutic peptides for demyelinating conditions
CA2558655A1 (en) * 2004-03-01 2005-09-15 Kai W. Wucherpfennig Methods and compositions for treatment of autoimmune diseases
US7655221B2 (en) * 2004-05-07 2010-02-02 Peptimmune, Inc. Methods of treating disease with random copolymers
US20090275496A1 (en) * 2004-05-07 2009-11-05 Peptimmune, Inc. Effective quantitation of complex peptide mixtures in tissue samples and improved therapeutic methods
ES2560448T3 (es) * 2004-05-07 2016-02-19 Ares Trading S.A. Procedimientos de tratamiento de enfermedades con copolímeros aleatorios
US20060194725A1 (en) * 2004-05-07 2006-08-31 James Rasmussen Methods of treating disease with random copolymers
WO2007120834A2 (en) 2006-04-13 2007-10-25 Peptimmune, Inc. Methods for designing and synthesizing directed sequence polymer compositions via the directed expansion of epitope permeability
KR101751406B1 (ko) 2007-10-16 2017-06-27 펩팀문, 인코포레이티드 에피토프의 지정 확장에 의해 지정 서열 중합체 조성물을 포함하는 백신을 설계하고 제조하는 방법
WO2009075854A2 (en) * 2007-12-10 2009-06-18 Peptimmune Inc. Effective quantitation of complex peptide mixtures in tissue samples and improved therapeutic methods
US8377885B2 (en) 2010-01-04 2013-02-19 Mapi Pharma Ltd. Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
EP3536333B1 (en) 2010-01-04 2022-08-03 Mapi Pharma Limited Depot system comprising glatiramer acetate
USRE49251E1 (en) 2010-01-04 2022-10-18 Mapi Pharma Ltd. Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
ES2601892T3 (es) * 2011-04-21 2017-02-16 Mapi Pharma Limited Pentapolímero aleatorio para el tratamiento de enfermedades autoinmunes
GB201300684D0 (en) 2013-01-15 2013-02-27 Apitope Int Nv Peptide
AU2015228372B2 (en) 2014-03-12 2018-05-31 Yeda Research And Development Co. Ltd Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS
EP3170836B1 (en) 2015-11-23 2018-10-24 Chemi SPA Rp-hplc analysis of complex polypeptide mixtures
CA3029654A1 (en) * 2016-07-01 2018-01-04 Declion Holdings Llc Amino acid copolymer compositions and uses thereof
US12097292B2 (en) 2016-08-28 2024-09-24 Mapi Pharma Ltd. Process for preparing microparticles containing glatiramer acetate
CN110382052A (zh) 2017-03-26 2019-10-25 Mapi医药公司 用于治疗进展型形式的多发性硬化症的格拉替雷储库系统
EP4243834A2 (en) * 2020-11-10 2023-09-20 Palena Therapeutics, Inc. Compositions of embedded epitope random peptides (eerp) for treatment of immune-mediated conditions, and methods of use

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Also Published As

Publication number Publication date
WO2003029276A3 (en) 2003-11-27
ZA200402601B (en) 2005-07-27
CA2462459A1 (en) 2003-04-10
NO20041345L (no) 2004-03-31
EP1438061B1 (en) 2016-05-11
NZ532199A (en) 2008-02-29
IL161121A (en) 2010-11-30
WO2003029276A2 (en) 2003-04-10
EP2123669A1 (en) 2009-11-25
US7381790B2 (en) 2008-06-03
EP1438061A4 (en) 2005-02-23
HUP0401863A3 (en) 2012-09-28
JP5525749B2 (ja) 2014-06-18
JP2012162545A (ja) 2012-08-30
US8017125B2 (en) 2011-09-13
DE02800437T1 (de) 2004-11-11
NO337092B1 (no) 2016-01-18
AU2002362445B2 (en) 2006-09-21
US20080241099A1 (en) 2008-10-02
CA2462459C (en) 2007-12-18
JP2009185057A (ja) 2009-08-20
JP5010798B2 (ja) 2012-08-29
EP1438061A2 (en) 2004-07-21
NO20041759L (no) 2004-04-29
JP2005511518A (ja) 2005-04-28
IL161121A0 (en) 2004-08-31
US9028835B2 (en) 2015-05-12
US20110286959A1 (en) 2011-11-24
US20040038887A1 (en) 2004-02-26

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