HUP0303418A2 - Papilloma vírus inhibitorai - Google Patents

Papilloma vírus inhibitorai

Info

Publication number
HUP0303418A2
HUP0303418A2 HU0303418A HUP0303418A HUP0303418A2 HU P0303418 A2 HUP0303418 A2 HU P0303418A2 HU 0303418 A HU0303418 A HU 0303418A HU P0303418 A HUP0303418 A HU P0303418A HU P0303418 A2 HUP0303418 A2 HU P0303418A2
Authority
HU
Hungary
Prior art keywords
optionally
group
condensed
het
disubstituted
Prior art date
Application number
HU0303418A
Other languages
English (en)
Inventor
Nathalie Goudreau
Bruno Haché
Jeffrey O'meara
William W. Ogilvie
Peter White
Christiane Yoakim
Original Assignee
Boehringer Ingelheim (Canada) Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim (Canada) Ltd. filed Critical Boehringer Ingelheim (Canada) Ltd.
Publication of HUP0303418A2 publication Critical patent/HUP0303418A2/hu
Publication of HUP0303418A3 publication Critical patent/HUP0303418A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

A találmány az általános képletű vegyületekre - ahol A 5 vagy 6 tagúhomo- vagy 1-2 heteroatomot tartalmazó heterociklusos gyűrű; Xhidrogénatom és W hidroxicsoport; vagy X és W együtt karbonil- vagyepoxi-csoportot képez; R1 hidrogénatom vagy 1 vagy 2 szubsztituens; Yadott esetben mono- vagy diszubsztituált fenilcsoport, amely adottesetben egy telített vagy telítetlen 4-6-tagú gyűrűvel kondenzáltlehet; vagy Y egy vagy több heteroatomot tartalmazó, adott esetbenmono- vagy diszubsztituált heterociklus (Het), ahol Het adott esetbentelített vagy telítetlen 4-6-tagú gyűrűvel kondenzált lehet; vagy Yadott esetben mono- vagy diszubsztituált etilén-fenil- vagy etilén-Het-csoport, ahol az etilén adott esetben monoszubsztituált, és Hetadott esetben telített vagy telítetlen 4-6- tagú, adott esetbenheteroatomot tartalmazó gyűrűvel kondenzált lehet; R3 adott esetbenmono- vagy diszubsztituált alkil-, cikloalkil-, alkenil-, aril-,aralkil- vagy adott esetben kondenzált Het csoport; és R4karbonsavcsoport vagy sója vagy észtere - és enantiomereikre vagydiasztereoizomereikre, továbbá ezeket tartalmazó, papilloma vírusellen alkalmazható gyógyszerkészítményekre vonatkozik. Ó
HU0303418A 2000-12-18 2001-12-14 Inhibitors of papilloma virus HUP0303418A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25670600P 2000-12-18 2000-12-18
PCT/CA2001/001800 WO2002050082A2 (en) 2000-12-18 2001-12-14 Inhibitors of papilloma virus

Publications (2)

Publication Number Publication Date
HUP0303418A2 true HUP0303418A2 (hu) 2004-01-28
HUP0303418A3 HUP0303418A3 (en) 2007-05-02

Family

ID=22973265

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0303418A HUP0303418A3 (en) 2000-12-18 2001-12-14 Inhibitors of papilloma virus

Country Status (12)

Country Link
EP (1) EP1345943B1 (hu)
JP (1) JP4458745B2 (hu)
AT (1) ATE357447T1 (hu)
AU (1) AU2002218897A1 (hu)
CA (1) CA2430909C (hu)
DE (1) DE60127451T2 (hu)
ES (1) ES2282196T3 (hu)
HU (1) HUP0303418A3 (hu)
IL (1) IL156191A0 (hu)
MX (1) MXPA03005479A (hu)
NZ (1) NZ526978A (hu)
WO (1) WO2002050082A2 (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7167801B2 (en) 2001-07-12 2007-01-23 Boehringer Ingelheim (Canada) Ltd. Method of identifying potential inhibitors of human papillomavirus protein E2 using x-ray atomic coordinates
NZ535051A (en) * 2002-02-07 2006-04-28 Boehringer Ingelheim Ca Ltd E2 displacement assay for identifying inhibitors of HPV
DE602004025708D1 (de) * 2003-07-11 2010-04-08 Proteologics Inc Ubiquitin-ligase-hemmer und verwandte verfahren
WO2011133929A2 (en) * 2010-04-23 2011-10-27 University Of Rochester Reducing transmission of sexually transmitted infections
CN111606914B (zh) * 2019-02-22 2023-01-17 中国科学院昆明植物研究所 [吡咯并呋喃]-螺环茚酮类化合物及药物组合物和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4106283A1 (de) * 1991-02-28 1992-09-03 Boehringer Mannheim Gmbh Verwendung von tricyclischen isoindolinonen als antivirale arzneimittel, sowie neue optisch aktive isoindolinone
WO2000017206A1 (en) * 1998-09-18 2000-03-30 Cubist Pharmaceuticals, Inc. Tetracyclic heterocycles as antimicrobial agents

Also Published As

Publication number Publication date
JP2004515555A (ja) 2004-05-27
EP1345943B1 (en) 2007-03-21
DE60127451T2 (de) 2007-11-29
AU2002218897A1 (en) 2002-07-01
IL156191A0 (en) 2003-12-23
HUP0303418A3 (en) 2007-05-02
NZ526978A (en) 2005-12-23
WO2002050082A3 (en) 2002-12-19
WO2002050082A2 (en) 2002-06-27
ES2282196T3 (es) 2007-10-16
JP4458745B2 (ja) 2010-04-28
MXPA03005479A (es) 2004-05-31
DE60127451D1 (de) 2007-05-03
EP1345943A2 (en) 2003-09-24
CA2430909A1 (en) 2002-06-27
ATE357447T1 (de) 2007-04-15
CA2430909C (en) 2010-12-14

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