HUP0401006A2 - Eljárás 7-amino-szin-3,5-dihidroxi-heptánsav-származékok előállítására, ezek köztitermékei és módszerek az előállításukra - Google Patents
Eljárás 7-amino-szin-3,5-dihidroxi-heptánsav-származékok előállítására, ezek köztitermékei és módszerek az előállításukraInfo
- Publication number
- HUP0401006A2 HUP0401006A2 HU0401006A HUP0401006A HUP0401006A2 HU P0401006 A2 HUP0401006 A2 HU P0401006A2 HU 0401006 A HU0401006 A HU 0401006A HU P0401006 A HUP0401006 A HU P0401006A HU P0401006 A2 HUP0401006 A2 HU P0401006A2
- Authority
- HU
- Hungary
- Prior art keywords
- preparation
- methods
- protecting group
- intermediates
- dihidroxy
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 239000000543 intermediate Substances 0.000 title abstract 2
- MNWFXJYAOYHMED-UHFFFAOYSA-N heptanoic acid Chemical class CCCCCCC(O)=O MNWFXJYAOYHMED-UHFFFAOYSA-N 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 3
- 125000006239 protecting group Chemical group 0.000 abstract 3
- 239000013067 intermediate product Substances 0.000 abstract 2
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 abstract 1
- 150000001408 amides Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000001308 synthesis method Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000001131 transforming effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
- C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Carbon And Carbon Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01810670 | 2001-07-06 | ||
| PCT/EP2002/007308 WO2003004455A2 (en) | 2001-07-06 | 2002-07-02 | Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives, intermediates thereof and methods for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0401006A2 true HUP0401006A2 (hu) | 2004-08-30 |
Family
ID=41546668
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0401006A HUP0401006A2 (hu) | 2001-07-06 | 2002-07-02 | Eljárás 7-amino-szin-3,5-dihidroxi-heptánsav-származékok előállítására, ezek köztitermékei és módszerek az előállításukra |
Country Status (15)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002057229A1 (en) | 2001-01-19 | 2002-07-25 | Biocon India Limited | FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN) |
| EP1404639A1 (en) | 2001-07-06 | 2004-04-07 | Ciba SC Holding AG | Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino 3,5-dihydroxy heptanoic acid derivatives, and intermediates thereof |
| US7361772B2 (en) | 2001-08-16 | 2008-04-22 | Biocon Limited | Process for the production of atorvastatin calcium |
| WO2003078379A1 (en) | 2002-03-18 | 2003-09-25 | Biocon Limited | AMORPHOUS Hmg-CoA REDUCTASE INHIBITORS OF DESIRED PARTICLE SIZE |
| US7179942B2 (en) | 2002-07-05 | 2007-02-20 | Bicon Limited | Halo-substituted active methylene compounds |
| EP1631533B1 (en) | 2003-04-22 | 2009-03-11 | Biocon Limited | Novel process for stereoselective reduction of beta-ketoesters |
| US7368468B2 (en) | 2003-06-18 | 2008-05-06 | Teva Pharmaceutical Industries Ltd. | Fluvastatin sodium crystal forms XIV, LXXIII, LXXIX, LXXX and LXXXVII, processes for preparing them, compositions containing them and methods of using them |
| EP1726583A3 (en) | 2003-06-18 | 2007-05-09 | Teva Pharmaceutical Industries Ltd | Fluvastatin sodium crystal form LXXIX, processes for preparing it, compositions containing it and methods of using it. |
| AU2003272080A1 (en) | 2003-09-18 | 2005-04-06 | Biocon Limited | Novel process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate |
| US7851624B2 (en) | 2003-12-24 | 2010-12-14 | Teva Pharamaceutical Industries Ltd. | Triol form of rosuvastatin and synthesis of rosuvastatin |
| WO2007022488A2 (en) | 2005-08-16 | 2007-02-22 | Teva Pharmaceutical Industries Ltd. | Crystalline rosuvastatin intermediate |
| EP2778229A1 (de) | 2013-03-11 | 2014-09-17 | Sandoz Ag | Verfahren zur enantioselektiven Herstellung von 3-Hydroxyglutarsäuremonoestern und deren Verwendung |
| CN103361386B (zh) * | 2013-06-28 | 2015-04-15 | 苏州汉酶生物技术有限公司 | 一种罗素伐他汀中间体的制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5097045A (en) | 1989-02-01 | 1992-03-17 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| US5003080A (en) | 1988-02-22 | 1991-03-26 | Warner-Lambert Company | Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis |
| IT1226726B (it) * | 1988-07-29 | 1991-02-05 | Zambon Spa | Composti attivi come inibitori della biosintesi del colesterolo. |
| JPH02115234A (ja) | 1988-10-26 | 1990-04-27 | Tdk Corp | 架橋ポリフッ化ビニリデンの製造方法 |
| DE69009237T2 (de) * | 1989-02-27 | 1994-12-01 | Takasago Perfumery Co Ltd | Verfahren zur Herstellung von optisch aktiven Estern der 6-t-Butoxy-3,5-dihydroxyhexansäure. |
| JPH0791223B2 (ja) * | 1989-02-27 | 1995-10-04 | 高砂香料工業株式会社 | 光学活性６―ｔ―ブトキシ―３，５―ジヒドロキシヘキサン酸エステルの製造法 |
| IT1237792B (it) * | 1989-12-21 | 1993-06-17 | Zambon Spa | Composti attivi come inibitori dell'enzima hmg-coa reduttasi |
| US5051502A (en) * | 1990-06-06 | 1991-09-24 | University Of Notre Dame Du Lac | Rhodium catalyzed cyclization process for bicyclic β-lactams |
| US5248793A (en) | 1990-10-17 | 1993-09-28 | Warner-Lambert Company | Process for the synthesis of (4R-cis)-1,1-dimethylethyl 6-iodomethyl or 6-(phenyl-substituted)sulfonyloxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate |
| US5155251A (en) | 1991-10-11 | 1992-10-13 | Warner-Lambert Company | Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate |
| US5298627A (en) | 1993-03-03 | 1994-03-29 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| JP3652394B2 (ja) * | 1995-01-27 | 2005-05-25 | 高砂香料工業株式会社 | Ｎ−置換−７−アミノ−５−ヒドロキシ−３−オキソヘプタン酸誘導体およびその製造法 |
| KR100681366B1 (ko) | 1997-12-19 | 2007-02-12 | 워너-램버트 익스포트 리미티드 | 1,3-디올의 합성방법 |
| DE19920784A1 (de) | 1999-05-05 | 2000-11-09 | Bayer Ag | Stilbenaufheller |
-
2002
- 2002-07-02 SK SK79-2004A patent/SK792004A3/sk not_active Application Discontinuation
- 2002-07-02 CZ CZ2004158A patent/CZ2004158A3/cs unknown
- 2002-07-02 HU HU0401006A patent/HUP0401006A2/hu unknown
- 2002-07-02 DK DK02764615.7T patent/DK1404642T3/da active
- 2002-07-02 AT AT02764615T patent/ATE457972T1/de not_active IP Right Cessation
- 2002-07-02 JP JP2003510423A patent/JP2004533481A/ja active Pending
- 2002-07-02 WO PCT/EP2002/007308 patent/WO2003004455A2/en active Search and Examination
- 2002-07-02 US US10/482,946 patent/US7317123B2/en not_active Expired - Fee Related
- 2002-07-02 AU AU2002328835A patent/AU2002328835A1/en not_active Abandoned
- 2002-07-02 PL PL02367774A patent/PL367774A1/xx unknown
- 2002-07-02 CA CA002453211A patent/CA2453211A1/en not_active Abandoned
- 2002-07-02 IL IL15971802A patent/IL159718A0/xx unknown
- 2002-07-02 DE DE60235365T patent/DE60235365D1/de not_active Expired - Fee Related
- 2002-07-02 EP EP02764615A patent/EP1404642B1/en not_active Expired - Lifetime
-
2004
- 2004-02-03 HR HR20040117A patent/HRP20040117A2/hr not_active Application Discontinuation
-
2007
- 2007-11-16 US US11/941,347 patent/US7504532B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PL367774A1 (en) | 2005-03-07 |
| HRP20040117A2 (en) | 2004-10-31 |
| EP1404642B1 (en) | 2010-02-17 |
| EP1404642A2 (en) | 2004-04-07 |
| ATE457972T1 (de) | 2010-03-15 |
| CA2453211A1 (en) | 2003-01-16 |
| US7504532B2 (en) | 2009-03-17 |
| CZ2004158A3 (cs) | 2005-01-12 |
| SK792004A3 (sk) | 2005-03-04 |
| US20080125601A1 (en) | 2008-05-29 |
| DK1404642T3 (da) | 2010-05-17 |
| WO2003004455A3 (en) | 2003-03-20 |
| US7317123B2 (en) | 2008-01-08 |
| DE60235365D1 (de) | 2010-04-01 |
| US20040242916A1 (en) | 2004-12-02 |
| AU2002328835A1 (en) | 2003-01-21 |
| IL159718A0 (en) | 2004-06-20 |
| JP2004533481A (ja) | 2004-11-04 |
| WO2003004455A2 (en) | 2003-01-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP0401006A2 (hu) | Eljárás 7-amino-szin-3,5-dihidroxi-heptánsav-származékok előállítására, ezek köztitermékei és módszerek az előállításukra | |
| AU2003247522A1 (en) | Methods for synthesis of acyloxyalkyl derivatives of gaba analogs | |
| WO2003084938A3 (en) | Pyrimidone derivatives useful for the treatment of inflammatin and immunological diseases | |
| IL214164A0 (en) | Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino 3,5-dihydroxy heptanoic acid derivatives, and intermediates thereof | |
| AU2002368505A1 (en) | Novel intermediates for synthesis of cephalosporins and process for preparation of such intermediates | |
| HUP0401014A2 (hu) | Eljárás 7-amino-szin-3,5-dihidroxi-heptánsavszármazékok előállítására, 6-ciano-szin-3,5-dihidroxi-hexánsav származékokon keresztül | |
| ZA200404752B (en) | 6-aminomorphinane derivatives method for the production and use thereof | |
| MXPA02009643A (es) | Sintesis acortada de derivados de 3,3-diarilpropilamina. | |
| AU2003249484A1 (en) | Novel bio-active molecules | |
| AU2003295061A1 (en) | Method of producing synthesis gas | |
| HUP0300231A3 (en) | Process for the preparation of high purity perindopril and intermediates useful in the synthesis, pharmaceutical compositions containing the compound and their use | |
| AU2003241060A1 (en) | New atorvastatin salts and pharmaceutical compositions containing them | |
| IL141212A0 (en) | Process for the synthesis of (1h)-benzo [c] quinolizin-3-one derivatives | |
| MY139289A (en) | Process for the synthesis of perindopril and pharmaceutically acceptable salts thereof | |
| AU2002247949A1 (en) | Process for synthesis of trans-alkenoic acid, use thereof | |
| HUP0401921A2 (hu) | Közbenső termékek mirtazapin előállítására és az előállításukra szolgáló eljárások | |
| AU2003290396A1 (en) | A method for the manufacture of lovastatin | |
| AU2003288252A1 (en) | Bacterial strains delftia acidovorans mc1-s, production and use thereof for the production of the s enantiomers of 2-phenoxypropionic acid derivatives | |
| NO20024999L (no) | Syntese av mellomprodukter for fremstilling av vitamin D- derivater | |
| WO2003045909A3 (en) | Methods and intermediates for the synthesis of azepines | |
| WO2001092251A3 (en) | Aryloxy ester and acid compounds | |
| EP1572615B8 (en) | Process for the synthesis of peptides containing a 4-hydorxy-proline substructure | |
| DE60324776D1 (de) | Verfahren zur synthese von pergolid | |
| TW200420552A (en) | Dihydro-furan-2-one derivatives, their intermediates and methods of manufacture | |
| MXPA04004537A (es) | Derivados de gabusectina, metodo para produccion de los mismos y uso de los mismos. |