HUP0303110A2 - Szubsztituált 5-amino-1-penten-3-ol-származékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents

Szubsztituált 5-amino-1-penten-3-ol-származékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk

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Publication number
HUP0303110A2
HUP0303110A2 HU0303110A HUP0303110A HUP0303110A2 HU P0303110 A2 HUP0303110 A2 HU P0303110A2 HU 0303110 A HU0303110 A HU 0303110A HU P0303110 A HUP0303110 A HU P0303110A HU P0303110 A2 HUP0303110 A2 HU P0303110A2
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HU
Hungary
Prior art keywords
group
carbon atom
aryl
cycloalkyl
alkyl
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HU0303110A
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English (en)
Inventor
Helmut Buschmann
Boris Chizh
Michael Haurand
Utz-Peter Jagusch
Corinna Maul
Bernd Sundermann
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Grünenthal GmbH
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Publication date
Application filed by Grünenthal GmbH filed Critical Grünenthal GmbH
Publication of HUP0303110A2 publication Critical patent/HUP0303110A2/hu
Publication of HUP0303110A3 publication Critical patent/HUP0303110A3/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)

Abstract

A találmány (I) általános képletű szubsztituált 5-amino-1-penten-3-ol-származékokra vonatkozik - a képletben R1 és R2 1-6 szénatomosalkilcsoportot jelent, vagy együtt (CH2)2-9 csoportot alkothatnak, R3és R4 1-6 szénatomos alkil-, 3-6 szénatomos cikloalkil-, fenil-,benzil- vagy fenetilcsoportot jelent, vagy együtt CH2CH2OCH2CH2,CH2CH2NR22CH2CH2 vagy (CH2)3-6 csoportot alkothatnak, R5 1-10szénatomos alkil-, 3-9 szénatomos cikloaikil-, aril- vagy heteroaril-csoportot vagy a molekula többi részéhez 1-3 szénatomos alkilcsoportonkeresztül kapcsolódó 3-10 szénatomos cikloalkil-, aril- vagyheteroaril-csoportot jelent, R6 1-10 szénatomos alkil-, 5-7 szénatomoscikloalkil-; aril- vagy heteroaril-csoportot jelent, és R7hidrogénatomot vagy aril- vagy heteroaril-csoportot jelent, mimelletta felsorolt csoportok szubsztituálatlanok vagy egyszeresen vagytöbbszörösen szubsztituáltak lehetnek, és a szénhidrogéncsoportoktelítettek vagy telítetlenek lehetnek. A találmány kiterjed avegyületek előállítására, alkalmazására és a vegyületeket tartalmazógyógyszerkészítményekre is. Ó
HU0303110A 2000-09-30 2001-09-28 5-amino-1-pentene-3-ol substituted derivatives, process for their preparation and pharmaceutical compositions containing them and their use HUP0303110A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10048714A DE10048714A1 (de) 2000-09-30 2000-09-30 5-Amino-1-penlen-3-ol-Derivate
PCT/EP2001/011244 WO2002030869A1 (de) 2000-09-30 2001-09-28 Substituierte 5-amino-1-penten-3-ol-derivate

Publications (2)

Publication Number Publication Date
HUP0303110A2 true HUP0303110A2 (hu) 2004-03-01
HUP0303110A3 HUP0303110A3 (en) 2006-02-28

Family

ID=7658375

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0303110A HUP0303110A3 (en) 2000-09-30 2001-09-28 5-amino-1-pentene-3-ol substituted derivatives, process for their preparation and pharmaceutical compositions containing them and their use

Country Status (29)

Country Link
US (1) US6815443B2 (hu)
EP (1) EP1322590B1 (hu)
JP (1) JP2004511458A (hu)
KR (1) KR20030059161A (hu)
CN (1) CN1649826A (hu)
AR (1) AR034159A1 (hu)
AT (1) ATE361274T1 (hu)
AU (3) AU2002212263A1 (hu)
BR (1) BR0114459A (hu)
CA (1) CA2424103A1 (hu)
CY (1) CY1106712T1 (hu)
DE (2) DE10048714A1 (hu)
DK (1) DK1322590T3 (hu)
EC (1) ECSP034533A (hu)
ES (1) ES2286154T3 (hu)
HK (1) HK1053103A1 (hu)
HU (1) HUP0303110A3 (hu)
IL (1) IL155104A0 (hu)
MX (1) MXPA03002734A (hu)
MY (1) MY127328A (hu)
NO (1) NO20031388L (hu)
NZ (1) NZ525250A (hu)
PE (1) PE20020446A1 (hu)
PL (1) PL362398A1 (hu)
PT (1) PT1322590E (hu)
RU (1) RU2289571C2 (hu)
SK (1) SK286785B6 (hu)
WO (2) WO2002028816A1 (hu)
ZA (1) ZA200303301B (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10049483A1 (de) * 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte 1-Aminobutan-3-ol-Derivate
SI1471054T1 (sl) * 2002-01-11 2009-12-31 Daiichi Sankyo Co Ltd Amino alkoholni derivati ali derivati fosfoniäśne kisline in medicinski sestavki, ki vsebujejo le-te
BRPI0507944A (pt) 2004-02-24 2007-07-24 Sankyo Co composição farmacêutica
CN104521963A (zh) * 2014-12-31 2015-04-22 江阴苏利化学股份有限公司 一种含有环己酮的防治水稻二化螟的农药组合物
CN115745922B (zh) * 2022-11-22 2024-02-20 沈阳药科大学 藏东瑞香中的二芳基戊烷类化合物及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE239403C (hu)
NL6407943A (hu) * 1964-07-11 1966-01-12
CH500162A (de) * 1968-05-20 1970-12-15 Ankermann & Co Vitaminchemie F Verfahren zur Herstellung von D-4-Dimethylamino-3-methyl-1,2-diphenyl-2-butanol aus L-4-Dimethylamino-3-methyl-1,2-diphenyl-2-butanol
US3974157A (en) * 1974-03-04 1976-08-10 Pennwalt Corporation 1-(Amino-alkyl)-2-aryl-cyclohexane alcohols and esters
FR2559765B1 (fr) 1984-02-16 1986-06-13 Rhone Poulenc Sante Nouveaux derives de la phenyl-3 propene-2 amine, leur preparation et les medicaments qui les contiennent
GB2323594A (en) * 1997-03-25 1998-09-30 Victor Martin 2-amino-alkanoic acid derivatives, 2-amino alcohols and diamines
AU2463099A (en) * 1998-01-23 1999-08-09 Warner-Lambert Company Gabapentin and its derivatives for the treatment of muscular and skeletal pain
ID28972A (id) * 1998-07-09 2001-07-19 Warner Lambert Co Komposisi-komposisi yang terdiri dari analog-analog gaba dan suatu dekongestan untuk mengurangi sakit kepala sinus
CA2339273C (en) * 1998-09-14 2005-10-18 Warner-Lambert Company Branched alkyl pyrrolidine-3-carboxylic acids

Also Published As

Publication number Publication date
BR0114459A (pt) 2003-09-23
AR034159A1 (es) 2004-02-04
RU2289571C2 (ru) 2006-12-20
CA2424103A1 (en) 2003-03-28
WO2002030869A1 (de) 2002-04-18
AU2002221632B8 (en) 2006-05-18
JP2004511458A (ja) 2004-04-15
NO20031388L (no) 2003-05-22
MXPA03002734A (es) 2003-07-28
WO2002028816A1 (en) 2002-04-11
ECSP034533A (es) 2003-05-26
EP1322590A1 (de) 2003-07-02
CY1106712T1 (el) 2012-05-23
ES2286154T3 (es) 2007-12-01
US6815443B2 (en) 2004-11-09
AU2163202A (en) 2002-04-22
HUP0303110A3 (en) 2006-02-28
NZ525250A (en) 2005-11-25
DE10048714A1 (de) 2002-04-11
HK1053103A1 (zh) 2003-10-10
KR20030059161A (ko) 2003-07-07
AU2002221632B2 (en) 2006-04-27
PE20020446A1 (es) 2002-05-18
AU2002212263A1 (en) 2002-04-15
ATE361274T1 (de) 2007-05-15
MY127328A (en) 2006-11-30
PL362398A1 (en) 2004-11-02
PT1322590E (pt) 2007-05-31
IL155104A0 (en) 2003-10-31
CN1649826A (zh) 2005-08-03
SK286785B6 (sk) 2009-05-07
SK3392003A3 (en) 2003-09-11
NO20031388D0 (no) 2003-03-26
US20030220390A1 (en) 2003-11-27
EP1322590B1 (de) 2007-05-02
DK1322590T3 (da) 2007-09-03
DE50112454D1 (de) 2007-06-14
ZA200303301B (en) 2004-08-12

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